Enhanced resting activity of the oral somatosensory cortex in obese subjects
Abstract
The cerebral mechanisms underlying excess food intake in obese subjects are poorly understood. We used PET and 2-deoxy-2[18F]fluoro-D-glucose to assess differences in regional brain metabolism between obese and lean subjects at rest. Brain metabolic images were analyzed using statistical parameter maps. We found that obese subjects have significantly higher metabolic activity in the bilateral parietal somatosensory cortex in the regions where sensation to the mouth, lips and tongue are located. The enhanced activity in somatosensory regions involved with sensory processing of food in the obese subjects could make them more sensitive to the rewarding properties of food related to palatability and could be one of the variables contributing to their excess food consumption.
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When compared with lean subjects, obese subjects had higher baseline metabolism in the somatosensory areas where the mouth, lips and tongue are represented and which are involved with processing food palatability.
“When compared with lean subjects, obese subjects had higher baseline metabolism in the somatosensory areas where the mouth, lips and tongue are represented and which are involved with processing food palatability.”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Wang et al 2002
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- Authors
- Wang, G.-J., Volkow, N. D., Felder, C., Fowler, J. S., Levy, A. V., Pappas, N. R., Wong, C. T., Zhu, W., & Netusil, N.
- Affiliations
- Brookhaven National Laboratory (US)
- Venue
- Neuroreport
- Published
- 2002-07
- Volume
- 13
- Issue
- 9
- Pages
- 1151-1155
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2068776288
- Cited by
- 121
- References
- 23
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 4 · 2015: 2 · 2014: 8 · 2013: 6 · 2012: 13
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA 06 891-02, R01DA006891)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- obesity, dietary intake, food reward, palatability, parietal cortex, regional cerebral glucose metabolism
- MeSH terms
- Adult, Afferent Pathways, Feeding and Eating Disorders, Appetite Regulation, Brain Mapping, Energy Metabolism, Female, Glucose, Humans, Functional Laterality, Male, Middle Aged, Mouth, Obesity, Morbid, Somatosensory Cortex, Tomography, Emission-Computed, Up-Regulation, Body Mass Index, Fluorodeoxyglucose F18
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