Cited by 202T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesHIV Research and Treatment

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Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28− cytotoxic effector clones

Posnett, David N., Edinger, James W., Manavalan, J. Sanil, Irwin, Craig, Marodon, Gilles·1999·International Immunology

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Abstract

CD8 T cells contain a distinct subset of CD8+ CD28- cells. These cells are not present at birth and their frequency increases with age. They frequently contain expanded clones using various TCRalphabeta receptors and these clones can represent >50% of all CD8 cells, specially in old subjects or patients with chronic viral infections such as HIV-1. Herein, it is shown that a large fraction of CD8+ CD28- cells expresses intracellular perforin by three-color flow cytometry, in particular when this subset is expanded. Together with their known ability to exert potent re-directed cytotoxicity, this indicates that CD8+ CD28- T cells comprise cytotoxic effector cells. With BrdU labeling, we show that CD8+ CD28- cells derive from CD8+ CD28+ precursors in vitro. In addition, sorted CD8+ CD28+ cells gave rise to a population of CD8+ CD28- cells after allo-stimulation. Moreover, ex vivo CD8+ CD28+ cells contain the majority of CD8 blasts, supporting the notion that they contain the proliferative precursors of CD8+ CD28- cells. CD95 (Fas) expression was lower in CD8+ CD28- cells, and this subset was less prone to spontaneous apoptosis in ex vivo samples and more resistant to activation-induced cell death induced by a superantigen in vitro. Thus, the persistence of expanded clones in vivo in the CD8+ CD28- subset may be explained by antigen-driven differentiation from CD8+ CD28+ memory precursors, with relative resistance to apoptosis as the clones become perforin(+) effector cells.

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Posnett, D. N., Romagne, F., Necker, A., Kotzin, B. L. and Sekaly, R.-P. 1996. Summary: first human TCR monoclonal antibody workshop. The Immunologist4:5.

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Messaoudi, I., Fischer, M., Warner, J., Park, B., Mattison, J., Ingram, D. K., Totonchy, T., Mori, M., & Nikolich‐Žugich, J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00440.x · Cited by 57
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Functional Subsets within Clonally Expanded CD8+ Memory T Cells in Elderly Humans
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Melenhorst, J. J., Eniafe, R. B., Follmann, D. A., Nakamura, R., Kirby, M., & Barrett, A. J. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03802.x · Cited by 47
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Labalette, M., Leteurtre, E., Thumerelle, C., Grutzmacher, C., Tourvieille, B., & Dessaint, J. (1999) · International Immunology · doi:10.1093/intimm/11.8.1327 · Cited by 47
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Serrano, D., Becker, K., Cunningham‐Rundles, C., & Mayer, L. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4941 · Cited by 45
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Effros, R. B. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00207-4 · Cited by 45
Tumor Necrosis Factor-α and CD80 Modulate CD28 Expression through a Similar Mechanism of T-cell Receptor-independent Inhibition of Transcription
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Authors: Posnett, D. N., Edinger, J. W., Manavalan, J. S., Irwin, C., & Marodon, G.
Affiliations: Cornell University (US)
Corresponding author: Posnett, David N.
ORCID: Marodon, Gilles
Venue: International Immunology
Publisher: Oxford University Press (OUP)
Published: 1999-02
Volume: 11
Issue: 2
Pages: 229-241
ISSN: 0953-8178 (ISSN-L)
1460-2377
DOI: 10.1093/intimm/11.2.229
OpenAlex: W2117623957
Cited by: 202
References: 58
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 5 · 2012: 5
FWCI: 6.06
Type: journal article
Language: en
Open access: closed
Locations: International Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse
National Institute of Allergy and Infectious Diseases (AI-22333)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: CD8+CD28- T cells, T cell differentiation, cytotoxic effector cells, perforin, apoptosis resistance, Fas/CD95, T cell clonal expansion, HIV-1, chronic viral infection, T cell persistence
MeSH terms: Adult, Aged, Aging, Cell Differentiation, Clone Cells, Humans, Membrane Glycoproteins, Middle Aged, T-Lymphocytes, Cytotoxic, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, alpha-beta, Apoptosis, Superantigens, CD28 Antigens, CD8-Positive T-Lymphocytes, Pore Forming Cytotoxic Proteins, Perforin

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Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28− cytotoxic effector clones

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