The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Autistic disorder and gastrointestinal disease
Abstract
Autistic disorder is a pervasive developmental disorder manifested in the first 3 years of life by dysfunction in social interaction and communication. Many efforts have been made to explore the biologic basis of this disorder, but the etiology remains unknown. Recent publications describing upper gastrointestinal abnormalities and ileocolitis have focused attention on gastrointestinal function and morphology in these children. High prevalence of histologic abnormalities in the esophagus, stomach, small intestine and colon, and dysfunction of liver conjugation capacity and intestinal permeability were reported. Three surveys conducted in the United States described high prevalence of gastrointestinal symptoms in children with autistic disorder. Treatment of the digestive problems may have positive effects on their behavior.
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Children with ASD are very selective eaters and most show aversions to specific food colors, textures, smells, or other food characteristics.
“Indeed, children with ASD are very selective eaters (“picky eaters”) and most of them show aversions to specific food colors, texture, smells or other foods’ characteristics [26,27].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [26]
Unexplained irritable behavior was found in 43% of ASD children with esophagitis.
“For example, unexplained irritable behavior was found in 43% of ASD children with esophagitis 38”
From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [38]
Citations
Cites
2 retracted
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RetractedEnterocolitis in children with developmental disorders
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RetractedPrevalence of Autism in a United States Population: The Brick Township, New Jersey, Investigation
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The sleep patterns of infants and young children with gastro‐oesophageal reflux
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Sleep‐wake rhythm of autistic children
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Flagged first, then by citations
Research works printed but not linked: 7
- Horvath, 1998, J Assoc Acad Minor Phys, 9, 9
- Melmed, 2000, J Pediatr Gastroenterol Nutr, 31, S31
- Lightdale, 2000, J Pediatr Gastroenterol Nutr, 31, s31
- Horvath, 2000, J Pediatr Gastroenterol Nutr, 31, S174
- Lenzen, 1992, Am J Physiol, 263, G527
- Horvath, 2000, J Pediatr Gastroenterol Nutr, 31, S30
- O'Reilly, 1993, Journal of Orthomolecular Medicine, 4, 198
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Metadata
- Authors
- Horvath, K., & Perman, J. A.
- Affiliations
- University of Maryland, Baltimore (US)
- Venue
- Current Opinion in Pediatrics
- Published
- 2002-10
- Volume
- 14
- Issue
- 5
- Pages
- 583-587
- ISSN
- 1040-8703 (ISSN-L)
- OpenAlex
- W1980247570
- Cited by
- 224
- References
- 21
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 13 · 2022: 7 · 2021: 7 · 2020: 17 · 2019: 13 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 15 · 2012: 17
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- autistic disorder, gastrointestinal symptoms, pervasive developmental disorders, ileocolitis, intestinal permeability, gastrointestinal dysfunction
- MeSH terms
- Age Factors, Autistic Disorder, Child, Child, Preschool, Gastrointestinal Diseases, Humans
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