AutismKB: an evidence-based knowledgebase of autism genetics
Open accessAbstract
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with a prevalence of 0.9-2.6%. Twin studies showed a heritability of 38-90%, indicating strong genetic contributions. Yet it is unclear how many genes have been associated with ASD and how strong the evidence is. A comprehensive review and analysis of literature and data may bring a clearer big picture of autism genetics. We show that as many as 2193 genes, 2806 SNPs/VNTRs, 4544 copy number variations (CNVs) and 158 linkage regions have been associated with ASD by GWAS, genome-wide CNV studies, linkage analyses, low-scale genetic association studies, expression profiling and other low-scale experimental studies. To evaluate the evidence, we collected metadata about each study including clinical and demographic features, experimental design and statistical significance, and used a scoring and ranking approach to select a core data set of 434 high-confidence genes. The genes mapped to pathways including neuroactive ligand-receptor interaction, synapse transmission and axon guidance. To better understand the genes we parsed over 30 databases to retrieve extensive data about expression patterns, protein interactions, animal models and pharmacogenetics. We constructed a MySQL-based online database and share it with the broader autism research community at http://autismkb.cbi.pku.edu.cn, supporting sophisticated browsing and searching functionalities.
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Previous curated lists of genes implicated in ASDs and loosely defined evidence scores for entries are incomplete, non-systematic, and static.
“Previous work has crafted curated lists of genes implicated in autism spectrum disorders (ASDs) [1-5], and in some cases developed loosely defined “evidence scores” for entries [6-8]. Such efforts are incomplete, non-systematic and static.”
From SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs) (2013) · cites this paper as [8]
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849 · see citing works
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696 · see citing works
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works
Database resources of the National Center for Biotechnology Information: update
Wheeler, D. L. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh073 · Cited by 10,691 · see citing works
KEGG for linking genomes to life and the environment
Kanehisa, M. I., Araki, M., Goto, S., Hattori, M., Hirakawa, M., Itoh, M., Katayama, T., Kawashima, S., Okuda, S., Tokimatsu, T., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm882 · Cited by 6,828 · see citing works
Alternative isoform regulation in human tissue transcriptomes
Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181 · see citing works
KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases
Xie, C., Mao, X., Huang, J., Ding, Y., Wu, J., Dong, S., Kong, L., Gao, G., Li, C., & Wei, L. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr483 · Cited by 5,078 · see citing works
Self-citationDiagnostic and Statistical Manual of Mental Disorders ( DSM ‐ IV ‐ TR )
Segal, D. L. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy0271 · Cited by 4,683 · see citing works
Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013 · see citing works
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400782101 · Cited by 3,475 · see citing works
Human Protein Reference Database--2009 update
Prasad, T. S. K., Goel, R., Kandasamy, K., Keerthikumar, S., Kumar, S., Mathivanan, S., Telikicherla, D., Raju, R., Shafreen, R. B., Venugopal, A., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn892 · Cited by 3,205 · see citing works
PANTHER: A Library of Protein Families and Subfamilies Indexed by FunctionPreprint
Thomas, P. D., Campbell, M. J., Kejariwal, A., Mi, H., Karlak, B., Daverman, R., Diemer, K., Muruganujan, A., & Narechania, A. (2003) · Genome Research · doi:10.1101/gr.772403 · Cited by 2,912 · see citing works
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works
KEGG for representation and analysis of molecular networks involving diseases and drugs
Kanehisa, M., Goto, S., Furumichi, M., Tanabe, M., & Hirakawa, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp896 · Cited by 2,322 · see citing works
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
Hallmayer, J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.76 · Cited by 1,970 · see citing works
Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology
Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., Mill, J., Cantor, R. M., Blencowe, B. J., & Geschwind, D. H. (2011) · Nature · doi:10.1038/nature10110 · Cited by 1,874 · cited 1× · see citing works
“The result is consistent with recent findings that synapse development, axon targeting and neuron motility are related to autism etiology (60,61).”
ResultAdvances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866 · see citing works
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857 · see citing works
The UCSC Genome Browser database: update 2011
Fujita, P. A., Rhead, B. L., Zweig, A. S., Hinrichs, A. S., Karolchik, D., Cline, M., Goldman, M. J., Barber, G. P., Clawson, H., Coelho, A., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq963 · Cited by 1,836 · see citing works
DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs
Knox, C., Law, V., Jewison, T., Liu, P., Ly, S., Frolkis, A., Pon, A., Banco, K., Mak, C., Neveu, V., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1126 · Cited by 1,832 · see citing works
Structural Variation of Chromosomes in Autism Spectrum Disorder
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · see citing works
Reactome: a database of reactions, pathways and biological processes
Croft, D., O'Kelly, G., Wu, G., Haw, R., Gillespie, M., Matthews, L., Caudy, M., Garapati, P., Gopinath, G., Jassal, B., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1018 · Cited by 1,751 · see citing works
Dweep, H., Sticht, C., Pandey, P., & Gretz, N. (2011) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2011.05.002 · Cited by 1,699 · see citing works
PID: the Pathway Interaction Database
Schaefer, C. F., Anthony, K., Krupa, S., Buchoff, J., Day, M., Hannay, T., & Buetow, K. H. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn653 · Cited by 1,603 · see citing works
Prevalence of Autism Spectrum Disorders in a Total Population Sample
Kim, Y. S., Leventhal, B. L., Koh, Y.-J., Fombonne, E., Laska, E., Lim, E.-C., Cheon, K.-A., Kim, S.-J., Kim, Y.-K., Lee, H., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10101532 · Cited by 1,524 · see citing works
Muhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207 · see citing works
Allen, N. C., Bagade, S., McQueen, M. B., Ioannidis, J. P. A., Kavvoura, F. K., Khoury, M. J., Tanzi, R. E., & Bertram, L. (2008) · Nature Genetics · doi:10.1038/ng.171 · Cited by 1,054 · see citing works
Initial impact of the sequencing of the human genome
Lander, E. S. (2011) · Nature · doi:10.1038/nature09792 · Cited by 1,044 · see citing works
The Genetic Association Database
Becker, K. G., Barnes, K. C., Bright, T. J., & Wang, S. A. (2004) · Nature Genetics · doi:10.1038/ng0504-431 · Cited by 971 · see citing works
Betancur, C. (2011) · Brain Research · doi:10.1016/j.brainres.2010.11.078 · Cited by 954 · see citing works
Prevalence of Parent-Reported Diagnosis of Autism Spectrum Disorder Among Children in the US, 2007
Kogan, M. D., Blumberg, S. J., Schieve, L. A., Boyle, C. A., Perrin, J. M., Ghandour, R. M., Singh, G. K., Strickland, B. B., Trevathan, E., & van Dyck, P. C. (2009) · Pediatrics · doi:10.1542/peds.2009-1522 · Cited by 892 · see citing works
The BioGRID Interaction Database: 2011 update
Stark, C., Breitkreutz, B., Chatr‐aryamontri, A., Boucher, L., Oughtred, R., Livstone, M. S., Nixon, J., Auken, K. M. V., Wang, X., Shi, X., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1116 · Cited by 853 · see citing works
FlyBase: enhancing Drosophila Gene Ontology annotations
Tweedie, S., Ashburner, M., Falls, K. M., Leyland, P. C., McQuilton, P., Marygold, S. J., Millburn, G., Osumi-Sutherland, D., Schroeder, A., Seal, R. L., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn788 · Cited by 702 · see citing works
Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.021 · Cited by 701 · see citing works
The genetics of autistic disorders and its clinical relevance: a review of the literature
Freitag, C. M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001896 · Cited by 638 · see citing works
Database resources of the National Center for Biotechnology Information
Sayers, E. W., Barrett, T., Benson, D. A., Bolton, E., Bryant, S. H., Canese, K., Chetvernin, V., Church, D. M., DiCuccio, M. N., Federhen, S., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1172 · Cited by 632 · see citing works
Expansion of the BioCyc collection of pathway/genome databases to 160 genomes
Karp, P. D. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki892 · Cited by 611 · see citing works
Relling, M. V., Gardner, E. E., Sandborn, W. J., Schmiegelow, K., Pui, C.-H., Yee, S. W., Stein, C. M., Whirl‐Carrillo, M., Evans, W. E., & Klein, T. E. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.320 · Cited by 573 · see citing works
A High-Confidence Human Plasma Proteome Reference Set with Estimated Concentrations in PeptideAtlas
Farrah, T., Deutsch, E. W., Omenn, G. S., Campbell, D. S., Sun, Z., Bletz, J., Mallick, P., Katz, J. E., Malmström, J. A., Ossola, R., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.006353 · Cited by 446 · see citing works
The database of experimentally supported targets: a functional update of TarBase
Papadopoulos, G. L., Reczko, M., Simossis, V. A., Sethupathy, P., & Hatzigeorgiou, A. G. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn809 · Cited by 398 · see citing works
AutDB: a gene reference resource for autism research
Basu, S. N., Kollu, R., & Banerjee-Basu, S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn835 · Cited by 394 · see citing works
SFARI Gene: an evolving database for the autism research community
Banerjee-Basu, S., & Packer, A. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.005439 · Cited by 357 · see citing works
The Allen Brain Atlas: 5 years and beyond
Jones, A. R., Overly, C. C., & Sunkin, S. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2722 · Cited by 322 · see citing works
Annotating the human genome with Disease Ontology
Osborne, J. D., Flatow, J. M., Holko, M., Lin, S. M., Kibbe, W. A., Zhu, L. J., Danila, M. I., Feng, G., & Chisholm, R. L. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-s1-s6 · Cited by 265 · see citing works
The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics
Blake, J. A., Bult, C. J., Kadin, J. A., Richardson, J. E., Eppig, J. T., & the Mouse Genome Database Group (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1008 · Cited by 263 · see citing works
A guide to the Proteomics Identifications Database proteomics data repository
Vizcaíno, J. A., Cote, R., Reisinger, F., Foster, J. M., Mueller, M., Rameseder, J., Hermjakob, H., & Martens, L. (2009) · PROTEOMICS · doi:10.1002/pmic.200900402 · Cited by 237 · see citing works
The Comparative Toxicogenomics Database: update 2011
Davis, A. P., King, B. L., Mockus, S. M., Murphy, C. G., Saraceni-Richards, C. A., Rosenstein, M., Wiegers, T. C., & Mattingly, C. J. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq813 · Cited by 235 · see citing works
ZFIN: enhancements and updates to the zebrafish model organism database
Bradford, Y. M., Conlin, T., Dunn, N., Fashena, D. S., Frazer, K., Howe, D. G., Knight, J., Mani, P., Martin, R., Moxon, S. A. T., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1077 · Cited by 230 · see citing works
Zhang, J., Feuk, L., Duggan, G. E., Khaja, R., & Scherer, S. W. (2006) · Cytogenetic and Genome Research · doi:10.1159/000095916 · Cited by 204 · see citing works
Wu, J. Q., Habegger, L., Noisa, P., Szekely, A., Qiu, C., Hutchison, S., Raha, D., Egholm, M., Lin, H., Weissman, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914114107 · Cited by 189 · see citing works
Zhang, Y. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl473 · Cited by 180 · see citing works
(2006) · CRC Press eBooks · doi:10.1201/9781420004205 · Cited by 171 · see citing works
The genetics of child psychiatric disorders: focus on autism and Tourette syndrome
State, M. W. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.004 · Cited by 162 · see citing works
Du, P., Feng, G., Flatow, J. M., Song, J. Y., Holko, M., Kibbe, W. A., & Lin, S. M. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp193 · Cited by 109 · see citing works
Current Developments in the Genetics of Autism: From Phenome to Genome
Losh, M. C., Sullivan, P. F., Trembath, D. G., & Piven, J. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318184482d · Cited by 106 · see citing works
Genetics of autism spectrum disorder
Klauck, S. M. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201610 · Cited by 102 · see citing works
Biomolecular Interaction Network Database
Gilbert, D. (2005) · Briefings in Bioinformatics · doi:10.1093/bib/6.2.194 · Cited by 94 · see citing works
Sun, J., Jia, P., Fanous, A. H., Webb, B. T., van den Oord, E. J. C. G., Chen, X., Bukszár, J., Kendler, K. S., & Zhao, Z. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp428 · Cited by 80 · see citing works
A comprehensive resource for integrating and displaying protein post-translational modifications
Lee, T.-Y., Hsu, J. B., Chang, W., Wang, T., Hsu, P., & Huang, H. (2009) · BMC Research Notes · doi:10.1186/1756-0500-2-111 · Cited by 57 · see citing works
Matuszek, G., & Talebizadeh, Z. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-102 · Cited by 48 · see citing works
Ganz, M. L. (2006) · CRC Press eBooks · doi:10.1201/9781420004205.ch20 · Cited by 41 · see citing works
WebLab: a data-centric, knowledge-sharing bioinformatic platform
Liu, X., Wu, J., Wang, J., Liu, X., Zhao, S., Li, Z., Kong, L., Gu, X., Luo, J., & Gao, G. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp428 · Cited by 29 · see citing works
Flagged first, then by citations
1 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)
Abrahams, B. S., Arking, D. E., Campbell, D. B., Mefford, H. C., Morrow, E. M., Weiss, L. A., Menashe, I., Wadkins, T., Banerjee-Basu, S., & Packer, A. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-36 · Cited by 873 · see citing works
“Letter to the Editor Previous work has crafted curated lists of genes implicated in autism spectrum disorders (ASDs) [1-5], and in some cases developed loosely defined “evidence scores” for entries [6-8].”
Sugathan, A., Biagioli, M., Golzio, C., Erdin, S., Blumenthal, I., Manavalan, P., Ragavendran, A., Brand, H., Lucente, D., Miles, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405266111 · Cited by 342 · see citing works
miRWalk Database for miRNA–Target Interactions
Dweep, H., Gretz, N., & Sticht, C. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1062-5_25 · Cited by 319 · see citing works
Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103740 · Cited by 294 · see citing works
Autism spectrum disorder and the cerebellum.
Becker, E. B. E., & Stoodley, C. J. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-418700-9.00001-0 · Cited by 248 · see citing works
Wang, P., Mokhtari, R., Pedrosa, E., Kirschenbaum, M. A., Bayrak, C., Zheng, D., & Lachman, H. M. (2017) · Molecular Autism · doi:10.1186/s13229-017-0124-1 · Cited by 255 · see citing works
Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons
Griesi-Oliveira, K., Acab, A., Gupta, A. R., Sunaga, D. Y., Chailangkarn, T., Nicol, X., Nunez, Y., Walker, M. F., Murdoch, J. D., Sanders, S. J., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.141 · Cited by 236 · see citing works
Brain Transcriptional and Epigenetic Associations with Autism
Ginsberg, M. R., Rubin, R. A., Falcone, T., Ting, A. H., & Natowicz, M. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044736 · Cited by 164 · see citing works
Wang, P., Lin, M., Pedrosa, E., Hrabovsky, A., Zhang, Z., Guo, W., Lachman, H. M., & Zheng, D. (2015) · Molecular Autism · doi:10.1186/s13229-015-0048-6 · Cited by 169 · see citing works
Salivary biomarkers for the diagnosis and monitoring of neurological diseases
Farah, R., Haraty, H., Salame, Z., Fares, Y., Ojcius, D. M., & Sadier, N. S. (2018) · Biomedical Journal · doi:10.1016/j.bj.2018.03.004 · Cited by 170 · see citing works
Disruption of POGZ Is Associated with Intellectual Disability and Autism Spectrum Disorders
Stessman, H. A. F., Willemsen, M. H., Fencková, M., Penn, O., Hoischen, A., Xiong, B., Wang, T., Hoekzema, K., Vives, L., Vogel, I., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.02.004 · Cited by 155 · see citing works
Placental H3K27me3 establishes female resilience to prenatal insults
Nugent, B. M., O’Donnell, C. M., Epperson, C. N., & Bale, T. L. (2018) · Nature Communications · doi:10.1038/s41467-018-04992-1 · Cited by 150 · see citing works
Blumenthal, I., Ragavendran, A., Erdin, S., Klei, L., Sugathan, A., Guide, J. R., Manavalan, P., Zhou, J. Q., Wheeler, V. C., Levin, J. Z., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.05.004 · Cited by 145 · see citing works
Autism-Associated Promoter Variant in MET Impacts Functional and Structural Brain Networks
Rudie, J. D., Hernandez, L. M., Brown, J. A., Beck-Pancer, D., Colich, N. L., Gorrindo, P., Thompson, P. M., Geschwind, D. H., Bookheimer, S. Y., Levitt, P., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.010 · Cited by 142 · see citing works
Sarachana, T., & Hu, V. W. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-14 · Cited by 135 · see citing works
Codina‐Solà, M., Rodríguez‐Santiago, B., Homs, A., Santoyo‐López, J., Rigau, M., Laín, G. A., Campo, M. D., Gener, B., Gabau, E., Botella, M. P., et al. (2015) · Molecular Autism · doi:10.1186/s13229-015-0017-0 · Cited by 132 · see citing works
Hicks, S. D., Ignacio, C., Gentile, K. L., & Middleton, F. A. (2016) · BMC Pediatrics · doi:10.1186/s12887-016-0586-x · Cited by 128 · see citing works
Developmental activities of the complement pathway in migrating neurons
Gorelik, A., Sapir, T., Haffner‐Krausz, R., Olender, T., Woodruff, T. M., & Reiner, O. (2017) · Nature Communications · doi:10.1038/ncomms15096 · Cited by 120 · see citing works
Wei, J., Liu, J., Liang, S., Sun, M., & Duan, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s254480 · Cited by 118 · see citing works
The Dynamics of Autism Spectrum Disorders: How Neurotoxic Compounds and Neurotransmitters Interact
Quaak, I., Brouns, M. R., & van de Bor, M. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10083384 · Cited by 103 · see citing works
Air pollution and autism in Denmark
Ritz, B. R., Liew, Z., Yan, Q. J., Cuia, X., Virk, J., Ketzel, M., & Raaschou‐Nielsen, O. (2018) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000028 · Cited by 100 · see citing works
Al-Mubarak, B. R., Abouelhoda, M. I., Omar, A., Aldhalaan, H., Aldosari, M., Nester, M. J., Al-Shamrani, H., El-Kalioby, M., Goljan, E., Albar, R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06033-1 · Cited by 97 · see citing works
Genomic and genetic aspects of autism spectrum disorder
Liu, X., & Takumi, T. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.108 · Cited by 93 · see citing works
An inside job: how endosomal Na+/H+ exchangers link to autism and neurological disease
Kondapalli, K. C., Prasad, H., & Rao, R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00172 · Cited by 93 · see citing works
Hu, V. W., Sarachana, T., Sherrard, R. M., & Kocher, K. M. (2015) · Molecular Autism · doi:10.1186/2040-2392-6-7 · Cited by 90 · see citing works
Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism
Liu, X., Han, D., Somel, M., Jiang, X., Hu, H., Guijarro, P., Zhang, N., Mitchell, A., Halene, T., Ely, J. J., et al. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002558 · Cited by 87 · see citing works
EpilepsyGene: a genetic resource for genes and mutations related to epilepsy
Xia, R., Li, J., Shao, Q., Chen, H., Lin, Z., Sun, Z. S., & Wu, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku943 · Cited by 86 · see citing works
Self-citationIn-Silico Algorithms for the Screening of Possible microRNA Binding Sites and Their Interactions
Dweep, H., Sticht, C., & Gretz, N. (2013) · Current Genomics · doi:10.2174/1389202911314020005 · Cited by 83 · see citing works
Zhu, Y., Mordaunt, C. E., Yasui, D. H., Marathe, R., Coulson, R. L., Dunaway, K. W., Jianu, J. M., Walker, C. K., Ozonoff, S. J., Hertz‐Picciotto, I., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz084 · Cited by 85 · see citing works
Dou, Y., Yang, X., Li, Z., Wang, S., Zhang, Z., Ye, A. Y., Yan, L., Yang, C., Wu, Q., Li, J., et al. (2017) · Human Mutation · doi:10.1002/humu.23255 · Cited by 73 · see citing works
Self-citationAutism and the Grand Challenges in Global Mental Health
Khan, N. Z., Albores‐Gallo, L., Arghir, A., Budişteanu, B., Budișteanu, M., Dobrescu, I., Donald, K. A., El‐Tabari, S., Hoogenhout, M., Kalambayi, F. N., et al. (2012) · Autism Research · doi:10.1002/aur.1239 · Cited by 76 · see citing works
Chen, Y., Chen, C.-Y., Mai, T., Chuang, C.-F., Chen, Y., Gupta, S. K., Yen, L., Wang, Y.-D., & Chuang, T. (2020) · Genome Research · doi:10.1101/gr.255463.119 · Cited by 67 · see citing works
Wagner, F., French, L., & Veh, R. W. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0891-9 · Cited by 64 · see citing works
Lysine Acetylation and Deacetylation in Brain Development and Neuropathies
Tapias, A., & Wang, Z. (2017) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.09.002 · Cited by 66 · see citing works
The landscape of copy number variations in F innish families with autism spectrum disorders
Kanduri, C., Kantojärvi, K., Salo, P., Vanhala, R., Buck, G., Blancher, C., Lähdesmäki, H. J., & Järvelä, I. E. (2015) · Autism Research · doi:10.1002/aur.1502 · Cited by 69 · see citing works
Casanova, M., Sharp, J. L., Chakraborty, H., Sumi, N. S., & Casanova, M. F. (2016) · Molecular Autism · doi:10.1186/s13229-016-0082-z · Cited by 60 · see citing works
Devanna, P., & Vernes, S. C. (2014) · Scientific Reports · doi:10.1038/srep03994 · Cited by 59 · see citing works
Joseph, S., Barai, R. S., Rasika, B., & Idicula‐Thomas, S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1146 · Cited by 59 · see citing works
The neuronal migration hypothesis of dyslexia: a critical evaluation 30 years on.
Guidi, L. G., Velayos‐Baeza, A., Martinez‐Garay, I., Monaco, A. P., Paracchini, S., Bishop, D. V. M., & Molnár, Z. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14149 · Cited by 59 · see citing works
Mahfouz, A. E., Ziats, M. N., Rennert, O. M., Lelieveldt, B. P. F., & Reinders, M. J. T. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0641-3 · Cited by 58 · see citing works
Cogill, S., & Wang, L. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw498 · Cited by 58 · see citing works
Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons
Wang, P., Zhao, D., Lachman, H. M., & Zheng, D. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0058-6 · Cited by 58 · see citing works
Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders
Rajamani, K. T., Wagner, S., Grinevich, V., & Harony-Nicolas, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00017 · Cited by 53 · see citing works
AutismKB 2.0: a knowledgebase for the genetic evidence of autism spectrum disorder
Yang, C., Li, J., Wu, Q., Yang, X., Huang, A. Y., Zhang, J., Ye, A. Y., Dou, Y., Yan, L., Zhou, W., et al. (2018) · Database · doi:10.1093/database/bay106 · Cited by 52 · see citing works
Self-citationCogné, B., Ehresmann, S., Beauregard‐Lacroix, É., Rousseau, J., Besnard, T., Garcia, T., Petrovski, S., Avni, S., McWalter, K. M., Blackburn, P. R., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.01.010 · Cited by 53 · see citing works
Kimura‐Kuroda, J., Nishito, Y., Yanagisawa, H., Kuroda, Y., Komuta, Y., Kawano, H., & Hayashi, M. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13100987 · Cited by 51 · see citing works
Devanna, P., Chen, X., Ho, J., Gajewski, D., Smith, S. D., Gialluisi, A., Francks, C., Fisher, S. E., Newbury, D. F., & Vernes, S. C. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.30 · Cited by 49 · see citing works
A systematic variant annotation approach for ranking genes associated with autism spectrum disorders
Larsen, E., Menashe, I., Ziats, M. N., Pereanu, W., Packer, A. I., & Banerjee‐Basu, S. (2016) · Molecular Autism · doi:10.1186/s13229-016-0103-y · Cited by 50 · see citing works
Simpson, N. H., Ceroni, F., Reader, R. H., Covill, L., Knight, J. C., Hennessy, E. R., Bolton, P., Conti‐Ramsden, G., O'Hare, A. E., Baird, G., et al. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.296 · Cited by 47 · see citing works
A case of autism spectrum disorder arising from a de novo missense mutation in POGZ
Fukai, R., Hiraki, Y., Yofune, H., Tsurusaki, Y., Nakashima, M., Saitsu, H., Tanaka, F., Miyake, N., & Matsumoto, N. (2015) · Journal of Human Genetics · doi:10.1038/jhg.2015.13 · Cited by 46 · see citing works
Network-based Phenome-Genome Association Prediction by Bi-Random Walk
Xie, M., Xu, Y., Zhang, Y., Hwang, T., & Kuang, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125138 · Cited by 46 · see citing works
Casanova, M., & Casanova, M. F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00397 · Cited by 46 · see citing works
Machine learning in schizophrenia genomics, a case‐control study using 5,090 exomes
Trakadis, Y. J., Sardaar, S., Chen, A., Fulginiti, V., & Krishnan, A. (2018) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32638 · Cited by 46 · see citing works
Regulatory genes and pathways disrupted in autism spectrum disorders
Ayhan, F., & Konopka, G. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.017 · Cited by 44 · see citing works
Etiopathogenesis of autism spectrum disorders: Fitting the pieces of the puzzle together
Gentile, I., Zappulo, E., Militerni, R., Pascotto, A., Borgia, G., & Bravaccio, C. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.04.002 · Cited by 42 · see citing works
Wiśniowiecka‐Kowalnik, B., Kastory-Bronowska, M., Bartnik, M., Derwińska, K., Dymczak-Domini, W., Szumbarska, D., Ziemka, E., Szczałuba, K., Sykulski, M., Gambin, T., et al. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.219 · Cited by 43 · see citing works
Zhou, W., Zhang, J., Li, Z., Lin, X., Li, J., Wang, S., Yang, C., Wu, Q., Ye, A. Y., Wang, M., et al. (2019) · Human Mutation · doi:10.1002/humu.23724 · Cited by 43 · see citing works
Self-citationVerma, D., Chakraborti, B., Karmakar, A., Bandyopadhyay, T., Singh, A. S., Sinha, S., Chatterjee, A., Ghosh, S., Mohanakumar, K. P., Mukhopadhyay, K., et al. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.11.010 · Cited by 41 · see citing works
Ceolin, L., Bouquier, N., Boubaker-Vitre, J., Rialle, S., Séverac, D., Valjent, E., Perroy, J., & Puighermanal, E. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00340 · Cited by 38 · see citing works
Yu, Q., & He, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-04356-7 · Cited by 38 · see citing works
Cho, H., Yoo, T., Moon, H., Kang, H., Yang, Y., Kang, M., Yang, E., Lee, D., Hwang, D., Kim, H., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02129-5 · Cited by 36 · see citing works
Pichitpunpong, C., Thongkorn, S., Kanlayaprasit, S., Yuwattana, W., Plaingam, W., Sangsuthum, S., Aizat, W. M., Baharum, S. N., Tencomnao, T., Hu, V. W., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214198 · Cited by 37 · see citing works
Eisinger, B. E., Saul, M. C., Driessen, T. M., & Gammie, S. C. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-147 · Cited by 33 · see citing works
Wu, H.-H., & Levitt, P. (2013) · Developmental Neuroscience · doi:10.1159/000346367 · Cited by 35 · see citing works
Liang, S., Wang, X.-L., Zou, M.-Y., Wang, H., Zhou, X., Sun, C.-H., Xia, W., Wu, L.-J., Fujisawa, T. X., & Tomoda, A. (2014) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1300133 · Cited by 33 · see citing works
Chiocchetti, A. G., Haslinger, D., Stein, J. L., de la Torre-Ubieta, L., Cocchi, E., Rothämel, T., Lindlar, S., Waltes, R., Fulda, S., Geschwind, D. H., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.119 · Cited by 33 · see citing works
Rasmussen, M. B., Nielsen, J. V., Lourenço, C. M., Melo, J. B., Halgren, C., Geraldi, C. V. L., Marques, W., Rodrigues, G. R., Thomassen, M., Bak, M., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102535 · Cited by 30 · see citing works
Modeling of Autism Genetic Variations in Mice: Focusing on Synaptic and Microcircuit Dysfunctions
Qiu, S., Aldinger, K. A., & Levitt, P. R. (2012) · Developmental Neuroscience · doi:10.1159/000336644 · Cited by 31 · see citing works
Sex-biased gene expression in the developing brain: implications for autism spectrum disorders
Ziats, M. N., & Rennert, O. M. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-10 · Cited by 32 · see citing works
Liu, Y., Liang, Y., Çiçek, A. E., Li, Z., Li, J., Muhle, R., Krenzer, M., Mei, Y., Wang, Y., Knoblauch, N., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.03.023 · Cited by 32 · see citing works
Self-citationGlutamatergic candidate genes in autism spectrum disorder: an overview
Chiocchetti, A. G., Bour, H. S., & Freitag, C. M. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1161-y · Cited by 30 · see citing works
Temporal proteomic profiling of postnatal human cortical development
Breen, M. S., Özcan, S., Ramsey, J. M., Wang, Z., Ma’ayan, A., Rustogi, N., Gottschalk, M. G., Webster, M. J., Weickert, C. S., Buxbaum, J. D., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0306-4 · Cited by 29 · see citing works
Co-expression of long non-coding RNAs and autism risk genes in the developing human brain
Cogill, S., Srivastava, A. K., Yang, M. Q., & Wang, L. (2018) · BMC Systems Biology · doi:10.1186/s12918-018-0639-x · Cited by 30 · see citing works
Functional Genomic Analyses Identify Pathways Dysregulated in Animal Model of Autism
Huang, J., Tian, Y., Wang, H., Shen, H., Wang, H., Long, S., Liao, M., Liu, Z., Wang, Z., Li, D., et al. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12582 · Cited by 31 · see citing works
Zheng, F., Kasper, L. H., Bedford, D. C., Lerach, S., Teubner, B. J. W., & Brindle, P. K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146366 · Cited by 28 · see citing works
Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation
Kang, M.-S., Choi, T.-Y., Ryu, H. G., Lee, D., Lee, S., Choi, S., & Kim, K. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160974 · Cited by 29 · see citing works
Golden, C. E. M., Breen, M. S., Koro, L., Sonar, S., Niblo, K., Browne, A., Burlant, N., Di Marino, D., De Rubeis, S., Baxter, M. G., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz029 · Cited by 29 · see citing works
Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment
Lü, J., Zhu, Y., Williams, S., Watts, M. E., Tonta, M. A., Coleman, H. A., Parkington, H. C., & Claudianos, C. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01106-8 · Cited by 29 · see citing works
Zhang, K., Qu, S., Chang, S., Li, G., Cao, C., Fang, K., Olff, M., Wang, L., & Wang, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.021 · Cited by 28 · see citing works
Liang, S., Li, Z., Wang, Y., Li, X., Yang, X., Zhan, X., Huang, Y., Gao, Z., Zhang, M., Sun, C., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00712 · Cited by 28 · see citing works
Self-citationLiu, J., Yang, A., Zhang, Q., Yang, G., Yang, W., Lei, H., Quan, J., Qu, F., Wang, M., Zhang, Z., et al. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32304 · Cited by 26 · see citing works
Focus on the Social Aspect of Autism
Kałużna‐Czaplińska, J., Żurawicz, E., & Jóźwik-Pruska, J. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3407-7 · Cited by 25 · see citing works
Liu, H., Barnes, J., Pedrosa, E., Herman, N. S., Salas, F., Wang, P., Zheng, D., & Lachman, H. M. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09317-2 · Cited by 24 · see citing works
Broderick, G., & Craddock, T. J. A. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.008 · Cited by 25 · see citing works
Protein signatures of oxidative stress response in a patient specific cell line model for autism
Chiocchetti, A. G., Haslinger, D., Boesch, M., Karl, T., Wiemann, S., Freitag, C. M., Poustka, F., Scheibe, B., Bauer, J. W., Hintner, H., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-10 · Cited by 24 · see citing works
Autworks: a cross-disease network biology application for Autism and related disorders
Nelson, T. H., Jung, J.-Y., DeLuca, T. F., Hinebaugh, B. K., Gabriel, K. C. S., & Wall, D. P. (2012) · BMC Medical Genomics · doi:10.1186/1755-8794-5-56 · Cited by 22 · see citing works
Wang, W., & Fu, P. (2023) · Microorganisms · doi:10.3390/microorganisms11020291 · Cited by 20 · see citing works
Griesi‐Oliveira, K., Sunaga, D. Y., Alvizi, L., Vadasz, E., & Passos‐Bueno, M. R. (2013) · Autism Research · doi:10.1002/aur.1296 · Cited by 20 · see citing works
Tzetis, M., Kitsiou‐Tzeli, S., Fryssira, H., Xaidara, A., & Kanavakis, E. (2012) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.12.40 · Cited by 20 · see citing works
Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons
Seabra, C. M., Aneichyk, T., Erdin, S., Tai, D. J. C., de Esch, C. E. F., Razaz, P., An, Y., Manavalan, P., Ragavendran, A., Stortchevoi, A., et al. (2020) · Molecular Autism · doi:10.1186/s13229-020-00354-1 · Cited by 20 · see citing works
Kim, H., Kim, D., Cho, Y., Kim, K., Roh, J. D., Kim, Y., Yang, E., Kim, S. S., Ahn, S., Kim, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32748-5 · Cited by 19 · see citing works
Cerebellum and neurodevelopmental disorders: RORα is a unifying force
Ribeiro, S., & Sherrard, R. M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1108339 · Cited by 19 · see citing works
Simões, S. N., Martins, D., Pereira, C. A. D. B., Hashimoto, R. F., & Brentani, H. (2015) · BMC Bioinformatics · doi:10.1186/1471-2105-16-s19-s9 · Cited by 19 · see citing works
Predicting the Risk Genes of Autism Spectrum Disorders
Lin, Y.-C., Sathipati, S. Y., & Ho, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.665469 · Cited by 20 · see citing works
Xu, X., Xu, Q., Zhang, Y., Zhang, X., Cheng, T., Wu, B., Ding, Y., Lü, P., Zheng, J., Zhang, M., et al. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-75 · Cited by 18 · see citing works
Prioritization of Disease Susceptibility Genes Using LSM/SVD
Gong, L., Yang, R., Yan, Q., & Sun, X. S. (2013) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2013.2257767 · Cited by 17 · see citing works
IQdb: an intelligence quotient score-associated gene resource for human intelligence
Kong, L., Cheng, L., Fan, L.-Y., Zhao, M., & Qu, H. (2013) · Database · doi:10.1093/database/bat063 · Cited by 17 · see citing works
Self-citationLiu, W., Cheng, P., Zhang, K., Gong, M., Zhong, Z., & Zhang, R. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010245 · Cited by 15 · see citing works
Looking for prosocial genes: ITRAQ analysis of proteins involved in MDMA-induced sociability in mice
Kuteykin‐Teplyakov, K. B., & Maldonado, R. J. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.08.007 · Cited by 16 · see citing works
Onaolapo, O. J., & Onaolapo, A. Y. (2018) · AIMS Medical Science · doi:10.3934/medsci.2018.2.122 · Cited by 16 · see citing works
- Authors
- Xu, L.-M., Li, J.-R., Huang, Y., Zhao, M., Tang, X., & Wei, L.
- Affiliations
- Peking University (CN)
- Corresponding author
- Wei, Liping
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-12-01
- Volume
- 40
- Issue
- D1
- Pages
- D1016-D1022
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC3245106
- OpenAlex
- W2039778388
- Cited by
- 179
- References
- 65
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 14 · 2019: 8 · 2018: 19 · 2017: 14 · 2016: 16 · 2015: 14 · 2014: 21 · 2013: 22 · 2012: 12
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Natural Science Foundation of China (31025014, 2011CBA01102)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- autism spectrum disorder, autism genetics, gene ranking, copy number variation, single nucleotide polymorphisms, linkage region, neurodevelopmental disorders, axon guidance, neuroactive ligand-receptor interaction, gene expression profiling, protein-protein interaction, animal models, pharmacogenetics
- MeSH terms
- Autistic Disorder, Humans, Genetic Linkage, User-Computer Interface, Genetic Variation, Databases, Genetic, Knowledge Bases, Molecular Sequence Annotation
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