Corollary discharge dysfunction in schizophrenia: Can it explain auditory hallucinations?

Ford, Judith M.; Mathalon, Daniel H.

doi:10.1016/j.ijpsycho.2005.01.014

Cited by 267Schizophrenia research and treatmentHallucinations in medical conditionsNeural dynamics and brain function

Corollary discharge dysfunction in schizophrenia: Can it explain auditory hallucinations?

Ford, Judith M., Mathalon, Daniel H.·2005·International Journal of Psychophysiology

DOI 10.1016/j.ijpsycho.2005.01.014

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Abstract

Failure of corollary discharge, a mechanism for distinguishing self-generated from externally generated percepts, has been posited to underlie certain positive symptoms of schizophrenia, including auditory hallucinations. Although originally described in the visual system, corollary discharge may exist in the auditory system, whereby signals from motor speech commands prepare auditory cortex for self-generated speech. While associated with sensorimotor systems, it might also apply to inner speech or thought, regarded as our most complex motor act. In this paper, we describe the results of a series of studies in which we have shown that: (1) event-related brain potentials (ERPs) can be used to demonstrate the corollary discharge phenomenon during talking, (2) corollary discharge is abnormal in patients with schizophrenia, (3) EEG gamma band coherence between frontal and temporal lobes is greater during talking than listening and is disrupted by distorted feedback during talking in normals, and (4) patients with schizophrenia do not show this pattern for EEG gamma coherence. While these studies have identified ERPs and EEG gamma coherence indices of the efference copy/corollary discharge system and documented abnormalities in these systems in patients with schizophrenia, we have so far had limited success in establishing a relationship between these neurobiologic indicators of corollary discharge abnormality and reports of hallucinations in patients.

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In the case of voice hearing this can result in attribution of inner speech to an external source such as another agent.
“In the case of voice hearing this can result in attribution of inner speech to an external source such as another agent (Ford and Mathalon 2005; Ford et al. 2007).”
From Consciousness in active inference: Deep self-models, other minds, and the challenge of psychedelic-induced ego-dissolution (2021) · cites this paper as Ford and Mathalon 2005
The symptomatology of schizophrenia-such as thought insertion-has been understood in terms of a failure of sensory attenuation mechanisms.
“For instance, the symptomatology of schizophrenia—such as thought insertion, where patients report feeling that their thoughts are not their own—have been understood in terms of a failure of these sensory attenuation mechanisms (Ford and Mathalon 2005; Frith 2005; Rösler et al. 2015; Thakkar et al. 2021).”
From Consciousness in active inference: Deep self-models, other minds, and the challenge of psychedelic-induced ego-dissolution (2021) · cites this paper as Ford and Mathalon 2005

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“This matching process is both time-sensitive and content-specific (Jack et al., 2019), leading to perceptual attenuation of our own speech (Ford and Mathalon, 2005).”
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Neurophysiological evidence of corollary discharge dysfunction in schizophrenia
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Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations
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Impaired corollary discharge as a predictor of reality monitoring deficits in schizophrenia: Implications for auditory verbal hallucinations.
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Corollary Discharge Dysfunction as a Possible Substrate of Anomalous Self-experiences in Schizophrenia
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Authors: Ford, J. M., & Mathalon, D. H.
Affiliations: Veterans Health Administration (US)
Corresponding author: Ford, Judith M.
ORCID: Ford, Judith M.
Mathalon, Daniel H.
Venue: International Journal of Psychophysiology
Publisher: Elsevier BV
Published: 2005-11
Volume: 58
Issue: 2-3
Pages: 179-189
ISSN: 0167-8760 (ISSN-L)
DOI: 10.1016/j.ijpsycho.2005.01.014
OpenAlex: W1964551378
Cited by: 267
References: 35
Citations by year: 2026: 18 · 2025: 9 · 2024: 11 · 2023: 11 · 2022: 21 · 2021: 9 · 2020: 18 · 2019: 15 · 2018: 11 · 2017: 14 · 2016: 15 · 2015: 19 · 2014: 10 · 2013: 11 · 2012: 7
FWCI: 5.18
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: International Journal of Psychophysiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 58262, MH40052)
National Alliance for Research on Schizophrenia and Depression
U.S. Department of Veterans Affairs
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: corollary discharge, schizophrenia, auditory hallucinations, efference copy, event-related potentials, positive symptoms, inner speech
MeSH terms: Auditory Cortex, Efferent Pathways, Evoked Potentials, Hallucinations, Humans, Schizophrenia, Schizophrenic Psychology, Speech

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Corollary discharge dysfunction in schizophrenia: Can it explain auditory hallucinations?

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