Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis

González-Ramos, Reinaldo; Van Langendonckt, Anne; Defrère, Sylvie; Lousse, Jean-Christophe; Colette, Sebastien; Devoto, Luigi; Donnez, Jacques

doi:10.1016/j.fertnstert.2010.01.013

Cited by 179Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementDiagnosis and treatment of tuberculosis

Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis

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González-Ramos, Reinaldo, Van Langendonckt, Anne, Defrère, Sylvie, Lousse, Jean-Christophe, Colette, Sebastien, Devoto, Luigi, Donnez, Jacques·2010·Fertility and Sterility

DOI 10.1016/j.fertnstert.2010.01.013

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Abstract

Objective To evaluate the role of nuclear factor-κB (NF-κB) in the pathogenesis of endometriosis.Design A literature search was conducted in PubMed to identify all relevant citations.Result(s) Our findings highlight the important role of NF-κB in the pathophysiology of endometriosis. In vitro and in vivo studies show that NF-κB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells. Constitutive activation of NF-κB has been demonstrated in endometriotic lesions and peritoneal macrophages of endometriosis patients. Agents blocking NF-κB are effective inhibitors of endometriosis development and some drugs with known NF-κB inhibitory properties have proved efficient at reducing endometriosis-associated symptoms in women. Iron overload activates NF-κB in macrophages. NF-κB activation in macrophages and ectopic endometrial cells stimulates synthesis of proinflammatory cytokines, generating a positive feedback loop in the NF-κB pathway and promoting endometriotic lesion establishment, maintenance and development.Conclusion(s) NF-κB transcriptional activity modulates key cell processes contributing to the initiation and progression of endometriosis. Because endometriosis is a multifactorial disease, inhibiting NF-κB appears to be a promising strategy for future therapies targeting different cell functions involved in endometriosis development, such as cell adhesion, invasion, angiogenesis, inflammation, proliferation, and apoptosis. Upcoming research will elucidate these hypotheses.

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Proinflammatory factors (heme, iron) and cytokines (TNFα, IL1β) may disrupt PR function and play a role in progesterone resistance, leading to increased NF-kB activity involved in endometriosis development.
“Proinflammatory factors (like heme and iron) and cytokines (like tumor necrosis factor-alpha (TNFα) and interleukin 1 beta (IL1β)) may also disrupt PR function and play a role in progesterone resistance which finally leads to increased nuclear factor kappa B (NF-kB) activity, which is involved in endometriosis development [27,33,34].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [34]
Human epithelial and stromal endometrial cells express NF-kB proteins.
“Human epithelial and stromal endometrial cells express nuclear factor-kappa B (NF-kB) proteins; NF-kB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells.63”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [63]
NF-kB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells.
“Human epithelial and stromal endometrial cells express nuclear factor-kappa B (NF-kB) proteins; NF-kB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells.63”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [63]

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Authors: González-Ramos, R., Van Langendonckt, A., Defrère, S., Lousse, J.-C., Colette, S., Devoto, L., & Donnez, J.
Affiliations: Hospital San Borja Arriarán (CL)
UCLouvain (BE)
Corresponding author: González-Ramos, Reinaldo
ORCID: Donnez, Jacques
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2010-11
Volume: 94
Issue: 6
Pages: 1985-1994
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2010.01.013
OpenAlex: W2035214296
Cited by: 179
References: 169
Citations by year: 2026: 7 · 2025: 11 · 2024: 14 · 2023: 13 · 2022: 12 · 2021: 22 · 2020: 6 · 2019: 13 · 2018: 13 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 14
FWCI: 1.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4225 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Americanae (AECID Library) (submittedVersion, other-oa)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
Keywords: endometriosis, nuclear factor-kappaB, NF-κB signaling, endometriosis pathogenesis, inflammation, angiogenesis, cell invasion, cell proliferation, apoptosis, peritoneal macrophages, iron overload, inflammatory cytokines, NF-κB inhibitors, endometriotic lesions
MeSH terms: Animals, Endometriosis, Female, Humans, Inflammation, Models, Biological, Uterine Diseases, Signal Transduction, NF-kappa B

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Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis

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