The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: a combined morphometric and diffusion tensor MRI study
Abstract
The corpus callosum (CC) is one of focused target areas which may play an important role in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Conventional structural magnetic resonance imaging (MRI) studies have revealed the macrostructural abnormalities of CC and its subdivisions in ADHD compared with controls. However, no study has examined the macrostructural and microstructural characteristics of the CC in the same ADHD group. In this study, MRI morphometric and diffusion tensor imaging (DTI) techniques were combined to explore the area and measure fractional anisotropy (FA) abnormality of CC and its seven subdivisions in children with ADHD. Twenty-eight boys with ADHD (13.3+/-1.5 years) and 27 age- and gender- matched controls (13.2+/-0.9 years) were included. We co-registered individual structural MRI and DTI images manually and subdivided the midsagittal CC into seven subdivisions. The area and FA of the CC and its subdivisions were then compared between the patients and the matched controls. Results showed that ADHD had decreased area of entire CC, anterior middle-body, and isthmus. Meanwhile, reduced FA value of the isthmus was found in the ADHD group compared with the controls. Our study indicated that not only macrostructural abnormalities but also microstructural alterations in CC, especially in isthmus occurred in ADHD. The abnormality of the isthmus, the subdivision that contains the fibers connecting posterior regions of brain, may play an important role in the pathophysiology of ADHD and may be implicated in the disorders of attention.
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The reduced FA and MD in the corpus callosum corroborate previous findings in children and adults with ADHD.
“Reduced FA and MD were found in the corpus callosum, which corroborates previous findings in children [48, 49] and adults with ADHD [50, 51].”
From The brain anatomy of attention-deficit/hyperactivity disorder in young adults—a magnetic resonance imaging study (2017) · cites this paper as [48]
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- Authors
- Cao, Q., Sun, L., Gong, G., Lv, Y., Cao, X., Shuai, L., Zhu, C., Zang, Y., & Wang, Y.
- Affiliations
- Peking University (CN)
- Montreal Neurological Institute and Hospital (CA)
- Beijing Normal University (CN)
- Corresponding author
- Wang, Yufeng
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 1310
- Pages
- 172-180
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1994190062
- Cited by
- 98
- References
- 62
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 10 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 9 · 2012: 13
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Sciences Foundation of China (30770774)
- Commonweal Sciences Foundation, Ministry of Health, China (200802073)
- National Foundation, Ministry of Science and Technology, China (2007BAI17B03)
- NSFC (30621130074)
- 863 program (2008AA02Z405)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, corpus callosum, fractional anisotropy, white matter microstructure, corpus callosum area, children, ADHD pathophysiology, diffusion tensor imaging, morphometrics
- MeSH terms
- Adolescent, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Corpus Callosum, Humans, Anisotropy, Statistics, Nonparametric, Diffusion Magnetic Resonance Imaging
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