Cited by 236Eating Disorders and BehaviorsNeurotransmitter Receptor Influence on BehaviorRegulation of Appetite and Obesity

Brain dopamine is associated with eating behaviors in humans

Volkow, Nora D., Wang, Gene‐Jack, Maynard, Laurence, Jayne, Millard, Fowler, Joanna S., Zhu, Wei, Logan, Jean, Gatley, S. John +3 more·2003·International Journal of Eating Disorders

Abstract

OBJECTIVE: Eating behavior in humans is influenced by variables other than just hunger-satiety including cognitive restraint, emotional distress, and sensitivity to food stimuli. We investigate the role of dopamine (DA), a neurotransmitter involved with food motivation, in these variables. METHODS: We used the Dutch Eating Behavior Questionnaire (DEBQ) to measure Restraint, Emotionality, and Externality in 10 subjects. We correlated DEBQ scores with brain DA levels. Positron emission tomography and [(11)C]raclopride uptake were used to measure baseline D(2) receptors (neutral stimulation) and to assess changes in extracellular DA to food stimulation (display of food). RESULTS: Restraint was correlated with DA changes with food stimulation (higher restraint, greater responsivity), emotionality was negatively correlated with baseline D(2) receptors (higher emotionality, lower D(2) receptors), whereas externality was not. These correlations were significant in the dorsal but not in the ventral striatum. DISCUSSION: These results provide evidence that DA in the dorsal striatum is involved with the restraint and emotionality components regulating eating behavior and that these two dimensions reflect different neurobiologic processes.

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Crossref · 10.1002/eat.10118

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  • D2 receptor availability in the striatum of healthy controls modulates eating behavior, with low D2 binding correlating with a greater tendency to eat when exposed to stress.

    “This group has also previously reported that D2 receptor availability in the striatum of healthy controls modulates eating behavior, where low D2 receptor binding correlated with a greater tendency to eat when exposed to stress (Volkow et al., 2003).”

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Authors
Volkow, N. D., Wang, G., Maynard, L., Jayne, M., Fowler, J. S., Zhu, W., Logan, J., Gatley, S. J., Ding, Y., Wong, C., & Pappas, N.
Affiliations
  • Brookhaven National Laboratory (US)
  • Stony Brook University (US)
Corresponding author
Volkow, Nora D.
Venue
International Journal of Eating Disorders
Publisher
Wiley
Published
2003-02-25
Volume
33
Issue
2
Pages
136-142
ISSN
  • 0276-3478 (ISSN-L)
  • 1098-108X
OpenAlex
W1987913422
Cited by
235
References
33
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 3 · 2017: 9 · 2016: 11 · 2015: 16 · 2014: 16 · 2013: 10 · 2012: 19
FWCI
11.39
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Eating Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01da009490-08)
  • National Institute on Drug Abuse (DA 09490-01, DA-06278, R01DA006278)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
dopamine, dietary habits, food motivation, cognitive restraint, emotionality, dopamine D2 receptor, dorsal striatum, ventral striatum, food stimulation
MeSH terms
Adult, Cerebellum, Corpus Striatum, Dopamine, Feeding Behavior, Female, Humans, Male, Surveys and Questionnaires, Tomography, Emission-Computed, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride

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