Progression of Influenza Viral Infection Through the Murine Respiratory Tract: The Protective Role of Sleep Deprivation
Abstract
Sleep deprivation is reported to have both beneficial and harmful effects upon host defenses. In the work reported herein, we address the effects of sleep deprivation on the mucosal anti-influenza defenses of both immune and nonimmune BALB/c mice. Sleep deprivation does not depress existing mucosal antiviral defenses in the respiratory tracts of BALB/c mice; in fact, it may actually be beneficial. Nasal mucosal immunity is not adversely affected in immune mice by sleep deprivation. In nonimmune mice, sleep deprivation slows or prevents the progress of nasal influenza viral infection down the trachea into the lungs. By 72 hours post-infection, 12 of 12 control mice shed virus into bronchioalveolar lavages (BAL) while only 2 of 12 sleep deprived mice shed virus (p<0.001). BAL levels of IL-1beta and interferon alpha were increased in sleep deprived animals, suggesting that sleep deprivation may exert its beneficial effects on the respiratory tract by upregulating the production of antiviral cytokines.
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Overall, animal studies revealed inconsistent results with sleep, compared with conditions of sleep deprivation, enhancing or weakening markers of recall, or showing no effect.
“Overall, these studies revealed inconsistent results with sleep, compared with conditions of sleep deprivation, enhancing or weakening markers of recall, or showing no effect (145, 980, 981, 1206).”
From About Sleep's Role in Memory (2013) · cites this paper as [980]
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- Authors
- Renegar, K. B., Crouse, D., Floyd, R. A., & Krueger, J.
- Affiliations
- University of Tennessee Health Science Center (US)
- Washington State University (US)
- Corresponding author
- Krueger, James
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-10-01
- Volume
- 23
- Issue
- 7
- Pages
- 1-5
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W58937571
- Cited by
- 38
- References
- 0
- Citations by year
- 2022: 1 · 2019: 4 · 2018: 1 · 2016: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08ai001359-03)
- National Institute of Allergy and Infectious Diseases (1 K08AI01359)
- National Institute of Neurological Disorders and Stroke (NS-25378, R01NS025378)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep deprivation, influenza virus, respiratory infections, mucosal immunity, nasal mucosa, viral shedding, interferon-alpha, IL-1β, antiviral cytokines, BALB/c mice, host defense
- MeSH terms
- Animals, Antibodies, Viral, Female, Interferons, Mice, Inbred BALB C, Nasal Mucosa, Orthomyxoviridae, Respiratory Tract Infections, Sleep Deprivation, Up-Regulation, Bronchoalveolar Lavage, Mice
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