Cited by 228Endometriosis Research and TreatmentReproductive System and PregnancyGynecological conditions and treatments

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Altered expression of HOXA10 in endometriosis: potential role in decidualization

Kim, J.Julie, Taylor, H.S., Lu, Z., Ladhani, O., Hastings, J.M., Jackson, K.S., Wu, Y., Guo, S.W., Fazleabas, A.T.·2007·MHR: Basic science of reproductive medicine

DOI 10.1093/molehr/gam005

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Abstract

Endometriosis is a poorly understood gynaecologic disorder that is associated with infertility. In this study, we examined the expression of HOXA10 in the eutopic endometrium of baboons with induced endometriosis. A decrease in HOXA10 mRNA was observed after 3, 6, 12 and 16 months of disease, which reached statistical significance at 12 and 16 months. HOXA10 protein levels were decreased in both the epithelial and stromal cells of the endometrium. Furthermore, expression of beta3 integrin (ITGB3), which is upregulated by HOXA10, was decreased, whereas EMX2, a gene that is inhibited by HOXA10, was increased. Next, methylation patterns of the HOXA10 gene were analysed in the diseased and control animals. The F1 region on the promoter was found to be the most significantly methylated in the endometriosis animals and this may account for the decrease in HOXA10 expression. Finally, we demonstrate that stromal cells from the eutopic endometrium of baboons with endometriosis expressed significantly higher levels of insulin-like growth factor binding protein-1 (IGFBP1) mRNA than disease-free animals in response to estradiol, medroxyprogesterone acetate and dibutyryl cAMP (H + dbcAMP). The functional role of HOXA10 in IGFBP1 expression was further explored using human endometrial stromal cells (HSC). Overexpression of HOXA10 in HSC resulted in a decrease of IGFBP1 mRNA, whereas silencing HOXA10 caused an increase of IGFBP1 mRNA, even in the presence of H + dbcAMP. These data demonstrate that HOXA10 negatively influences IGFBP1 expression in decidualizing cells. Thus, the decrease in HOXA10 levels may in part be involved with the altered uterine environment associated with endometriosis.

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Authors: Kim, J. J., Taylor, H. S., Lu, Z., Ladhani, O., Hastings, J. M., Jackson, K. S., Wu, Y., Guo, S. W., & Fazleabas, A. T.
Affiliations: Northwestern University (US)
Yale University (US)
University of Illinois Chicago (US)
Medical College of Wisconsin (US)
Corresponding author: Kim, J.Julie
ORCID: Kim, J.Julie
Taylor, H.S.
Hastings, J.M.
Jackson, K.S.
Wu, Y.
Guo, S.W.
Fazleabas, A.T.
Venue: MHR: Basic science of reproductive medicine
Publisher: Oxford University Press (OUP)
Published: 2007-03-09
Volume: 13
Issue: 5
Pages: 323-332
ISSN: 1360-9947 (ISSN-L)
1460-2407
DOI: 10.1093/molehr/gam005
OpenAlex: W2137799669
Cited by: 228
References: 71
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 13 · 2020: 2 · 2019: 8 · 2018: 15 · 2017: 11 · 2016: 19 · 2015: 11 · 2014: 13 · 2013: 11 · 2012: 17
FWCI: 20.63
Type: journal article
Language: en
Open access: closed
Locations: Molecular Human Reproduction (publishedVersion)
PubMed (publishedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-036887, U54HD040093, U54-HD40093, R01HD044715, HD 044715)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords: endometriosis, HOXA10, decidualization, eutopic endometrium, IGFBP-1, CD61, Emx2, DNA methylation, promoter methylation, endometrial stromal cells, baboon model, infertility, estradiol, medroxyprogesterone acetate, cyclic AMP
MeSH terms: Homeobox A10 Proteins, Empty Spiracles Homeobox Proteins, Animals, Cells, Cultured, Decidua, Bucladesine, Endometriosis, Endometrium, Epithelial Cells, Estradiol, Female, Gene Expression Regulation, Humans, Papio, Promoter Regions, Genetic, RNA, Messenger, Transcription Factors, Stromal Cells, Medroxyprogesterone Acetate, Homeodomain Proteins, Insulin-Like Growth Factor Binding Protein 1, DNA Methylation, Gene Silencing

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Altered expression of HOXA10 in endometriosis: potential role in decidualization

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