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Cited by 56Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMaternal Mental Health During Pregnancy and Postpartum

Mood and Neuropsychological Changes in Women With Midlife Depression Treated With Escitalopram

Wroolie, Tonita E., Williams, Katherine E., Keller, Jennifer, Zappert, Laurel N., Shelton, Stephanie D., Kenna, Heather A., Reynolds, Margaret F., Rasgon, Natalie L.·2006·Journal of Clinical Psychopharmacology
DOI 10.1097/01.jcp.0000227699.26375.f8
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Abstract

OBJECTIVE: This study assessed mood and neuropsychological function in a population of middle-aged women with major depressive disorder treated with escitalopram. METHODS: Psychometric data measuring severity of depression were collected from 19 women and neuropsychological data were collected from 17 women aged between 45 and 65 years with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of major depression in a study in the Behavioral Neuroendocrinology Program at the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine. All women were treated with escitalopram in an open-label design. Mean age was 55.94 years and mean number of years of education was 16.36 years. Diagnosis of major depressive disorder was assessed with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and mood was evaluated with the 21-item Hamilton Depression Rating Scale (HAM-D) at baseline and at weekly follow-ups for 12 weeks. Cognition was assessed at baseline and 3 months after treatment using a neuropsychological test battery, which included an abbreviated measure of Full Scale Intelligence Quotient, measures of attention and processing speed, verbal and nonverbal memory, executive functioning, and verbal fluency. Self-report data were collected on current menopause status and current hormone therapy use in the postmenopausal women. Paired sample t tests were used to analyze the change in total HAM-D scores and neuropsychological variables. RESULTS: Statistically significant improvements were found in total HAM-D score, Wechsler Memory Scale III Logical Memory 1st Recall, I, and II scores, Wechsler Memory Scale III Visual Reproduction I scores, and Trail Making Test Part B scores. There was a statistically significant decrease in Controlled Oral Word Association Test FAS scores. CONCLUSIONS: Treatment of depression with escitalopram in a population of middle-aged women was shown to improve mood and cognitive efficiency in complex attention, short- and long-term recall of contextual information, short-term recall of visual information, and cognitive flexibility; however, it was shown to worsen phonemic fluency.

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Crossref · 10.1097/01.jcp.0000227699.26375.f8

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  • The Controlled Oral Word Association Test (COWAT) has been classified as a test of phonemic verbal fluency, which falls within language function, and has also been deemed a measure of processing speed or executive function.

    “the Controlled Oral Word Association Test (COWAT) has been classified as a test of phonemic verbal fluency, which falls within the cognitive domain of language function,31 but it has also been deemed a measure of processing speed or executive function.57”

    From Cognitive Effects of Pharmacotherapy for Major Depressive Disorder: A Systematic Review (2014) · cites this paper as [31]

  • Selective serotonin reuptake inhibitor treatment led to a significant improvement in memory performance in individuals with major depressive disorder.

    “For example, it was reported that SSRI treatment led to a significant improvement in memory performance (i.e. immediate and delayed verbal, immediate visual, and declarative memory) in individuals with MDD [59, 60].”

    From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [60]

  • Significant impairment of executive functioning (i.e. phonemic fluency) has been reported following treatment with selective serotonin reuptake inhibitors.

    “Significant impairment of executive functioning (i.e. phonemic fluency) has also been reported following treatment with SSRIs [60].”

    From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [60]

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Authors
Wroolie, T. E., Williams, K. E., Keller, J., Zappert, L. N., Shelton, S. D., Kenna, H. A., Reynolds, M. F., & Rasgon, N. L.
Affiliations
Stanford Medicine (US)
Corresponding author
Rasgon, Natalie L.
ORCID
Venue
Journal of Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-08
Volume
26
Issue
4
Pages
361-366
ISSN
0271-0749 (ISSN-L)
DOI
10.1097/01.jcp.0000227699.26375.f8
OpenAlex
W1975658612
Cited by
56
References
41
Citations by year
2025: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 7 · 2012: 1
FWCI
2.30
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
School of Medicine, Stanford University
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
escitalopram, major depressive disorder, middle-aged women, mood, neuropsychological performance, cognitive flexibility, memory retrieval, attention, phonemic fluency, menopause, hormone therapy, selective serotonin reuptake inhibitors
MeSH terms
Cognition Disorders, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Menopause, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Time Factors, Reproducibility of Results, Citalopram, Treatment Outcome, Antidepressive Agents, Second-Generation, Mood Disorders, Diagnostic and Statistical Manual of Mental Disorders

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