Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling
Open accessAbstract
Inflammation in arterial walls leads to coronary artery disease (CAD). Because specialized proresolving lipid mediators (SPMs; lipoxins, resolvins, and protectins) stimulate resolution of inflammation in animal models, we tested whether n‐3 fatty acids impact SPM profiles in patients with CAD and promote clot remodeling. Six patients with stable CAD were randomly assigned to either treatment with daily 3.36 g Lovaza for 1 yr or without. Targeted lipid mediator‐metabololipidomics showed that both groups had absence of resolvin D1 (RvD1), RvD2, RvD3, RvD5 and resolvin E1—all of which are present in healthy patients. Those not taking Lovaza had an absence of aspirin‐triggered resolvin D3 (AT‐RvD3) and aspirin‐triggered lipoxin B 4 (AT‐LXB 4 ). Lovaza treatment restored AT‐RvD3 and AT‐LXB 4 and gave levels of RvD6 and aspirin‐triggered protectin D1 (AT‐PD1) twice as high (resolvin E2 ~5 fold) as well as lower prostaglandins. Principal component analysis indicated positive relationships for patients with CAD who were receiving Lovaza with increased AT‐RvD3, RvD6, AT‐PD1, and AT‐LXB4.SPMs identified in Lovaza‐treated patients with CAD enhanced ~50% at 1 nM macrophage uptake of blood clots. These results indicate that patients with CAD have lower levels and/or absence of specific SPMs that were restored with Lovaza; these SPMs promote macrophage phagocytosis of blood clots. Together, they suggest that low vascular SPMs may enable progression of chronic vascular inflammation predisposing to coronary atherosclerosis and to thrombosis.—Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., Welty, F. K. Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling. FASEB J. 30, 2792‐2801 (2016). www.fasebj.org
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aspirin-triggered pro-resolving omega-3 fatty acid derivatives can be detected in patients with diabetes and coronary artery disease treated with a mixture of DHA and EPA together with aspirin and statins.
“aspirin-triggered, pro-resolving omega-3 fatty acid derivatives can be detected in patients with diabetes and coronary artery disease who were treated with a mixture of DHA and EPA concomitantly with aspirin and statins126.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [126]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works
Self-citationn−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525 · see citing works
(1999) · PubMed · Cited by 2,062 · see citing works
Psychogios, N., Hau, D., Peng, J., Guo, A. C., Mandal, R., Bouatra, S., Sinelnikov, I. V., Krishnamurthy, R., Eisner, R., Gautam, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016957 · Cited by 1,718 · see citing works
Robbins and Cotran Pathologic Basis of Disease
Hoda, S. A., & Hoda, R. S. (2005) · Advances in Anatomic Pathology · doi:10.1097/01.pap.0000155072.86944.7d · Cited by 1,578 · see citing works
Lipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453 · see citing works
Self-citationDistribution, interconversion, and dose response of n-3 fatty acids in humans.
Arterburn, L. M., Hall, E. B., & Oken, H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1467s · Cited by 1,162 · see citing works
Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities
Tabas, I., & Glass, C. K. (2013) · Science · doi:10.1126/science.1230720 · Cited by 1,093 · see citing works
n–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia
The ORIGIN Trial Investigators (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1203859 · Cited by 929 · see citing works
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875 · see citing works
The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors: A Randomized Trial
Covas, M.-I., Nyyssönen, K., Poulsen, H. E., Kaikkonen, J., Zunft, H.-J. F., Kiesewetter, H., Gaddi, A., de la Torre, R., Mursu, J., Bäumler, H., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-5-200609050-00006 · Cited by 758 · see citing works
n–3 Fatty Acids in Cardiovascular Disease
Caterina, R. D. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1008153 · Cited by 568 · see citing works
Dalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 556 · see citing works
Self-citationInflammation and its Resolution as Determinants of Acute Coronary Syndromes
Libby, P., Tabas, I. A., Fredman, G., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302699 · Cited by 523 · see citing works
Colas, R. A., Shinohara, M., Dalli, J., Chiang, N., & Serhan, C. N. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00024.2014 · Cited by 424 · see citing works
Self-citationMerched, A. J., Ko, K., Gotlinger, K. H., Serhan, C. N., & Chan, L. (2008) · The FASEB Journal · doi:10.1096/fj.08-112201 · Cited by 414 · see citing works
Self-citationDefective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
Karp, C. L., Flick, L. M., Park, K. W., Softic, S., Greer, T. M., Keledjian, R., Yang, R., Uddin, J., Guggino, W. B., Atabani, S. F., et al. (2004) · Nature Immunology · doi:10.1038/ni1056 · Cited by 344 · see citing works
Scoditti, E., Calabriso, N., Massaro, M., Pellegrino, M., Storelli, C., Martines, G., Caterina, R. D., & Carluccio, M. A. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.05.003 · Cited by 323 · see citing works
Safety and Efficacy of Omacor in Severe Hypertriglyceridemia
Harris, W. S., Ginsberg, H. N., Arunakul, N., Shachter, N. S., Windsor, S. L., Adams, M., Berglund, L., & Osmundsen, K. (1997) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182679700400511 · Cited by 306 · see citing works
Mozaffarian, D., Lemaitre, R. N., King, I. B., Song, X., Huang, H., Sacks, F. M., Rimm, E. B., Wang, M., & Siscovick, D. S. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-7-201304020-00003 · Cited by 283 · see citing works
Mas, E., Croft, K. D., Zahra, P., Barden, A., & Mori, T. A. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.190199 · Cited by 270 · see citing works
Chiang, N., Bermudez, E. A., Ridker, P. M., Hurwitz, S., & Serhan, C. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405445101 · Cited by 266 · see citing works
Self-citationSchwingshackl, L., Christoph, M., & Hoffmann, G. (2015) · Nutrients · doi:10.3390/nu7095356 · Cited by 252 · see citing works
Safety and efficacy of Omacor in severe hypertriglyceridemia
Harris, W. S., Ginsberg, H. N., Arunakul, N., Shachter, N. S., Windsor, S. L., Adams, M., Berglund, L., & Osmundsen, K. (1997) · Journal of Cardiovascular Risk · doi:10.1097/00043798-199710000-00011 · Cited by 252 · see citing works
Diminished Lipoxin Biosynthesis in Severe Asthma
Levy, B. D., Bonnans, C., Silverman, E. S., Palmer, L. J., Marigowda, G., & Israel, E. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200410-1413oc · Cited by 250 · see citing works
Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution
Kasuga, K., Yang, R., Porter, T. F., Agrawal, N., Petasis, N. A., Irimia, D., Toner, M., & Serhan, C. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8677 · Cited by 240 · see citing works
Self-citationKain, V., Ingle, K. A., Colas, R. A., Dalli, J., Prabhu, S. D., Serhan, C. N., Joshi, M. D., & Halade, G. V. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.003 · Cited by 234 · see citing works
Self-citationDona, M., Fredman, G., Schwab, J. M., Chiang, N., Arita, M., Goodarzi, A., Cheng, G., von Andrian, U. H., & Serhan, C. N. (2008) · Blood · doi:10.1182/blood-2007-11-122598 · Cited by 228 · see citing works
Self-citationHo, K. J., Spite, M., Owens, C. D., Lancero, H., Kroemer, A. H. K., Pande, R., Creager, M. A., Serhan, C. N., & Conte, M. S. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.091082 · Cited by 204 · see citing works
Self-citationHasturk, H., Abdallah, R., Kantarci, A., Nguyen, D., Giordano, N., Hamilton, J., & Van Dyke, T. E. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.115.305324 · Cited by 199 · see citing works
Omega-3 Polyunsaturated Fatty Acids and the Treatment of Rheumatoid Arthritis: A Meta-analysis
Lee, Y. H., Bae, S., & Song, G. G. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.06.011 · Cited by 197 · see citing works
Otto, M. C. D. O., Wu, J. H. Y., Baylín, A., Vaidya, D. M., Rich, S. S., Tsai, M. Y., Jacobs, D. R., & Mozaffarian, D. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000506 · Cited by 178 · see citing works
Birnbaum, Y., Ye, Y., Lin, Y., Freeberg, S. Y., Nishi, S. P. E., Martinez, J. D., Huang, M.-H., Uretsky, B. F., & Perez-Polo, J. R. (2006) · Circulation · doi:10.1161/circulationaha.106.629907 · Cited by 173 · see citing works
Role of Basic Science in the Development of New Medicines: Examples from the Eicosanoid Field
Samuelsson, B. O. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.x112.351437 · Cited by 157 · see citing works
Impaired Phagocytosis in Localized Aggressive Periodontitis: Rescue by Resolvin E1
Fredman, G., Oh, S. F., Ayilavarapu, S., Hastürk, H., Serhan, C. N., & Dyke, T. E. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024422 · Cited by 154 · see citing works
Self-citationCasula, M., Soranna, D., Catapano, A. L., & Corrao, G. (2013) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(13)70005-9 · Cited by 152 · see citing works
Miyahara, T., Runge, S. J., Chatterjee, A., Chen, M., Mottola, G., Fitzgerald, J. M., Serhan, C. N., & Conte, M. S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225615 · Cited by 134 · see citing works
Self-citationResolvin E1 Metabolome in Local Inactivation during Inflammation-Resolution
Hong, S., Porter, T. F., Lu, Y., Oh, S. F., Pillai, P. S., & Serhan, C. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3512 · Cited by 107 · see citing works
Self-citationCleland, L. G., Caughey, G. E., James, M. J., & Proudman, S. (2006) · PubMed · Cited by 105 · see citing works
Akagi, D., Chen, M., Toy, R., Chatterjee, A., & Conte, M. (2015) · The FASEB Journal · doi:10.1096/fj.14-265363 · Cited by 104 · see citing works
Chatterjee, A., Sharma, A., Chen, M., Toy, R., Mottola, G., & Conte, M. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113480 · Cited by 90 · see citing works
Barden, A. E., Mas, E., Croft, K. D., Phillips, M. R., & Mori, T. A. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m045583 · Cited by 86 · see citing works
Amano, T., Matsubara, T., Uetani, T., Kato, M., Kato, B., Yoshida, T., Harada, K., Kumagai, S., Kunimura, A., Shinbo, Y., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.05.030 · Cited by 83 · see citing works
Yacoubian, S., & Serhan, C. N. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0616 · Cited by 80 · see citing works
Self-citationn-3 Fatty acid supplementation and proresolving mediators of inflammation
Barden, A. E., Mas, E., & Mori, T. A. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000262 · Cited by 77 · see citing works
Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS
Sasaki, A., Fukuda, H., Shiida, N., Tanaka, N. K., Furugen, A., Ogura, J., Shuto, S., Mano, N., & Yamaguchi, H. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8412-5 · Cited by 58 · see citing works
James, M. J., Proudman, S., & Cleland, L. G. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(03)00064-4 · Cited by 55 · see citing works
Assimes, T. L., Knowles, J. W., Priest, J. R., Basu, A., Borchert, A., Volcik, K. A., Grove, M. L., Tabor, H. K., Southwick, A. M., Tabibiazar, R., et al. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.09.003 · Cited by 49 · see citing works
Leeb, B. F., Sautner, J., Andel, I., & Rintelen, B. (2006) · Lipids · doi:10.1007/11745-006-5066-x · Cited by 41 · see citing works
Wittwer, J., Bayer, M., Mosandl, A., Muntwyler, J., & Hersberger, M. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.103 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
Serhan, C. N., & Levy, B. D. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97943 · Cited by 1,344 · see citing works
Self-citationInflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Serhan, C. N. (2017) · The FASEB Journal · doi:10.1096/fj.201601222r · Cited by 553 · see citing works
Self-citationFredman, G., Hellmann, J., Proto, J. D., Kuriakose, G., Colas, R. A., Dorweiler, B., Connolly, E. S., Solomon, R., Jones, D. M., Heyer, E. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms12859 · Cited by 411 · see citing works
Self-citationChiang, N., & Serhan, C. N. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.03.005 · Cited by 330 · see citing works
Self-citationMechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300 · see citing works
Resolvins suppress tumor growth and enhance cancer therapy
Sulciner, M. L., Serhan, C. N., Gilligan, M. M., Mudge, D. K., Chang, J., Gartung, A., Lehner, K. A., Bielenberg, D. R., Schmidt, B. A. R., Dalli, J., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170681 · Cited by 259 · see citing works
Self-citationDas, U. N. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.01.001 · Cited by 256 · see citing works
New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration
Serhan, C. N., Chiang, N., & Dalli, J. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.08.002 · Cited by 246 · see citing works
Self-citationSansbury, B. E., & Spite, M. R. (2016) · Circulation Research · doi:10.1161/circresaha.116.307308 · Cited by 226 · see citing works
Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis
Moore, K. J., Koplev, S., Fisher, E. A. A., Tabas, I. A., Björkegren, J., Doran, A. C., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2147 · Cited by 221 · see citing works
Inflammation and resolution in obesity
Soták, M., Clark, M., Suur, B. E., & Börgeson, E. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01047-y · Cited by 234 · see citing works
Carcinogenesis: Failure of resolution of inflammation?
Fishbein, A., Hammock, B. D., Serhan, C. N., & Panigrahy, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107670 · Cited by 207 · see citing works
Self-citationThe role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation
Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. A. (2023) · Immunological Reviews · doi:10.1111/imr.13214 · Cited by 181 · see citing works
Boosting Inflammation Resolution in Atherosclerosis
Fredman, G., & Tabas, I. A. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.01.018 · Cited by 173 · see citing works
Inflammation Resolution: Implications for Atherosclerosis
Doran, A. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319822 · Cited by 177 · see citing works
Dietary fats and cardiometabolic disease: mechanisms and effects on risk factors and outcomes
Wu, J. H. Y., Micha, R., & Mozaffarian, D. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0206-1 · Cited by 167 · see citing works
Fredman, G., & Serhan, C. N. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00984-x · Cited by 160 · see citing works
Self-citationHarwood, J. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108838 · Cited by 144 · see citing works
Gromovsky, A. D., Schugar, R. C., Brown, A. L., Helsley, R. N., Burrows, A. C., Ferguson, D., Zhang, R., Sansbury, B. E., Lee, R. G., Morton, R. E., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.309660 · Cited by 115 · see citing works
Zaloga, G. P. (2021) · Nutrients · doi:10.3390/nu13020662 · Cited by 106 · see citing works
Specialized pro-resolving mediators in cardiovascular diseases
Fredman, G., & Spite, M. R. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.02.003 · Cited by 98 · see citing works
Resolvin D4 attenuates the severity of pathological thrombosis in mice
Cherpokova, D., Jouvene, C. C., Libreros, S., DeRoo, E., Chu, L., de la Rosa, X., Norris, P. C., Wagner, D. D., & Serhan, C. N. (2019) · Blood · doi:10.1182/blood.2018886317 · Cited by 97 · see citing works
Self-citationAlfaddagh, A., Elajami, T. K., Ashfaque, H., Saleh, M. A., Bistrian, B. R., & Welty, F. K. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006981 · Cited by 95 · see citing works
Self-citationTargeting immune cell recruitment in atherosclerosis
Döring, Y., van der Vorst, E. P. C., & Weber, C. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01023-z · Cited by 90 · see citing works
Carracedo, M., Artiach, G., Arnardottir, H. H., & Bäck, M. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00767-y · Cited by 92 · see citing works
Pro-resolving lipid mediators in vascular disease
Conte, M. S., Desai, T. A., Wu, B., Schaller, M. S., & Werlin, E. C. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97947 · Cited by 81 · see citing works
Fattori, V., Zaninelli, T. H., Rasquel-Oliveira, F. S., Casagrande, R., & Verri, W. A., Jr. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104549 · Cited by 80 · see citing works
Stotts, C., Corrales‐Medina, V., & Rayner, K. J. (2023) · Circulation Research · doi:10.1161/circresaha.122.321636 · Cited by 86 · see citing works
Arnardottir, H. H., Pawelzik, S., Öhlund‐Wistbacka, U., Artiach, G., Hofmann, R., Reinholdsson, I., Braunschweig, F., Tornvall, P., Religa, D., & Bäck, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.624657 · Cited by 75 · see citing works
A cluster of immunoresolvents links coagulation to innate host defense in human blood
Norris, P. C., Libreros, S., Chiang, N., & Serhan, C. N. (2017) · Science Signaling · doi:10.1126/scisignal.aan1471 · Cited by 68 · see citing works
Self-citationOmega-3 Fatty Acids in Atherosclerosis and Coronary Artery Disease
Bäck, M. (2017) · Future Science OA · doi:10.4155/fsoa-2017-0067 · Cited by 69 · see citing works
Omega 3 Fatty Acid and Skin Diseases
Sawada, Y., Saito‐Sasaki, N., & Nakamura, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.623052 · Cited by 68 · see citing works
Regidor, P., Mueller, A., Sailer, M., Santos, F. G., Rizo, J. M., & Egea, F. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010384 · Cited by 69 · see citing works
The great obstetrical syndromes and the placenta
Hoffman, M. (2023) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17613 · Cited by 67 · see citing works
Wu, B., Mottola, G., Schaller, M. S., Upchurch, G. R., & Conte, M. S. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.07.005 · Cited by 64 · see citing works
Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial)
Ramirez, J. L., Gasper, W. J., Khetani, S. A., Zahner, G. J., Hills, N. K., Mitchell, P. T., Sansbury, B. E., Conte, M. S., Spite, M. R., & Grenon, S. M. (2019) · Journal of Surgical Research · doi:10.1016/j.jss.2019.01.038 · Cited by 62 · see citing works
Welty, F. K., Schulte, F., Alfaddagh, A., Elajami, T. K., Bistrian, B. R., & Hardt, M. (2021) · The FASEB Journal · doi:10.1096/fj.202002471r · Cited by 57 · see citing works
Self-citationAtherosclerosis, Periodontal Disease, and Treatment with Resolvins
Hamilton, J. A., Hastürk, H., Kantarcı, A., Serhan, C. N., & Dyke, T. E. V. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0696-4 · Cited by 54 · see citing works
Self-citationAspirin for the Primary Prevention of Cardiovascular Disease: Time for a Platelet-Guided Approach
Cofer, L. B., Barrett, T. J., & Berger, J. S. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318020 · Cited by 52 · see citing works
Darwesh, A. M., Sosnowski, D. K., Lee, T. Y., Keshavarz-Bahaghighat, H., & Seubert, J. M. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.04.037 · Cited by 49 · see citing works
Effects of Aspirin on Endothelial Function and Hypertension
Dzeshka, M. S., Shantsila, A., & Lip, G. Y. H. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0688-8 · Cited by 47 · see citing works
Tułowiecka, N., Kotlęga, D., Prowans, P., & Szczuko, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207628 · Cited by 45 · see citing works
Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension
del Campo, L. S. D., García‐Redondo, A. B., Rodrı́guez, C., Zaragoza, C., Duro‐Sánchez, S., Palmas, F., de Benito-Bueno, Á., Socuéllamos, P. G., Peraza, D. A., Rodrigues‐Díez, R., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19448 · Cited by 44 · see citing works
Self-citationModulation of innate immunity of patients with Alzheimer's disease by omega‐3 fatty acids
Fiala, M., Kooij, G., Wagner, K. M., Hammock, B. D., & Pellegrini, M. A. (2017) · The FASEB Journal · doi:10.1096/fj.201700065r · Cited by 44 · see citing works
Perucci, L. O., Sugimoto, M. A., Gomes, K. B., Dusse, L. M. S., Teixeira, M. M., & Sousa, L. P. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1364363 · Cited by 45 · see citing works
Kim, N., Lannan, K. L., Thatcher, T. H., Pollock, S. J., Woeller, C. F., & Phipps, R. P. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700503 · Cited by 42 · see citing works
Al‐Shaer, A. E., Buddenbaum, N., & Shaikh, S. R. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158936 · Cited by 44 · see citing works
Resolvins as proresolving inflammatory mediators in cardiovascular disease
Capó, X., Martorell, M., Busquets-Cortés, C., Tejada, S., Tur, J. A., Pons, A., & Sureda, A. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.07.018 · Cited by 42 · see citing works
Fosshaug, L. E., Colas, R. A., Anstensrud, A. K., Gregersen, I., Nymo, S. H., Sagen, E. L., Michelsen, A. E., Vinge, L. E., Øie, E., Gullestad, L. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.024 · Cited by 42 · see citing works
Self-citationPham, T. L., Kakazu, A. H., He, J., Jun, B., Bazan, N. G., & Bazán, H. E. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-61390-8 · Cited by 42 · see citing works
Roles of Resolvins in Chronic Inflammatory Response
Liu, C., Fan, D., Lei, Q., Lü, A., & He, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314883 · Cited by 41 · see citing works
Mottola, G., Chatterjee, A., Wu, B., Chen, M., & Conte, M. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174936 · Cited by 41 · see citing works
Omega‐3 fatty acids in coronary heart disease: Recent updates and future perspectives
Ajith, T. A., & Jayakumar, T. G. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13034 · Cited by 41 · see citing works
Function of Pro-Resolving Lipid Mediator Resolvin E1 in Type 2 Diabetes
Sima, C., Paster, B. J., & Dyke, T. E. V. (2018) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2018026750 · Cited by 39 · see citing works
Specialized pro-resolving lipid mediators in cardiovascular disease, diagnosis, and therapy
Kim, A. S., & Conte, M. S. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.011 · Cited by 40 · see citing works
Callan, N. G. L., Hanes, D., & Bradley, R. D. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02569-5 · Cited by 40 · see citing works
Atherothrombosis and the NLRP3 inflammasome – endogenous mechanisms of inhibition
Satish, M., & Agrawal, D. K. (2019) · Translational research · doi:10.1016/j.trsl.2019.08.003 · Cited by 37 · see citing works
Mazidimoradi, A., Alemzadeh, E., Alemzadeh, E., & Salehiniya, H. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120489 · Cited by 37 · see citing works
Dean, S. M., Wang, C., Nam, K., Maruyama, C. L., Trump, B., & Baker, O. J. (2019) · Lara D. Veeken · doi:10.1093/rheumatology/kez072 · Cited by 36 · see citing works
Bäck, M. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108439 · Cited by 34 · see citing works
Specialized pro‐resolving mediators enhance the clearance of dead cells
Fredman, G., & Khan, S. (2023) · Immunological Reviews · doi:10.1111/imr.13278 · Cited by 34 · see citing works
Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers
Pelclová, D., Ždı́mal, V., Komarc, M., Vlčková, Š., Fenclová, Z., Ondráček, J., Schwarz, J., Koštejn, M., Kačer, P., Dvorackova, S., et al. (2018) · Nanomaterials · doi:10.3390/nano8090731 · Cited by 34 · see citing works
Specialized Pro-Resolving Lipid Mediators: New Therapeutic Approaches for Vascular Remodeling
del Campo, L. S. D., Rodrigues‐Díez, R., Salaíces, M., Briones, A. M., & García‐Redondo, A. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073592 · Cited by 33 · see citing works
Regidor, P., Santos, F. G., Rizo, J. M., & Egea, F. M. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110340 · Cited by 33 · see citing works
Arnardottir, H. H., Pawelzik, S., Sarajlic, P., Quaranta, A., Kolmert, J., Religa, D., Wheelock, C. E., & Bäck, M. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.895 · Cited by 33 · see citing works
Michaeloudes, C., Christodoulides, S., Christodoulou, P., Kyriakou, T.-C., Patrikios, I. S., & Stephanou, A. (2023) · Nutrients · doi:10.3390/nu15224830 · Cited by 32 · see citing works
Pro-Resolving Ligands Orchestrate Phagocytosis
Decker, C., Sadhu, S., & Fredman, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660865 · Cited by 30 · see citing works
Classes of Lipid Mediators and Their Effects on Vascular Inflammation in Atherosclerosis
Lubrano, V., Ndreu, R., & Balzan, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021637 · Cited by 30 · see citing works
Balta, M. G., Papathanasiou, E., & CHRISTOPOULOS, P. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632238 · Cited by 28 · see citing works
Kraft, J. D., Blomgran, R., Bergström, I., Soták, M., Clark, M., Rani, A., Rajan, M. R., Dalli, J., Nyström, S., Quiding‐Järbrink, M., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101219rr · Cited by 29 · see citing works
Self-citationRapid Metabolization of Protectin D1 by β-Oxidation of Its Polar Head Chain
Balas, L., Risé, P., Dayaker, G., Rovati, G. E., Bolego, C., Stellari, F. F., Trenti, A., Buccellati, C., Durand, T., & Sala, A. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01463 · Cited by 27 · see citing works
Dietary Control of Inflammation and Resolution
Sears, B., & Saha, A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.709435 · Cited by 22 · see citing works
Specialized pro-resolving mediators in diabetes: novel therapeutic strategies
Brennan, E. P., Mohan, M., Andrews, D. C., Bose, M., & Kantharidis, P. (2019) · Clinical Science · doi:10.1042/cs20190067 · Cited by 27 · see citing works
Specialized Proresolving Lipid Mediators: A Potential Therapeutic Target for Atherosclerosis
Salazar, J. J., Pírela, D., Nava, M., Castro, A. V., Angarita, L., Parra, H., Durán‐Agüero, S., Rojas-Gómez, D. M., Galbán, N., Áñez, R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063133 · Cited by 26 · see citing works
Aspirin modulates production of pro-inflammatory and pro-resolving mediators in endothelial cells
Rood, K. M., Patel, N., DeVengencie, I., Quinn, J. P., Gowdy, K. M., Costantine, M. M., & Kniss, D. A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283163 · Cited by 25 · see citing works
The role of Resolvin D1 in liver diseases
Yang, M., Song, X.-Q., Han, M., & Liu, H. (2022) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2022.106634 · Cited by 24 · see citing works
Teopompi, E., Risé, P., Pisi, R., Buccellati, C., Aiello, M., Pisi, G., Tripodi, M. C., Fainardi, V., Clini, E. M., Chetta, A. A., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00938 · Cited by 24 · see citing works
Can Inflammation-Resolution Provide Clues to Treat Patients According to Their Plaque Phenotype?
Fredman, G. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00205 · Cited by 22 · see citing works
Halade, G. V., & Tourki, B. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21735-8_6 · Cited by 21 · see citing works
Can Specialized Pro-resolving Mediators Deliver Benefit Originally Expected from Fish Oil?
Rosenthal, M. D., Patel, J. J., Staton, K. M., Martindale, R. G., Moore, F. A., & Upchurch, G. R. (2018) · Current Gastroenterology Reports · doi:10.1007/s11894-018-0647-4 · Cited by 20 · see citing works
Karayiğit, O., Nurkoç, S. G., Başyiğit, F., & Kızıltunç, E. (2022) · Medical Principles and Practice · doi:10.1159/000527064 · Cited by 19 · see citing works
Duchez, A., Fauteux‐Daniel, S., Sut, C., Ebermeyer, T., Heestermans, M., Arthaud, C., Eyraud, M., Prier, A., Audoux, E., Bertrand‐Michel, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1031968 · Cited by 18 · see citing works
Ruhanen, H., Haridas, P. A. N., Jauhiainen, M., & Olkkonen, V. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158791 · Cited by 18 · see citing works
Bartolo, A. D., Romeo, N., Angelone, T., & Rocca, C. (2025) · Acta Physiologica · doi:10.1111/apha.70062 · Cited by 16 · see citing works
Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication
Li, C., Wang, Z., Yang, Y., Jiang, Q., Jiang, Y., Xiao, J., Shen, L., Wu, W., & Li, C. (2026) · Molecular Biomedicine · doi:10.1186/s43556-025-00400-5 · Cited by 19 · see citing works
Ruhanen, H., Haridas, P. A. N., Minicocci, I., Taskinen, J., Palmas, F., Costanzo, A. D., D’Erasmo, L., Metso, J., Partanen, J., Dalli, J., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158679 · Cited by 16 · see citing works
Self-citationDooley, M., Saliani, A., & Dalli, J. (2024) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.4c00211 · Cited by 15 · see citing works
Self-citationSatish, M., & Agrawal, D. K. (2018) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2019.1563483 · Cited by 15 · see citing works
Livshits, G., & Kalinkovich, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105340 · Cited by 15 · see citing works
DHA, RvD1, RvD5, and MaR1 reduce human coronary arteries contractions induced by PGE2
Bouhadoun, A., Manikpurage, H. D., Deschildre, C., Zalghout, S., Dubourdeau, M., Urbach, V., Ho‐Tin‐Noé, B., Deschamps, L., Michel, J., Longrois, D., et al. (2022) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2022.106700 · Cited by 13 · see citing works
Lipoxins and their relationship with inflammation-associated diseases. A systematic review
Serna-Orozco, M. F., Mosquera, M., & García‐Perdomo, H. A. (2023) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2023.06.001 · Cited by 13 · see citing works
Mottola, G., Werlin, E. C., Wu, B., Chen, M., Chatterjee, A., Schaller, M. S., & Conte, M. S. (2019) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2019.106401 · Cited by 13 · see citing works
Han, X., Xu, S., Li, L., Wu, Y., Mai, S.-Y., Xie, Y., Tan, Y., Li, A., Xue, F., He, X., et al. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00685-6 · Cited by 12 · see citing works
Dietary Technologies to Optimize Healing from Injury-Induced Inflammation
Sears, B., Perry, M., & Saha, A. K. (2020) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523019666200512114210 · Cited by 12 · see citing works
COVID-19 and cancer: start the resolution!
Barksdale, C., Kipper, F. C., Tripathy, S., Subbian, S., Serhan, C. N., & Panigrahy, D. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10017-z · Cited by 13 · see citing works
Self-citationOffman, E. M., Davidson, M. H., Abu-Rashid, M., Chai, P., & Nilsson, C. A. M. (2017) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-016-0398-2 · Cited by 12 · see citing works
Aznar, A. G., Egea, F. M., Banzo, R. G., Gutiérrez, R., Rizo, J. M., Ledo, P. R., Nerín, I., & Regidor, P. (2024) · Biomedicines · doi:10.3390/biomedicines12102221 · Cited by 10 · see citing works
Cheng, W., Zhang, J., Peng, S., Liu, J., Xu, Y. Q., Zhao, M., Xu, S., Pan, W. D., Yin, Z., Zheng, Z., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003610 · Cited by 10 · see citing works
- Authors
- Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., & Welty, F. K.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Welty, Francine K.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2016-04-27
- Volume
- 30
- Issue
- 8
- Pages
- 2792-2801
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- PMC
- PMC4970606
- OpenAlex
- W2344216384
- Cited by
- 143
- References
- 51
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 11 · 2023: 17 · 2022: 23 · 2021: 10 · 2020: 15 · 2019: 19 · 2018: 13 · 2017: 17 · 2016: 5
- FWCI
- 18.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The FASEB Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P01GM095467, RO1GM03865, P50HL083813)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- coronary artery disease, omega-3 fatty acids, lipoxin B4, protectin D1, vascular inflammation, thrombosis, atherosclerosis
- MeSH terms
- Aged, Aspirin, Coronary Disease, Docosahexaenoic Acids, Drug Combinations, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Platelet Aggregation Inhibitors, Eicosapentaenoic Acid, Biomarkers, Fatty Acids, Omega-3, Lipoxins, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review