Cited by 496Gut microbiota and healthAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Pistollato, Francesca, Sumalla Cano, Sandra, Elio, Iñaki, Masias Vergara, Manuel, Giampieri, Francesca, Battino, Maurizio·2016·Nutrition Reviews

DOI 10.1093/nutrit/nuw023

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Abstract

It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory cytokines related to the pathogenesis of Alzheimer disease. Additionally, nutrients have been shown to affect the composition of the gut microbiota as well as the formation and aggregation of cerebral amyloid-β. This suggests that modulating the gut microbiome and amyloidogenesis through specific nutritional interventions might prove to be an effective strategy to prevent or reduce the risk of Alzheimer disease. This review examines the possible role of the gut in the dissemination of amyloids, the role of the gut microbiota in the regulation of the gut-brain axis, the potential amyloidogenic properties of gut bacteria, and the possible impact of nutrients on modulation of microbiota composition and amyloid formation in relation to the pathogenesis of Alzheimer disease.

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Authors: Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M.
Affiliations: Marche Polytechnic University (IT)
ORCID: Pistollato, Francesca
Giampieri, Francesca
Battino, Maurizio
Venue: Nutrition Reviews
Publisher: Oxford University Press (OUP)
Published: 2016-09-15
Volume: 74
Issue: 10
Pages: 624-634
ISSN: 0029-6643 (ISSN-L)
1753-4887
DOI: 10.1093/nutrit/nuw023
OpenAlex: W2519408637
Cited by: 496
References: 177
Citations by year: 2026: 22 · 2025: 32 · 2024: 48 · 2023: 53 · 2022: 61 · 2021: 80 · 2020: 72 · 2019: 59 · 2018: 37 · 2017: 30 · 2016: 2
FWCI: 3.85
Type: journal article
Language: en
Open access: closed
Locations: Nutrition Reviews (publishedVersion)
PubMed (publishedVersion)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Fondazione Umberto Veronesi
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, gut microbiota, amyloid-beta, amyloid fibril formation, gut-brain axis, lipopolysaccharide, inflammatory cytokines, dietary nutrients, microbiota composition, neuroinflammation, amyloidogenesis, dietary intervention
MeSH terms: Gastrointestinal Microbiome, Alzheimer Disease, Amyloid, Bacteria, Brain, Diet, Humans, Cytokines, Prebiotics

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Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

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