Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia

Uhlhaas, Peter J

doi:10.1016/j.conb.2012.11.004

Cited by 179Neural dynamics and brain functionSchizophrenia research and treatmentFunctional Brain Connectivity Studies

Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia

Uhlhaas, Peter J·2013·Current Opinion in Neurobiology

DOI 10.1016/j.conb.2012.11.004

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Abstract

Schizophrenia remains a daunting challenge for efforts aimed at identifying fundamental pathophysiological processes and to develop evidence-based effective treatments and interventions. One reason for the lack of progress lies in the fact that the pathophysiology of schizophrenia has been predominantly conceived in terms of circumscribed alterations in cellular and anatomical variables. In the current review, it is proposed that this approach needs to be complemented by a focus on the neuronal dynamics in large-scale networks which is compatible with the notion of dysconnectivity, highlighting the involvement of both reduced and increased interactions in extended cortical circuits in schizophrenia. Neural synchrony is one candidate mechanisms for achieving functional connectivity in large-scale networks and has been found to be impaired in schizophrenia. Importantly, alterations in the synchronization of neural oscillations can be related to dysfunctions in the excitation-inhibition (E/I)-balance and developmental modifications with important implications for translational research.

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Malfunctioning synaptic communication inside and across brain regions may produce schizophrenia symptoms by disrupting cognitive and perceptual circuitry.
“the symptoms associated with schizophrenia may arise from a malfunctioning synaptic communication within and between brain regions, leading to a functional disruption of the circuitry that underlies many of the cognitive and perceptive functions (Uhlhaas, 2013)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Uhlhaas, 2013

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Authors: Uhlhaas, P. J.
Affiliations: Max Planck Society (DE)
Corresponding author: Uhlhaas, Peter J
ORCID: Uhlhaas, Peter J
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2013-04
Volume: 23
Issue: 2
Pages: 283-290
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/j.conb.2012.11.004
OpenAlex: W2068181401
Cited by: 178
References: 60
Citations by year: 2026: 7 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 17 · 2016: 15 · 2015: 21 · 2014: 22 · 2013: 11
FWCI: 1.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Max-Planck Society
LOEWE Grant ‘Neuronale Koordination Forschungsschwerpunkt Frankfurt’
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: schizophrenia, dysconnectivity, large-scale brain networks, neural dynamics, neuronal synchronization, neural oscillations, functional connectivity, excitation-inhibition balance, cortical circuits
MeSH terms: Brain, Brain Mapping, Humans, Nerve Net, Neurons, Schizophrenia, Nonlinear Dynamics

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Dysconnectivity, large-scale networks and neuronal dynamics in schizophrenia

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