Cited by 344Muscle Physiology and DisordersMuscle metabolism and nutritionNutrition and Health in Aging

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Patterns of gene expression in atrophying skeletal muscles: response to food deprivation

Jagoe, R. Thomas, Lecker, Stewart H., Gomes, Marcelo, Goldberg, Alfred L.·2002·The FASEB Journal

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Abstract

During fasting and many systemic diseases, muscle undergoes rapid loss of protein and functional capacity. To define the transcriptional changes triggering muscle atrophy and energy conservation in fasting, we used cDNA microarrays to compare mRNAs from muscles of control and food‐deprived mice. Expression of >94% of genes did not change, but interesting patterns emerged among genes that were differentially expressed: 1) mRNAs encoding polyubiquitin, ubiquitin extension proteins, and many (but not all) proteasome subunits increased, which presumably contributes to accelerated protein breakdown; 2) a dramatic increase in mRNA for the ubiquitin ligase, atrogin‐1, but not most E3s; 3) a significant suppression of mRNA for myosin binding protein H (but not other myofibrillar proteins) and IGF binding protein 5, which may favor cell protein loss; 4) decreases in mRNAs for several glycolytic enzymes and phosphorylase kinase subunits, and dramatic increases in mRNAs for pyruvate dehydrogenase kinase 4 and glutamine synthase, which should promote glucose sparing and gluconeogenesis. During fasting, metallothionein mRNA increased dramatically, mRNAs for extracellular matrix components fell, and mRNAs that may favor cap‐independent mRNA translation rose. Significant changes occurred in mRNAs for many growth‐related proteins and transcriptional regulators. These transcriptional changes indicate a complex adaptive program that should favor protein degradation and suppress glucose oxidation in muscle. Similar analysis of muscles atrophying for other causes is allowing us to identify a set of atrophy‐specific changes in gene expression.—Jagoe, R. T., Lecker, S. H., Gomes, M., Goldberg, A. L. Patterns of gene expression in atrophying skeletal muscles: response to food deprivation. FASEB J . 16, 1697–1712 (2002)

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Authors: Jagoe, R. T., Lecker, S. H., Gomes, M., & Goldberg, A. L.
Affiliations: Harvard University (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Jagoe, R. Thomas
Lecker, Stewart H.
Goldberg, Alfred L.
Venue: The FASEB Journal
Publisher: Wiley
Published: 2002-11
Volume: 16
Issue: 13
Pages: 1697-1712
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.02-0312com
OpenAlex: W2101050876
Cited by: 344
References: 102
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 13 · 2018: 10 · 2017: 14 · 2016: 12 · 2015: 16 · 2014: 10 · 2013: 13 · 2012: 28
FWCI: 7.90
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Funders: National Space Biomedical Research Institute
National Institutes of Health (DK02707)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: skeletal muscle atrophy, fasting, food deprivation, gene expression, protein degradation, ubiquitin-proteasome system, atrogin-1, IGF binding protein-5, glycolytic enzymes, PDK4, glutamine synthetase, gluconeogenesis, glucose sparing, metallothionein, extracellular matrix, cap-independent translation, transcriptional regulation
MeSH terms: Animals, Atrophy, Body Weight, Cell Division, Creatine Kinase, Electron Transport, Food Deprivation, Gene Expression Regulation, Glutamate-Ammonia Ligase, Glycolysis, Male, Mice, Inbred C57BL, Endopeptidases, RNA, Messenger, Transcription Factors, Apoptosis, Muscle, Skeletal, Insulin-Like Growth Factor Binding Protein 5, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Carbonic Anhydrase III, Mice

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Patterns of gene expression in atrophying skeletal muscles: response to food deprivation

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