Cited by 4Probiotics and Fermented FoodsDermatology and Skin DiseasesReproductive tract infections research

Anti-inflammatory and barrier-restoring effects of heat-killed Lactiplantibacillus plantarum postbiotics in an in vitro model of atopic dermatitis

Lee, Young-Sun, Noh, Da-In, Lee, Su-Jeong, Jeon, Mi-Hyeon, Kim, Yu-Ri, Jang, Won Je, Lee, Eun-Woo·2025·Journal of Applied Microbiology

Abstract

Aims: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by damage to the epidermal barrier. This study explores the potential of postbiotics as therapeutic agents for AD by evaluating their effects on inflammation-induced keratinocytes. Methods and results: Lactiplantibacillus plantarum strains isolated from Kimchi, a traditional Korean fermented food, were heat-treated and used as postbiotic candidates. Three postbiotic candidates were selected and evaluated for their antimicrobial activity, antioxidant capacity, and cellular effects. Postbiotics exhibited antimicrobial activity against skin inflammation–related bacteria and demonstrated strong antioxidant capacity. In addition, they positively modulated pro-inflammatory cytokines (IL-6, IL-8, TSLP) and skin barrier–related genes (INV, FLG, LOR) in keratinocytes stimulated with TNF-α/IFN-γ. Conclusions: Heat-killed postbiotics from L. plantarum showed antimicrobial, antioxidant activities, suppressed inflammatory cytokines, and enhanced skin barrier function. These results suggest their potential as therapeutic agents for AD and related skin conditions.

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Crossref · 10.1093/jambio/lxaf256

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68 of 68 references verified0 citation errors · 0 not checkable

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  • Previous studies have demonstrated that heat-killed L. plantarum postbiotics exert direct beneficial effects on skin cells, including antioxidant activity, suppression of pro-inflammatory cytokines, and enhancement of skin barrier function.

    “Previous studies have demonstrated that heat-killed L. plantarum postbiotics exert direct beneficial effects on skin cells, including antioxidant activity, suppression of pro-inflammatory cytokines, and enhancement of skin barrier function [20].”

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Authors
Lee, Y.-S., Noh, D.-I., Lee, S.-J., Jeon, M.-H., Kim, Y.-R., Jang, W. J., & Lee, E.-W.
Affiliations
  • Dong-Eui University (KR)
  • Dong-Eui University Department of Biomedicine and Pharmaceutics, , Busan 47340 ,
Corresponding author
  • Jang, Won Je
  • Lee, Eun-Woo
Venue
Journal of Applied Microbiology
Published
2025-10
Volume
136
Issue
10
ISSN
  • 1364-5072 (ISSN-L)
  • 1365-2672
OpenAlex
W4415249744
Cited by
3
References
68
Citations by year
2026: 3
FWCI
1.42
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
atopic dermatitis, postbiotics, Lactobacillus plantarum, heat-killed bacteria, skin barrier function, keratinocytes, antimicrobial activity, antioxidant capacity, inflammatory cytokines, interleukin-6, interleukin-8, thymic stromal lymphopoietin, antimicrobial peptides, FLG, LOR, inv, kimchi
MeSH terms
Fermented Foods, Filaggrin Proteins, Anti-Inflammatory Agents, Antioxidants, Dermatitis, Atopic, Hot Temperature, Humans, Keratinocytes, Cytokines, Probiotics, Lactiplantibacillus plantarum, Lactobacillus plantarum

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