The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years
Open accessAbstract
OBJECTIVES: To examine whether cytomegalovirus (CMV) and herpes simplex virus type‐1 (HSV‐1) are associated with cognitive decline over a 4‐year period and to assess whether C‐reactive protein (CRP) modifies these relationships. DESIGN: Prospective cohort study over a 4‐year period. SETTING: Community‐dwelling elderly population. PARTICIPANTS: The sample was a subset (1,204/1,789) of participants in the Sacramento Area Latino Study on Aging (SALSA) aged 60 to 100. MEASUREMENTS: Participants were screened annually over a 4‐year period for cognitive function and episodic memory. Cognitive function was assessed using the modified Mini‐Mental State Examination, and episodic memory was assessed using a word list‐learning test of delayed recall. Baseline serum samples were assayed for levels of immunoglobulin G antibodies to CMV and HSV‐1 and for levels of CRP. RESULTS: There was a significantly higher rate of cognitive decline over the 4‐year period in subjects with the highest CMV antibody levels at baseline than in individuals with the lowest levels (β=−0.053, standard error =0.018; P =.003), after controlling for age, sex, education, income, and chronic health conditions. There was no association between HSV‐1 antibody levels and cognitive decline. CRP did not modify the relationship between viral antibody levels and cognitive decline. CONCLUSION: This is the first study to show that individuals with higher levels of antibody to CMV experience a more‐rapid rate of cognitive decline than those with lower levels. Understanding the mechanisms by which CMV influences cognition may aid development of intervention strategies targeting infection, viral reactivation, and immune response over the life course.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In older participants of Latin American descent in the SALSA study, those with the highest CMV antibody levels had more cognitive decline relative to the lowest levels.
“Similarly, in older participants of Latin American descent in the SALSA study in the United States [55], those with the highest CMV antibody levels had more cognitive decline relative to the lowest levels.”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [55]
Mechanisms underlying viral pathogenesis in these conditions may include a direct viral effect or indirect mechanisms, such as inflammation, epigenetic changes, and hypercoagulable changes, that may impact brain structure and function in healthy or cognitively impaired individuals.
“Mechanisms underlying viral pathogenesis in these conditions may include a direct viral effect or indirect mechanisms, such as inflammation, epigenetic changes, and hypercoagulable changes, that may impact on brain structure and function in healthy or in cognitively impaired individuals [6, 11–15].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [12]
The interaction between viral presence and AD may also operate through a specific mechanism within the core pathogenesis, hastening amyloid overproduction.
“This interaction may also operate through a specific mechanism within the core pathogenesis, hastening amyloid overproduction [10, 12].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [12]
According to the viral hypothesis of AD, the interaction between viral presence and AD may be non-specifically associated with up-regulation of inflammatory responses and oxidative stress.
“According to the ‘viral hypothesis of AD’, this interaction may be non-specifically associated with up-regulation of inflammatory responses and oxidative stress, which are secondary, but relevant components of the amyloid cascade.”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Linear Mixed Models for Longitudinal Data
Verbeke, G. (1997) · Lecture Notes in Statistics · doi:10.1007/978-1-4612-2294-1_3 · Cited by 3,506 · see citing works
Linear Mixed Models for Longitudinal Data
Molenberghs, G., & Verbeke, G. N. (2000) · Springer series in statistics · doi:10.1007/978-1-4419-0300-6 · Cited by 2,681 · see citing works
Two Shorter Forms of the CES-D Depression Symptoms Index
Kohout, F. J., Berkman, L. F., Evans, D. A., & Cornoni‐Huntley, J. C. (1993) · Journal of Aging and Health · doi:10.1177/089826439300500202 · Cited by 2,292 · see citing works
Inflammatory mediators in the elderly
Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works
Individual differences in rates of change in cognitive abilities of older persons.
Wilson, R. S., Beckett, L. A., Barnes, L. L., Schneider, J. A., Bach, J., Evans, D. A., & Bennett, D. A. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.2.179 · Cited by 842 · see citing works
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754 · see citing works
Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan
Tang, M. ‐., Cross, P. S., Andrews, H., Jacobs, D. M., Small, S. A., Bell, K., Merchant, C., Lantigua, R., Costa, R., Stern, Y., et al. (2001) · Neurology · doi:10.1212/wnl.56.1.49 · Cited by 721 · see citing works
Inflammatory markers and cognition in well-functioning African-American and white elders
Yaffe, K., Lindquist, K., Penninx, B. W., Simonsick, E. M., Pahor, M., Kritchevsky, S., Launer, L., Kuller, L., Rubin, S., & Harris, T. (2003) · Neurology · doi:10.1212/01.wnl.0000073620.42047.d7 · Cited by 706 · see citing works
Herpes simplex virus type 1 in brain and risk of Alzheimer's disease
Itzhaki, R. F., Lin, W., Shang, D., Wilcock, G. K., Faragher, B. E., & Jamieson, G. A. (1997) · The Lancet · doi:10.1016/s0140-6736(96)10149-5 · Cited by 671 · see citing works
The US economic and social costs of Alzheimer's disease revisited.
Ernst, R. L., & Hay, J. W. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.8.1261 · Cited by 593 · see citing works
Notes on the use of data transformations
Osborne, J. W. (2020) · ScholarWorks@UMassAmherst (University of Massachusetts Amherst) · doi:10.7275/4vng-5608 · Cited by 587 · see citing works
Predictors of cognitive decline and mortality of aged people over a 10‐year period
Tilvis, R. S., Kahonen-Vare, M. H., Jolkkonen, J., Valvanne, J., Pitkala, K. H., & Strandberg, T. E. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m268 · Cited by 578 · see citing works
Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging
Weaver, J. D., Huang, M.-H., Albert, M., Harris, T., Rowe, J. W., & Seeman, T. E. (2002) · Neurology · doi:10.1212/wnl.59.3.371 · Cited by 536 · see citing works
Sero-epidemiological and -sociological patterns of herpes simplex virus infection in the world.
Nahmias, A. J., Lee, F. K., & Beckman-Nahmias, S. (1990) · PubMed · Cited by 531 · see citing works
Widener, R. W., & Whitley, R. J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53488-0.00011-0 · Cited by 479 · see citing works
Risk Factors for Delirium in Hospitalized Elderly
Schor, J. D. (1992) · JAMA · doi:10.1001/jama.1992.03480060073033 · Cited by 471 · see citing works
Haan, M. N., Mungas, D. M., Gonzalez, H. M., Ortiz, T. A., Acharya, A., & Jagust, W. J. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51054.x · Cited by 420 · see citing works
Self-citationThe risk of dementia and death after delirium
Rockwood, K. J. (1999) · Age and Ageing · doi:10.1093/ageing/28.6.551 · Cited by 410 · see citing works
Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407 · see citing works
Ritchie, K. A., & Lovestone, S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11667-9 · Cited by 386 · see citing works
Almanzar, G., Schwaiger, S., Jenewein, B., Keller, M., Herndler‐Brandstetter, D., Würzner, R., Schönitzer, D., & Grubeck‐Loebenstein, B. (2005) · Journal of Virology · doi:10.1128/jvi.79.6.3675-3683.2005 · Cited by 356 · see citing works
Trzonkowski, P., Myśliwska, J. M., Szmit, E., Wickiewicz, J., Łukaszuk, K., Brydak, L. B., Machała, M. K., & Myśliwski, A. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00309-8 · Cited by 341 · see citing works
Depressive Symptoms and Cognitive Decline in Late Life: A Prospective Epidemiological Study
Ganguli, M., Du, Y., Dodge, H. H., Ratcliff, G. G., & Chang, C.-C. H. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.153 · Cited by 314 · see citing works
Acute Delirium and Functional Decline in the Hospitalized Elderly Patient
Murray, A. M., Levkoff, S. E., Wetle, T. T., Beckett, L. A., Cleary, P. D., Schor, J. D., Lipsitz, L. A., Rowe, J. W., & Evans, D. A. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.5.m181 · Cited by 294 · see citing works
Inflammation, Depressive Symptomatology, and Coronary Artery Disease
Appels, A., Bär, F. W. H. M., Bär, J., Bruggeman, C., & de Baets, A. M. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200009000-00001 · Cited by 270 · see citing works
Depressive Symptomatology and Incident Cognitive Decline in an Elderly Community Sample
Bassuk, S. S., Berkman, L. F., & Wypij, D. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.12.1073 · Cited by 264 · see citing works
Is immunosenescence infectious?
Pawelec, G., Akbar, A. N., Caruso, C., Effros, R. B., Grubeck‐Loebenstein, B., & Wikby, A. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.05.006 · Cited by 260 · see citing works
Biondi, M., & Zannino, L.-G. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000289101 · Cited by 255 · see citing works
Xu, F., Schillinger, J. A., Sternberg, M., Johnson, R. E., Lee, F. K., Nahmias, A. J., & Markowitz, L. E. (2002) · The Journal of Infectious Diseases · doi:10.1086/340041 · Cited by 253 · see citing works
Role of Cytomegalovirus in the T Cell Changes Seen in Elderly Individuals
Looney, R. J., Falsey, A. R., Campbell, D., Torres, A., Kolassa, J. E., Brower, C., McCann, R. M., Menegus, M. A., McCormick, K., Frampton, M. W., et al. (1999) · Clinical Immunology · doi:10.1006/clim.1998.4638 · Cited by 243 · see citing works
The Costs of Caring: Impact of Dementia on Family Caregivers
Connell, C. M., Janevic, M. R., & Gallant, M. P. (2001) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198870101400403 · Cited by 241 · see citing works
Schmaltz, H. N., Fried, L. P., Xue, Q., Walston, J. D., Leng, S. X., & Semba, R. D. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53250.x · Cited by 240 · see citing works
Ouyang, Q., Wagner, W. M., Wikby, A., Walter, S., Aubert, G., Dodi, A. I., Travers, P. J., & Pawelec, G. (2003) · Journal of Clinical Immunology · doi:10.1023/a:1024580531705 · Cited by 239 · see citing works
Reactivation and Shedding of Cytomegalovirus in Astronauts during Spaceflight
Mehta, S. K., Stowe, R. P., Feiveson, A. H., Tyring, S. K., & Pierson, D. L. (2000) · The Journal of Infectious Diseases · doi:10.1086/317624 · Cited by 223 · see citing works
Inflammation markers in relation to cognition in a healthy aging population
Teunissen, C. E., van Boxtel, M. P. J., Bosma, H., Bosmans, E., Delanghe, J., Bruijn, C. D., Wauters, A., Maes, M. H. J., Jolles, J., Steinbusch, H. W. M., et al. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00398-3 · Cited by 220 · see citing works
Stress-related activation of Epstein-Barr virus
Glaser, R., Pearson, G. R., Jones, J. F., Hillhouse, J., Kennedy, S., Mao, H., & Kiecolt-Glaser, J. K. (1991) · Brain Behavior and Immunity · doi:10.1016/0889-1591(91)90018-6 · Cited by 206 · see citing works
Age-related neuropathology, cognitive decline, and Alzheimer's disease.
Keller, J. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2005.06.002 · Cited by 188 · see citing works
Infiltration of the brain by pathogens causes Alzheimer’s disease
Itzhaki, R. F., Wozniak, M. A., Appelt, D. M., & Balin, B. J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.021 · Cited by 188 · see citing works
Herpesviruses in brain and Alzheimer's disease
Lin, W., Wozniak, M. A., Cooper, R. J., Wilcock, G. K., & Itzhaki, R. F. (2002) · The Journal of Pathology · doi:10.1002/path.1127 · Cited by 187 · see citing works
Dysfunctional CMV-specific CD8+ T cells accumulate in the elderly
Ouyang, Q., Wagner, W. M., Zheng, W., Wikby, A., Remarque, E. J., & Pawelec, G. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.016 · Cited by 179 · see citing works
Chronic stress modulates the virus-specific immune response to latent herpes simplex virus Type 1
Glaser, R., & Kiecolt‐Glaser, J. K. (1997) · Annals of Behavioral Medicine · doi:10.1007/bf02883323 · Cited by 173 · see citing works
Jamieson, G. A., Maitland, N. J., Wilcock, G. K., Yates, C. M., & Itzhaki, R. F. (1992) · The Journal of Pathology · doi:10.1002/path.1711670403 · Cited by 172 · see citing works
Summary of the II International Symposium on Cytomegalovirus
de Jong, M. D., Galasso, G. J., Gazzard, B., Griffiths, P., Jabs, D. A., Kern, E. R., & Spector, S. A. (1998) · Antiviral Research · doi:10.1016/s0166-3542(98)00044-8 · Cited by 169 · see citing works
Functions of lipoprotein receptors in neurons
Beffert, U., Stolt-Bergner, P. C., & Herz, J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300017-jlr200 · Cited by 156 · see citing works
Nakayama, T., Sonoda, S., Urano, T., Yamada, T., & Okada, M. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.2.293 · Cited by 149 · see citing works
Incidence and prevalence of dementia in a multiethnic cohort of municipal retirees
Perkins, P. C., Annegers, J. F., Doody, R. S., Cooke, N., Aday, L. A., & Vernon, S. W. (1997) · Neurology · doi:10.1212/wnl.49.1.44 · Cited by 146 · see citing works
Herpesviruses in brains in Alzheimer's and Parkinson's diseases
Hemling, N., Röyttä, M., Rinne, J. O., Pöllänen, P., Broberg, E., Tapio, V., Vahlberg, T. J., & Hukkanen, V. (2003) · Annals of Neurology · doi:10.1002/ana.10662 · Cited by 142 · see citing works
Strandberg, T. E., Pitkälä, K. H., Linnavuori, K. H., & Tilvis, R. S. (2003) · Stroke · doi:10.1161/01.str.0000086754.32238.da · Cited by 134 · see citing works
Iwamoto, N., Nishiyama, E., Ohwada, J., & Arai, H. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90035-3 · Cited by 129 · see citing works
Distress proneness and cognitive decline in a population of older persons
Wilson, R. S., Bennett, D. A., de Leon, C. F. M., Bienias, J. L., Morris, M. C., & Evans, D. A. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.04.005 · Cited by 129 · see citing works
C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease
Duong, T., Nikolaeva, M. A., & Acton, P. J. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01359-5 · Cited by 127 · see citing works
Earlier Onset of Alzheimer Disease Symptoms in Latino Individuals Compared With Anglo Individuals
Clark, C. M., DeCarli, C. S., Mungas, D., Chui, H., Higdon, R., Nuñez, J., Fernandez, H., Negrón, M., Manly, J. J., Ferris, S. H., et al. (2005) · Archives of Neurology · doi:10.1001/archneur.62.5.774 · Cited by 127 · see citing works
Itzhaki, R. F., & Wozniak, M. A. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.003 · Cited by 100 · see citing works
Changes in the immune system in depression and dementia: causal or co‐incidental effects?
Leonard, B. E. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(01)00014-4 · Cited by 91 · see citing works
Nilsson, B.-O., Ernerudh, J., Johansson, B. E. A., Evrin, P., Löfgren, S., Ferguson, F. G., & Wikby, A. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00024-1 · Cited by 87 · see citing works
Correlations between serum amyloid A protein and C-reactive protein in infectious diseases
Lannergård, A., Larsson, A., Kragsbjerg, P., & Friman, G. (2003) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510310001636 · Cited by 79 · see citing works
Stress-associated immunomodulation and herpes simplex virus infections
Sáinz, B., Loutsch, J. M., Marquart, M. E., & Hill, J. M. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1219 · Cited by 78 · see citing works
Cytomegalovirus Is Present in a Very High Proportion of Brains from Vascular Dementia Patients
Lin, W., Wozniak, M. A., Wilcock, G. K., & Itzhaki, R. F. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0465 · Cited by 72 · see citing works
Human herpes virus infections and Alzheimer's disease
Deatly, A. M., Haase, A. T., Fewster, P. H., LEWIS, E., & Ball, M. J. (1990) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1990.tb01158.x · Cited by 70 · see citing works
Ringheim, G. E., & Conant, K. E. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.013 · Cited by 68 · see citing works
The in vitro neuronal toxicity of pentraxins associated with Alzheimer's disease brain lesions.
Duong, T., Acton, P., & Johnson, R. A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00966-4 · Cited by 59 · see citing works
Baldwin, S. J. (2015) · Routledge eBooks · doi:10.4324/97813156684406 · Cited by 57 · see citing works
Accuracy of early diagnosis and its impact on the management and course of Alzheimer’s disease
Chang, C. Y., & Silverman, D. H. S. (2004) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.4.1.63 · Cited by 52 · see citing works
Pulliam, L., Moore, D., & West, D. C. (1995) · Journal of NeuroVirology · doi:10.3109/13550289509113968 · Cited by 48 · see citing works
Prevalence of Cytomegalovirus Antibody in Subjects Between the Ages of 6 and 22 Years
White, N. H., Yow, M. D., Demmler, G. J., Norton, H. J., Hoyle, J., Pinckard, K., Mishaw, C. O., & Pokorny, S. F. (1989) · The Journal of Infectious Diseases · doi:10.1093/infdis/159.6.1013 · Cited by 46 · see citing works
Alzheimer's disease, herpes simplex virus type 1, cold sores and apolipoprotein E4
Lin, W., Shang, D., Wilcock, G. K., & Itzhaki, R. F. (1995) · Biochemical Society Transactions · doi:10.1042/bst023594s · Cited by 43 · see citing works
Rothenbacher, D., Brenner, H., Hoffmeister, A., Mertens, T., Persson, K., & Köenig, W. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00300-9 · Cited by 37 · see citing works
Herpes simplex virus and risk of Alzheimer's disease.
Itabashi, S., Arai, H., Matsui, T., Higuchi, S., & Sasaki, H. (1997) · The Lancet · doi:10.1016/s0140-6736(05)62325-2 · Cited by 35 · see citing works
Ravaglia, G., Forti, P., Maioli, F., Arnone, G., Pantieri, G., Cocci, C., Nativio, V., Muscari, A., Pedone, V., & Mariani, E. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000072815 · Cited by 29 · see citing works
Neurotropic viruses and Alzheimer disease
Lin, W.-R., Shang, D., & Itzhaki, R. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815215 · Cited by 28 · see citing works
Overview of infections and cardiovascular diseases☆☆☆
Vercellotti, G. M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.117976 · Cited by 28 · see citing works
Human cytomegalovirus salivary antibodies as related to stress.
Sarid, O., Anson, O., Yaari, A., & Margalith, M. (2002) · PubMed · Cited by 27 · see citing works
Goade, D., Nofchissey, R. A., Kusewitt, D. F., Hjelle, B. L., Kreisel, J., Moore, J., & Lyons, C. R. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740108uliria2.0.co2 · Cited by 24 · see citing works
Depression as a risk factor for later dementia: a robust relationship?
Mitchell, A. J. (2005) · Age and Ageing · doi:10.1093/ageing/afi078 · Cited by 19 · see citing works
Inflammatory Proteins in Plasma and the Risk of Dementia: The Rotterdam Study
Engelhart, M. J., Geerlings, M. I., Meijer, J., Kiliaan, A., Ruitenberg, A., van Swieten, J. C., Stijnen, T., Hofman, A., Witteman, J. C. M., & Breteler, M. M. B. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.668 · Cited by 10 · see citing works
Hyams, K. C., Cross, E. R., Bianco, M. A., Soyk‐Sarty, D. R., Roper, C., Dahut, W. L., & Holmberg, J. A. (1992) · Transfusion · doi:10.1046/j.1537-2995.1992.32792391038.x · Cited by 10 · see citing works
Earlier Alzheimer Onset in Latino Persons: Ethnic Difference vs Selection Bias
Ringman, J. M., & Flores, D. L. (2005) · Archives of Neurology · doi:10.1001/archneur.62.11.1786-c · Cited by 9 · see citing works
The Terms Latino and Anglo and Tendency to Early Alzheimer Disease
Rivera, V. M. (2005) · Archives of Neurology · doi:10.1001/archneur.62.11.1787-a · Cited by 2 · see citing works
Flagged first, then by citations
3 of the 81 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Simanek, A. M., Dowd, J. B., Pawelec, G., Melzer, D. R., Dutta, A., & Aiello, A. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016103 · Cited by 398 · see citing works
Self-citationRoberts, E. T., Haan, M. N., Dowd, J. B., & Aiello, A. E. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq177 · Cited by 281 · see citing works
Self-citationHarris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279 · see citing works
Wang, G. C., Kao, W. H. L., Murakami, P. N., Xue, Q., Chiou, R. B., Detrick, B., McDyer, J. F., Semba, R. D., Casolaro, V., Walston, J. D., et al. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq062 · Cited by 266 · see citing works
Letenneur, L., Pérès, K., Fleury, H., Garrigue, I., Barberger-Gateau, P., Helmer, C., Orgogozo, J.-M., Gauthier, S., & Dartigues, J.-F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003637 · Cited by 252 · see citing works
When aging reaches CD4+ T-cells: phenotypic and functional changes
Moro‐García, M. A. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00107 · Cited by 212 · see citing works
DOWD, J. B., AIELLO, A. E., & ALLEY, D. E. (2009) · Epidemiology and Infection · doi:10.1017/s0950268808000551 · Cited by 210 · see citing works
Self-citationHerpes virus in Alzheimer's disease: relation to progression of the disease
Carbone, I., Lazzarotto, T., Ianni, M., Porcellini, E., Forti, P., Masliah, E., Gabrielli, L., & Licastro, F. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.024 · Cited by 208 · see citing works
Reactivated herpes simplex infection increases the risk of Alzheimer's disease
Lövheim, H., Gilthorpe, J. D., Adolfsson, R., Nilsson, L., & Elgh, F. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.522 · Cited by 202 · see citing works
Emerging roles of pathogens in Alzheimer disease
Miklossy, J. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411002006 · Cited by 199 · see citing works
Can oral infection be a risk factor for Alzheimer's disease?
Olsen, I., & Singhrao, S. K. (2015) · Journal of Oral Microbiology · doi:10.3402/jom.v7.29143 · Cited by 182 · see citing works
Cytomegalovirus Infection and Risk of Alzheimer Disease in Older Black and White Individuals
Barnes, L. L., Capuano, A. W., Aiello, A. E., Turner, A. D., Yolken, R. H., Torrey, Ε. F., & Bennett, D. A. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu437 · Cited by 178 · see citing works
Self-citationDowd, J. B., Zajacova, A., & Aiello, A. E. (2009) · Social Science & Medicine · doi:10.1016/j.socscimed.2008.12.010 · Cited by 175 · see citing works
Self-citationDeeks, S. G., Verdin, E. M., & McCune, J. M. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.05.004 · Cited by 158 · see citing works
Chapter 5 Biomarkers Related To Aging In Human Populations
Crimmins, E. M., Vasunilashorn, S. M., Kim, J. K., & Alley, D. E. (2008) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)00405-8 · Cited by 156 · see citing works
Lurain, N. S., Hanson, B. A., Martinson, J., Leurgans, S. E., Landay, A. L., Bennett, D. A., & Schneider, J. A. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit210 · Cited by 159 · see citing works
Cytomegalovirus and HIV: A Dangerous Pas de Deux
Gianella, S., & Letendre, S. L. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw217 · Cited by 146 · see citing works
The impact of CMV infection on survival in older humans
Pawelec, G., McElhaney, J. E., Aiello, A. E., & Derhovanessian, E. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.002 · Cited by 145 · see citing works
Self-citationHerpes Simplex Virus Type 1 in Alzheimer's Disease: The Enemy Within
Itzhaki, R. F., & Wozniak, M. A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13405 · Cited by 143 · see citing works
Infectious burden and cognitive function: The Northern Manhattan Study
Katan, M., Moon, Y. P., Paik, M. C., Sacco, R. L., Wright, C. B., & Elkind, M. S. V. (2013) · Neurology · doi:10.1212/wnl.0b013e3182896e79 · Cited by 141 · see citing works
Infectious agents and Alzheimer's disease
Piekut, T., Hurła, M., Banaszek, N., Szejn, P., Dorszewska, J., Kozubski, W., & Prendecki, M. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2102073 · Cited by 123 · see citing works
Parry, H. M., Zuo, J., Frumento, G., Mirajkar, N., Inman, C., Edwards, E., Griffiths, M., Pratt, G., & Moss, P. (2016) · Immunity & Ageing · doi:10.1186/s12979-015-0056-6 · Cited by 125 · see citing works
Watts, A. S., Gatz, M., & Crimmins, E. M. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s3610 · Cited by 126 · see citing works
Warren-Gash, C., Forbes, H. J., Williamson, E., Breuer, J., Hayward, A. C., Mavrodaris, A., Ridha, B. H., Rossor, M. N., Thomas, S. L., & Smeeth, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-41218-w · Cited by 125 · see citing works
Viral infections and their relationship to neurological disorders
Wouk, J., Rechenchoski, D. Z., Rodrigues, B. C. D., Ribelato, E. V., & Galhardi, L. C. F. (2021) · Archives of Virology · doi:10.1007/s00705-021-04959-6 · Cited by 120 · see citing works
Herpes simplex virus type 1 and Alzheimer's disease: possible mechanisms and signposts
Itzhaki, R. F. (2017) · The FASEB Journal · doi:10.1096/fj.201700360 · Cited by 118 · see citing works
Crimmins, E. M., Kim, J. K., & Vasunilashorn, S. M. (2010) · Demography · doi:10.1353/dem.2010.0005 · Cited by 111 · see citing works
Nimgaonkar, V. L., Yolken, R. H., Wang, T., Chang, C.-C. H., McClain, L., McDade, E., Snitz, B. E., & Ganguli, M. (2016) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000133 · Cited by 109 · see citing works
Lövheim, H., Olsson, J., Weidung, B., Johansson, A., Eriksson, S., Hallmans, G., & Elgh, F. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161305 · Cited by 103 · see citing works
Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works
Socioeconomic Differentials in Immune Response
Dowd, J. B., & Aiello, A. E. (2009) · Epidemiology · doi:10.1097/ede.0b013e3181bb5302 · Cited by 98 · see citing works
Self-citationShirts, B. H., Prasad, K. M. R., Pogue‐Geile, M. F., Dickerson, F., Yolken, R., & Nimgaonkar, V. L. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.07.017 · Cited by 94 · see citing works
Persistent Infection, Inflammation, and Functional Impairment in Older Latinos
Aiello, A. E., Haan, M. N., Pierce, C. M., Simanek, A. M., & Liang, J. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.6.610 · Cited by 96 · see citing works
Self-citationSocioeconomic and Race/Ethnic Patterns in Persistent Infection Burden Among U.S. Adults
Zajacova, A., Dowd, J. B., & Aiello, A. E. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln012 · Cited by 94 · see citing works
Self-citationImmunity and ageing in man: Annual review 2006/2007
Pawelec, G., & Larbi, A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.09.009 · Cited by 94 · see citing works
Linking perceived control, physical activity, and biological health to memory change.
Infurna, F. J., & Gerstorf, D. (2013) · Psychology and Aging · doi:10.1037/a0033327 · Cited by 90 · see citing works
Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age
Stowe, R. P., Peek, M. K., Cutchin, M. P., & Goodwin, J. S. (2012) · Journal of Medical Virology · doi:10.1002/jmv.23397 · Cited by 88 · see citing works
Vescovini, R., Biasini, C., Telera, A. R., Basaglia, M., Stella, A., Magalini, F., Bucci, L., Monti, D., Lazzarotto, T., Monte, P. D., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902890 · Cited by 84 · see citing works
Exposure to Herpes Simplex Virus Type 1 and Cognitive Impairments in Individuals With Schizophrenia
Prasad, K. M. R., Watson, A. M. M., Dickerson, F., Yolken, R. H., & Nimgaonkar, V. L. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs046 · Cited by 83 · see citing works
Tarter, K. D., Simanek, A. M., Dowd, J. B., & Aiello, A. E. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit616 · Cited by 78 · see citing works
Self-citationMüller, L., & Benedetto, S. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020753 · Cited by 82 · see citing works
Matheï, C., Vaes, B., Wallemacq, P. E., & Degryse, J. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03719.x · Cited by 78 · see citing works
Chen, S., de Craen, A. J. M., Raz, Y., Derhovanessian, E., Vossen, A. C. T. M., Rudi, G. J. W., Pawelec, G., & Maier, A. B. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-18 · Cited by 77 · see citing works
Rector, J. L., Dowd, J. B., Loerbroks, A., Burns, V. E., Moss, P. A. H., Jarczok, M. N., Tobias Stalder, A., Hoffman, K. R., Fischer, J. E., & Bosch, J. A. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.01.012 · Cited by 76 · see citing works
Viral Hypothesis and Antiviral Treatment in Alzheimer’s Disease
Devanand, D. P. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0863-1 · Cited by 74 · see citing works
Lövheim, H., Norman, T., Weidung, B., Olsson, J., Josefsson, M., Adolfsson, R., Nyberg, L. H., & Elgh, F. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-171162 · Cited by 73 · see citing works
Socioeconomic Gradients in Immune Response to Latent Infection
Dowd, J. B., Haan, M. N., Blythe, L., Moore, K., & Aiello, A. E. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm247 · Cited by 72 · see citing works
Self-citationNeuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia
Schretlen, D. J., Vannorsdall, T. D., Winicki, J. M., Mushtaq, Y., Hikida, T., Sawa, A., Yolken, R. H., Dickerson, F., & Cascella, N. G. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.01.008 · Cited by 68 · see citing works
Correa, B. L., Ornaghi, A. P., Müller, G. C., Engroff, P., Lopes, R. P., Filho, I. G. D. S., Bosch, J. A., Bonorino, C., & Bauer, M. E. (2014) · NeuroImmunoModulation · doi:10.1159/000356827 · Cited by 69 · see citing works
Alonso‐Arias, R., Moro‐García, M. A., Echeverría, A., Solano-Jaurrieta, J. J., Suárez-García, F. M., & López‐Larrea, C. (2013) · Journal of Virology · doi:10.1128/jvi.02425-12 · Cited by 69 · see citing works
Effects of Aging on Immune Function
Stowe, R. P., & Goodwin, J. S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-6999-6_4 · Cited by 68 · see citing works
Persistent infection with neurotropic herpes viruses and cognitive impairment
Watson, A. M. M., Prasad, K. M. R., Klei, L., Wood, J. A., Yolken, R. H., Gur, R. C., Bradford, L. D., Calkins, M. E., Richard, J. A., Edwards, N. B., et al. (2012) · Psychological Medicine · doi:10.1017/s003329171200195x · Cited by 68 · see citing works
Human anelloviruses and the central nervous system
Maggi, F., & Bendinelli, M. (2010) · Reviews in Medical Virology · doi:10.1002/rmv.668 · Cited by 64 · see citing works
Persistent pathogens linking socioeconomic position and cardiovascular disease in the US
Simanek, A. M., Dowd, J. B., & Aiello, A. E. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn273 · Cited by 63 · see citing works
Self-citationPeriodontitis: a potential risk factor for Alzheimer's disease
Cerajewska, T., Davies, M., & West, N. (2015) · BDJ · doi:10.1038/sj.bdj.2014.1137 · Cited by 71 · see citing works
Family poverty is associated with cytomegalovirus antibody titers in U.S. Children.
Dowd, J. B., Palermo, T., & Aiello, A. E. (2011) · Health Psychology · doi:10.1037/a0025337 · Cited by 59 · see citing works
Self-citationThe Tiers and Dimensions of Evasion of the Type I Interferon Response by Human Cytomegalovirus
Amsler, L., Verweij, M. C., & DeFilippis, V. R. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.08.023 · Cited by 58 · see citing works
Alzheimer's disease gene signature says: beware of brain viral infections
Porcellini, E., Carbone, I., Ianni, M., & Licastro, F. (2010) · Immunity & Ageing · doi:10.1186/1742-4933-7-16 · Cited by 57 · see citing works
Aiello, A. E., Roux, A. V. D., Noone, A., Ranjit, N., Cushman, M., Tsai, M. Y., & Szklo, M. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.12.006 · Cited by 58 · see citing works
Self-citationHouenou, J., d’Albis, M.-A., Daban, C., Hamdani, N., Delavest, M., Lépine, J., Vederine, F.-E., Carde, S., Lajnef, M., Cabon, C., et al. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.003 · Cited by 52 · see citing works
Infectious burden and cognitive decline in the northern Manhattan study
Wright, C. B., Gardener, H., Dong, C., Yoshita, M., DeCarli, C., Sacco, R. L., Stern, Y., & Elkind, M. S. V. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13557 · Cited by 52 · see citing works
Noppert, G. A., Stebbins, R. C., Dowd, J. B., & Aiello, A. E. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.10.019 · Cited by 51 · see citing works
Self-citationHerpes simplex virus 1 and the risk of dementia: a population-based study
Murphy, M. J., Fani, L., Ikram, M. K., Ghanbari, M., & Ikram, M. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-87963-9 · Cited by 47 · see citing works
Cytomegalovirus infection and cognitive abilities in old age
Gow, A. J., Firth, C. M., Harrison, R., Starr, J. M., Moss, P., & Deary, I. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.011 · Cited by 45 · see citing works
Yong, S. J., Yong, M. H., Teoh, S. L., Soga, T., Parhar, I. S., Chew, J., & Lim, W. L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.695738 · Cited by 45 · see citing works
Pfister, G., & Savino, W. (2008) · NeuroImmunoModulation · doi:10.1159/000156477 · Cited by 44 · see citing works
Margolick, J. B., Bream, J. H., Nilles, T. L., Li, H., Langan, S. J., Deng, S., Wang, R., Wada, N., & Leng, S. X. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy005 · Cited by 44 · see citing works
Increased HCMV seroprevalence in patients with hepatocellular carcinoma
Lepiller, Q., Tripathy, M. K., Martino, V. D., Kantelip, B. M., & Herbein, G. (2011) · Virology Journal · doi:10.1186/1743-422x-8-485 · Cited by 43 · see citing works
Association between Cytomegalovirus Antibody Levels and Cognitive Functioning in Non-Elderly Adults
Dickerson, F., Stallings, C. R., Origoni, A. E., Katsafanas, E., Schweinfurth, L. A. B., Savage, C. L. G., & Yolken, R. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095510 · Cited by 43 · see citing works
Pablo-Bernal, R. S. D., Cañizares, J., Rosado‐Sánchez, I., Galvá, M. I., Álvarez‐Ríos, A. I., Carrillo‐Vico, A., Ferrando‐Martínez, S., Muñoz‐Fernández, M. Á., Benhnia, M. R., Pacheco, Y. M., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv121 · Cited by 42 · see citing works
Infectious disease burden and cognitive function in young to middle-aged adults
Gale, S. D., Erickson, L. D., Berrett, A. N., Brown, B. L., & Hedges, D. W. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.014 · Cited by 42 · see citing works
Torniainen‐Holm, M., Suvisaari, J., Lindgren, M., Härkänen, T., Dickerson, F., & Yolken, R. H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.006 · Cited by 42 · see citing works
Letendre, S. L., Bharti, A., Valero, I., Hanson, B. A., Franklin, D. R., Woods, S. P., Gianella, S., Oliveira, M. F., Heaton, R. K., Grant, I., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy170 · Cited by 41 · see citing works
Exposure to herpes simplex virus, type 1 and reduced cognitive function
Thomas, P., Triptish Bhatia, A., Gauba, D., Wood, J. A., Long, C., Prasad, K. M. R., Dickerson, F., Gur, R. E., Gur, R. C., Yolken, R. H., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.07.010 · Cited by 40 · see citing works
Cytomegalovirus, aging, and HIV: a perfect storm.
Barrett, L., Fowke, K. R., & Grant (2012) · PubMed · Cited by 40 · see citing works
Shim, S.-M., Cheon, H., Jo, C., Koh, Y. H., Song, J., & Jeon, J. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160563 · Cited by 40 · see citing works
Lack of Evidence for a Role of HHV-6 in the Pathogenesis of Alzheimer’s Disease
Agostini, S., Mancuso, R., Baglio, F., Cabinio, M., Hernis, A., Guerini, F. R., Calabrese, E., Nemni, R., & Clerici, M. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150464 · Cited by 39 · see citing works
Gene Signature in Alzheimer's Disease and Environmental Factors: The Virus Chronicle
Licastro, F., Carbone, I., Ianni, M., & Porcellini, E. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110755 · Cited by 38 · see citing works
Torniainen‐Holm, M., Suvisaari, J., Lindgren, M., Härkänen, T., Dickerson, F., & Yolken, R. H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.016 · Cited by 37 · see citing works
Rizzo, R., Bortolotti, D., Gentili, V., Rotola, A., Bolzani, S., Caselli, E., Tola, M. R., & Luca, D. D. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180777 · Cited by 36 · see citing works
Association between erythrocyte sedimentation rate and IQ in Swedish males aged 18–20
Karlsson, H., Ahlborg, B., Dalman, C., & Hemmingsson, T. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.02.009 · Cited by 35 · see citing works
Iglesias-Escudero, M., Moro‐García, M. A., Marcos-Fernández, R., García‐Torre, A., Álvarez-Argüelles, M. E., Suárez-Fernández, M. L., Martínez‐Camblor, P., Rodríguez, M., & Alonso‐Arias, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194789 · Cited by 35 · see citing works
Cytomegalovirus is associated with reduced telomerase activity in the Whitehall II cohort
Dowd, J. B., Bosch, J. A., Steptoe, A., Blackburn, E. H., Lin, J., Rees-Clayton, E., & Aiello, A. E. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.01.016 · Cited by 33 · see citing works
Self-citationViral Infections, Are They a Trigger and Risk Factor of Alzheimer’s Disease?
Rippee‐Brooks, M. D., Wu, W., Dong, J., Pappolla, M. A., Fang, X., & Bao, X. (2024) · Pathogens · doi:10.3390/pathogens13030240 · Cited by 31 · see citing works
Stebbins, R. C., Noppert, G. A., Yang, Y. C., Dowd, J. B., Simanek, A. M., & Aiello, A. E. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa238 · Cited by 32 · see citing works
Self-citationAssociation between toxocariasis and cognitive function in young to middle-aged adults
Erickson, L. D., Gale, S. D., Berrett, A., Brown, B. L., & Hedges, D. W. (2015) · Folia Parasitologica · doi:10.14411/fp.2015.048 · Cited by 31 · see citing works
Decreased HHV-6 IgG in Alzheimer’s Disease
Westman, G., Blomberg, J., Yun, Z., Lannfelt, L., Ingelsson, M., & Eriksson, B. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00040 · Cited by 31 · see citing works
The Role of Chronic Infection in Alzheimer’s Disease: Instigators, Co-conspirators, or Bystanders?
Butler, L., & Walker, K. A. (2021) · Current Clinical Microbiology Reports · doi:10.1007/s40588-021-00168-6 · Cited by 31 · see citing works
Kilgour, A. H. M., Firth, C. M., Harrison, R., Moss, P. A. H., Bastin, M. E., Wardlaw, J. M., Deary, I. J., & Starr, J. M. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-33 · Cited by 31 · see citing works
Licastro, F., Carbone, I., Raschi, E., & Porcellini, E. (2014) · Immunity & Ageing · doi:10.1186/s12979-014-0022-8 · Cited by 30 · see citing works
Fruchter, E., Goldberg, S. C., Fenchel, D., Grotto, I., Ginat, K., & Weiser, M. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.08.036 · Cited by 30 · see citing works
Early life socioeconomic position and immune response to persistent infections among elderly Latinos
Meier, H. C. S., Haan, M. N., de Leon, C. F. M., Simanek, A. M., Dowd, J. B., & Aiello, A. E. (2016) · Social Science & Medicine · doi:10.1016/j.socscimed.2016.07.004 · Cited by 29 · see citing works
Self-citationJones, R., & Goldeck, D. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.04.016 · Cited by 28 · see citing works
C‐Reactive Protein Mediates the Effect of Apolipoprotein E on Cytomegalovirus Infection
Aiello, A. E., Nguyen, H. T., & Haan, M. N. (2007) · The Journal of Infectious Diseases · doi:10.1086/524144 · Cited by 28 · see citing works
Self-citationDoes cytomegalovirus infection contribute to socioeconomic disparities in all-cause mortality?
Feinstein, L., Douglas, C. E., Stebbins, R. C., Pawelec, G., Simanek, A. M., & Aiello, A. E. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.06.001 · Cited by 28 · see citing works
Self-citationEvaluation of HLA Polymorphisms in Relation to Schizophrenia Risk and Infectious Exposure
Bamne, M. N., Wood, J. A., Chowdari, K. V., Watson, A. M. M., Çeli̇k, C., Mansour, H., Klei, L., Gur, R. C., Bradford, L. D., Calkins, M. E., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs087 · Cited by 28 · see citing works
Benedetto, S. D., Gaetjen, M., & Müller, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040990 · Cited by 27 · see citing works
Dowd, J. B., Aiello, A. E., Chyu, L., Huang, Y.-Y., & McDade, T. W. (2011) · Immunity & Ageing · doi:10.1186/1742-4933-8-3 · Cited by 26 · see citing works
Self-citationZhang, J., Liu, Y.-Y., Sun, H., Li, S., Xiong, H., Yang, Z., Xiang, G., & Jiang, X. (2015) · Medical Science Monitor · doi:10.12659/msm.896071 · Cited by 26 · see citing works
Farina, M. P., Kim, J. K., Hayward, M. D., & Crimmins, E. M. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100559 · Cited by 26 · see citing works
- Authors
- Aiello, A. E., Haan, M. N., Blythe, L., Moore, K., Gonzalez, J. M., & Jagust, W.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Aiello, Allison E.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2006-07
- Volume
- 54
- Issue
- 7
- Pages
- 1046-1054
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1946070691
- Cited by
- 210
- References
- 81
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 14 · 2020: 8 · 2019: 10 · 2018: 11 · 2017: 7 · 2016: 10 · 2015: 16 · 2014: 11 · 2013: 14 · 2012: 12
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health (DK20572)
- National Institute on Aging (AG-12975, R01AG012975, R03AG033751)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-60753, P60DK020572, NIH5P60, R01DK060753)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- cytomegalovirus, herpes simplex virus type 1, viral latency, cognitive decline, C-reactive protein, immunoglobulin G antibodies, episodic memory, older adults, aging, viral reactivation, immune response
- MeSH terms
- Aged, Aged, 80 and over, Antibodies, Viral, C-Reactive Protein, California, Cognition Disorders, Cytomegalovirus Infections, Dose-Response Relationship, Immunologic, Female, Herpes Simplex, Humans, Immunoglobulin G, Male, Middle Aged, Prospective Studies, Time Factors, Effect Modifier, Epidemiologic, Mexican Americans, Herpesvirus 1, Human
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
