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Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease
Abstract
It has been hypothesized that alterations in the composition of the gut microbiota might be associated with the onset of certain human pathologies, such as Alzheimer disease, a neurodegenerative syndrome associated with cerebral accumulation of amyloid-β fibrils. It has been shown that bacteria populating the gut microbiota can release significant amounts of amyloids and lipopolysaccharides, which might play a role in the modulation of signaling pathways and the production of proinflammatory cytokines related to the pathogenesis of Alzheimer disease. Additionally, nutrients have been shown to affect the composition of the gut microbiota as well as the formation and aggregation of cerebral amyloid-β. This suggests that modulating the gut microbiome and amyloidogenesis through specific nutritional interventions might prove to be an effective strategy to prevent or reduce the risk of Alzheimer disease. This review examines the possible role of the gut in the dissemination of amyloids, the role of the gut microbiota in the regulation of the gut-brain axis, the potential amyloidogenic properties of gut bacteria, and the possible impact of nutrients on modulation of microbiota composition and amyloid formation in relation to the pathogenesis of Alzheimer disease.
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“As a result, proinflammatory miRNA-34a is up regulated, causing downregulation of TREM-2 (trigger receptor expressed in microglial/myeloid cell-2), which can cause deposition of Aβ-42 peptide [25].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [25]
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Cites
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Suez, J., Korem, T., Zeevi, D., Zilberman-Schapira, G., Thaiss, C. A., Maza, O., Israeli, D., Zmora, N., Gilad, S., Weinberger, A., et al. (2014) · Nature · doi:10.1038/nature13793 · Cited by 2,067
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748
Kim, H. J., Huh, D., Hamilton, G., & Ingber, D. E. (2012) · Lab on a Chip · doi:10.1039/c2lc40074j · Cited by 1,734
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
Ehrnhoefer, D. E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R., Engemann, S., Pastore, A., & Wanker, E. E. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1437 · Cited by 1,462
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426
Microbes in Gastrointestinal Health and Disease
Neish, A. S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.080 · Cited by 1,423
How informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241
Consumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192
Hemarajata, P., & Versalovic, J. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12459294 · Cited by 1,083
Everard, A., Lazarevic, V., Derrien, M., Girard, M., Muccioli, G. G., Neyrinck, A. M., Possemiers, S., Van Holle, A., François, P., de Vos, W. M., et al. (2011) · Diabetes · doi:10.2337/db11-0227 · Cited by 1,076
The influence of diet on the gut microbiota
Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
Bieschke, J., Russ, J., Friedrich, R. P., Ehrnhoefer, D. E., Wobst, H. J., Neugebauer, K., & Wanker, E. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910723107 · Cited by 1,044
Microbiota and diabetes: an evolving relationship
Tilg, H., & Moschen, A. R. (2014) · Gut · doi:10.1136/gutjnl-2014-306928 · Cited by 853
LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms
Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.017 · Cited by 828
The role of microbiome in central nervous system disorders
Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40126j · Cited by 750
The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases
Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731
Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota
Lee, H. C., Jenner, A. M., Low, C. S., & Lee, Y. K. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2006.07.004 · Cited by 697
Interactions of gut microbiota with functional food components and nutraceuticals
Laparra, J. M., & Sanz, Y. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.11.001 · Cited by 684
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637
Review article: dietary fibre-microbiota interactions
Simpson, H. L., & Campbell, B. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13248 · Cited by 602
The gut microbiota, obesity and insulin resistance
Shen, J., Obin, M. S., & Zhao, L. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.11.001 · Cited by 599
Petra, A. I., Panagiotidou, S., Hatziagelaki, E., Stewart, J. M., Conti, P., & Theoharides, T. C. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.002 · Cited by 592
Antibiotics, Pediatric Dysbiosis, and Disease
Vangay, P., Ward, T., Gerber, J. S., & Knights, D. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.006 · Cited by 556
Infant antibiotic exposures and early-life body mass
Trasande, L., Blustein, J., Liu, M., Corwin, E. J., Cox, L. M., & Blaser, M. J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.132 · Cited by 514
A Unifying Role for Prions in Neurodegenerative Diseases
Prusiner, S. B. (2012) · Science · doi:10.1126/science.1222951 · Cited by 507
Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485
Brain metabolic dysfunction at the core of Alzheimer's disease
de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 472
Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
Calder, P. C. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700289 · Cited by 465
The dormant blood microbiome in chronic, inflammatory diseases
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv013 · Cited by 384
Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
Ferreira, S. T., Clarke, J. R., Bomfim, T. R., & Felice, F. G. D. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.010 · Cited by 363
Park, J., Lee, B. K., Jeong, G. S., Hyun, J. K., Lee, C. J., & Lee, S. (2014) · Lab on a Chip · doi:10.1039/c4lc00962b · Cited by 363
Neurodegenerative Diseases: Expanding the Prion Concept
Walker, L. C., & Jucker, M. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033828 · Cited by 361
Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration
Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338
Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease
Pablo, J. P., Banack, S. A., Cox, P. A., Johnson, T. E., Papapetropoulos, S., Bradley, W. G., Buck, A., & Mash, D. C. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01150.x · Cited by 333
Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice
Carvalho, B. M., Guadagnini, D., Tsukumo, D. M. L., Schenka, A. A., Latuf-Filho, P., Vassallo, J., Dias, J. C., Kubota, L. T., Carvalheira, J. B. C., & Saad, M. J. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2648-4 · Cited by 324
Diversity, biogenesis and function of microbial amyloids
Blanco, L. P., Evans, M. L., Smith, D. R., Badtke, M. P., & Chapman, M. R. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2011.11.005 · Cited by 320
Age-Associated Remodeling of the Intestinal Epithelial Barrier
Tran, L., & Greenwood-Van Meerveld, B. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt106 · Cited by 320
The Role of Lipocalin 2 in the Regulation of Inflammation in Adipocytes and Macrophages
Zhang, J., Wu, Y., Zhang, Y., LeRoith, D., Bernlohr, D., & Chen, X. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0420 · Cited by 302
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300
Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L., et al. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130722 · Cited by 288
Blood–brain-barriers in aging and in Alzheimer’s disease
Marques, F., Sousa, J. C., Sousa, N., & Palha, J. A. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-38 · Cited by 285
Bastianetto, S., Yao, Z., Papadopoulos, V., & Quirion, R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04532.x · Cited by 283
Gut microbiota and gastrointestinal health: current concepts and future directions
Aziz, Q., Doré, J., Emmanuel, A., Guarner, F., & Quigley, E. M. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12046 · Cited by 280
Gut microorganisms as promising targets for the management of type 2 diabetes
Delzenne, N. M., Cani, P. D., Everard, A., Neyrinck, A. M., & Bindels, L. B. (2015) · Diabetologia · doi:10.1007/s00125-015-3712-7 · Cited by 271
Insulin resistance predicts brain amyloid deposition in late middle‐aged adults
Willette, A. A., Johnson, S. C., Birdsill, A. C., Sager, M. A., Christian, B., Baker, L. D., Craft, S., Oh, J. M., Statz, E. H., Hermann, B. P., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.03.011 · Cited by 267
Abuznait, A. H., Qosa, H., Busnena, B. A., Sayed, K. A. E., & Kaddoumi, A. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400024q · Cited by 266
Alzheimer's disease and the microbiome
Bhattacharjee, S., & Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00153 · Cited by 253
Shoemark, D. K., & Allen, S. J. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141170 · Cited by 251
Stecher, B. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mbp-0008-2014 · Cited by 250
(2012) · PubMed Central · Cited by 248
U.S. Outpatient Antibiotic Prescribing, 2010
Hicks, L. A., Taylor, T. H., & Hunkler, R. J. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1212055 · Cited by 247
Zhang, J., Ke, K., Liu, Z., Qiu, Y., & Peng, Y.-P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075786 · Cited by 243
Delzenne, N. M., Neyrinck, A. M., & Cani, P. D. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s10 · Cited by 241
New Technologies for Studying Biofilms
Franklin, M. J., Chang, C. B., Akiyama, T., & Bothner, B. B. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mb-0016-2014 · Cited by 238
Microbiota and the gut–brain axis
Bienenstock, J., Kunze, W., & Forsythe, P. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv019 · Cited by 234
Microbiome disturbances and autism spectrum disorders
Rosenfeld, C. S. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.063826 · Cited by 229
Morales, R., Moreno‐González, I., & Soto, C. A. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003537 · Cited by 225
Wang, I. ‐., Wu, Y. Y., Yang, Y., Ting, I., Lin, C. C., Yen, T., Chen, J.-H., Wang, C., Huang, C.-F., & Lin, H. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0088 · Cited by 223
Kim, M., Hwang, S., Park, E., & Bae, J. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12079 · Cited by 220
Urieli-Shoval, S., Cohen, P., Eisenberg, S., & Matzner, Y. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804601206 · Cited by 219
Transmissible Proteins: Expanding the Prion Heresy
Soto, C. A. (2012) · Cell · doi:10.1016/j.cell.2012.05.007 · Cited by 215
Fernando, W. M. A. D. B., Martins, I. J., Goozee, K. G., Brennan, C. S., Jayasena, V., & Martins, R. N. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515001452 · Cited by 200
John, S., Luben, R., Shrestha, S. S., Welch, A. A., Khaw, K., & Hart, A. R. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283352d05 · Cited by 184
Hultman, K., Strickland, S., & Norris, E. H. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.76 · Cited by 183
Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?
Asti, A., & Gioglio, L. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-131394 · Cited by 180
Daubioul, C., Rousseau, N., Taper, H. S., Declerck, B., Delzenne, N. M., Demeure, R., & Gallez, B. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.967 · Cited by 178
Microbial amyloids – functions and interactions within the host
Schwartz, K., & Boles, B. R. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.12.001 · Cited by 177
Microbial-generated amyloids and Alzheimer's disease (AD)
Hill, J. M., & Lukiw, W. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00009 · Cited by 173
Rhee, S. H. (2014) · Intestinal Research · doi:10.5217/ir.2014.12.2.90 · Cited by 171
Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease
Paula‐Lima, A. C., Brito‐Moreira, J., & Ferreira, S. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12304 · Cited by 170
Higher normal fasting plasma glucose is associated with hippocampal atrophy
Cherbuin, N., Sachdev, P. S., & Anstey, K. J. (2012) · Neurology · doi:10.1212/wnl.0b013e31826846de · Cited by 170
Impaired glycemia increases disease progression in mild cognitive impairment
Morris, J. K., Vidoni, E. D., Honea, R. A., & Burns, J. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.033 · Cited by 163
NMDA Receptor Activity in Neuropsychiatric Disorders
Lakhan, S. E., Caro, M. A., & Hadzimichalis, N. M. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00052 · Cited by 160
Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals
Berti, V., Murray, J., Davies, M., Spector, N. C., Tsui, W. H., Li, Y., Williams, S. K., Pirraglia, E., Vallabhajosula, S., McHugh, P. F., et al. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0534-0 · Cited by 156
Tomasik, J., Yolken, R. H., Bahn, S., & Dickerson, F. (2015) · Biomarker Insights · doi:10.4137/bmi.s22007 · Cited by 155
Cardiovascular Risk Factors for Alzheimer's Disease
Rosendorff, C., Beeri, M. S., & Silverman, J. M. (2007) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2007.06696.x · Cited by 154
Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD).
Zhao, Y., & Lukiw, W. J. (2015) · PubMed · Cited by 149
Qosa, H., Abuasal, B. S., Romero, I. A., Weksler, B., Couraud, P.-O., Keller, J. N., & Kaddoumi, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.023 · Cited by 146
The effects of gut microbiota on CNS function in humans
Tillisch, K. (2014) · Gut Microbes · doi:10.4161/gmic.29232 · Cited by 144
Functional amyloid formation by Streptococcus mutans
Oli, M. W., Otoo, H. N., Crowley, P. J., Heim, K. P., Nascimento, M. M., Ramsook, C. B., Lipke, P. N., & Brady, L. J. (2012) · Microbiology · doi:10.1099/mic.0.060855-0 · Cited by 144
Daulatzai, M. A. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1266-6 · Cited by 143
Microbial Sources of Amyloid and Relevance to Amyloidogenesis and Alzheimer’s Disease (AD)
P, Z. Y. D. (2015) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000177 · Cited by 141
Zloković, B. V. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00310-4 · Cited by 139
Altered synapses and gliotransmission in Alzheimer's disease and AD model mice
Mitew, S., Kirkcaldie, M. T. K., Dickson, T. C., & Vickers, J. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.010 · Cited by 138
The role of microbes and autoimmunity in the pathogenesis of neuropsychiatric illness
Hornig, M. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32836208de · Cited by 138
Esteve, E., Ricart, W., & Fernández-Real, J.-M. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328348c06d · Cited by 133
Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-β and α-Synuclein Fibrils
Grelle, G., Otto, A., Lorenz, M., Frank, R. F., Wanker, E. E., & Bieschke, J. (2011) · Biochemistry · doi:10.1021/bi2012383 · Cited by 133
Amyloidogenic potential of foie gras
Solomon, A., Richey, T., Murphy, C. L., Weiss, D. T., Wall, J. S., Westermark, G. T., & Westermark, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700848104 · Cited by 132
Eun, C. S., Mishima, Y., Wohlgemuth, S., Liu, B., Bower, M., Carroll, I. M., & Sartor, R. B. (2014) · Infection and Immunity · doi:10.1128/iai.01513-13 · Cited by 128
An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases
Lorente‐Cebrián, S., Costa, A. G. V., Navas‐Carretero, S., Zabala, M., Laiglesia, L. M., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0395-y · Cited by 124
Probiotics, prebiotics, and the host microbiome: the science of translation
Petschow, B., Doré, J., Hibberd, P., Dinan, T., Reid, G., Blaser, M., Cani, P. D., Degnan, F. H., Foster, J., Gibson, G., et al. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12303 · Cited by 124
Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation.
Liu, Y.-Q., Pukala, T., Musgrave, I., Williams, D. M., Dehle, F., & Carver, J. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.09.071 · Cited by 121
Wang, Y., Xia, Z., Xu, J., Wang, Y., Hou, L., Qiu, Y. L., & Chen, H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.016 · Cited by 119
Is Altered BDNF Biosynthesis a General Feature in Patients with Cognitive Dysfunctions?
Carlino, D., Vanna, M. D., & Tongiorgi, E. (2012) · The Neuroscientist · doi:10.1177/1073858412469444 · Cited by 117
Platten, F., Jeworrek, C., Tiemeyer, S., Weise, K., Sellin, D., Paulus, M., Struth, B., Tolan, M., & Winter, R. (2009) · Journal of the American Chemical Society · doi:10.1021/ja8097417 · Cited by 114
Cheng, L., Quek, C. Y. J., Sun, X., Bellingham, S. A., & Hill, A. F. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00150 · Cited by 113
Disease to Dirt: The Biology of Microbial Amyloids
Hufnagel, D. A., Tükel, Ç., & Chapman, M. R. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003740 · Cited by 113
Will caloric restriction and folate protect against AD and PD?
Mattson, M. P. (2003) · Neurology · doi:10.1212/01.wnl.0000042785.02850.11 · Cited by 111
Zamolodchikov, D., & Strickland, S. (2012) · Blood · doi:10.1182/blood-2011-11-389668 · Cited by 109
Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease
Naseer, M. I., Bibi, F., Al-Qahtani, M. H., Chaudhary, A., Azhar, E. I., Kamal, M. A., & Yasir, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660147 · Cited by 109
Prions and the Potential Transmissibility of Protein Misfolding Diseases
Kraus, A., Groveman, B. R., & Caughey, B. W. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155735 · Cited by 107
Stefani, M., & Rigacci, S. (2014) · BioFactors · doi:10.1002/biof.1171 · Cited by 106
Hammer, N. D., Wang, X., McGuffie, B. A., & Chapman, M. R. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13406 · Cited by 96
Humans Have Antibodies against a Plant Virus: Evidence from Tobacco Mosaic Virus
Liu, R., Vaishnav, R., Roberts, A. M., & Friedland, R. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060621 · Cited by 95
The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA
Colussi, T. M., Costantino, D. A., Hammond, J. A., Ruehle, G. M., Nix, J. C., & Kieft, J. S. (2014) · Nature · doi:10.1038/nature13378 · Cited by 91
Mosconi, L., Murray, J., Davies, M., Williams, S., Pirraglia, E., Spector, N. C., Tsui, W. H., Li, Y., Butler, T., Osorio, R. S., et al. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-004850 · Cited by 89
Ding, P., & Jin, L. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12081 · Cited by 85
Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer’s Disease
Rigacci, S. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_1 · Cited by 84
Shared genetic etiology underlying Alzheimer’s disease and type 2 diabetes
Hao, K., Di Narzo, A. F., Ho, L., Luo, W., Li, S., Chen, R., Li, T., Dubner, L., & Pasinetti, G. M. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.06.006 · Cited by 84
Liang, J.-S., Sloane, J. A., Wells, J. M., Abraham, C. R., Fine, R. E., & Sipe, J. D. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00196-1 · Cited by 84
Irritable bowel syndrome correlates with increased risk of Parkinson’s disease in Taiwan
Lai, S., Liao, K., Lin, C., & Sung, F. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9878-3 · Cited by 84
Understanding gut microbiota in elderly's health will enable intervention through probiotics
Pérez‐Martínez, G., Bäuerl, C., & Collado, M. C. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0079 · Cited by 82
Bastianetto, S., Krantic, S., & Quirion, R. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708784223512 · Cited by 81
The various states of von Willebrand factor and their function in physiology and pathophysiology
Huck, V., Gorzelanny, C., Schneider, M. F., & Schneider, S. W. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-09-0800 · Cited by 81
Oral Delivery of Bioencapsulated Proteins Across Blood–Brain and Blood–Retinal Barriers
Kohli, N., Westerveld, D., Ayache, A., Verma, A., Shil, P. K., Prasad, T., Zhu, P., Chan, S. L., Li, Q., & Daniell, H. (2013) · Molecular Therapy · doi:10.1038/mt.2013.273 · Cited by 81
Daulatzai, M. A. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150202152436 · Cited by 80
Bekkering, P., Jafri, I., van Overveld, F. J., & Rijkers, G. T. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.848793 · Cited by 78
Oral probiotic VSL #3 attenuates the circulatory disturbances of patients with cirrhosis and ascites
Rincón, D., Vaquero, J., Hernando, A., Galindo, E., Ripoll, C., Puerto, M., Salcedo, M., Francés, R., Matilla, A. M., Catalina, M., et al. (2014) · Liver International · doi:10.1111/liv.12539 · Cited by 76
Microfluidic construction of minimalistic neuronal co-cultures
Dinh, N., Chiang, Y.-Y., Hardelauf, H., Baumann, J., Jackson, E., Waide, S., Sisnaiske, J., Frimat, J., van Thriel, C., Janasek, D., et al. (2013) · Lab on a Chip · doi:10.1039/c3lc41224e · Cited by 76
Viegas, P., Chaverot, N., Enslen, H., Perrière, N., Couraud, P., & Cazaubon, S. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03222 · Cited by 73
Pistollato, F., & Battino, M. A. (2014) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.07.012 · Cited by 73
Self-citationChauhan, N., Wang, K., Węgiel, J., & Malik, M. N. (2004) · Current Alzheimer Research · doi:10.2174/1567205043332144 · Cited by 71
Gupta, V. B., Indi, S. S., & Rao, K. S. J. (2008) · Phytotherapy Research · doi:10.1002/ptr.2574 · Cited by 70
Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols
Rigacci, S., & Stefani, M. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.986101 · Cited by 69
Fasting plasma insulin and the default mode network in women at risk for Alzheimer's disease
Kenna, H. A., Hoeft, F., Kelley, R. G., Wroolie, T., DeMuth, B. N., Reiss, A. L., & Rasgon, N. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.006 · Cited by 69
Campbell, A. W. (2014) · Autoimmune Diseases · doi:10.1155/2014/152428 · Cited by 67
Role of the Gut Microbiota in Age-Related Chronic Inflammation
Rehman, T. (2012) · Endocrine, Metabolic & Immune Disorders-Drug Targets · doi:10.2174/187153012803832620 · Cited by 67
Björklund, M., Ouwehand, A. C., Forssten, S. D., Nikkilä, J., Tiihonen, K., Rautonen, N., & Lahtinen, S. J. (2012) · AGE · doi:10.1007/s11357-011-9294-5 · Cited by 67
Essa, M. M., Braidy, N., Awlad-Thani, K., Vaishnav, R., Al-Asmi, A. R., Guillemin, G. J., Al‐Adawi, S., & Subash, S. (2015) · Journal of Ayurveda and Integrative Medicine · doi:10.4103/0975-9476.159073 · Cited by 67
Fallucca, F., Porrata, C., Fallucca, S., & Pianesi, M. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2518 · Cited by 66
Fold modulating function: bacterial toxins to functional amyloids
Syed, A. K., & Boles, B. R. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00401 · Cited by 65
The importance of fish and docosahexaenoic acid in Alzheimer disease
Connor, W. E., & Connor, S. L. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.929 · Cited by 61
Apathy and APOE4 are associated with Reduced BDNF Levels in Alzheimer's Disease
Álvarez, A., Aleixandre, M., Linares, C., Masliah, E., & Moessler, H. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140849 · Cited by 61
Chemoprevention in Gastrointestinal Physiology and Disease. Natural products and microbiome
Greiner, A. K., Papineni, R. V. L., & Umar, S. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00044.2014 · Cited by 60
Brain Food for Alzheimer-Free Ageing: Focus on Herbal Medicines
Hügel, H. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_5 · Cited by 57
Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study
Lolicato, F., Raudino, A., Milardi, D., & Rosa, C. L. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.01.047 · Cited by 55
Blom, K., Emmelot‐Vonk, M. H., & Koek, H. L. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.06.011 · Cited by 54
Stenvinkel, P. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu338 · Cited by 54
TREM2 and Risk of Alzheimer’s Disease — Friend or Foe?
Tanzi, R. E. (2015) · New England Journal of Medicine · doi:10.1056/nejmcibr1503954 · Cited by 52
How free of germs is germ-free? Detection of bacterial contamination in a germ free mouse unit
Fontaine, C., Skorupski, A. M., Vowles, C. J., Anderson, N. E., Poe, S., & Eaton, K. A. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1054596 · Cited by 52
de Gonzalo‐Calvo, D., Fernández‐Garcia, B., de Luxán‐Delgado, B., Rodríguez‐González, S., Macia, M. G., Suárez, F. M., Solano, J. J., Rodríguez‐Colunga, M. J., & Coto‐Montes, A. M. (2011) · AGE · doi:10.1007/s11357-011-9266-9 · Cited by 49
microRNA (miRNA)-Mediated Pathogenetic Signaling in Alzheimer’s Disease (AD)
Hill, J. M., & Lukiw, W. J. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1734-7 · Cited by 48
Gutiérrez‐Orozco, F., Thomas‐Ahner, J. M., Berman-Booty, L. D., Galley, J. D., Chitchumroonchokchai, C., Mace, T. A., Suksamrarn, S., Bailey, M. T., Clinton, S. K., Lesinski, G. B., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300771 · Cited by 48
Alam, M., Alam, Q., Kamal, M., Abuzenadah, A., & Haque, A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660151 · Cited by 47
Apolipoprotein Serum Amyloid A in Alzheimer's Disease
Kindy, M. S., Yu, J., Guo, J., & Zhu, H. (1999) · Journal of Alzheimer s Disease · doi:10.3233/jad-1999-1303 · Cited by 44
Molecular detection of bacterial contamination in gnotobiotic rodent units
Packey, C. D., Shanahan, M. T., Manick, S., Bower, M., Ellermann, M., Tonkonogy, S. L., Carroll, I. M., & Sartor, R. B. (2013) · Gut Microbes · doi:10.4161/gmic.25824 · Cited by 43
Role of Stress, Depression, and Aging in Cognitive Decline and Alzheimer’s Disease
Daulatzai, M. A. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_350 · Cited by 42
Considering a new paradigm for Alzheimer's disease research
Langley, G. R. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.03.013 · Cited by 42
Lipiński, B., & Pretorius, E. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00735 · Cited by 39
MicroRNA (miRNA): Sequence and stability, viroid-like properties, and disease association in the CNS
Pogue, A. I., Hill, J. M., & Lukiw, W. J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.042 · Cited by 39
Serum Amyloid A Differentially Activates Microglia and Astrocytes via the PI3K Pathway
Yu, Y., Liu, J., Li, S.-Q., Lei, P., & Ye, R. D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130818 · Cited by 35
TREM2 signaling, miRNA-34a and the extinction of phagocytosis
Zhao, Y., & Lukiw, W. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00131 · Cited by 33
Antibodies to Potato Virus Y Bind the Amyloid β Peptide
Friedland, R. P., Tedesco, J. M., Wilson, A. C., Atwood, C., Smith, M. A., Perry, G. L., & Zagorski, M. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802088200 · Cited by 28
Uptake and Dynamics of Infectious Prion Protein in the Intestine
Ano, Y., Sakudo, A., Nakayama, H., & Onodera, T. (2009) · Protein and Peptide Letters · doi:10.2174/092986609787601642 · Cited by 27
Fighting Alzheimer's Disease and Type 2 Diabetes: Pathological links and Treatment Strategies
Dai, Y., & Kamal, M. A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660134 · Cited by 26
miRNAs and viroids utilize common strategies in genetic signal transfer
Hill, J. M., Zhao, Y., Bhattacharjee, S., & Lukiw, W. J. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00010 · Cited by 25
A Human-Based Integrated Framework forAlzheimer’s Disease Research
Pistollato, F., Cavanaugh, S. E., & Chandrasekera, P. C. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150281 · Cited by 21
Self-citationModulation of fibrin assembly and polymerization by the ??-amyloid of Alzheimer??s disease
Merkle, D. L., Cheng, C.-H., Castellino, F., & Chibber, B. A. (1996) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-199609000-00011 · Cited by 19
Cross-kingdom sequence similarities between human micro-RNAs and plant viruses
Rebolledo-Mendez, J. D., Vaishnav, R., Cooper, N., & Friedland, R. P. (2013) · Communicative & Integrative Biology · doi:10.4161/cib.24951 · Cited by 19
From Gut to Brain: Bioencapsulated Therapeutic Protein Reduces Amyloid Load Upon Oral Delivery
Mäger, I., Roberts, T. C., Wood, M. J. A., & Andaloussi, S. E. (2014) · Molecular Therapy · doi:10.1038/mt.2014.13 · Cited by 19
Why nutraceuticals do not prevent or treat Alzheimer's disease
Fisher, A. E. O., & Naughton, D. P. (2005) · Nutrition Journal · doi:10.1186/1475-2891-4-14 · Cited by 13
Ali‐Khan, Z., Normand, J., Alizadeh-Khiavi, K., Robitaille, Y., & Chronopoulos, S. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90849-3 · Cited by 13
Immunohistochemical Examination of Peyer's Patches in Senescence-Accelerated Mice
Yoshioka, H., Takeda, T., Higuchi, K., Ohshio, G., Miyake, T., Sugiyama, T., & Kita, T. (1990) · Autoimmunity · doi:10.3109/08916939008998429 · Cited by 9
Intestinal uptake of amyloid beta protein through columnar epithelial cells in suckling mice.
Ano, Y., Nakayama, H., Sakudo, A., Sawano, Y., Tanokura, M., Itohara, S., & Onodera, T. (2009) · PubMed · doi:10.14670/hh-24.283 · Cited by 5
Role of dietary patterns in the prevention and regression of insulin resistance-related cancers
Pistollato, F. (2015) · Mediterranean Journal of Nutrition and Metabolism · doi:10.3233/mnm-140024 · Cited by 4
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Influence of diet on the gut microbiome and implications for human health
Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599
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Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137
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Gomaa, E. Z. (2020) · Antonie van Leeuwenhoek · doi:10.1007/s10482-020-01474-7 · Cited by 1,294
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Kho, Z. Y., & Lal, S. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01835 · Cited by 1,180
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Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852
Metadata
- Authors
- Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M.
- Affiliations
- Marche Polytechnic University (IT)
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-09-15
- Volume
- 74
- Issue
- 10
- Pages
- 624-634
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2519408637
- Cited by
- 496
- References
- 177
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 48 · 2023: 53 · 2022: 61 · 2021: 80 · 2020: 72 · 2019: 59 · 2018: 37 · 2017: 30 · 2016: 2
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Fondazione Umberto Veronesi
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, gut microbiota, amyloid-beta, amyloid fibril formation, gut-brain axis, lipopolysaccharide, inflammatory cytokines, dietary nutrients, microbiota composition, neuroinflammation, amyloidogenesis, dietary intervention
- MeSH terms
- Gastrointestinal Microbiome, Alzheimer Disease, Amyloid, Bacteria, Brain, Diet, Humans, Cytokines, Prebiotics
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