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Mechanisms and implications of the age‐associated decrease in DNA repair capacity

Goukassian, David, Gad, Faten, Yaar, Mina, Eller, Mark S., Nehal, Umbereen S., Gilchrest, Barbara A.·2000·The FASEB Journal
DOI 10.1096/fasebj.14.10.1325
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Abstract

Skin cancer incidence is clearly linked to UV irradiation and increases exponentially with age. We studied the rate of removal of thymine dimers and (6–4) photoproducts in UV‐irradiated human dermal fibroblasts derived from donors of different ages. There was a significant decrease with aging in the repair rates of both thymine dimers and (6–4) photoproducts ( P < 0.001). In addition, there was an age‐associated decrease in the protein levels of ERCC3, PCNA, RPA, XPA, and p53 that participate in nucleotide excision repair. Moreover, the mRNA levels of XPA, ERCC3, and PCNA were significantly reduced with aging, suggesting that these decreases are often regulated at the mRNA level. Furthermore, with age induction of p53 after UV irradiation was significantly reduced. Taken together, our data suggest that the age‐associated decrease in the repair of UV‐induced DNA damage results at least in part from decreased levels of proteins that participate in the repair process.—Goukassian, D., Gad, F., Yaar, M., Eller, M. S., Nehal, U. S., Gilchrest, B. A. Mechanisms and implications of the age‐associated decrease in DNA repair capacity. FASEB J. 14, 1325–1334 (2000)

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Research works printed but not linked: 91

  1. 10.1016/S0190-9622(08)81509-5 · DOI · Paper page
  2. Kochevar I. E., 1993, Dermatology in General Medicine, 1627
  3. 10.1111/1523-1747.ep12541084 · DOI · Paper page
  4. 10.1073/pnas.88.22.10124 · DOI · Paper page
  5. 10.1073/pnas.90.9.4216 · DOI · Paper page
  6. 10.1111/j.1751-1097.1977.tb07355.x · DOI
  7. 10.1073/pnas.87.21.8252 · DOI · Paper page
  8. 10.1093/nar/20.2.225 · DOI · Paper page
  9. 10.1007/978-1-4899-2406-3_12 · DOI · Paper page
  10. Sancar G. B., 1996, Repair and processing of DNA damage: a summary of recent progress, Mutat. Res., 362, 127, 10.1016/0921-8777(95)00029-1 · doi:10.1016/0921-8777(95)00029-1
  11. 10.1146/annurev.bi.65.070196.001031 · DOI · Paper page
  12. 10.1128/MCB.15.10.5396 · DOI · Paper page
  13. 10.1016/S0021-9258(19)39170-7 · DOI · Paper page
  14. 10.1074/jbc.272.38.23896 · DOI
  15. 10.1074/jbc.272.37.22991 · DOI
  16. 10.1002/j.1460-2075.1996.tb00506.x · DOI · Paper page
  17. 10.1016/S0962-8924(00)88934-5 · DOI
  18. 10.1126/science.7801120 · DOI · Paper page
  19. 10.1101/gad.10.9.1054 · DOI · Paper page
  20. Hall P. A., 1993, High levels of p53 protein in UV‐irradiated normal human skin, Oncogene, 8, 203
  21. 10.1016/S0092-8674(00)81871-1 · DOI · Paper page
  22. 10.1074/jbc.272.44.28073 · DOI · Paper page
  23. 10.1093/carcin/16.10.2295 · DOI
  24. 10.1046/j.1365-2133.1998.02306.x · DOI
  25. Tron V. A., 1998, p53‐dependent regulation of nucleotide excision repair in murine epidermis, J. Cutan. Med. Surg., 3, 16, 10.1177/120347549800300104 · DOI
  26. 10.1111/1523-1747.ep12606207 · DOI
  27. 10.1016/0921-8777(96)00029-8 · DOI · Paper page
  28. Grossman L., 1997, Epidemiology of ultraviolet‐DNA repair capacity and human cancer, Environ. Health Perspect., 105, 927
  29. 10.1111/1523-1747.ep12504707 · DOI
  30. 10.1093/geronj/35.4.537 · DOI
  31. Werninghaus K., 1991, Protective effect of alpha‐tocopherol in carrier liposomes on ultraviolet‐mediated human epidermal cell damage in vitro, Photodermatol. Photoimmun. Photomed., 8, 236
  32. 10.1111/1523-1747.ep12371673 · DOI
  33. 10.1111/j.1751-1097.1991.tb03926.x · DOI
  34. 10.1016/0014-4827(92)90387-N · DOI
  35. 10.1073/pnas.94.23.12627 · DOI · Paper page
  36. 10.1172/JCI117496 · DOI
  37. 10.1083/jcb.115.3.821 · DOI · Paper page
  38. 10.1016/0092-8674(94)90165-1 · DOI · Paper page
  39. 10.1093/clinchem/41.12.1854 · DOI
  40. 10.1074/jbc.270.28.16507 · DOI
  41. Crowley D. J., 1998, Induction of the SOS response increases the efficiency of global nucleotide excision repair of cyclobutane pyrimidine dimers, but not 6–4‐photoproducts, in UV‐irradiated Escherichia coli, J. Bacteriol., 180, 3345, 10.1128/JB.180.13.3345-3352.1998 · DOI
  42. 10.1046/j.1523-1747.1999.00468.x · DOI
  43. Medrano E. E., 1995, Ultraviolet B induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long‐term expression of the p21 Waf‐1/SDI‐1/Cip‐1 protein, Cancer Res., 55, 4047
  44. Yamaizumi M., 1994, U.V.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle, Oncogene, 9, 2775
  45. 10.1128/MCB.17.1.355 · DOI · Paper page
  46. 10.1006/excr.1998.4269 · DOI
  47. 10.1016/S0027-5107(98)00088-8 · DOI
  48. 10.1016/0022-2836(88)90455-X · DOI
  49. 10.1111/1523-1747.ep12456316 · DOI
  50. 10.1111/1523-1747.ep12873312 · DOI
  51. 10.1093/carcin/16.10.2455 · DOI
  52. 10.1111/j.1600-0781.1996.tb00239.x · DOI
  53. 10.1111/1523-1747.ep12335984 · DOI
  54. Ruven H. J., 1993, Ultraviolet‐induced cyclobutane pyrimidine dimers are selectively removed from transcriptionally active genes in the epidermis of the hairless mouse, Cancer Res., 53, 1642
  55. Ruven H. J., 1994, Strand‐specific removal of cyclobutane pyrimidine dimers from the p53 gene in the epidermis of UVB‐irradiated hairless mice, Oncogene, 9, 3427
  56. 10.1073/pnas.90.21.9823 · DOI
  57. Van Remmen H., 1995, Handbook of Physiology: Aging, 171
  58. 10.1073/pnas.91.6.2230 · DOI · Paper page
  59. 10.1073/pnas.93.2.895 · DOI
  60. 10.1073/pnas.94.14.7186 · DOI
  61. 10.1016/0027-5107(76)90235-9 · doi:10.1016/0027-5107(76)90235-9
  62. 10.1093/carcin/7.3.381 · doi:10.1093/carcin/7.3.381
  63. Smith M. L., 1995, Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage, Oncogene, 10, 1053
  64. 10.1016/0092-8674(95)90165-5 · DOI · Paper page
  65. Lu X., 1996, Discordance between accumulated p53 protein level and its transcriptional activity in response to UV radiation, Oncogene, 13, 413
  66. 10.1073/pnas.93.26.15075 · DOI · Paper page
  67. 10.1006/excr.1996.0274 · DOI
  68. Lambert B., 1979, Age‐related decrease of ultraviolet light‐induced DNA repair synthesis in human peripheral leukocytes, Cancer Res., 39, 2792
  69. Nette E. G., 1984, A correlation between aging and DNA repair in human epidermal cells, Mech. Ageing Dev., 24, 238
  70. 10.1016/0165-1161(94)90053-1 · doi:10.1016/0165-1161(94)90053-1
  71. 10.1016/0921-8734(94)90010-8 · DOI
  72. 10.2307/3577923 · DOI · Paper page
  73. 10.1111/1523-1747.ep12349031 · DOI
  74. 10.1128/MCB.7.9.3353 · DOI
  75. 10.1016/0921-8777(92)90051-4 · DOI
  76. 10.1111/j.1751-1097.1988.tb02786.x · DOI · Paper page
  77. 10.1111/j.1751-1097.1989.tb05578.x · DOI · Paper page
  78. 10.1016/0165-1218(93)90103-K · DOI
  79. 10.1093/nar/26.20.4662 · DOI
  80. 10.1001/archderm.1994.01690080084012 · DOI · Paper page
  81. 10.1002/(SICI)1098-2744(199712)20:4<340::AID-MC3>3.0.CO;2-N · DOI
  82. 10.1038/sj.gt.3300495 · DOI
  83. 10.1093/carcin/19.9.1701 · doi:10.1093/carcin/19.9.1701
  84. Kastan M. B., 1991, Participation of p53 protein in the cellular response to DNA damage, Cancer Res., 51, 6304
  85. 10.1128/MCB.14.10.7013 · DOI · Paper page
  86. 10.1038/ng0695-188 · DOI · Paper page
  87. 10.1126/science.7973727 · DOI · Paper page
  88. 10.1016/0092-8674(92)90416-A · DOI · Paper page
  89. 10.1073/pnas.94.23.12255 · DOI
  90. Gilchrest B. A., 1997, Aging processes. DNA damage, and repair, FASEB J., 11, 332, 10.1096/fasebj.11.5.9141498 · DOI
  91. Gilchrest B. A., The Role of DNA Damage and Repair in Cell Aging

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Metadata

Authors
Goukassian, D., Gad, F., Yaar, M., Eller, M. S., Nehal, U. S., & Gilchrest, B. A.
Venue
The FASEB Journal
Publisher
Wiley
Published
2000-07
Volume
14
Issue
10
Pages
1325-1334
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fasebj.14.10.1325
OpenAlex
W1998590670
Cited by
218
References
3
FWCI
3.72
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
National Institutes of Health (T32AG00115, 5T32AR07562)

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CoChat. (2026). Citation check: Mechanisms and implications of the age‐associated decrease in DNA repair capacity. https://app.cochat.ai/papers/10.1096/fasebj.14.10.1325
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Goukassian, D., Gad, F., Yaar, M., Eller, M. S., Nehal, U. S., & Gilchrest, B. A. (2000). Mechanisms and implications of the age‐associated decrease in DNA repair capacity. The FASEB Journal. https://doi.org/10.1096/fasebj.14.10.1325

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