Cited by 383Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorMental Health and Psychiatry

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Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia

Maynard, T. M., Sikich, L., Lieberman, J. A., LaMantia, A.-S.·2001·Schizophrenia Bulletin

DOI 10.1093/oxfordjournals.schbul.a006887

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Abstract

To account for the complex genetics, the developmental biology, and the late adolescent/early adulthood onset of schizophrenia, the "two-hit" hypothesis has gained increasing attention. In this model, genetic or environmental factors disrupt early central nervous system (CNS) development. These early disruptions produce long-term vulnerability to a "second hit" that then leads to the onset of schizophrenia symptoms. The cell-cell signaling pathways involved in nonaxial induction, morphogenesis, and differentiation in the brain, as well as in the limbs and face, could be targets for a "first hit" during early development. These same pathways, redeployed for neuronal maintenance rather than morphogenesis, may be targets for a "second hit" in the adolescent or adult brain. Furthermore, dysregulation of cell-cell signaling by a "first hit" may prime the CNS for a pathologic response to a "second hit" via the same signaling pathway. Thus, parallel disruption of cell-cell signaling in both the developing and the mature CNS provides a plausible way of integrating genetic, developmental, and environmental factors that contribute to vulnerability and pathogenesis in schizophrenia.

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Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904
Physiology and Behavior
Falk, J. L. (1973) · Contemporary Psychology · doi:10.1037/0011818 · Cited by 2,288
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
Jonjić, S., Mutter, W., Weiland, F., Reddehase, M. J., & Koszinowski, U. H. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1199 · Cited by 2,106
Retinoic acid embryopathy
Lammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., Curry, C. J., Fernhoff, P. M., Grix, A. W., Lott, I. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510033131401 · Cited by 1,942
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685
Meta-analysis of regional brain volumes in schizophrenia
Wright, I. C., Rabe-Hesketh, S., Woodruff, P. W. R., David, A. S., Murray, R. M., & Bullmore, E. T. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.16 · Cited by 1,662
Predictors of Relapse Following Response From a First Episode of Schizophrenia or Schizoaffective Disorder
Robinson, D., Woerner, M. G., Alvir, J. M. J., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.241 · Cited by 1,327
Self-citation
Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis
Weiss, S., Dunne, C., Hewson, J., Wohl, C. A., Wheatley, M., Peterson, A. C., & Reynolds, B. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07599.1996 · Cited by 1,219
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.Preprint
Mangelsdorf, D. J., Borgmeyer, U., Heyman, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A., & Evans, R. M. (1992) · Genes & Development · doi:10.1101/gad.6.3.329 · Cited by 1,193
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,111
Notch signaling is essential for vascular morphogenesis in micePreprint
Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., et al. (2000) · Genes & Development · doi:10.1101/gad.14.11.1343 · Cited by 1,065
High rates of schizophrenia in adults with velo-cardio-facial syndrome
Murphy, K. C., Jones, L. A., & Owen, M. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.940 · Cited by 1,024
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002
The reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909
Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients
Benes, F. M. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350036005 · Cited by 891
The Dopamine Hypothesis of Schizophrenia: A Review*
Meltzer, H. Y., & Stahl, S. M. (1976) · Schizophrenia Bulletin · doi:10.1093/schbul/2.1.19 · Cited by 883
Duration of psychosis and outcome in first-episode schizophrenia
Loebel, A. D., Lieberman, J. A., Alvir, J. M., Mayerhoff, D. I., Geisler, S. H., & Szymanski, S. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1183 · Cited by 880
Self-citation
Schizophrenia genesis: the origins of madness
(1991) · Choice Reviews Online · doi:10.5860/choice.28-6500 · Cited by 832
Molecular Basis of Visual Excitation
Wald, G. (1968) · Science · doi:10.1126/science.162.3850.230 · Cited by 832
The Molecular Basis of Visual Excitation
WALD, G. (1968) · Nature · doi:10.1038/219800a0 · Cited by 824
Neurotransmitters as growth regulatory signals: role of receptors and second messengers
Lauder, J. M. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90162-f · Cited by 806
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 762
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
Allenby, G., Bocquel, M. T., Saunders, M., Kazmer, S., Speck, J., Rosenberger, M., Lovey, A. J., Kastner, P., Grippo, J. F., & Chambon, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.30 · Cited by 755
Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain
Gaiano, N., Nye, J. S., & Fishell, G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81172-1 · Cited by 727
Inductive interactions direct early regionalization of the mouse forebrain
Shimamura, K., & Rubenstein, J. L. R. (1997) · Development · doi:10.1242/dev.124.14.2709 · Cited by 659
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
Belloni, E., Muenke, M., Roessler, E., Traverse, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C. A., Hing, A. V., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-353 · Cited by 643
Positional signalling and specification of digits in chick limb morphogenesis
Tickle, C. A., Summerbell, D., & Wolpert, L. (1975) · Nature · doi:10.1038/254199a0 · Cited by 588
Molecular Models for Vertebrate Limb Development
Johnson, R. L., & Tabin, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80364-5 · Cited by 584
Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling
Šestan, N., Artavanis‐Tsakonas, S., & RAKIC, P. T. (1999) · Science · doi:10.1126/science.286.5440.741 · Cited by 573
From neuropathology to neurodevelopment
Weinberger, D. R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91386-6 · Cited by 558
Provocative tests with psychostimulant drugs in schizophrenia
Lieberman, J. A., Kane, J. M., & Alvir, J. (1987) · Psychopharmacology · doi:10.1007/bf00216006 · Cited by 535
Self-citation
Emerging principles of altered neural circuitry in schizophrenia
Benes, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00041-7 · Cited by 513
Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment.
Shenefelt, R. (1972) · Teratology · doi:10.1002/tera.1420050115 · Cited by 512
Attention, Memory, and Motor Skills as Childhood Predictors of Schizophrenia-Related Psychoses: The New York High-Risk Project
Erlenmeyer‐Kimling, L., Rock, D., Roberts, S. A., Janal, M. N., Kestenbaum, C. J., Cornblatt, B. A., Adamo, U. H., & Gottesman, I. I. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.9.1416 · Cited by 511
Catecholamines in the Brain as Mediators of Amphetamine Psychosis
Snyder, S. H. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750260021004 · Cited by 432
Congenital heart disease in mice deficient for the DiGeorge syndrome region
Lindsay, E. A., Botta, A., Jurecic, V., Carattini-Rivera, S., Cheah, Y.-C., Rosenblatt, H. M., Bradley, A., & Baldini, A. (1999) · Nature · doi:10.1038/43900 · Cited by 426
Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
BEASLEY, C., & REYNOLDS, G. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00122-3 · Cited by 426
Velo‐cardio‐facial syndrome: A review of 120 patients
Goldberg, R. B., Motzkin, B., Marion, R., Scambler, P. J., & Shprintzen, R. J. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320450307 · Cited by 422
Defects in limb, craniofacial, and thymic development in Jagged2 mutant micePreprint
Jiang, R., Lan, Y., Chapman, H. D., Shawber, C. J., Norton, C. R., SERREZE, D. V., Weinmaster, G., & Gridley, T. (1998) · Genes & Development · doi:10.1101/gad.12.7.1046 · Cited by 418
Physiological Evidence for Habenula as Major Link Between Forebrain and Midbrain Raphe
Wang, R. Y., & Aghajanian, G. K. (1977) · Science · doi:10.1126/science.194312 · Cited by 411
Late‐Onset psychosis in the velo‐cardio‐facial syndrome
Shprintzen, R. J., Goldberg, R. B., Golding‐Kushner, K. J., & Marion, R. W. (1992) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320420131 · Cited by 402
THE BIOLOGICAL FUNCTION OF VITAMIN A ACID.
Dowling, J., & Wald, G. (1960) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.46.5.587 · Cited by 393
Motor Neuron–Derived Retinoid Signaling Specifies the Subtype Identity of Spinal Motor Neurons
Sockanathan, S., & Jessell, T. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81591-3 · Cited by 388
The Ins and Outs of Notch Signaling
Weinmaster, G. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0612 · Cited by 385
Establishing the onset of psychotic illness
Beiser, M., Erickson, D., Fleming, J. A. E., & Iacono, W. G. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.9.1349 · Cited by 373
Viruses, schizophrenia, and bipolar disorder
Yolken, R. H., & Torrey, Ε. F. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.1.131 · Cited by 360
Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice
Krężel, W., Ghyselinck, N. B., Samad, T. A., Dupé, V., Kastner, P., Borrelli, E., & Chambon, P. (1998) · Science · doi:10.1126/science.279.5352.863 · Cited by 349
Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “Two hit hypothesis.”
Bayer, T. A., Falkai, P., & Maier, W. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00039-4 · Cited by 346
Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients
Takahashi, M., Shirakawa, O., Toyooka, K., Kitamura, N., Hashimoto, T., Maeda, K., Koizumi, S., Wakabayashi, K., Takahashi, H., Someya, T., et al. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000718 · Cited by 343
Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics
Joyce, J. N., Shane, A. L., Lexow, N., Winokur, A., Casanova, M. F., & Kleinman, J. E. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.32 · Cited by 340
An Essential Role for Retinoid Receptors RARβ and RXRγ In Long-Term Potentiation and Depression
Chiang, M.-Y., Misner, D., Kempermann, G., Schikorski, T., Giguère, V., Sucov, H. M., Gage, F. H., Stevens, C. F., & Evans, R. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80654-6 · Cited by 332
Comparison of Amphetamine Psychosis and Schizophrenia
Bell, D. S. (1965) · The British Journal of Psychiatry · doi:10.1192/bjp.111.477.701 · Cited by 328
Olfactory Dysfunction in Schizophrenia A Qualitative and Quantitative Review
Moberg, P. J. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00019-6 · Cited by 317
Cocaine, kindling, and psychosis
Post, R. M., & Kopanda, R. T. (1976) · American Journal of Psychiatry · doi:10.1176/ajp.133.6.627 · Cited by 308
Imaging dopamine transmission in schizophrenia. A review and meta-analysis.
Laruelle, M. (1998) · PubMed · Cited by 280
Velo-cardio-facial syndrome: language and psychological profiles.
Golding‐Kushner, K. J., Weller, G. M., & Shprintzen, R. J. (1985) · PubMed · Cited by 266
NUMB Localizes in the Basal Cortex of Mitotic Avian Neuroepithelial Cells and Modulates Neuronal Differentiation by Binding to NOTCH-1
Wakamatsu, Y., Maynard, T. M., Jones, S. U., & Weston, J. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80754-0 · Cited by 256
Self-citation
Children and Adolescents With Velocardiofacial Syndrome: A Volumetric MRI Study
D, S. E. M., Schmitt, J. E., White, C. D., & Reiss, A. L. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.3.409 · Cited by 251
Cocaine-Induced Psychosis
Brady, K. T., Lydiard, R. B., Malcolm, R. J., & Ballenger, J. C. (1992) · PsycEXTRA Dataset · doi:10.1037/e324222004-013 · Cited by 247
Differential expression of retinoid receptors in the adult mouse central nervous system
Krężel, W., Kastner, P., & Chambon, P. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00342-x · Cited by 238
Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia.
Arnold, S. E., Lee, V. M., Gur, R. E., & Trojanowski, J. Q. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10850 · Cited by 236
RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.
Krężel, W., Dupé, V., Mark, M., Dierich, A., Kastner, P., & Chambon, P. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.17.9010 · Cited by 231
E2F-6, a member of the E2F family that can behave as a transcriptional repressor
Trimarchi, J. M., Fairchild, B., Verona, R. I., Moberg, K. H., Andon, N. L., & Lees, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2850 · Cited by 223
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Siris, S. G. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800350089019 · Cited by 222
Prenatal Exposure to Famine and Brain Morphology in Schizophrenia
Pol, H. E. H., Hoek, H. W., Susser, E., Brown, A. S., Dingemans, A. E., Schnack, H. G., van Haren, N. E. M., Ramos, L. M. P., Wied, C. C. G., & Kahn, R. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1170 · Cited by 215
Factors influencing treatment response and outcome of first-episode schizophrenia: implications for understanding the pathophysiology of schizophrenia.
Lieberman, J. A., Koreen, A., Chakos, M., Sheitman, B., Woerner, M. G., Alvir, J. M. J., & Bilder, R. M. (1996) · PubMed · Cited by 211
Self-citation
The behavioural phenotype in velo-cardio-facial syndrome (VCFS): from infancy to adolescence.
Swillen, A., Devriendt, K., Legius, E., Prinzie, P., Vogels, A., Ghesquière, P., & Fryns, J. (1999) · PubMed · Cited by 208
Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluRl and GluR2 in medial temporal lobe neurons in schizophrenia
Eastwood, S. L., McDonald, B., Burnet, P. W. J., Beckwith, J. P., Kerwin, R. W., & Harrison, P. J. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00247-c · Cited by 207
MINOR PHYSICAL ANOMALIES AND BEHAVIOR IN PRESCHOOL CHILDREN
Waldrop, M. F., Pedersen, F. A., & Bell, R. Q. (1968) · Child Development · doi:10.1111/j.1467-8624.1968.tb04433.x · Cited by 206
Minor Physical Anomalies and Behavior in Preschool Children
Waldrop, M. F., Pedersen, F. A., & Bell, R. Q. (1968) · Child Development · doi:10.2307/1126953 · Cited by 203
Reduced Olfactory Bulb Volume in Patients With Schizophrenia
Turetsky, B. I., Moberg, P. J., Yousem, D. M., Doty, R. L., Arnold, S. E., & Gur, R. E. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.828 · Cited by 197
Premorbid and Onset Features of First-Episode Schizophrenia
Haas, G. L., & Sweeney, J. A. (1992) · Schizophrenia Bulletin · doi:10.1093/schbul/18.3.373 · Cited by 196
Three independent lines of evidence suggest retinoids as causal to schizophrenia
Goodman, A. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7240 · Cited by 190
Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula
Ellison, G. D. (1994) · Brain Research Reviews · doi:10.1016/0165-0173(94)90012-4 · Cited by 182
The NOTCH4 locus is associated with susceptibility to schizophrenia
Wei, J., & Hemmings, G. P. (2000) · Nature Genetics · doi:10.1038/78044 · Cited by 180
Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6
Gaubatz, S., Wood, J. G., & Livingston, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9190 · Cited by 180
Drugs and Aging
McKim, W. A., & Mishara, B. L. (1987) · Medical Entomology and Zoology · Cited by 177
The initiation of the limb bud: Growth factors, Hox genes, and retinoids
Tabin, C. (1995) · Cell · doi:10.1016/0092-8674(95)90343-7 · Cited by 171
Schizoid personality disorder after prenatal exposure to famine
Hoek, H. W., Susser, E., Buck, K. A., Lumey, L. H., Lin, S. P., & Gorman, J. M. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.12.1637 · Cited by 168
Transgenic indicator mice for studying activated retinoic acid receptors during development.
Balkan, W., Colbert, M., Bock, C., & Linney, E. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3347 · Cited by 166
Mesenchymal/Epithelial Induction Mediates Olfactory Pathway Formation
LaMantia, A., Bhasin, N., Rhodes, K., & Heemskerk, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00121-5 · Cited by 164
Self-citation
Minor Physical Anomalies in Schizophrenic Patients and Their Siblings
Ismail, B., Cantor‐Graae, E., & McNeil, T. F. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.12.1695 · Cited by 164
Increased expression of Wnt-1 in schizophrenic brains
Miyaoka, T., Seno, H., & Ishino, H. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00179-0 · Cited by 162
Ectodermal-mesodermal interactions in the growth of limb buds in the chick embryo: Constancy and temporal limits of the ectodermal induction
Rubin, L., & Saunders, J. W. (1972) · Developmental Biology · doi:10.1016/0012-1606(72)90129-7 · Cited by 160
Altered levels of the synaptosomal associated protein SNAP-25 in schizophrenia
Thompson, P. M., Sower, A. C., & Perrone‐Bizzozero, N. I. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00204-7 · Cited by 158
The Incidence of Minor Physical Anomalies in Adult Male Schizophrenics
Guy, J. D., Majorski, L. V., Wallace, C. J., & Guy, M. P. (1983) · Schizophrenia Bulletin · doi:10.1093/schbul/9.4.571 · Cited by 154
Abnormalities of Wnt signalling in schizophrenia – evidence for neurodevelopmental abnormality
Cotter, D., Kerwin, R. W., Al-Sarraji, S., Brion, J., Chadwich, A., Lovestone, S., Anderton, B. H., & Everall, I. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00024 · Cited by 152
Notch Is Expressed in Adult Brain, Is Coexpressed with Presenilin-1, and Is Altered in Alzheimer Disease
Berezovska, O., Xia, M., & Hyman, B. T. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199808000-00003 · Cited by 150
Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain
LaMantia, A., Colbert, M. C., & Linney, E. A. (1993) · Neuron · doi:10.1016/0896-6273(93)90052-s · Cited by 146
Self-citation
Basal ganglia organization in amphibians: Chemoarchitecture
Marín, Ó., Smeets, W. J. A. J., & González, A. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980316)392:3 · Cited by 145
The natural history and pathophysiology of treatment resistant schizophrenia
Sheitman, B. B., & Lieberman, J. A. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(97)00052-6 · Cited by 140
Self-citation
Molecular analysis of velo-cardio-facial syndrome patients with psychiatric disorders.
Carlson, C., Papolos, D. F., PANDITA, R. K., Faedda, G. L., Veit, S., Goldberg, R. B., Shprintzen, R. J., Kucherlapati, R., & Morrow, B. E. (1997) · PubMed · Cited by 138
Retinoic acid and retinoic acid receptors in development
Sucov, H. M., & Evans, R. M. (1995) · Molecular Neurobiology · doi:10.1007/bf02740674 · Cited by 136
Minor physical anomalies in alcoholic and schizophrenic adults and hyperactive and autistic children
Gualtieri, C. T., Adams, A., Shen, C., & Loiselle, D. L. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.5.640 · Cited by 134
No evidence for astrogliosis in brains of schizophrenic patients. A post‐mortem study
Falkai, P., Honer, David, Bogerts, Majtenyi, & Bayer (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00162.x · Cited by 132
The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients
Haracz, J. L. (1982) · Schizophrenia Bulletin · doi:10.1093/schbul/8.3.438 · Cited by 128
Localization of cellular retinoid-binding proteins suggests specific roles for retinoids in the adult central nervous system
Zetterström, R. H., Simon, A., Giacobini, M., Eriksson, U., & Olson, L. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90482-0 · Cited by 121
Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogenesis.
Perez-Castro, A. V., Toth, L. E., Wei, L., & Nguyen-Huu, M. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8813 · Cited by 121
Newborn Minor Physical Anomalies Predict Short Attention Span, Peer Aggression, and Impulsivity at Age 3
Waldrop, M. F., Bell, R. Q., McLaughlin, B., & Halverson, C. F. (1978) · Science · doi:10.1126/science.622559 · Cited by 119
Prenatal Development of Monozygotic Twins and Concordance for Schizophrenia
Davis, J. O., Phelps, J. A., & Bracha, H. S. (1995) · Schizophrenia Bulletin · doi:10.1093/schbul/21.3.357 · Cited by 118
Ventricular volume and asymmetry in schizotypal personality disorder and schizophrenia assessed with magnetic resonance imaging
Buchsbaum, M. S., Yang, S., Hazlett, E. A., Siegel, B. V., Germans, M. K., Haznedar, M. M., O'Flaithbheartaigh, S., Wei, T.-C., Silverman, J. M., & Siever, L. J. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00087-x · Cited by 115
Deletion of 150 kb in the Minimal Digeorge/Velocardiofacial Syndrome Critical Region in Mouse
Kimber, W. L., Hsieh, P., Hirotsune, S., Yuva‐Paylor, L. A., Sutherland, H. F., Chen, A., Ruiz‐Lozano, P., Hoogstraten-Miller, S. L., Chien, K. R., Paylor, R. E., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.12.2229 · Cited by 113
Central amygdala lesions affect behavioral and autonomic balance during stress in rats
Roozendaal, B., Koolhaas, J. M., & Bohus, B. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90017-i · Cited by 110
Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.
Yang, N., Schüle, R., Mangelsdorf, D. J., & Evans, R. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3559 · Cited by 109
Forebrain induction, retinoic acid, and vulnerability to schizophrenia: insights from molecular and genetic analysis in developing mice
LaMantia, A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00002-5 · Cited by 106
Self-citation
Potential behavioral modification of glucocorticoid damage to the hippocampus
Sapolsky, R. M. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90133-b · Cited by 105
Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development.
Colbert, M. C., Linney, E. A., & LaMantia, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6572 · Cited by 103
Self-citation
Childhood behavioral characteristics and adult brain morphology in schizophrenia
Walker, E. F., Lewine, R. R. J., & Neumann, C. S. (1996) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00070-9 · Cited by 91
Cerebral ventricle dimensions as risk factors for schizophrenia and affective psychosis: an epidemiological approach to analysis
Jones, P. B., Harvey, I., Lewis, S. W., Toone, B., van Os, J., Williams, M., & Murray, R. M. (1994) · Psychological Medicine · doi:10.1017/s0033291700029081 · Cited by 91
Stress Pathway Activation Induces Phosphorylation of Retinoid X Receptor
Lee, H., Suh, Y., Robinson, M. J., Clifford, J. L., Hong, W. K., Woodgett, J. R., Cobb, M. H., Mangelsdorf, D. J., & Kurie, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005490200 · Cited by 91
Influence of the choroid plexus on cerebellar development: analysis of retinoic acid synthesis
Yamamoto, M., McCaffery, P. J. A., & Dräger, U. C. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00038-7 · Cited by 85
Benign Intracranial Hypertension Associated With Hypervitaminosis A
Feldman, M. H., & Schlezinger, N. S. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480190005001 · Cited by 85
Abnormal Expression of Cell Recognition Molecules in Schizophrenia
Vawter, M. P., Cannon-Spoor, H. E., Hemperly, J. J., Hyde, T. M., VanderPutten, D. M., Kleinman, J. E., & Freed, W. J. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6721 · Cited by 84
Effort and stress influence the effect of lesion of the habenula complex in one-way active avoidance learning
Thornton, E. W., & Bradbury, G. E. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90217-5 · Cited by 83
Neuropsychiatric Adverse Effects of Antiparkinsonian Drugs
Young, B. K., Camicioli, R. M., & Ganzini, L. K. (1997) · Drugs & Aging · doi:10.2165/00002512-199710050-00005 · Cited by 81
Velo‐cardio‐facial syndrome and psychotic disorders: Implications for psychiatric genetics
Chow, E. W. C., Bassett, A. S., & Weksberg, R. (1994) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320540205 · Cited by 79
Newly-generated cells from the rostral migratory stream in the accessory olfactory bulb of the adult rat
Bonfanti, L., Peretto, P., Merighi, A., & Fasolo, A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00090-0 · Cited by 76
Transmitters contained in the efferents of the habenula
Vincent, S. R., Staines, W. A., McGeer, E. G., & Fibiger, H. C. (1980) · Brain Research · doi:10.1016/0006-8993(80)90084-0 · Cited by 74
Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo
Gustafson, A.-L., Dencker, L., & Eriksson, U. (1993) · Development · doi:10.1242/dev.117.2.451 · Cited by 71
Retinoic Acid Embryopathy
Harada, M. (1986) · New England Journal of Medicine · doi:10.1056/nejm198607243150416 · Cited by 70
Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/ DiGeorge syndrome region
Puech, A., Saint-Jore, B., Merscher, S., Russell, R. G., Chérif, D., Sirotkin, H. I., Xu, H., Factor, S. M., Kucherlapati, R., & Skoultchi, A. I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.10090 · Cited by 68
Differential expression of Notch1 and Notch2 in developing and adult mouse brain
Higuchi, M., Kiyama, H., Hayakawa, T., Hamada, Y., & Tsujimoto, Y. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00257-f · Cited by 67
Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone
Kurosaki, M., Demontis, S., Barzago, M. M., Garattini, E., & Terao, M. (1999) · Biochemical Journal · doi:10.1042/bj3410071 · Cited by 66
Advances in developmental biology
Wassarman, P. M. (1992) · JAI Press Inc. eBooks · Cited by 65
Psychotic complications of long-term levodopa treatment of Parkinson's disease
Friedman, A., & Sienkiewicz, J. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04918.x · Cited by 65
Retinoid‐binding proteins in the cerebellum and choroid plexus and their relationship to regionalized retinoic acid synthesis and degradation
Yamamoto, M., Dräger, U. C., Ong, D. E., & McCaffery, P. J. A. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2570344.x · Cited by 65
Retinoid receptors in transcriptional regulation
Minucci, S., & Ozato, K. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80085-2 · Cited by 61
The usual suspects: GABA and glutamate may regulate proliferation in the neocortex
LaMantia, A. (1995) · Neuron · doi:10.1016/0896-6273(95)90002-0 · Cited by 61
Self-citation
Attenuation of positional signalling in the chick limb by high doses of γ-radiation
Smith, J. C., Tickle, C. A., & Wolpert, L. (1978) · Nature · doi:10.1038/272612a0 · Cited by 58
Neurobehavioral teratology of isotretinoin
Adams, J., & Lammer, E. J. (1993) · Reproductive Toxicology · doi:10.1016/0890-6238(93)90273-a · Cited by 57
Factors affecting the development and regeneration of visual purple in the mammalian retina
Tansley, K. (1933) · Proceedings of the Royal Society of London Series B Containing Papers of a Biological Character · doi:10.1098/rspb.1933.0072 · Cited by 56
Adult rabbit brain synthesizes retinoic acid
Dev, S., Adler, A. J., & Edwards, R. B. (1993) · Brain Research · doi:10.1016/0006-8993(93)91170-w · Cited by 56
Genetic basis of DiGeorge and velocardiofacial syndromes
Driscoll, D. A. (1994) · Current Opinion in Pediatrics · doi:10.1097/00008480-199412000-00016 · Cited by 55
Chromosomal locations and modes of action of genes of the retinoid (vitamin A) system support their involvement in the etiology of schizophrenia
Goodman, A. B. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600415 · Cited by 53
Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene.
Li, L.-H., Huang, G., Banta, A., Deng, Y., Smith, T., Dong, P. N., Friedman, C., Chen, L., Trask, B., Spies, T., et al. (1998) · Genomics · doi:10.1006/geno.1998.5330 · Cited by 49
Vitamin A Deficiency and Its Effects on the Eye
Harris, E. W., Loewenstein, J. I., & Azar, D. T. (1998) · International Ophthalmology Clinics · doi:10.1097/00004397-199803810-00013 · Cited by 49
Two Different Enzymes Are Primarily Responsible for Retinoic Acid Synthesis in Rabbit Liver Cytosol
Huang, D., & Ichikawa, Y. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2803 · Cited by 46
Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors
Maynard, T. M., Wakamatsu, Y., & Weston, J. A. (2000) · Development · doi:10.1242/dev.127.21.4561 · Cited by 39
Self-citation
Effect of retinol and retinoic acid on testosterone production by rat Leydig cells in primary culture
Chaudhary, L. R., Hutson, J. C., & Stocco, D. M. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(89)80061-0 · Cited by 38
Effects of small amygdala lesions on fear, but not aggression, in the rat
Oakes, M. E., & Coover, G. D. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00348-4 · Cited by 36
Is schizophrenia a neurodevelopmental disorder?
Waddington, J. L., & Youssef, H. A. (1987) · BMJ · doi:10.1136/bmj.295.6604.997-b · Cited by 33
Involvement of the entopeduncular nucleus and the habenula in methamphetamine-induced inhibition of dopamine neurons in the substantia nigra of rats
Sasaki, K., Suda, H., Watanabe, H., & Yagi, H. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90262-x · Cited by 32
Neurological Disturbances in Rats Reared on Diets Deficient in Vitamin A
Aberle, S. B. D. (1934) · Journal of Nutrition · doi:10.1093/jn/7.4.445 · Cited by 27
Increased immobility in an automated forced swimming test following lesion of the habenula in rats: Absence of evidence for a contribution from motor impairment.
Thornton, E. W., Bradbury, G. E., & Davies, C. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.1.37 · Cited by 27
The Neurotoxic Effects of Continuous Cocaine and Amphetamine in Habenula: Implications for the Substrates of Psychosis
Ellison, G. D., Irwin, S. A., Noguchi, K., Sulur, G., & Keys, A. S. (1996) · PsycEXTRA Dataset · doi:10.1037/e495672006-007 · Cited by 24
Seasonality of births in schizophrenia and bipolar disorder: A review of the literature
Torrey, Ε. F., Miller, J., Rawlings, R. R., & Yolken, R. H. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)82751-x · Cited by 24
Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons
Bendotti, C., Prosperini, E., Kurosaki, M., Garattini, E., & Terao, M. (1997) · Neuroreport · doi:10.1097/00001756-199707070-00048 · Cited by 23
Effects of Habenular Lesions upon Two-Way Active Avoidance Conditioning in Rats
Vale-Martı́nez, A., Martí‐Nicolovius, M., Guillazo‐Blanch, G., Coll-Andreu, M., & Morgado-Bernal, I. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3777 · Cited by 22
Increased immobility in an automated forced swimming test following lesion of the habenula in rats: Absence of evidence for a contribution from motor impairment.
Thornton, E. W., Bradbury, G. E., & Davies, C. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.1.37 · Cited by 22
Chronic hypervitaminosis A in an adult
Benedetto, R. J. D. (1967) · JAMA · doi:10.1001/jama.201.9.700 · Cited by 19
Retinoid Signaling in Mouse Embryos
Linney, E. A., & LaMantia, A. (1994) · Advances in developmental biology · doi:10.1016/s1566-3116(08)60007-9 · Cited by 18
Self-citation
Glucagon-like peptide-1 does not mediate amylase release from AR42J cells
Zhou, J., Montrose‐Rafizadeh, C., Janczewski, A. M., Piñeyro, M. A., Sollott, S. J., Wang, Y., & Egan, J. M. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199912)181:3 · Cited by 18
Habenular lesion attenuates methamphetamine-induced inhibition of dopamine neuronal activity in the substantia nigra pars compacta of rats
Sasaki, K., Suda, H., Watanabe, H., Kaneko, S., Nomura, Y., Nishino, H., & Ono, T. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90184-x · Cited by 18
Chronic Hypervitaminosis A in an Adult
Benedetto, R. J. D. (1967) · JAMA · doi:10.1001/jama.1967.03130090064022 · Cited by 17
Effect of Vitamin A Deficiency on the Retina of the Experimental Rabbit
Sorsby, A., Reading, H. W., & Bunyan, J. (1966) · Nature · doi:10.1038/2101011a0 · Cited by 11
Prenatal exposure to famine and brain morphology in schizophrenia
Pol, H. E. H., Hoek, H. W., Susser, E., Brown, A., Dingemans, A. E., Schnack, H. G., van Haren, N. E. M., Ramos, L. M. P., Wied, C. C. G., & Kahn, R. S. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(00)90321-9 · Cited by 10
Untitled work
Kritzer (1997) · doi:10.1002/(sici)1096-9861(19970310)379:2
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Cardno, A. G., & Gottesman, I. I. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(200021)97:1
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Authors: Maynard, T. M., Sikich, L., Lieberman, J. A., & LaMantia, A.-S.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: LaMantia, A.-S.
ORCID: Maynard, T. M.
Sikich, L.
LaMantia, A.-S.
Venue: Schizophrenia Bulletin
Publisher: Oxford University Press (OUP)
Published: 2001-01-01
Volume: 27
Issue: 3
Pages: 457-476
ISSN: 0586-7614 (ISSN-L)
1745-1701
DOI: 10.1093/oxfordjournals.schbul.a006887
OpenAlex: W2056370816
Cited by: 383
References: 160
Citations by year: 2026: 10 · 2025: 18 · 2024: 18 · 2023: 22 · 2022: 22 · 2021: 29 · 2020: 20 · 2019: 16 · 2018: 19 · 2017: 22 · 2016: 18 · 2015: 17 · 2014: 29 · 2013: 24 · 2012: 20
FWCI: 2.80
Type: journal article
Language: en
Open access: closed
Locations: Schizophrenia Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 33127)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-29178)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, two-hit hypothesis
MeSH terms: Brain, Cell Communication, Chromosome Deletion, Chromosomes, Human, Pair 22, Environment, Humans, Neural Pathways, Psychological Theory, Schizophrenia, Tretinoin

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Neural development, cell-cell signaling, and the “two-hit” hypothesis of schizophrenia

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