The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?
Abstract
Vitamin D insufficiency is common in the United States;the elderly and African‐Americans are at particularly high risk of deficiency. This review, written for a broad scientific readership, presents a critical overview of scientific evidence relevant to a possible causal relationship between vitamin D deficiency and adverse cognitive or behavioral effects. Topics discussed are 1 ) biological functions of vitamin D relevant to cognition and behavior; 2 ) studies in humans and rodents that directly examine effects of vitamin D inadequacy on cognition or behavior;and 3 ) immunomodulatory activity of vitamin D relative to the proinflammatory cytokine theory of cognitive/behavioral dysfunction. We conclude there is ample biological evidence to suggest an important role for vitamin D in brain development and function. However, direct effects of vitamin D inadequacy on cognition/behavior in human or rodent systems appear to be subtle, and in our opinion, the current experimental evidence base does not yet fully satisfy causal criteria. Possible explanations for the apparent inconsistency between results of biological and cognitive/behavioral experiments, as well as suggested areas for further research are discussed. Despite residual uncertainty, recommendations for vitamin D supplementation of at‐risk groups, including nursing infants, the elderly, and African‐Americans appear warranted to ensure adequacy. McCann, J. C., Ames, B. N. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 22, 982–1001 (2008)
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Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
The molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860
Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
Gill, S. S., Patel, N. K., Hotton, G. R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D. J., Svendsen, C. N., & Heywood, P. (2003) · Nature Medicine · doi:10.1038/nm850 · Cited by 1,290
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
Tomac, A., Lindqvist, E., Lin, L.-F. H., Ögren, S. O., Young, D., Hoffer, B. J., & Olson, L. (1995) · Nature · doi:10.1038/373335a0 · Cited by 1,079
A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 927
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637
The prevalence of co‐morbid depression in adults with Type 1 diabetes: systematic literature review
Barnard, K. D., Skinner, T. C., & Peveler, R. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01814.x · Cited by 350
Maier, S. F. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00032-1 · Cited by 300
Junge, H. J., Rhee, J.-S., Jahn, O., Varoqueaux, F., Spiess, J., Waxham, M. N., Rosenmund, C., & Brose, N. (2004) · Cell · doi:10.1016/j.cell.2004.06.029 · Cited by 290
McGrath, J., Saari, K., Hakko, H., Jokelainen, J., Jones, P., Järvelin, M.-R., Chant, D., & Isohanni, M. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2003.08.005 · Cited by 288
Neveu, I., Naveilhan, P., Jehan, F., Baudet, C., Wion, D., De Luca, H. F., & Brachet, P. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90119-8 · Cited by 241
Madrigal, J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00292-5 · Cited by 232
Mikocka-Walus, A. A., Turnbull, D. A., Moulding, N. T., Wilson, I. G., Andrews, J. M., & Holtmann, G. J. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20062 · Cited by 178
Epidemiology and natural history of multiple sclerosis: new insights
Kantarci, O., & Wingerchuk, D. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000227033.47458.82 · Cited by 156
VDR gene variants associate with cognitive function and depressive symptoms in old age
Kuningas, M., Mooijaart, S. P., Jolles, J., Slagboom, P. E., Westendorp, R. G. J., & van Heemst, D. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.001 · Cited by 149
Psychosocial functioning in pediatric inflammatory bowel disease
MacKner, L. M., Crandall, W. V., & Szigethy, E. M. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000217769.83142.c6 · Cited by 122
Nadjar, A., Bluthé, R.-M., May, M. J., Dantzer, R., & Parnet, P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300755 · Cited by 120
Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice
Kalueff, A. V., Minasyan, A., & Tuohimaa, P. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.06.022 · Cited by 94
Questions raised by the cytokine hypothesis of depression
de Beaurepaire, R. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00005-3 · Cited by 39
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Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism
Patrick, R. P., & Ames, B. N. (2014) · The FASEB Journal · doi:10.1096/fj.13-246546 · Cited by 414
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Gowda, U., Mutowo, M. P., Smith, B. J., Wluka, A. E., & Renzaho, A. M. N. (2015) · Nutrition · doi:10.1016/j.nut.2014.06.017 · Cited by 229
Metadata
- Authors
- McCann, J. C., & Ames, B. N.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2007-12-04
- Volume
- 22
- Issue
- 4
- Pages
- 982-1001
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2159846383
- Cited by
- 411
- References
- 24
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- closed
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