Cited by 98Attention Deficit Hyperactivity DisorderAdvanced Neuroimaging Techniques and ApplicationsAutism Spectrum Disorder Research

The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: a combined morphometric and diffusion tensor MRI study

Cao, Qingjiu, Sun, Li, Gong, Gaolang, Lv, Yating, Cao, Xiaohua, Shuai, Lan, Zhu, Chaozhe, Zang, Yufeng +1 more·2010·Brain Research

Abstract

The corpus callosum (CC) is one of focused target areas which may play an important role in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Conventional structural magnetic resonance imaging (MRI) studies have revealed the macrostructural abnormalities of CC and its subdivisions in ADHD compared with controls. However, no study has examined the macrostructural and microstructural characteristics of the CC in the same ADHD group. In this study, MRI morphometric and diffusion tensor imaging (DTI) techniques were combined to explore the area and measure fractional anisotropy (FA) abnormality of CC and its seven subdivisions in children with ADHD. Twenty-eight boys with ADHD (13.3+/-1.5 years) and 27 age- and gender- matched controls (13.2+/-0.9 years) were included. We co-registered individual structural MRI and DTI images manually and subdivided the midsagittal CC into seven subdivisions. The area and FA of the CC and its subdivisions were then compared between the patients and the matched controls. Results showed that ADHD had decreased area of entire CC, anterior middle-body, and isthmus. Meanwhile, reduced FA value of the isthmus was found in the ADHD group compared with the controls. Our study indicated that not only macrostructural abnormalities but also microstructural alterations in CC, especially in isthmus occurred in ADHD. The abnormality of the isthmus, the subdivision that contains the fibers connecting posterior regions of brain, may play an important role in the pathophysiology of ADHD and may be implicated in the disorders of attention.

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2009.10.031

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

3 of the 62 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Cao, Q., Sun, L., Gong, G., Lv, Y., Cao, X., Shuai, L., Zhu, C., Zang, Y., & Wang, Y.
Affiliations
  • Peking University (CN)
  • Montreal Neurological Institute and Hospital (CA)
  • Beijing Normal University (CN)
Corresponding author
Wang, Yufeng
Venue
Brain Research
Publisher
Elsevier BV
Published
2010-01
Volume
1310
Pages
172-180
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1994190062
Cited by
98
References
62
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 10 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 9 · 2012: 13
FWCI
5.12
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Sciences Foundation of China (30770774)
  • Commonweal Sciences Foundation, Ministry of Health, China (200802073)
  • National Foundation, Ministry of Science and Technology, China (2007BAI17B03)
  • NSFC (30621130074)
  • 863 program (2008AA02Z405)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
attention deficit hyperactivity disorder, corpus callosum, fractional anisotropy, white matter microstructure, corpus callosum area, children, ADHD pathophysiology, diffusion tensor imaging, morphometrics
MeSH terms
Adolescent, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Corpus Callosum, Humans, Anisotropy, Statistics, Nonparametric, Diffusion Magnetic Resonance Imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review