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Cited by 159Cytomegalovirus and herpesvirus researchAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease

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Lurain, Nell S., Hanson, Barbara A., Martinson, Jeffrey, Leurgans, Sue E., Landay, Alan L., Bennett, David A., Schneider, Julie A.·2013·The Journal of Infectious Diseases
DOI 10.1093/infdis/jit210PMC PMC3719902
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Abstract

Serum, cerebrospinal fluid (CSF), and cryopreserved lymphocytes from subjects in the Rush Alzheimer's Disease Center Religious Orders Study were analyzed for associations between cytomegalovirus (CMV) infection and clinical and pathological markers of Alzheimer disease. CMV antibody levels were associated with neurofibrillary tangles (NFTs). CSF interferon γ was only detected in seropositive subjects and was significantly associated with NFTs. The percentage of senescent T cells (CD4+ or CD8+CD28-CD57+) was significantly higher for CMV-seropositive as compared to CMV-seronegative subjects and was marginally associated with the pathologic diagnosis of Alzheimer disease (CD4+) or amyloid-β (CD8+). Immunocytochemical analysis showed induction of amyloid-β in human foreskin fibroblasts (HFFs) infected with each of 3 clinical CMV strains. In the same subjects, there was no association of herpes simplex virus type 1 (HSV-1) antibody levels with CMV antibody levels or clinical or pathological markers of Alzheimer disease. HSV-1 infection of HFFs did not induce amyloid-β. These data support an association between CMV and the development of Alzheimer disease.

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  • In the Religious Orders Study, CMV antibody levels were related to higher immunologic biomarkers and post-mortem AD markers.

    “In the Religious Orders Study among clergy in the United States [56], for example, CMV antibody levels were related to higher immunologic biomarkers and post-mortem AD markers.”

    From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [56]

    The Serum IgG section (page not supplied) reports that CMV antibody levels were significantly associated with neurofibrillary-tangle density, a post-mortem Alzheimer disease marker. The Discussion reports an association between CMV seropositivity and CSF interferon-γ, but does not establish that higher antibody levels were related to higher immunologic biomarkers. The study used Religious Orders Study specimens. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Lurain, N. S., Hanson, B. A., Martinson, J., Leurgans, S. E., Landay, A. L., Bennett, D. A., & Schneider, J. A.
Affiliations
Rush University Medical Center (US)
Corresponding author
Lurain, Nell S.
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2013-05-09
Volume
208
Issue
4
Pages
564-572
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/jit210
PMC
PMC3719902
OpenAlex
W2151190343
Cited by
159
References
4
Citations by year
2026: 10 · 2025: 9 · 2024: 12 · 2023: 7 · 2022: 10 · 2021: 19 · 2020: 16 · 2019: 8 · 2018: 13 · 2017: 10 · 2016: 12 · 2015: 14 · 2014: 10 · 2013: 9
FWCI
10.95
Type
journal article
Language
en
Open access
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (P30-AG 10161, R01 AG15819, R01AG015819, P30AG010161)
Topics
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
human cytomegalovirus, Alzheimer's disease, neurofibrillary tangles, interferon-gamma, cerebrospinal fluid, senescent T cells, CD4+ T cells, amyloid-beta, herpes simplex virus type 1, viral infection, Religious Orders Study, CMV seropositivity
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Antibodies, Viral, Cytomegalovirus Infections, Female, Fibroblasts, Humans, Interferon-gamma, Male, T-Lymphocyte Subsets, Amyloid beta-Peptides, Neurofibrillary Tangles

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