Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders
Open accessAbstract
Alterations in gut microbiome composition have an emerging role in health and disease including brain function and behavior. Short chain fatty acids (SCFA) like propionic (PPA), and butyric acid (BA), which are present in diet and are fermentation products of many gastrointestinal bacteria, are showing increasing importance in host health, but also may be environmental contributors in neurodevelopmental disorders including autism spectrum disorders (ASD). Further to this we have shown SCFA administration to rodents over a variety of routes (intracerebroventricular, subcutaneous, intraperitoneal) or developmental time periods can elicit behavioral, electrophysiological, neuropathological and biochemical effects consistent with findings in ASD patients. SCFA are capable of altering host gene expression, partly due to their histone deacetylase inhibitor activity. We have previously shown BA can regulate tyrosine hydroxylase (TH) mRNA levels in a PC12 cell model. Since monoamine concentration is known to be elevated in the brain and blood of ASD patients and in many ASD animal models, we hypothesized that SCFA may directly influence brain monoaminergic pathways. When PC12 cells were transiently transfected with plasmids having a luciferase reporter gene under the control of the TH promoter, PPA was found to induce reporter gene activity over a wide concentration range. CREB transcription factor(s) was necessary for the transcriptional activation of TH gene by PPA. At lower concentrations PPA also caused accumulation of TH mRNA and protein, indicative of increased cell capacity to produce catecholamines. PPA and BA induced broad alterations in gene expression including neurotransmitter systems, neuronal cell adhesion molecules, inflammation, oxidative stress, lipid metabolism and mitochondrial function, all of which have been implicated in ASD. In conclusion, our data are consistent with a molecular mechanism through which gut related environmental signals such as increased levels of SCFA's can epigenetically modulate cell function further supporting their role as environmental contributors to ASD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Short-chain fatty acids may modulate the levels of neurotransmitters and neurotrophic factors.
“It was described that SCFAs may modulate the levels of neurotransmitters and neurotrophic factors.”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [116]
Table 1 (Methods > Microarrays; page unavailable) shows that propionic and butyric acid changed expression of neurotransmitter-related genes in PC12 cells. The paper does not establish changes in neurotransmitter levels, and the passages found do not support the added claim about neurotrophic-factor levels. (LLM, conf=0.84)
Experimental — accuracy not yet measuredShort-chain fatty acids regulate the expression levels of tryptophan 5-hydroxylase 1 and tyrosine hydroxylase, producing an effect on brain neurochemistry.
“these SCFAs regulate the expression levels of tryptophan 5-hydroxylase 1, the enzyme involved in synthesis of serotonin, and tyrosine hydroxylase, which is involved in a rate-limiting step in the biosynthesis of dopamine, noradrenaline and adrenaline; therefore, producing an effect on brain neurochemistry (21, 55, 56, 116, 117).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [116]
Results, Table 6, shows altered TPH1 and TH gene expression after short-chain fatty acid treatment of PC12 cells; the Discussion specifies that only propionic acid altered TPH1 expression. The paper does not establish a resulting effect on brain neurochemistry: its Discussion says whether comparable dysregulation occurs in vivo remains to be examined. (LLM, conf=0.88)
Experimental — accuracy not yet measuredOther SCFA effects, especially of propionate and butyrate, are mediated through their HDAC inhibitory activity.
“Other SCFA effects, especially of propionate and butyrate, are mediated through their HDAC inhibitory activity (108, 116).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [116]
Propionate and butyrate can influence cell signaling via modification of intracellular potassium levels and regulate expression of tryptophan 5-hydroxylase 1 and tyrosine hydroxylase.
“Propionate and butyrate can influence the cell signaling system via modification of the intracellular potassium levels (104), and they regulate the expression levels of tryptophan 5-hydroxylase 1, involved in the synthesis of serotonin, and tyrosine hydroxylase, which is involved in the biosynthesis of dopamine, adrenaline, and noradrenaline (105).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [105]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101 · see citing works
Greene, L., & Tischler, A. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2424 · Cited by 5,594 · see citing works
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409 · see citing works
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
Hallmayer, J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.76 · Cited by 1,970 · see citing works
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,889 · see citing works
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758 · see citing works
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651 · see citing works
Risperidone in Children with Autism and Serious Behavioral Problems
McCracken, J. T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., Arnold, L. E., Lindsay, R., Nash, P., Hollway, J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013171 · Cited by 1,574 · see citing works
De Novo Gene Disruptions in Children on the Autistic Spectrum
Iossifov, I., Ronemus, M., Levy, D., Wang, Z., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y.-H., Narzisi, G., Leotta, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.009 · Cited by 1,446 · see citing works
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
The Autism Genome Project Consortium (2007) · Nature Genetics · doi:10.1038/ng1985 · Cited by 1,402 · see citing works
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Canani, R. B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i12.1519 · Cited by 1,381 · see citing works
Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism
Christensen, J., Grønborg, T. K., Sørensen, M. J., Schendel, D., Parner, E. T., Pedersen, L. H., & Vestergaard, M. (2013) · JAMA · doi:10.1001/jama.2013.2270 · Cited by 1,357 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells
Marks, P. A., Richon, V. M., & Rifkind, R. A. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.15.1210 · Cited by 1,152 · see citing works
Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., & Tsujimoto, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016088108 · Cited by 1,106 · see citing works
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076 · see citing works
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 913 · see citing works
Integration of metabolism and inflammation by lipid-activated nuclear receptors
Bensinger, S. J., & Tontonoz, P. (2008) · Nature · doi:10.1038/nature07202 · Cited by 813 · see citing works
From the gut to the peripheral tissues: the multiple effects of butyrate
Guilloteau, P., Martin, L., Eeckhaut, V., Ducatelle, R., Zabielski, R., & Immerseel, F. V. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000247 · Cited by 813 · see citing works
Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression
Kumer, S. C., & Vrana, K. E. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020443.x · Cited by 680 · see citing works
Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656 · see citing works
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works
Waldecker, M., Kautenburger, T., Daumann, H., Busch, C., & Schrenk, D. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.08.002 · Cited by 615 · see citing works
Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614 · see citing works
Johannessen, M., Delghandi, M. P., & Moens, U. L. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.05.001 · Cited by 592 · see citing works
Disruption of neurexin 1 associated with autism spectrum disorder
Kim, H.-G., Kishikawa, S., Higgins, A. W., Seong, I.-S., Donovan, D. J., Shen, Y., Lally, E., Weiss, L. A., Najm, J., Kutsche, K., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.011 · Cited by 578 · see citing works
Disorders of propionate and methylmalonate metabolism
CHALMERS, R. A., & Lawson, A. M. (1982) · Springer eBooks · doi:10.1007/978-94-009-5778-7_11 · Cited by 558 · see citing works
Catecholaminergic systems in stress: structural and molecular genetic approaches
Kvetnansky, R., Sabban, E. L., & Palkovits, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2006 · Cited by 548 · see citing works
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.165 · Cited by 545 · see citing works
MACFABE, D., CAIN, D., RODRIGUEZCAPOTE, K., FRANKLIN, A., HOFFMAN, J., BOON, F., TAYLOR, A., KAVALIERS, M., & OSSENKOPP, K. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.025 · Cited by 497 · see citing works
Self-citationMcDougle, C. J., Scahill, L. D., Aman, M. G., McCracken, J. T., Tierney, E., Davies, M., Arnold, L. E., Posey, D. J., Martin, A., GHUMAN, J. K., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1142 · Cited by 477 · see citing works
tana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01427.x · Cited by 474 · see citing works
Karaki, S.-I., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J., & Kuwahara, A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-005-0140-x · Cited by 465 · see citing works
Jones, L. L., McDonald, D. A., & Borum, P. R. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.08.004 · Cited by 455 · see citing works
Altered gut microbiota and activity in a murine model of autism spectrum disorders
de Theije, C. G. M., Wopereis, H., Ramadan, M., van Eijndthoven, T., Lambert, J., Knol, J., Garssen, J., Kraneveld, A. D., & Oozeer, R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.005 · Cited by 433 · see citing works
MacFabe, D. F. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.19260 · Cited by 432 · see citing works
Self-citationWang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2167-7 · Cited by 412 · see citing works
Ingram, J. L., Peckham, S. M., Tisdale, B., & Rodier, P. M. (2000) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00083-5 · Cited by 381 · see citing works
Mariadason, J. M., Corner, G. A., & Augenlicht, L. H. (2000) · PubMed · Cited by 375 · see citing works
MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365 · see citing works
Self-citationHeerdt, B. G., Houston, M. A., & Augenlicht, L. H. (1994) · PubMed · Cited by 357 · see citing works
Amminger, G. P., Berger, G. E., Schäfer, M. R., Klier, C., Friedrich, M. H., & Feucht, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.007 · Cited by 355 · see citing works
What is the pathogenesis of acne?
Zouboulis, C. C., Eady, E. A., Philpott, M., Goldsmith, L. A., Orfanos, C. E., Cunliffe, W. C., & Rosenfield, R. L. (2005) · Experimental Dermatology · doi:10.1111/j.0906-6705.2005.0285a.x · Cited by 340 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Deletions of NRXN1 (neurexin‐1) predispose to a wide spectrum of developmental disorders
Ching, M. S. L., Shen, Y., Tan, W., Jeste, S., Morrow, E. M., Chen, X., Mukaddes, N. M., Yoo, S.-Y., Hanson, E. M., Hundley, R. J., et al. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31063 · Cited by 298 · see citing works
Ganapathy, V., Thangaraju, M., Prasad, P. D., Martin, P. M., & Singh, N. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.08.006 · Cited by 290 · see citing works
The critical period of valproate exposure to induce autistic symptoms in Sprague–Dawley rats
Kim, K. C., Kim, P., Go, H. S., Choi, C. S., Yang, S., Cheong, J. H., Shin, C. Y., & Ko, K. H. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.12.018 · Cited by 285 · see citing works
Plasma fatty acid levels in autistic children
Vancassel, S., Durand, G., Barthélémy, C., Lejeune, B., Martineau, J., Guilloteau, D., Andres, C. R., & Chalon, S. (2001) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0281 · Cited by 265 · see citing works
Pathway Mapping Tools for Analysis of High Content Data
Ekins, S., Nikolsky, Y., Bugrim, A. E., Kirillov, E., & Nikolskaya, T. (2006) · Humana Press eBooks · doi:10.1385/1-59745-217-3:319 · Cited by 263 · see citing works
Shafer, T. J., & Atchison, W. D. (1991) · PubMed · Cited by 252 · see citing works
Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders
Boccuto, L., Lauri, M., Sarasua, S. M., Skinner, C. D., Buccella, D., Dwivedi, A., Orteschi, D., Collins, J. S., Zollino, M., Visconti, P., et al. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.175 · Cited by 240 · see citing works
Frye, R. E., Melnyk, S., & MacFabe, D. F. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.143 · Cited by 235 · see citing works
Self-citationZhu, W., & Otterson, G. A. (2003) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011033482440 · Cited by 226 · see citing works
James, S. J., Rose, S., Melnyk, S., Jernigan, S., Blossom, S. J., Pavliv, O., & Gaylor, D. W. (2009) · The FASEB Journal · doi:10.1096/fj.08-128926 · Cited by 223 · see citing works
Etiology of autistic features: the persisting neurotoxic effects of propionic acid
El-Ansary, A. K., Bacha, A. B., & Kotb, M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-74 · Cited by 209 · see citing works
Narita, N., Kato, M., Tazoe, M., Miyazaki, K., Narita, M., & Okado, N. (2002) · Pediatric Research · doi:10.1203/00006450-200210000-00018 · Cited by 205 · see citing works
Clinical spectrum of succinic semialdehyde dehydrogenase deficiency
Pearl, P. L., Gibson, K. M., Acosta, M. T., Vezina, L. G., Theodore, W. H., Rogawski, M. A., Novotny, E. J., Gropman, A. L., Conry, J. A., Berry, G. T., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000059549.70717.80 · Cited by 203 · see citing works
de Theije, C. G. M., Wu, J., da Silva, S. L., Kamphuis, P. J. G. H., Garssen, J., Korte, S. M., & Kraneveld, A. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.013 · Cited by 203 · see citing works
Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-153 · Cited by 200 · see citing works
Self-citationEssential fatty acids and phospholipase A2 in autistic spectrum disorders
Bell, J. G., Mackinlay, E. E., Dick, J. R., MacDonald, D. J., Boyle, R. M., & Glen, A. C. A. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.03.008 · Cited by 199 · see citing works
Short chain fatty acids dilate isolated human colonic resistance arteries.
Mortensen, F. V., Nielsen, H. K., Mulvany, M. J., & Hessov, I. (1990) · Gut · doi:10.1136/gut.31.12.1391 · Cited by 197 · see citing works
Brain Region-Specific Glutathione Redox Imbalance in Autism
Chauhan, A., AUDHYA, T. K., & Chauhan, V. P. S. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0775-4 · Cited by 196 · see citing works
Increased Norepinephrine Levels and Decreased Dopamine-β-Hydroxylase Activity in Primary Autism
Lake, C. R. (1977) · Archives of General Psychiatry · doi:10.1001/archpsyc.1977.01770170063005 · Cited by 182 · see citing works
Griswold, A. J., Ma, D., Cukier, H. N., Nations, L. D., Schmidt, M. A., Chung, R.-H., Jaworski, J. M., Salyakina, D., Konidari, I., Whitehead, P. L., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds164 · Cited by 180 · see citing works
AutismKB: an evidence-based knowledgebase of autism genetics
Xu, L.-M., Li, J.-R., Huang, Y., Zhao, M., Tang, X., & Wei, L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1145 · Cited by 179 · see citing works
Heerdt, B. G., Houston, M. A., & Augenlicht, L. H. (1997) · PubMed · Cited by 179 · see citing works
Short-Chain Fatty Acid Inhibitors of Histone Deacetylases: Promising Anticancer Therapeutics?
Chen, J. M., Faller, D. V., & Spanjaard, R. A. (2003) · Current Cancer Drug Targets · doi:10.2174/1568009033481994 · Cited by 174 · see citing works
Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.015 · Cited by 172 · see citing works
Langley, B. C., Gensert, J. M., Beal, M. F., & Ratan, R. R. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005091 · Cited by 169 · see citing works
The roles of TTP and BRF proteins in regulated mRNA decay
Sanduja, S., Blanco, F. F., & Dixon, D. A. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.28 · Cited by 164 · see citing works
Shultz, S. R., MacFabe, D. F., Martin, S. P., Jackson, J., Taylor, R., Boon, F. H., Ossenkopp, K., & Cain, D. P. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.023 · Cited by 156 · see citing works
Self-citationEarly medical history of children with autism spectrum disorders
NIEHUS, R., & LORD, C. (2006) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200604002-00010 · Cited by 152 · see citing works
DeCastro, M., Nankova, B. B., Shah, P., Patel, P., Mally, P. V., Mishra, R., & La Gamma, E. F. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.09.002 · Cited by 149 · see citing works
Self-citationReview Article: Carnitine, Valproate, and Toxicity
Coulter, D. L. (1991) · Journal of Child Neurology · doi:10.1177/088307389100600102 · Cited by 142 · see citing works
Short-Chain Carboxylic-Acid-Stimulated, PMN-Mediated Gingival Inflammation
Niederman, R., Zhang, J., & Kashket, S. (1997) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411970080030301 · Cited by 142 · see citing works
Molecular analysis of nicotinic receptor expression in autism
Martin-Ruiz, C. M., Lee, M., Perry, R. H., Baumann, M., Court, J. A., & Perry, E. K. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.01.003 · Cited by 141 · see citing works
Maternal behavior and developmental psychopathology
Leckman, J. F., & Herman, A. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01277-x · Cited by 139 · see citing works
Autism: Metabolism, Mitochondria, and the Microbiome
Macfabe, D. (2013) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2013.089 · Cited by 131 · see citing works
Self-citationBergersen, L. H., Rafiki, A., & Ottersen, O. P. (2002) · Neurochemical Research · doi:10.1023/a:1014806723147 · Cited by 128 · see citing works
Foley, K., Ossenkopp, K., Kavaliers, M., & Macfabe, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087072 · Cited by 128 · see citing works
Self-citationRole of polyunsaturated fatty acids in the management of Egyptian children with autism
Meguid, N. A., Atta, H. M., Gouda, A. S., & Khalil, R. O. (2008) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2008.05.013 · Cited by 125 · see citing works
Thomas, R., Foley, K. A., Mepham, J. R., Tichenoff, L. J., Possmayer, F., & MacFabe, D. F. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06614.x · Cited by 117 · see citing works
Self-citationFoley, K. A., MacFabe, D. F., Vaz, A., Ossenkopp, K., & Kavaliers, M. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.04.001 · Cited by 116 · see citing works
Self-citationState of the art; microbiology in health and disease. Intestinal bacterial flora in autism
Finegold, S. M. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.03.007 · Cited by 116 · see citing works
Dietary Inhibitors of Histone Deacetylases in Intestinal Immunity and Homeostasis
Schilderink, R., Verseijden, C., & de Jonge, W. J. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00226 · Cited by 115 · see citing works
The Neurobiology of Lipid Metabolism in Autism Spectrum Disorders
Tamiji, J., & Crawford, D. A. (2010) · Neurosignals · doi:10.1159/000323189 · Cited by 114 · see citing works
Biological networks and analysis of experimental data in drug discovery
Nikolsky, Y., Nikolskaya, T., & Bugrim, A. E. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03420-3 · Cited by 114 · see citing works
Clinical trials of fatty acid treatment in ADHD, dyslexia, dyspraxia and the autistic spectrum
Richardson, A. J. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.12.020 · Cited by 104 · see citing works
Bell, J. G., SARGENT, J. R., Tocher, D. R., & Dick, J. R. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0186 · Cited by 103 · see citing works
Neural and non‐neural mediation of propionate‐induced contractile responses in the rat distal colon
Mitsui, R., Ono, S., Karaki, S.-I., & Kuwahara, A. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2005.00669.x · Cited by 99 · see citing works
Inoue, D., Kimura, I., Wakabayashi, M., Tsumoto, H., Ozawa, K., Hara, T., Takei, Y., Hirasawa, A., Ishihama, Y., & Tsujimoto, G. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.04.021 · Cited by 99 · see citing works
Plasma fatty acid profiles in autism: A case-control study
Wiest, M. M., German, J. B., Harvey, D. J., Watkins, S. M., & Hertz‐Picciotto, I. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.01.007 · Cited by 97 · see citing works
Robinson, P. D., Schutz, C. K., Macciardi, F. M., White, B. N., & Holden, J. J. A. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1187 · Cited by 88 · see citing works
Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy
Schulpis, K. H., Karikas, G. A., Tjamouranis, J., Regoutas, S., & Tsakiris, S. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.47000.x · Cited by 86 · see citing works
Fatemi, S. H., & Folsom, T. D. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-6 · Cited by 84 · see citing works
Propionic Acidemia: A Neuropathology Case Report and Review of Prior Cases
Feliz, B., Witt, D. R., & Harris, B. T. (2003) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2003-127-e325-paancr · Cited by 84 · see citing works
Harrington, R., Lee, L.-C., Crum, R., Zimmerman, A., & Hertz-Picciotto, I. (2013) · Autism Research · doi:10.1002/aur.1288 · Cited by 83 · see citing works
Autism: The role of cholesterol in treatment
Aneja, A., & Tierney, E. (2008) · International Review of Psychiatry · doi:10.1080/09540260801889062 · Cited by 82 · see citing works
Heerdt, B. G., Houston, M. A., Anthony, G. M., & Augenlicht, L. H. (1998) · PubMed · Cited by 76 · see citing works
Gastrointestinal Microbiota and Metabolite Biomarkers in Children With Autism Spectrum Disorders
Wang, L., Conlon, M. A., Christophersen, C. T., Sorich, M. J., & Angley, M. T. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.12 · Cited by 72 · see citing works
Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein
Shah, P. G., Nankova, B. B., Parab, S., & Gamma, E. F. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.097 · Cited by 70 · see citing works
Self-citationMetabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study
Frye, R. E., DeLaTorre, R., Taylor, H., Slattery, J. M., Melnyk, S., Chowdhury, N., & James, S. J. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.14 · Cited by 70 · see citing works
Nguyen, N. H. T., Morland, C., González, S. V., Rise, F., Storm‐Mathisen, J., Gundersen, V., & Hassel, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04397.x · Cited by 67 · see citing works
Characterization of alpha-keto acid transport across blood-brain barrier in rats
Conn, A. R., Fell, D. I., & Steele, R. D. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.245.3.e253 · Cited by 65 · see citing works
Ossenkopp, K., Foley, K. A., Gibson, J., Fudge, M. A., Kavaliers, M., Cain, D. P., & MacFabe, D. F. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.045 · Cited by 63 · see citing works
Self-citationEffect of Chemically Induced Propionic Acidemia on Neurobehavioral Development of Rats
Brusque, A. M., Mello, C. F., BUCHANAN, D., TERRACCIANO, S., Rocha, M., Vargas, C. R., Wannmacher, C. M. D., & Wajner, M. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00127-6 · Cited by 62 · see citing works
Current concepts in organic acidurias: understanding intra‐ and extracerebral disease manifestation
Kölker, S., Burgard, P., Sauer, S. W., & Okun, J. G. (2013) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-013-9600-8 · Cited by 62 · see citing works
Pettenuzzo, L. F. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00856-0 · Cited by 62 · see citing works
Epigenetic, transcriptional and posttranscriptional regulation of the tyrosine hydroxylase gene
Lenartowski, R., & Goc, A. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.07.006 · Cited by 58 · see citing works
Cohen, O. S., Varlinskaya, E. I., Wilson, C., Glatt, S. J., & Mooney, S. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.09.002 · Cited by 57 · see citing works
NARITA, N. (2002) · Pediatric Research · doi:10.1203/01.pdr.0000028406.01104.76 · Cited by 57 · see citing works
Yorifuji, T., Kawai, M., Muroi, J., Mamada, M., Kurokawa, K., Shigematsu, Y., Hirano, S., Sakura, N., Yoshida, I., Kuhara, T., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0761-z · Cited by 56 · see citing works
Swim stress exaggerates the hyperactive mesocortical dopamine system in a rodent model of autism
Nakasato, A., Nakatani, Y., Seki, Y., Tsujino, N., Umino, M., & Arita, H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.11.043 · Cited by 52 · see citing works
D’Souza, A., Onem, E., Patel, P., Gamma, E. F. L., & Nankova, B. B. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.088 · Cited by 48 · see citing works
Self-citationControl of tyrosine hydroxylase gene expression in chromaffin and PC12 cells
Sabban, E. L. (1997) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1996.0129 · Cited by 46 · see citing works
Effect of short-chain fatty acids on contraction of smooth muscle in the canine colon
McManus, C. M., Michel, K. E., Simon, D. M., & Washabau, R. J. (2002) · American Journal of Veterinary Research · doi:10.2460/ajvr.2002.63.295 · Cited by 46 · see citing works
Interaction of cyclic AMP and cell-cell contact in the control of tyrosine hydroxylase RNA
Fader, D., & Lewis, E. J. (1990) · Molecular Brain Research · doi:10.1016/0169-328x(90)90005-x · Cited by 44 · see citing works
Nicotinic cholinergic antagonists: A novel approach for the treatment of autism
Lippiello, P. M. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.11.015 · Cited by 43 · see citing works
Mally, P., Mishra, R., Gandhi, S., DeCastro, M., Nankova, B. B., & LaGamma, E. F. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000119365.21770.45 · Cited by 41 · see citing works
Self-citationPatel, P., Nankova, B. B., & LaGamma, E. F. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.08.005 · Cited by 41 · see citing works
Self-citationCUCHE, & MALBERT (1999) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1999.00149.x · Cited by 37 · see citing works
Parab, S., Nankova, B. B., & Gamma, E. F. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.013 · Cited by 37 · see citing works
Self-citationModifier effects in autism at the MAO‐A and DBH loci
Jones, M. B., Palmour, R. M., Zwaigenbaum, L., & Szatmári, P. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20172 · Cited by 37 · see citing works
Mitsui, R., Ono, S., Karaki, S.-I., & Kuwahara, A. (2005) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.rp000205 · Cited by 29 · see citing works
Adrenergic differentiation potential in PC12 cells: influence of sodium butyrate and dexamethasone
Ebert, S. N., Lindley, S. E., Bengoechea, T. G., Bain, D. L., & Wong, D. L. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00032-6 · Cited by 28 · see citing works
Al-Ghamdi, M., Al-Ayadhi, L., & El-Ansary, A. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-34 · Cited by 25 · see citing works
Animal Models of Self-Injurious Behaviour: An Overview
Devine, D. P. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-458-2_4 · Cited by 23 · see citing works
Vascular Endothelial Growth Factor: Not Only for Vessels Anymore
Abman, S. H. (2003) · Pediatric Research · doi:10.1203/00006450-200301000-00001 · Cited by 23 · see citing works
Nankova, B. B., Chua, J., Mishra, R., Kobasiuk, C. D., & Gamma, E. F. L. (2003) · Pediatric Research · doi:10.1203/00006450-200301000-00019 · Cited by 22 · see citing works
Self-citationSodium butyrate modifies the stabilizing complexes of tyrosine hydroxylase mRNA
Arányi, T., Sarkis, C., Berrard, S., Sardin, K., Siron, V., Khalfallah, O., & Mallet, J. J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.025 · Cited by 15 · see citing works
Role of Ca2+ in induction of neurotransmitter-related gene expression by butyrate
Zia, M., Nankova, B. B., Krishnan, K., Gueorguiev, V. D., Frenz, C. M., Sabban, E. L., & Gamma, E. F. L. (2004) · Neuroreport · doi:10.1097/00001756-200405190-00019 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357 · see citing works
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
“In particular, these SCFAs regulate the expression levels of tryptophan 5-hydroxylase 1, the enzyme involved in synthesis of serotonin, and tyrosine hydroxylase, which is involved in a rate-limiting step in the biosynthesis of dopamine, noradrenaline and adrenaline; therefore, producing an effect on brain neurochemist…”
BackgroundPrebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019) · Foods · doi:10.3390/foods8030092 · Cited by 1,773 · see citing works
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota
Fusco, W. G., Bernabeu, M., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M. C., Gasbarrini, A., Collado, M. C., et al. (2023) · Nutrients · doi:10.3390/nu15092211 · Cited by 1,318 · see citing works
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182 · see citing works
The microbiota-gut-brain axis: from motility to mood
Margolis, K. G., Cryan, J. F., & Mayer, E. A. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.066 · Cited by 999 · see citing works
The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis
Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 551 · see citing works
Gut Bacteria and Neurotransmitters
Dicks, L. M. T. (2022) · Microorganisms · doi:10.3390/microorganisms10091838 · Cited by 482 · see citing works
Microbiota and the social brain
Sherwin, E., Bordenstein, S. R., Quinn, J. L., Dinan, T. G., & Cryan, J. F. (2019) · Science · doi:10.1126/science.aar2016 · Cited by 462 · see citing works
Role of microbiota-derived short-chain fatty acids in nervous system disorders
Mirzaei, R., Bouzari, B., Hosseini‐Fard, S. R., Mazaheri, M., Ahmadyousefi, Y., Abdi, M., Jalalifar, S., Karimitabar, Z., Teimoori, A., Keyvani, H., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111661 · Cited by 400 · see citing works
Gut microbiome and depression: what we know and what we need to know
Winter, G., Hart, R. A., Charlesworth, R. P. G., & Sharpley, C. F. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0072 · Cited by 394 · see citing works
A prebiotic intervention study in children with autism spectrum disorders (ASDs)
Grimaldi, R., Gibson, G. R., Vulevic, J., Giallourou, N., Castro-Mejía, J. L., Hansen, L. H., Leigh Gibson, E., Nielsen, D. S., & Costabile, A. (2018) · Microbiome · doi:10.1186/s40168-018-0523-3 · Cited by 369 · see citing works
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works
Sherwin, E., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0370-3 · Cited by 297 · see citing works
Gut microbial metabolites in depression: understanding the biochemical mechanisms
Caspani, G., Kennedy, S. H., Foster, J. A., & Swann, J. R. (2019) · Microbial Cell · doi:10.15698/mic2019.10.693 · Cited by 285 · see citing works
Faecal short chain fatty acids profile is changed in Polish depressive women
Skonieczna-Żydecka, K., Grochans, E., Maciejewska, D., Szkup, M., Schneider-Matyka, D., Jurczak, A., Łoniewski, I., Kaczmarczyk, M., Marlicz, W., Czerwińska-Rogowska, M., et al. (2018) · Nutrients · doi:10.3390/nu10121939 · Cited by 284 · see citing works
Kim, Y., & Shin, C. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170915141036 · Cited by 273 · see citing works
Communication of gut microbiota and brain via immune and neuroendocrine signaling
Kasarełło, K., Cudnoch‐Jędrzejewska, A., & Czarzasta, K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1118529 · Cited by 270 · see citing works
MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.28177 · Cited by 260 · see citing works
Self-citationThe microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder
Li, Q., & Zhou, J.-M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.013 · Cited by 253 · see citing works
Zhang, Z., Mu, X., Cao, Q., Shi, Y., Hu, X., & Zheng, H. (2022) · Nature Communications · doi:10.1038/s41467-022-29760-0 · Cited by 236 · see citing works
Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder
Rose, S., Niyazov, D. M., Rossignol, D. A., Goldenthal, M. J., Kahler, S. G., & Frye, R. E. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0352-x · Cited by 235 · see citing works
Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
Rose, S., Bennuri, S. C., Davis, J. E., Wynne, R., Slattery, J. C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S. G., MacFabe, D. F., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0089-z · Cited by 226 · see citing works
Self-citationThe Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease
Tran, S. M.-S., & Mohajeri, M. H. (2021) · Nutrients · doi:10.3390/nu13030732 · Cited by 207 · see citing works
Host microbiota modulates development of social preference in mice
Arentsen, T., Raith, H., Qian, Y., Forssberg, H., & Heijtz, R. D. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.29719 · Cited by 202 · see citing works
Luca, M., Di Mauro, M., Di Mauro, M., & Luca, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4730539 · Cited by 190 · see citing works
Gut Microbiota: The Brain Peacekeeper
Mu, C., Yang, Y., & Zhu, W. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00345 · Cited by 188 · see citing works
Zhang, M., Ma, W., Zhang, J., He, Y., & Wang, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-32219-2 · Cited by 188 · see citing works
Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases
Leo, E. E. M., & Campos, M. R. S. (2019) · Nutrition · doi:10.1016/j.nut.2019.110609 · Cited by 188 · see citing works
Dash, S., Syed, Y. A., & Khan, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.880544 · Cited by 179 · see citing works
Bojović, K., Ignjatović, Đ., Bajić, S. S., Milutinović, D. V., Tomić, M., Golić, N., & Tolinački, M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00223 · Cited by 169 · see citing works
Enteric short‐chain fatty acids promote proliferation of human neural progenitor cells
Yang, L. L., Millischer, V., Rodin, S., MacFabe, D. F., Villaescusa, J. C., & Lavebratt, C. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14928 · Cited by 157 · see citing works
Self-citationAltered gut microbiota in Rett syndrome
Strati, F., Cavalieri, D., Albanese, D., Felice, C. D., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Pindo, M., Renzi, D., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0185-y · Cited by 148 · see citing works
Microbiota‐gut‐brain axis as a regulator of reward processes
García‐Cabrerizo, R., Carbia, C., O’Riordan, K. J., Schellekens, H., & Cryan, J. F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15284 · Cited by 147 · see citing works
Potential Benefits of Probiotics and Prebiotics for Coronary Heart Disease and Stroke
Wu, H., & Chiou, J. A. (2021) · Nutrients · doi:10.3390/nu13082878 · Cited by 147 · see citing works
Frye, R. E., Rose, S., Slattery, J. M., & MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.27458 · Cited by 142 · see citing works
Self-citationChoi, J., Lee, S., Won, J., Jin, Y., Hong, Y., Hur, T.-Y., Kim, J.-H., Lee, S.-R., & Hong, Y. (2018) · PLOS ONE · doi:10.1371/journal.pone.0192925 · Cited by 139 · see citing works
Small talk: microbial metabolites involved in the signaling from microbiota to brain
Caspani, G., & Swann, J. R. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.08.001 · Cited by 138 · see citing works
Aljumaah, M. R., Bhatia, U., Roach, J., Gunstad, J., & Peril, M. A. A. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.09.012 · Cited by 138 · see citing works
Role of the gut microbiome in three major psychiatric disorders
Borkent, J., Ioannou, M., Laman, J. D., Haarman, B. C. M., & Sommer, I. E. (2022) · Psychological Medicine · doi:10.1017/s0033291722000897 · Cited by 132 · see citing works
Frye, R. E., Rose, S., Chacko, J., Wynne, R., Bennuri, S. C., Slattery, J. C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S. G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.189 · Cited by 130 · see citing works
Self-citationGut Microbiota, Inflammation, and Probiotics on Neural Development in Autism Spectrum Disorder
Doenyas, C. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.060 · Cited by 121 · see citing works
Short chain fatty acids, a possible treatment option for autoimmune diseases
Golpour, F., Abbasi-Alaei, M., Babaei, F., Mirzababaei, M., Parvardeh, S., Mohammadi, G., & Nassiri‐Asl, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114763 · Cited by 121 · see citing works
Lefter, R., Ciobica, A., Timofte, D., Stanciu, C., & Trifan, A. (2019) · Medicina · doi:10.3390/medicina56010011 · Cited by 120 · see citing works
The impact of maternal high-fat diet on offspring neurodevelopment
Urbonaite, G., Knyzeliene, A., Bunn, F. S., Smalskys, A., & Neniškytė, U. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.909762 · Cited by 118 · see citing works
Distant Site Effects of Ingested Prebiotics
Collins, S., & Reid, G. (2016) · Nutrients · doi:10.3390/nu8090523 · Cited by 112 · see citing works
Multiple roles of short-chain fatty acids in Alzheimer disease
Chen, H., Meng, L., & Shen, L. (2021) · Nutrition · doi:10.1016/j.nut.2021.111499 · Cited by 107 · see citing works
Shobeiri, P., Kalantari, A., Teixeira, A. L., & Rezaei, N. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00422-6 · Cited by 105 · see citing works
Liu, F., Horton-Sparks, K., Hull, V. L., Li, R. W., & Martínez‐Cerdeño, V. (2018) · Molecular Autism · doi:10.1186/s13229-018-0251-3 · Cited by 104 · see citing works
Mitochondrial function and abnormalities implicated in the pathogenesis of ASD
Castora, F. J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.015 · Cited by 104 · see citing works
The gut microbiome in Parkinson's disease: A culprit or a bystander?
Keshavarzian, A., Engen, P. A., Bonvegna, S., & Cilia, R. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.01.004 · Cited by 104 · see citing works
How important are fatty acids in human health and can they be used in treating diseases?
Dicks, L. M. T. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2420765 · Cited by 97 · see citing works
Foley, K. A., MacFabe, D. F., Kavaliers, M., & Ossenkopp, K. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.032 · Cited by 96 · see citing works
Self-citationGut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective
Jena, A., Montoya, C. A., Mullaney, J. A., Dilger, R. N., Young, W., McNabb, W. C., & Roy, N. C. (2020) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2020.00044 · Cited by 92 · see citing works
Distinct Roles of Honeybee Gut Bacteria on Host Metabolism and Neurological Processes
Zhang, Z., Mu, X., Shi, Y., & Zheng, H. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02438-21 · Cited by 91 · see citing works
Moțățăianu, A., Şerban, G. M., & Andone, S. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015094 · Cited by 90 · see citing works
Gut microbiota, kynurenine pathway and mental disorders – Review
Więdłocha, M., Marcinowicz, P., Janoska-Jaździk, M., & Szulc, A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110145 · Cited by 87 · see citing works
Sanborn, V. E., Azcárate-Peril, M. A., Updegraff, J. A., Manderino, L. M., & Gunstad, J. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s270035 · Cited by 86 · see citing works
Rose, S., Bennuri, S. C., Murray, K. F., Buie, T., Winter, H., & Frye, R. E. (2017) · PLOS ONE · doi:10.1371/journal.pone.0186377 · Cited by 82 · see citing works
Chen, Y.-H., Xue, F., Yu, S.-F., Li, X.-S., Liu, L., Jia, Y., Yan, W., Tan, Q.-R., Wang, H., & Peng, Z. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.143 · Cited by 80 · see citing works
An approach to gut microbiota profile in children with autism spectrum disorder
Andreo‐Martínez, P., García-Martínez, N., Sánchez‐Samper, E. P., & Martínez‐González, A. E. (2019) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12810 · Cited by 76 · see citing works
Dong, X.-L., Wang, X., Liu, F., Liu, X., Du, Z.-R., Li, R. W., Xue, C.-H., Wong, K.-H., Wong, W.-T., Zhao, Q., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.180 · Cited by 75 · see citing works
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms
Frye, R. E., Slattery, J. M., MacFabe, D. F., Allen‐Vercoe, E., Parker, W., Rodakis, J., Adams, J. B., Krajmalnik‐Brown, R., Bolte, E. R., Kahler, S. G., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26878 · Cited by 75 · see citing works
Self-citationRegulation of endocrine systems by the microbiome: Perspectives from comparative animal models
Williams, C. L., García‐Reyero, N., Martyniuk, C. J., Tubbs, C. W., & Bisesi, J. H. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113437 · Cited by 75 · see citing works
Slattery, J. M., MacFabe, D. F., & Frye, R. E. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38338 · Cited by 72 · see citing works
Self-citationHoney bee genetics shape the strain-level structure of gut microbiota in social transmission
Wu, J., Lang, H., Mu, X., Zhang, Z., Su, Q., Hu, X., & Zheng, H. (2021) · Microbiome · doi:10.1186/s40168-021-01174-y · Cited by 72 · see citing works
Microbiota Metabolite Regulation of Host Immune Homeostasis: A Mechanistic Missing Link
Steinmeyer, S. H., Lee, K., Jayaraman, A., & Alaniz, R. C. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0524-2 · Cited by 72 · see citing works
The Gut Microbiota and Oxidative Stress in Autism Spectrum Disorders (ASD)
Hu, T., Dong, Y., He, C., Zhao, M., & He, Q. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8396708 · Cited by 71 · see citing works
Gut microbiota and aging-A focus on centenarians
Cӑtoi, A. F., Corina, A., Katsiki, N., Vodnar, D. C., Andreicuț, A. D., Stoian, A. P., Rizzo, M., & Pérez-Martínez, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165765 · Cited by 70 · see citing works
Metformin, Cognitive Function, and Changes in the Gut Microbiome
Rosell-Díaz, M., & Fernández‐Real, J. M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad029 · Cited by 68 · see citing works
Hsu, C., Khachatryan, L., Younis, N. K., Mustafa, M. A., Ahmad, N., Athab, Z. H., Валерьевна, П. А., Викторовна, К. Е., Mirzaei, R., & Karampoor, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1456793 · Cited by 68 · see citing works
Gut Microbiota Influences Alzheimer’s Disease Pathogenesis by Regulating Acetate in Drosophila Model
Kong, Y., Jiang, B., & Luo, X. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0185 · Cited by 68 · see citing works
Palmas, V., Pisanu, S., Madau, V., Casula, E., Deledda, A., Cusano, R., Uva, P., Loviselli, A., Velluzzi, F., & Manzin, A. (2022) · Nutrients · doi:10.3390/nu14122436 · Cited by 67 · see citing works
The Microbiome and Sustainable Healthcare
Dietert, R. R., & Dietert, J. M. (2015) · Healthcare · doi:10.3390/healthcare3010100 · Cited by 67 · see citing works
The Role of Short Chain Fatty Acids in Irritable Bowel Syndrome
Jiang, W., Wu, J., Zhu, S., Xin, L., Yu, C., & Shen, Z. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm22093 · Cited by 66 · see citing works
Hofford, R. S., Mervosh, N. L., Euston, T. J., Meckel, K. R., Orr, A. T., & Kiraly, D. D. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01043-0 · Cited by 64 · see citing works
Zhao, R., Chu, L., Wang, Y., Song, Y., Liu, P., Li, C., Huang, J., & Kang, X. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.02.016 · Cited by 63 · see citing works
The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders
Marzal, L. N. P., Prince, N., Bajić, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810052 · Cited by 63 · see citing works
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis
Luo, P., Lednovich, K., Xu, K., Nnyamah, C., Layden, B. T., & Xu, P. (2022) · Translational research · doi:10.1016/j.trsl.2022.06.003 · Cited by 62 · see citing works
Carissimi, C., Laudadio, I., Palone, F., Fulci, V., Cesi, V., Cardona, F., Alfonsi, C., Cucchiara, S., Isoldi, S., & Stronati, L. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.06.006 · Cited by 62 · see citing works
Giuffrè, M., Moretti, R., Campisciano, G., da Silveira, A. B. M., Monda, V., Comar, M., Bella, S. D., Antonello, R. M., Luzzati, R., & Crocè, L. S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113705 · Cited by 61 · see citing works
Exploring the microbiota-gut-brain axis: impact on brain structure and function
Yassin, L. K., Nakhal, M. M., Alderei, A., Almehairbi, A., Mydeen, A. B., Akour, A. A., & Hamad, M. I. K. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1504065 · Cited by 60 · see citing works
Liang, Y., Cui, L., Gao, J., Zhu, M., Zhang, Y., & Zhang, H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02375-0 · Cited by 59 · see citing works
Rahi, S., Gupta, R., Sharma, A., & Mehan, S. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211013456 · Cited by 59 · see citing works
Al-Khafaji, A. H., Jepsen, S. D., Christensen, K. R., & Vigsnæs, L. K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104176 · Cited by 59 · see citing works
Khera, R., Mehan, S., Bhalla, S., Kumar, S., Alshammari, A., Alharbi, M., & Sadhu, S. S. (2022) · Molecules · doi:10.3390/molecules27030889 · Cited by 58 · see citing works
Kim, S., Park, S., Choi, T. G., & Kim, S. S. (2022) · Nutrients · doi:10.3390/nu14142982 · Cited by 58 · see citing works
Cutuli, D., Decandia, D., Giacovazzo, G., & Coccurello, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914686 · Cited by 58 · see citing works
Béopoulos, A., Géa, M., Fasano, A., & Iris, F. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.988735 · Cited by 54 · see citing works
Frye, R. E., Nankova, B., Bhattacharyya, S., Rose, S., Bennuri, S. C., & MacFabe, D. F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01670 · Cited by 51 · see citing works
Self-citationMudaliar, S. B., Poojary, S. S., Prasad, A. S. B., & Mazumder, N. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10214-6 · Cited by 49 · see citing works
Shiadeh, S. M. J., Chan, W. K., Rasmusson, S., Hassan, N., Joca, S. R. L., Westberg, L., Elfvin, A., Mallard, C. E., & Ardalan, M. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03504-2 · Cited by 49 · see citing works
Sharma, A. R., Batra, G., Saini, L. K., Sharma, S., Mishra, A., Singla, R., Singh, A. K., Singh, R. S., Jain, A., Bansal, S., et al. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210806165430 · Cited by 49 · see citing works
Ottria, R., Mirmajidi, S., & Ciuffreda, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27021095 · Cited by 48 · see citing works
Ağagündüz, D., Çelik, E., Cemali, Ö., Bingöl, F. G., Özenir, Ç., Özoğul, F., & Capasso, R. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10092-4 · Cited by 47 · see citing works
Sharma, A., Bhalla, S., & Mehan, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01026-0 · Cited by 47 · see citing works
RetractedOstendorf, F., Metzdorf, J., Gold, R., Haghikia, A., & Tönges, L. (2020) · Molecules · doi:10.3390/molecules25112502 · Cited by 46 · see citing works
Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases
Marrone, M. C., & Coccurello, R. (2019) · Biomolecules · doi:10.3390/biom10010012 · Cited by 46 · see citing works
A controversy on the role of short-chain fatty acids in the pathogenesis of Parkinson's disease
Mulak, A. (2018) · Movement Disorders · doi:10.1002/mds.27304 · Cited by 45 · see citing works
- Authors
- Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F.
- Affiliations
- New York Medical College (US)
- Western University (CA)
- Corresponding author
- Nankova, Bistra B.
- ORCID
- Nankova, Bistra B.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-08-29
- Volume
- 9
- Issue
- 8
- Pages
- e103740
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4149359
- OpenAlex
- W2028901643
- Cited by
- 294
- References
- 136
- Citations by year
- 2026: 24 · 2025: 26 · 2024: 30 · 2023: 29 · 2022: 43 · 2021: 34 · 2020: 37 · 2019: 19 · 2018: 21 · 2017: 8 · 2016: 14 · 2015: 8 · 2014: 1
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Autism Research Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- propionic acid, butyrate, short-chain fatty acids, gut microbiota, autism spectrum disorder, catecholaminergic neurotransmission, tyrosine hydroxylase, CREB transcription factor, PC12 cells, histone deacetylase inhibition, epigenetic regulation, monoamines, neurodevelopmental disorders, gut-brain axis
- MeSH terms
- Animals, Child Development Disorders, Pervasive, Enterobacteriaceae, Gene Expression Regulation, Synaptic Transmission, Propionates, Tyrosine 3-Monooxygenase, Transcriptional Activation, PC12 Cells, Cyclic AMP Response Element-Binding Protein, Butyric Acid, Rats, Gene Regulatory Networks, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
