Effects of Short-term Sleep Deprivation on Murine Immunity to Influenza Virus in Young Adult and Senescent Mice
Abstract
Sleep has been proposed as an innate host defense, exerting effects on both specific and nonspecific immunity. In one of the more striking papers dealing with the effects of sleep on specific immunity, Brown et al (Reg. Immunol. 1989; 2: 321-325) reported that depriving influenza virus-immune mice of sleep for 7 hours following total respiratory tract viral challenge abrogated anti-viral immunity within the lungs and lowered the level of anti-influenza antibody in lung homogenates. In the solidly-immune convalescent mouse, nasobronchial immunity to influenza virus has been shown to be due to secretory IgA (S-IgA) within the mucosal mucocilliary blanket, while serum IgG has been shown to mediate protection within the lung parenchyma. In this study we attempted to duplicate the work of Brown et al in solidly immune mice. We were unable to abrogate mucosal anti-influenza viral immunity with a single post-viral-challenge sleep-deprivation episode, nor were we able to depress this immunity with one pre- and two post-challenge sleep-deprivation episodes in young adult or old mice, or with two pre-challenge sleep-deprivation episodes in old mice. Sleep deprivation did not depress the level of serum influenza-specific IgG antibodies, and resulted in increased influenza-specific serum IgG compared with normally sleeping mice in aged immune mice boosted 3 weeks before challenge and sleep deprived once before and twice after challenge (p = 0.005). No differences in anti-viral respirator…
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Overall, animal studies revealed inconsistent results with sleep, compared with conditions of sleep deprivation, enhancing or weakening markers of recall, or showing no effect.
“Overall, these studies revealed inconsistent results with sleep, compared with conditions of sleep deprivation, enhancing or weakening markers of recall, or showing no effect (145, 980, 981, 1206).”
From About Sleep's Role in Memory (2013) · cites this paper as [981]
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- Authors
- Renegar, K. B., Floyd, R. A., & Krueger, J. M.
- Affiliations
- University of Tennessee Health Science Center (US)
- Corresponding author
- Rachael A. Floyd
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05-01
- Volume
- 21
- Issue
- 3
- Pages
- 241-8
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W38148246
- Cited by
- 54
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS025378)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep deprivation, influenza virus, mucosal immunity, secretory IgA, serum IgG, humoral immunity, aging, lung immunity, innate host defense, antiviral antibodies
- MeSH terms
- Aging, Animals, Antibody Formation, Female, Immunoglobulin G, Orthomyxoviridae, Sleep Deprivation, Time Factors, Mice
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