Attention-Deficit Hyperactivity Disorder: Magnetic Resonance Imaging Morphometric Analysis of the Corpus Callosum
Abstract
Objective The following study seeks to document possible differences in corpus callosal area and shape between children with attention-deficit hyperactivity disorder (ADHD) and controls. Methods Fifteen carefully diagnosed right-handed male subjects with ADHD with overactivity symptomatology were compared to 15 right-handed male control subjects. The corpus callosum was divided into seven areas on the midsagittal slice of a magnetic resonance image with shape analysis also conducted. Results An exploratory shape analysis showed no significant differences in shape between the groups. No group differences were found in the area, length, or anterior regions of the corpus callosum. The ADHD subjects were found to have significantly smaller posterior corpus callosum regions than the control group, with the splenium accounting for most of the variance between the groups. Conclusions The splenial area of the corpus callosum is smaller in children with ADHD than in a sample of normally developing children. These smaller areas may relate to commonly seen sustained attention deficits which in turn negatively impact on the development of more advanced levels of attention such as self-regulation. Further study of the regions surrounding the splenial area is suggested to determine whether they are correlated in size to the smaller corpus callosum.
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MPH is the most commonly prescribed medication to treat ADHD.
“MPH is the most commonly prescribed medication to treat ADHD [134, 135].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [135]
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BackgroundCorpus callosum in adolescent offspring exposed prenatally to maternal cigarette smoking
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- Authors
- SEMRUD-CLIKEMAN, M., FILIPEK, P. A., BIEDERMAN, J., STEINGARD, R., KENNEDY, D., RENSHAW, P., & BEKKEN, K.
- Affiliations
- Harvard University (US)
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 33
- Issue
- 6
- Pages
- 875-881
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W1970583855
- Cited by
- 261
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 3 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 6 · 2013: 2 · 2012: 3
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-14275, T32MH014275)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, corpus callosum, splenium, corpus callosum morphology, corpus callosum area, sustained attention, children, overactivity, structural brain differences
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Corpus Callosum, Desipramine, Humans, Magnetic Resonance Imaging, Male, Methylphenidate, Psychiatric Status Rating Scales, Radiography
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