Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?
Open accessAbstract
BACKGROUND: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. METHODS: We performed a nested case-control study using prospective data from a population-based cohort comprising 11088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol at enrolment and spontaneous abortion were analysed by means of logistic regression. RESULTS: Compared with women with a pre-pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1.72 (1.00-2.96) for a pre-pregnancy intake on 75-300, 301-500, 501-900 and >900 mg caffeine per day respectively (P = 0.05 for trend). A pre-pregnancy intake of alcohol was not a predictor for spontaneous abortion. CONCLUSIONS: A high intake of caffeine prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas a low-to-moderate alcohol intake does not influence the risk.
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Studies on sporadic miscarriage have shown associations with smoking, alcohol and caffeine.
“Studies on sporadic miscarriage have shown associations with smoking, 25,158 alcohol 26,159 and caffeine.27,160,161”
From Recurrent MiscarriageGreen‐top Guideline No. 17 (2023) · cites this paper as [161]
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Cites
Maternal age and fetal loss: population based register linkage study
Andersen, A.-M. N. (2000) · BMJ · doi:10.1136/bmj.320.7251.1708 · Cited by 1,690 · cited 2× · see citing works
“Register as time of the spontaneous abortion minus 9 weeks or date of birth minus 40 weeks (Andersen et al., 2000).”
BackgroundMethodRetrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions
Boué, J., Boué, A., & Lazar, P. (1975) · Teratology · doi:10.1002/tera.1420120103 · Cited by 666 · see citing works
ALCOHOL, SMOKING, AND INCIDENCE OF SPONTANEOUS ABORTIONS IN THE FIRST AND SECOND TRIMESTER
Harlap, S., & Shiono, P. H. (1980) · The Lancet · doi:10.1016/s0140-6736(80)90061-6 · Cited by 367 · see citing works
Caffeine content of common beverages
BUNKER, M. L., & McWilliams, M. (1979) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)39775-9 · Cited by 302 · see citing works
Caffeine Intake and the Risk of First-Trimester Spontaneous Abortion
Cnattingius, S., Signorello, L. B., Annerén, G., Clausson, B., Ekbom, A., Ljunger, E., Blot, W. J., McLaughlin, J. K., Petersson, G., Rane, A., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432503 · Cited by 264 · see citing works
Cigarette, alcohol, and coffee consumption and spontaneous abortion.
Armstrong, B., McDonald, A. D., & Sloan, M. (1992) · American Journal of Public Health · doi:10.2105/ajph.82.1.85 · Cited by 212 · see citing works
MODERATE ALCOHOL INTAKE IN PREGNANCY AND THE RISK OF SPONTANEOUS ABORTION
Kesmodel, U. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.1.87 · Cited by 191 · see citing works
Moderate Maternal Alcohol Consumption and Risk of Spontaneous Abortion
Windham, G. C., Behren, J. V., Fenster, L., Schaefer, C. A., & Swan, S. H. (1997) · Epidemiology · doi:10.1097/00001648-199709000-00007 · Cited by 147 · see citing works
Maternal Serum Paraxanthine, a Caffeine Metabolite, and the Risk of Spontaneous Abortion
Klebanoff, M. A., Levine, R. J., DerSimonian, R., Clemens, J. D., & Wilkins, D. G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199911253412202 · Cited by 143 · see citing works
Moderate Caffeine Use and the Risk of Spontaneous Abortion and Intrauterine Growth Retardation
Mills, J. L. (1993) · JAMA · doi:10.1001/jama.1993.03500050071028 · Cited by 134 · see citing works
Outcome of pregnancy in relation to irregular and inconvenient work schedules.
Axelsson, G., Rylander, R., & Molin, I. (1989) · Occupational and Environmental Medicine · doi:10.1136/oem.46.6.393 · Cited by 130 · see citing works
Fernandes, O. A., Sabharwal, M., Smiley, T., Pastuszak, A. L., Koren, G., & Einarson, T. R. (1998) · Reproductive Toxicology · doi:10.1016/s0890-6238(98)00024-0 · Cited by 128 · see citing works
Fetal Loss Associated With Caffeine Intake Before and During Pregnancy
Infante‐Rivard, C. (1993) · JAMA · doi:10.1001/jama.1993.03510240052031 · Cited by 114 · see citing works
The Associations of Maternal Caffeine Consumption and Nausea with Spontaneous Abortion
Wen, W., Shu, X., Jacobs, D. R., & Brown, J. E. (2001) · Epidemiology · doi:10.1097/00001648-200101000-00008 · Cited by 90 · see citing works
Maternal Caffeine Consumption and Spontaneous Abortion
Dlugosz, L., Belanger, K. D., HELLENBRAND, K. G., Holford, T. R., Leaderer, B. P., & Bracken, M. B. (1996) · Epidemiology · doi:10.1097/00001648-199605000-00006 · Cited by 87 · see citing works
Caffeine Consumption during Pregnancy and Spontaneous Abortion
Fenster, L., Eskenazi, B., Windham, G. C., & Swan, S. H. (1991) · Epidemiology · doi:10.1097/00001648-199105000-00002 · Cited by 87 · see citing works
Caffeinated Beverages, Decaffeinated Coffee, and Spontaneous Abortion
Fenster, L., Hubbard, A., Swan, S. H., Windham, G. C., Waller, K., Hiatt, R. A., & Benowitz, N. L. (1997) · Epidemiology · doi:10.1097/00001648-199709000-00008 · Cited by 72 · see citing works
Spontaneous abortion in a hospital population: Are tobacco and coffee intake risk factors?
Rojas, V. D., de Juanes-Pardo, J. R., Astasio, P., Molina, P. O., & Gordillo-Florencio, E. (1994) · European Journal of Epidemiology · doi:10.1007/bf01719278 · Cited by 71 · see citing works
MATERNAL ALCOHOL CONSUMPTION AND SPONTANEOUS ABORTION
Abel, E. L. (1997) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008260 · Cited by 71 · see citing works
Registration of Diagnoses in the Danish National Registry of Patients
Jürgensen, H. J., Frølund, C., Gustafsen, J., Mosbech, H., Guldhammer, B., & Mosbech, J. (1986) · Methods of Information in Medicine · doi:10.1055/s-0038-1635466 · Cited by 56 · see citing works
Pregnancy: Alcohol and risk of spontaneous abortion
Parazzini, F., Tozzi, L., Chatenoud, L., Restelli, S., Luchini, L., & Vecchia, C. L. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138365 · Cited by 46 · cited 3× · see citing works
“, 1997) whereas the majority of European studies have shown no harmful effect (Grisso et al., 1984; Halmesmaki et al., 1989; Dominguez-Rojas et al., 1994; Parazzini et al., 1994; Cavallo et al., 1995; reviewed by Abel, 1997).”
Maternal and paternal alcohol consumption and miscarriage
HALMESMÄKl, E., ÄLIMÄKI, M., ROTNE, R., et al. (1989) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1989.tb01660.x · Cited by 44 · see citing works
CAFFEINE AND SPONTANEOUS ABORTION OF KNOWN KARYOTYPE
Kline, J. K., Levin, B. L., Silverman, J., Kinney, A. M., STEIN, Z. A., Susser, M. W., & Warburton, D. (1991) · Epidemiology · doi:10.1097/00001648-199111000-00004 · Cited by 42 · see citing works
Alcohol consumption and outcome of pregnancy.
Grisso, J. A., Roman, E., Inskip, H. M., et al. (1984) · Journal of Epidemiology & Community Health · doi:10.1136/jech.38.3.232 · Cited by 33 · see citing works
Fetal loss associated with caffeine intake before and during pregnancy
Infante‐Rivard, C. (1993) · JAMA · doi:10.1001/jama.270.24.2940 · Cited by 32 · see citing works
Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation
Mills, J. L. (1993) · JAMA · doi:10.1001/jama.269.5.593 · Cited by 30 · see citing works
Retrospective and Prospective Epidemiological Studies of 1500 Karyotyped Spontaneous Human Abortions
Boué, J., Boué, A., & Lazar, P. (1975) · Springer eBooks · doi:10.1007/978-94-011-6621-8_14 · Cited by 28 · see citing works
Epidemiology of spontaneous abortions: the effects of alcohol consumption and cigarette smoking.
Anokute, C. C. (1986) · PubMed · Cited by 25 · see citing works
MODERATE ALCOHOL CONSUMPTION AND SPONTANEOUS ABORTION
Cavallo, F., Russo, R. L., Zotti, C. M., et al. (1995) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a045714 · Cited by 25 · see citing works
Chen, Y. A., Lin, H., & Chou, P. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960301)65:5 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- National Board of Health (1993) Evaluation of the Danish Hospital Discharge Register 1990. Copenhagen, Denmark, pp. 1±72.
Cited by
Sorted by citations
Homan, G. F., Davies, M., & Norman, R. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml056 · Cited by 546 · see citing works
Coffee and fetal death: a cohort study with prospective data
Bech, B. H., Nohr, E. A., Vaeth, M., Henriksen, T. B., & Olsen, J. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi317 · Cited by 202 · see citing works
Sengpiel, V., Elind, E., Bacelis, J., Nilsson, S., Grove, J., Myhre, R., Haugen, M., Meltzer, H. M., Alexander, J., Jacobsson, B., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-42 · Cited by 190 · see citing works
Lassi, Z. S., Imam, A. M., Dean, S. V., & Bhutta, Z. A. (2014) · Reproductive Health · doi:10.1186/1742-4755-11-s3-s6 · Cited by 186 · see citing works
Nutritional management in women with polycystic ovary syndrome: A review study.
Faghfoori, Z., Fazelian, S., Shadnoush, M., & Goodarzi, R. (2017) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2017.03.030 · Cited by 153 · see citing works
Recurrent MiscarriageGreen‐top Guideline No. 17
Regan, L., Rai, R., Saravelos, S., Li, T., & the Royal College of Obstetricians and Gynaecologists (2023) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17515 · Cited by 158 · see citing works
Chen, L.-W., Wu, Y., Neelakantan, N., Chong, M. F.-F., Pan, A., & van Dam, R. M. (2016) · Public Health Nutrition · doi:10.1017/s1368980015002463 · Cited by 100 · see citing works
Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
Ng, K. Y. B., Cherian, G., Kermack, A. J., Bailey, S., Macklon, N., Sunkara, S. K., & Cheong, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-86445-2 · Cited by 72 · see citing works
Caffeine intake during pregnancy, late miscarriage and stillbirth
Greenwood, D. C., Alwan, N., Boylan, S., Cade, J. E., Charvill, J., Chipps, K. C., Cooke, M. S., Dolby, V. A., Hay, A. W. M., Kassam, S., et al. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9443-7 · Cited by 74 · see citing works
Maternal smoking predicts the risk of spontaneous abortion
Nielsen, A., Gerd Hannibal, C., Eriksen Lindekilde, B., Tolstrup, J., Frederiksen, K., Munk, C., Bergholt, T., Buss, L., Ottesen, B., Grønbaek, M., et al. (2006) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1080/00016340600589560 · Cited by 73 · see citing works
Self-citationVolume and type of alcohol during early pregnancy and the risk of miscarriage
Avalos, L. A., Roberts, S. C., Kaskutas, L. A., Block, G., & Li, D.-K. (2014) · Substance Use & Misuse · doi:10.3109/10826084.2014.912228 · Cited by 59 · see citing works
Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion
Gaskins, A. J., Rich-Edwards, J. W., Williams, P. L., Toth, T. L., Missmer, S. A., & Chavarro, J. E. (2018) · European Journal of Nutrition · doi:10.1007/s00394-016-1301-2 · Cited by 55 · see citing works
Leviton, A. (2018) · Nutrients · doi:10.3390/nu10091152 · Cited by 27 · see citing works
- Authors
- Tolstrup, J. S.
- Affiliations
- Copenhagen University Hospital (DK)
- Corresponding author
- Tolstrup, J.S.
- ORCID
- Tolstrup, J.S.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-01
- Volume
- 18
- Issue
- 12
- Pages
- 2704-2710
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W1978320076
- Cited by
- 87
- References
- 30
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 8 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 2
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion, other-oa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- caffeine consumption, alcohol consumption, miscarriage, pregnancy outcomes, fetal viability, miscarriage risk factors
- MeSH terms
- Abortion, Spontaneous, Adult, Ethanol, Caffeine, Female, Humans, Pregnancy, Prospective Studies, Cohort Studies, Logistic Models, Odds Ratio, Case-Control Studies, Preconception Care
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