Anti-inflammatory and barrier-restoring effects of heat-killed Lactiplantibacillus plantarum postbiotics in an in vitro model of atopic dermatitis
Abstract
Aims: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by damage to the epidermal barrier. This study explores the potential of postbiotics as therapeutic agents for AD by evaluating their effects on inflammation-induced keratinocytes. Methods and results: Lactiplantibacillus plantarum strains isolated from Kimchi, a traditional Korean fermented food, were heat-treated and used as postbiotic candidates. Three postbiotic candidates were selected and evaluated for their antimicrobial activity, antioxidant capacity, and cellular effects. Postbiotics exhibited antimicrobial activity against skin inflammation–related bacteria and demonstrated strong antioxidant capacity. In addition, they positively modulated pro-inflammatory cytokines (IL-6, IL-8, TSLP) and skin barrier–related genes (INV, FLG, LOR) in keratinocytes stimulated with TNF-α/IFN-γ. Conclusions: Heat-killed postbiotics from L. plantarum showed antimicrobial, antioxidant activities, suppressed inflammatory cytokines, and enhanced skin barrier function. These results suggest their potential as therapeutic agents for AD and related skin conditions.
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Previous studies have demonstrated that heat-killed L. plantarum postbiotics exert direct beneficial effects on skin cells, including antioxidant activity, suppression of pro-inflammatory cytokines, and enhancement of skin barrier function.
“Previous studies have demonstrated that heat-killed L. plantarum postbiotics exert direct beneficial effects on skin cells, including antioxidant activity, suppression of pro-inflammatory cytokines, and enhancement of skin barrier function [20].”
From Anti-Photoaging and Anti-Melanogenic Effects of a Novel <i>Lactiplantibacillus plantarum</i> RKBP Isolated from Giant <i>Centella asiatica</i> (2026) · cites this paper as [20]
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- Authors
- Lee, Y.-S., Noh, D.-I., Lee, S.-J., Jeon, M.-H., Kim, Y.-R., Jang, W. J., & Lee, E.-W.
- Affiliations
- Dong-Eui University (KR)
- Dong-Eui University Department of Biomedicine and Pharmaceutics, , Busan 47340 ,
- Corresponding author
- Jang, Won Je
- Lee, Eun-Woo
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2025-10
- Volume
- 136
- Issue
- 10
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W4415249744
- Cited by
- 3
- References
- 68
- Citations by year
- 2026: 3
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- atopic dermatitis, postbiotics, Lactobacillus plantarum, heat-killed bacteria, skin barrier function, keratinocytes, antimicrobial activity, antioxidant capacity, inflammatory cytokines, interleukin-6, interleukin-8, thymic stromal lymphopoietin, antimicrobial peptides, FLG, LOR, inv, kimchi
- MeSH terms
- Fermented Foods, Filaggrin Proteins, Anti-Inflammatory Agents, Antioxidants, Dermatitis, Atopic, Hot Temperature, Humans, Keratinocytes, Cytokines, Probiotics, Lactiplantibacillus plantarum, Lactobacillus plantarum
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