High-Intensity Interval Training Improves Markers of Oxidative Metabolism in Skeletal Muscle of Individuals With Obesity and Insulin Resistance
Open accessAbstract
Background: The excess body fat characteristic of obesity is related to various metabolic alterations, which includes insulin resistance. Among the non-pharmacological measures used to improve insulin sensitivity are aerobic physical training, such as high intensity interval training (HIIT). This study investigated the effects of 8 weeks of HIIT on blood and skeletal muscle markers related to insulin resistance (IR) and oxidative metabolism in physically inactive individuals with obesity and compared the changes between insulin resistant and non-insulin resistant phenotypes. Methods: Nine non-insulin (OB) and eight insulin-resistant (OBR) volunteers with obesity completed 8 weeks of HIIT in a cycle ergometer. Venous blood and vastus lateralis muscle samples were obtained before and after the HIIT. Body composition and peak oxygen consumption (VO2peak) were estimated before and after HIIT. Results: HIIT reduced IR assessed by the homeostatic model assessment of insulin resistance (HOMA-IR) in OBR (4.4 ± 1.4 versus 4.1 ± 2.2 (mmol) (μU)/l2), but not in OB (HOMA-IR 1.8 ± 0.5 versus 2.3 ± 1.0 (mmol) (μU)/l2) volunteers. HIIT increased VO2peak with no change in body fat in both groups. In skeletal muscle, HIIT increased the phosphorylation of IRS (Tyr612), Akt (Ser473), and increased protein content of β-HAD and COX-IV in both groups. There was a reduction in ERK1/2 phosphorylation in OBR after HIIT. Conclusion: Eight weeks of HIIT improved markers of the insulin signaling pathway and increased the content of proteins related to oxidative metabolism in skeletal muscle of individuals with obesity, independent of changes in insulin resistance or total body fat.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In subjects with diabetes or obesity, exercise increases insulin sensitivity independently of changes in body fat with nutritional interventions.
“In subjects with diabetes or obesity, exercise is the cornerstone of therapeutic interventions. It increases insulin sensitivity independently of changes in body fat with nutritional interventions”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [238]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216 · see citing works
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works
Total energy intake: implications for epidemiologic analyses.
WILLETT, W., & STAMPFER, M. J. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114366 · Cited by 2,751 · see citing works
RE: “TOTAL ENERGY INTAKE: IMPLICATIONS FOR EPIDEMIOLOGIC ANALYSES”
Palmgren, J., & Kushi, L. H. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115841 · Cited by 2,712 · see citing works
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works
Obesity and Diabetes in the Developing World — A Growing Challenge
Hossain, P., Kawar, B., & El Nahas, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068177 · Cited by 2,200 · see citing works
Thompson, P. D., Arena, R. A., Riebe, D. A., & Pescatello, L. S. (2013) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e31829a68cf · Cited by 1,825 · see citing works
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770 · see citing works
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
Cantó, C., & Auwerx, J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0a4 · Cited by 1,624 · see citing works
p38 MAP-Kinases pathway regulation, function and role in human diseases
Cuenda, A., & Rousseau, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.03.010 · Cited by 1,397 · see citing works
Itani, S. I., Ruderman, N. B., Schmieder, F., & Boden, G. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2005 · Cited by 1,390 · see citing works
Aerobic High-Intensity Intervals Improve V˙O2max More Than Moderate Training
HELGERUD, J., HØYDAL, K., WANG, E., KARLSEN, T., BERG, P., BJERKAAS, M., SIMONSEN, T., HELGESEN, C., HJORTH, N., BACH, R., et al. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180304570 · Cited by 1,332 · see citing works
Burgomaster, K. A., Howarth, K. R., Phillips, S. M., Rakobowchuk, M., MacDonald, M. J., McGee, S. L., & Gibala, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142109 · Cited by 1,257 · see citing works
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation
Sano, H., Kane, S., Sano, E., Mı̂inea, C. P., Asara, J. M., Lane, W. S., Garner, C. W., & Lienhard, G. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300063200 · Cited by 964 · see citing works
Little, J. P., Gillen, J. B., Percival, M. E., Safdar, A., Tarnopolsky, M. A., Punthakee, Z., Jung, M. E., & Gibala, M. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00921.2011 · Cited by 787 · see citing works
Self-citationSkeletal muscle inflammation and insulin resistance in obesity
Wu, H., & Ballantyne, C. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88880 · Cited by 695 · see citing works
Little, J. P., Safdar, A., Wilkin, G. P., Tarnopolsky, M. A., & Gibala, M. J. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.181743 · Cited by 672 · see citing works
Self-citationThe behavioral determinants of exercise: implications for physical activity interventions.
Sherwood, N., & Jeffery, R. (2000) · Annual review of nutrition · doi:10.1146/annurev.nutr.20.1.21 · Cited by 652 · see citing works
Jheng, H.-F., Tsai, P.-J., Guo, S.-M., Kuo, L.-H., Chang, C.-S., Su, I.-J., Chang, C.-R., & Tsai, Y.-S. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05603-11 · Cited by 650 · see citing works
Update on the effects of physical activity on insulin sensitivity in humans
Bird, S. R., & Hawley, J. A. (2017) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2016-000143 · Cited by 646 · see citing works
Jelleyman, C., Yates, T., O'Donovan, G., Gray, L. J., King, J. A., Khunti, K., & Davies, M. J. (2015) · Obesity Reviews · doi:10.1111/obr.12317 · Cited by 588 · see citing works
Sethi, J. K., & Vidal‐Puig, A. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700005-jlr200 · Cited by 558 · see citing works
Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
Abdul-Ghani, M. A., Matsuda, M., Balas, B., & DeFronzo, R. A. (2006) · Diabetes Care · doi:10.2337/dc06-1519 · Cited by 555 · see citing works
St‐Pierre, J., Lin, J. D., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301850200 · Cited by 543 · see citing works
Invited Review: Effects of acute exercise and exercise training on insulin resistance
Henriksen, E. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01219.2001 · Cited by 535 · see citing works
Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression.
Wright, D. C., Han, D.-H., Garcia-Roves, P. M., Geiger, P. C., Jones, T. E., & Holloszy, J. O. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606116200 · Cited by 488 · see citing works
Kim, Y.-B., Nikoulina, S. E., Ciaraldi, T. P., Henry, R. R., & Kahn, B. B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6928 · Cited by 487 · see citing works
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
Sakamoto, K., & Holman, G. D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90331.2008 · Cited by 481 · see citing works
Muscle Glycogen Synthesis after Exercise : an Enhancing Factor localized to the Muscle Cells in Man
BERGSTRÖM, J., & HULTMAN, E. (1966) · Nature · doi:10.1038/210309a0 · Cited by 473 · see citing works
Simoneau, J.-A., & Kelley, D. E. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.166 · Cited by 441 · see citing works
de Álvaro, C., Teruel, T., Hernández, R., & Lorenzo, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312021200 · Cited by 430 · see citing works
Gibala, M. J., McGee, S. L., Garnham, A. P., Howlett, K. F., Snow, R. J., & Hargreaves, M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90880.2008 · Cited by 427 · see citing works
Whyte, L. J., Gill, J. M. R., & Cathcart, A. J. (2010) · Metabolism · doi:10.1016/j.metabol.2010.01.002 · Cited by 424 · see citing works
Oberbach, A., Bossenz, Y., Lehmann, S., Niebauer, J., Adams, V., Paschke, R., Schön, M. R., Blüher, M., & Punkt, K. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1854 · Cited by 385 · see citing works
Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults
HOOD, M. S., LITTLE, J. P., TARNOPOLSKY, M. A., MYSLIK, F., & GIBALA, M. J. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182199834 · Cited by 375 · see citing works
Self-citationInsulin action and insulin resistance in human skeletal muscle
Zierath, J. R., Krook, A., & Wallberg-Henriksson, H. (2000) · Diabetologia · doi:10.1007/s001250051457 · Cited by 367 · see citing works
Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle
Muoio, D. M., & Neufer, P. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.010 · Cited by 343 · see citing works
Little, J. P., Safdar, A., Bishop, D., Tarnopolsky, M. A., & Gibala, M. J. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00538.2010 · Cited by 342 · see citing works
Self-citationMAPK signalling in cellular metabolism: stress or wellness?
Gehart, H., Kumpf, S., Ittner, A., & Ricci, R. (2010) · EMBO Reports · doi:10.1038/embor.2010.160 · Cited by 327 · see citing works
Schmitz-Peiffer, C., Browne, C. L., Oakes, N. D., Watkinson, A., Chisholm, D. J., Kraegen, E. W., & Biden, T. J. (1997) · Diabetes · doi:10.2337/diab.46.2.169 · Cited by 314 · see citing works
AS160 Regulates Insulin- and Contraction-stimulated Glucose Uptake in Mouse Skeletal Muscle
Kramer, H. F., Witczak, C. A., Taylor, E. B., FUJII, N. L., Hirshman, M. F., & Goodyear, L. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605461200 · Cited by 285 · see citing works
Skeletal muscle insulin resistance: role of mitochondria and other ROS sources
Di Meo, S., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0598 · Cited by 282 · see citing works
Korkiakangas, E. E., Alahuhta, M. A., & Laitinen, J. H. (2009) · Health Promotion International · doi:10.1093/heapro/dap031 · Cited by 276 · see citing works
Acylcarnitines: potential implications for skeletal muscle insulin resistance
Aguer, C., McCoin, C. S., Knotts, T. A., Thrush, A. B., Ono‐Moore, K. D., McPherson, R., Dent, R., Hwang, D. H., Adams, S. H., & Harper, M. (2014) · The FASEB Journal · doi:10.1096/fj.14-255901 · Cited by 243 · see citing works
Muscle Oxidative Capacity Is a Better Predictor of Insulin Sensitivity than Lipid Status
Bruce, C. R., Anderson, M. J., Carey, A. L., Newman, D. G., Bonen, A., Kriketos, A. D., Cooney, G. J., & Hawley, J. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030791 · Cited by 234 · see citing works
Gibala, M. J., Gillen, J. B., & Percival, M. E. (2014) · Sports Medicine · doi:10.1007/s40279-014-0259-6 · Cited by 223 · see citing works
Pathways from obesity to diabetes
Felber, J. P., & Golay, A. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802126 · Cited by 217 · see citing works
Granata, C., Oliveira, R. S. F., Little, J. P., Renner, K., & Bishop, D. J. (2016) · The FASEB Journal · doi:10.1096/fj.15-276907 · Cited by 215 · see citing works
Self-citationSarafidis, P. A., Lasaridis, A. N., Nilsson, P. M., Pikilidou, M. I., STAFILAS, P., Kanaki, A., Kazakos, K., Yovos, J. G., & Bakris, G. L. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002201 · Cited by 197 · see citing works
Ramp Exercise Protocols for Clinical and Cardiopulmonary Exercise Testing
MYERS, J. N., & Bellin, D. A. (2000) · Sports Medicine · doi:10.2165/00007256-200030010-00003 · Cited by 192 · see citing works
Kong, Z., Fan, X., Sun, S., Song, L., Shi, Q., & Nie, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158589 · Cited by 192 · see citing works
Hansen, P. A., Nolte, L. A., Chen, M. M., & Holloszy, J. O. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.4.1218 · Cited by 189 · see citing works
Fujishiro, M., Gotoh, Y., Katagiri, H., Sakoda, H., Ogihara, T., Anai, M., Onishi, Y., Ono, H., Abe, M., Shojima, N., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0131 · Cited by 184 · see citing works
Heilbronn, L. K., Gan, S. K., Turner, N., Campbell, L. V., & Chisholm, D. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2210 · Cited by 184 · see citing works
Exercise-induced ’browning’ of adipose tissues
Aldiss, P., Betts, J., Sale, C., Pope, M., Budge, H., & Symonds, M. E. (2018) · Metabolism · doi:10.1016/j.metabol.2017.11.009 · Cited by 175 · see citing works
Zhang, L., Feng, Y., List, J. F., Kasichayanula, S., & Pfister, M. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01216.x · Cited by 170 · see citing works
High intensity interval training improves liver and adipose tissue insulin sensitivity
Marcinko, K., Sikkema, S. R., Samaan, M. C., Kemp, B. E., Fullerton, M. D., & Steinberg, G. R. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.006 · Cited by 141 · see citing works
Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
Holloway, G. P., Bonen, A., & Spriet, L. L. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717b · Cited by 140 · see citing works
Vind, B. F., Pehmøller, C., Treebak, J. T., Birk, J. B., Hey-Mogensen, M., Beck-Nielsen, H., Zierath, J. R., Wojtaszewski, J. F. P., & Højlund, K. (2011) · Diabetologia · doi:10.1007/s00125-010-1924-4 · Cited by 129 · see citing works
Antoun, G., McMurray, F., Thrush, A. B., Patten, D. A., Peixoto, A. C., Slack, R. S., McPherson, R., Dent, R., & Harper, M.-E. (2015) · Diabetologia · doi:10.1007/s00125-015-3772-8 · Cited by 112 · see citing works
Boyd, J. C., Simpson, C. A., Jung, M. E., & Gurd, B. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068091 · Cited by 99 · see citing works
Hwang, S., Jeong, Y., Li, X., Kim, Y. D., Lu, Y., Chang, Y., Lee, I., & Chang, H. W. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12124 · Cited by 91 · see citing works
Karstoft, K., Winding, K. M., Knudsen, S. H., James, N. G., Scheel, M. M., Olesen, J., Holst, J. J., Pedersen, B. K., & Solomon, T. P. J. (2014) · Diabetologia · doi:10.1007/s00125-014-3334-5 · Cited by 91 · see citing works
Hafizi Abu Bakar, M., Kian Kai, C., Wan Hassan, W. N., Sarmidi, M. R., Yaakob, H., & Zaman Huri, H. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2601 · Cited by 91 · see citing works
Schmitz‐Peiffer, C., Browne, C. L., Oakes, N. D., Watkinson, A., Chisholm, D. J., Kraegen, E. W., & Biden, T. J. (1997) · Diabetes · doi:10.2337/diabetes.46.2.169 · Cited by 89 · see citing works
Arad, A. D., DiMenna, F. J., Thomas, N., Tamis‐Holland, J. E., Weil, R. M., Geliebter, A., & Albu, J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00306.2015 · Cited by 82 · see citing works
Exercise Training and Insulin Resistance: A Current Review
Keshel, T. E. (2015) · Journal of Obesity & Weight Loss Therapy · doi:10.4172/2165-7904.s5-003 · Cited by 76 · see citing works
Zhang, Y., Uguccioni, G., Ljubicic, V., Irrcher, I., Iqbal, S., Singh, K., Ding, S., & Hood, D. A. (2014) · Physiological Reports · doi:10.14814/phy2.12008 · Cited by 68 · see citing works
Holloway, G. P., Perry, C. G. R., Thrush, A. B., Heigenhauser, G. J. F., Dyck, D. J., Bonen, A., & Spriet, L. L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00726.2007 · Cited by 48 · see citing works
Exercise reduces cellular stress related to skeletal muscle insulin resistance
de Matos, M. A., Ottone, V. D. O., Duarte, T. C., Sampaio, P. F. D. M., Costa, K. B., Fonseca, C. A., Neves, M. P. C., Schneider, S. M., Moseley, P. L., Coimbra, C. C., et al. (2013) · Cell Stress and Chaperones · doi:10.1007/s12192-013-0453-8 · Cited by 34 · see citing works
Self-citationInterval Training for Cardiometabolic Health: Why Such A HIIT?
Gibala, M. J. (2018) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000483 · Cited by 34 · see citing works
Carlson, C. J., & Rondinone, C. M. (2005) · Metabolism · doi:10.1016/j.metabol.2005.02.003 · Cited by 23 · see citing works
Alteration of insulin sensitivity by sex hormones during the menstrual cycle
Sheu, W. H. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2011.00116.x · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199 · see citing works
Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise
Fritzen, A. M., Lundsgaard, A.-M., & Kiens, B. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0405-1 · Cited by 180 · see citing works
High-Intensity Interval Training in Cardiac Rehabilitation
Dun, Y., Smith, J. R., Liu, S., & Olson, T. P. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.07.011 · Cited by 118 · see citing works
de Jesus Gomes, G., Diniz Magalhães, C. O., Queiroz, I. P., Alves de Andrade, J., Chaves Garcia, B. C., Ramalho de Souza Pereira, R., Moreira Costa, J. M., Cassilhas, R. C., Villela, D. C., Castro de Magalhães, F., et al. (2025) · European Journal of Sport Science · doi:10.1002/ejsc.12302 · Cited by 5 · see citing works
“The exercise protocols were adapted from previous research (Matos et al. 2018).”
Self-citation
- Authors
- Matos, M. A. D., Vieira, D. V., Pinhal, K. C., Lopes, J. F., Dias-Peixoto, M. F., Pauli, J. R., Castro Magalhães, F. D., Little, J. P., Rocha-Vieira, E., & Amorim, F. T.
- Affiliations
- Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of British Columbia (CA)
- University of New Mexico (US)
- Corresponding author
- Amorim, Fabiano Trigueiro
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2018-10-31
- Volume
- 9
- Pages
- 1451-1451
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC6220130
- OpenAlex
- W2899432037
- Cited by
- 75
- References
- 77
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 6 · 2023: 9 · 2022: 10 · 2021: 9 · 2020: 15 · 2019: 5
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (447007/2014-9)
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais (APQ-01915-13, APQ-03058-16)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PNPD-2455/2011)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- high-intensity interval training, obesity, insulin resistance, oxidative metabolism, skeletal muscle, insulin signaling pathway, Akt phosphorylation, ERK1/2 phosphorylation, beta-hydroxyacyl-CoA dehydrogenase, cytochrome c oxidase subunit IV, peak oxygen uptake, HOMA-IR
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
