Cited by 144Fatty Acid Research and HealthEicosanoids and Hypertension PharmacologyAtherosclerosis and Cardiovascular Diseases

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

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Elajami, Tarec K., Colas, Romain A., Dalli, Jesmond, Chiang, Nan, Serhan, Charles N., Welty, Francine K.·2016·The FASEB Journal

Abstract

Inflammation in arterial walls leads to coronary artery disease (CAD). Because specialized proresolving lipid mediators (SPMs; lipoxins, resolvins, and protectins) stimulate resolution of inflammation in animal models, we tested whether n‐3 fatty acids impact SPM profiles in patients with CAD and promote clot remodeling. Six patients with stable CAD were randomly assigned to either treatment with daily 3.36 g Lovaza for 1 yr or without. Targeted lipid mediator‐metabololipidomics showed that both groups had absence of resolvin D1 (RvD1), RvD2, RvD3, RvD5 and resolvin E1—all of which are present in healthy patients. Those not taking Lovaza had an absence of aspirin‐triggered resolvin D3 (AT‐RvD3) and aspirin‐triggered lipoxin B 4 (AT‐LXB 4 ). Lovaza treatment restored AT‐RvD3 and AT‐LXB 4 and gave levels of RvD6 and aspirin‐triggered protectin D1 (AT‐PD1) twice as high (resolvin E2 ~5 fold) as well as lower prostaglandins. Principal component analysis indicated positive relationships for patients with CAD who were receiving Lovaza with increased AT‐RvD3, RvD6, AT‐PD1, and AT‐LXB4.SPMs identified in Lovaza‐treated patients with CAD enhanced ~50% at 1 nM macrophage uptake of blood clots. These results indicate that patients with CAD have lower levels and/or absence of specific SPMs that were restored with Lovaza; these SPMs promote macrophage phagocytosis of blood clots. Together, they suggest that low vascular SPMs may enable progression of chronic vascular inflammation predisposing to coronary atherosclerosis and to thrombosis.—Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., Welty, F. K. Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling. FASEB J. 30, 2792‐2801 (2016). www.fasebj.org

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  • Aspirin-triggered pro-resolving omega-3 fatty acid derivatives can be detected in patients with diabetes and coronary artery disease treated with a mixture of DHA and EPA together with aspirin and statins.

    “aspirin-triggered, pro-resolving omega-3 fatty acid derivatives can be detected in patients with diabetes and coronary artery disease who were treated with a mixture of DHA and EPA concomitantly with aspirin and statins126.”

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Authors
Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., & Welty, F. K.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Welty, Francine K.
Venue
The FASEB Journal
Publisher
Wiley
Published
2016-04-27
Volume
30
Issue
8
Pages
2792-2801
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
OpenAlex
W2344216384
Cited by
143
References
51
Citations by year
2026: 8 · 2025: 5 · 2024: 11 · 2023: 17 · 2022: 23 · 2021: 10 · 2020: 15 · 2019: 19 · 2018: 13 · 2017: 17 · 2016: 5
FWCI
18.84
Type
journal article
Language
en
Open access
Locations
  • The FASEB Journal (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (P01GM095467, RO1GM03865, P50HL083813)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
coronary artery disease, omega-3 fatty acids, lipoxin B4, protectin D1, vascular inflammation, thrombosis, atherosclerosis
MeSH terms
Aged, Aspirin, Coronary Disease, Docosahexaenoic Acids, Drug Combinations, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Platelet Aggregation Inhibitors, Eicosapentaenoic Acid, Biomarkers, Fatty Acids, Omega-3, Lipoxins, Lipid Metabolism

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