The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Brain rhythm attractor breakdown in Alzheimer’s disease: Functional and pathologic implications
Open accessAbstract
This perspective binds emerging evidence on the bidirectional relationship between Alzheimer's disease (AD) and sleep disorders through a model of brain rhythm attractor breakdown. This approach explains behavioral‐cognitive changes in AD across the sleep‐wake cycle and supports a causal association between early brainstem tau pathology and subsequent cortical amyloid β accumulation. Specifically, early tau dysregulation within brainstem‐hypothalamic nuclei leads to breakdown of sleep‐wake attractor networks, with patients displaying an attenuated range of behavioral and electrophysiological activity patterns, a “twilight zone” of constant activity between deep rest and full alertness. This constant cortical activity promotes activity‐dependent amyloid β accumulation in brain areas that modulate their activity across sleep‐wake states, especially the medial prefrontal cortex. In addition, the accompanying breakdown of hippocampal–medial prefrontal cortex interplay across sleep stages could explain deficient memory consolidation through dysregulation of synaptic plasticity. Clinical implications include the potential therapeutic benefit of attractor consolidation (e.g., slow‐wave sleep enhancers) in delaying AD progression.
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The findings are in keeping with the therapeutic concept of consolidating brain rhythms of sleep and wakefulness toward delaying neurodegeneration and optimizing synaptic plasticity.
“The findings are also in keeping with the therapeutic concept of consolidating brain rhythms of sleep and wakefulness toward delaying neurodegeneration and optimizing synaptic plasticity [16]”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [16]
SWS enhancement shows promise towards neuroprotection.
“which in turn shows promise towards neuroprotection [16]”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [16]
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Cites
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Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers
La, A. L., Walsh, C. M., Neylan, T. C., Vossel, K. A., Yaffe, K., Krystal, A. D., Miller, B. L., & Karageorgiou, E. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181145 · Cited by 83
Self-citation
Metadata
- Authors
- Karageorgiou, E., & Vossel, K. A.
- Affiliations
- University of California, San Francisco (US)
- Gladstone Institutes (US)
- Corresponding author
- Karageorgiou, Elissaios
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2017-03-13
- Volume
- 13
- Issue
- 9
- Pages
- 1054-1067
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC5585024
- OpenAlex
- W2594957835
- Cited by
- 21
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 3 · 2017: 4
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (K23 AG038357)
- Alzheimer's Association (PCTRB‐13‐288476)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, sleep disorders
- MeSH terms
- Alzheimer Disease, Brain, Circadian Rhythm, Humans, Sleep Wake Disorders, Amyloid beta-Peptides, Neurofibrillary Tangles
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