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Cited by 255

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats

Mager, Donald E., Wan, Ruiqian, Brown, Martin, Cheng, Aiwu, Wareski, Przemyslaw, Abernethy, Darrell R., Mattson, Mark P.·2006·The FASEB Journal
DOI 10.1096/fj.05-5263com
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Abstract

Dietary restriction (DR) has been shown to increase life span, delay or prevent age‐associated diseases, and improve functional and metabolic cardiovascular risk factors in rodents and other species. To investigate the effects of DR on beat‐to‐beat heart rate and diastolic blood pressure variability (HRV and DPV) in male Sprague‐Dawley rats, we implanted telemetric transmitters and animals were maintained on either intermittent fasting (every other day feeding) or calorie‐restricted (40% caloric reduction) diets. Using power spectral analysis, we evaluated the temporal profiles of the low‐and high‐frequency oscillatory components in heart rate and diastolic blood pressure signals to assess cardiac autonomic activity. Body weight, heart rate, and systolic and diastolic blood pressure were all found to decrease in response to DR. Both methods of DR produced decreases in the low‐frequency component of DPV spectra, a marker for sympathetic tone, and the high‐frequency component of HRV spectra, a marker for parasympathetic activity, was increased. These parameters required at least 1 month to become maximal, but returned toward base‐line values rapidly once rats resumed ad libitum diets. These results suggest an additional cardiovascular benefit of DR that merits further studies of this potential effect in humans.‐Mager, D. E., Wan, R., Brown, M., Cheng, A., Wareski, P., Abernethy, D. R., Mattson, M. P. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J. 20, 631–637 (2006)

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Metadata

Authors
Mager, D. E., Wan, R., Brown, M., Cheng, A., Wareski, P., Abernethy, D. R., & Mattson, M. P.
Venue
The FASEB Journal
Publisher
Wiley
Published
2006-04
Volume
20
Issue
6
Pages
631-637
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fj.05-5263com
OpenAlex
W2170445507
Cited by
255
References
5
FWCI
6.34
Type
journal article
Language
en
Open access
closed

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