Megasatellites: A peculiar class of giant minisatellites in genes involved in cell adhesion and pathogenicity in Candida glabrata
Open accessAbstract
Minisatellites are DNA tandem repeats that are found in all sequenced genomes. In the yeast Saccharomyces cerevisiae, they are frequently encountered in genes encoding cell wall proteins. Minisatellites present in the completely sequenced genome of the pathogenic yeast Candida glabrata were similarly analyzed, and two new types of minisatellites were discovered: minisatellites that are composed of two different intermingled repeats (called compound minisatellites), and minisatellites containing unusually long repeated motifs (126-429 bp). These long repeat minisatellites may reach unusual length for such elements (up to 10 kb). Due to these peculiar properties, they have been named 'megasatellites'. They are found essentially in genes involved in cell-cell adhesion, and could therefore be involved in the ability of this opportunistic pathogen to colonize the human host. In addition to megasatellites, found in large paralogous gene families, there are 93 minisatellites with simple shorter motifs, comparable to those found in S. cerevisiae. Most of the time, these minisatellites are not conserved between C. glabrata and S. cerevisiae, although their host genes are well conserved, raising the question of an active mechanism creating minisatellites de novo in hemiascomycetes.
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The presence of a large number of adhesin genes and their complex environment-dependent differential regulation are likely to help C. glabrata colonize different host niches as well as form biofilms on a wide range of surfaces.
“Therefore, the presence of such a large number of adhesin genes and their complex environment-dependent differential regulation are likely to help C. glabrata colonize different host niches as well as to form biofilms on a wide range of surfaces [27,47,48].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [47]
Candida glabrata has been frequently reported as exhibiting variable karyotypes between isolates.
“C. glabrata has been frequently reported as exhibiting variable karyotypes between isolates [57,58,59,60,61,62,63,64]”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [59]
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- Authors
- Thierry, A., Bouchier, C., Dujon, B., & Richard, G.-F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Richard, G.-F.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09-06
- Volume
- 36
- Issue
- 18
- Pages
- 5970-5982
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC2566889
- OpenAlex
- W2163794183
- Cited by
- 45
- References
- 37
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-05-BLAN-0331)
- Institut Universitaire de France
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- minisatellites, tandem repeats, Candida glabrata, cell adhesion genes, pathogenicity, paralogous gene families, hemiascomycetes, yeast genome, Saccharomyces cerevisiae comparison
- MeSH terms
- Amino Acid Sequence, Bacterial Adhesion, Fungal Proteins, Genes, Fungal, Molecular Sequence Data, Virulence, Genome, Fungal, Minisatellite Repeats, Candida glabrata
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