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Cited by 364Inflammatory Bowel DiseaseProbiotics and Fermented FoodsGut microbiota and health

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohnʼs Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials

Shen, Jun, Zuo, Zhi-Xiang, Mao, Ai-Ping·2014·Inflammatory Bowel Diseases
DOI 10.1097/01.mib.0000437495.30052.be
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Abstract

BACKGROUND: Whether probiotics are beneficial at all stages of treatment in inflammatory bowel disease or superior to placebo remains controversial. METHODS: Two reviewers independently selected randomized controlled trials comparing probiotics with controls in inflammatory bowel disease and extracted data related to remission/response rates, relapse rates, and adverse events. Subanalyses were also performed. RESULTS: Twenty-three randomized controlled trials with a total of 1763 participants met the inclusion criteria. From the meta-analysis, probiotics significantly increase the remission rates in patients with active ulcerative colitis (UC) (P = 0.01, risk ratio [RR] = 1.51). The remission rates were significantly higher in patients with active UC treated with probiotics than placebo (P < 0.0001, RR = 1.80). Unfortunately, subgroup analysis found that only VSL#3 significantly increased the remission rates compared with controls in patients with active UC (P = 0.004, RR = 1.74). Interestingly, VSL#3 (P < 0.00001, RR = 0.18) also significantly reduced the clinical relapse rates for maintaining remission in patients with pouchitis. No significantly different adverse events were detected between probiotics and controls in the treatment of UC (P = 0.94, RR = 0.99) or CD (P = 0.33, RR = 0.87). CONCLUSIONS: Administration of probiotics results in additional benefit in inducing remission of patients with UC. VSL#3 are beneficial for maintaining remission in patients with pouchitis. And, probiotics can provide the similar effect as 5-aminosalicylic acid on maintaining remission of UC, although no additional adverse events presented.

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Crossref · 10.1097/01.mib.0000437495.30052.be

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Research works printed but not linked: 10

  1. Dotan, 2005, Curr Opin Gastroenterol, 21, 426
  2. Rutgeerts, 2007, 56, 453
  3. Ruseler-van Embden, 1994, 35, 658
  4. Klinge, 2006, 168, 3516
  5. Butterworth, 2008, Cochrane Database Syst Rev, &NA;, CD006634
  6. Malchow, 1997, A new approach in therapy to maintain remission of colonic Crohns disease J Clin Gastroenterol, 25, 653
  7. Tursi, 2004, Med Sci Monit, 10, PI126
  8. Dai, 2012, Int J Mol Med, 29, 202
  9. Schulze, 1995, 23, 184
  10. Fellermann, 2003, Crohns disease: a defensin deficiency syndrome Eur J Gastroenterol Hepatol, 15, 627

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Metadata

Authors
Shen, J., Zuo, Z.-X., & Mao, A.-P.
Affiliations
Shanghai Jiao Tong University (CN)
ORCID
Shen, Jun
Venue
Inflammatory Bowel Diseases
Publisher
Oxford University Press (OUP)
Published
2014-01
Volume
20
Issue
1
Pages
21-35
ISSN
1078-0998 (ISSN-L)
DOI
10.1097/01.mib.0000437495.30052.be
OpenAlex
W1997405434
Cited by
364
References
57
Citations by year
2026: 4 · 2025: 13 · 2024: 16 · 2023: 18 · 2022: 22 · 2021: 26 · 2020: 74 · 2019: 18 · 2018: 33 · 2017: 46 · 2016: 38 · 2015: 34 · 2014: 22
FWCI
3.85
Type
journal article
Language
en
Open access
closed
Locations
  • Inflammatory Bowel Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
probiotics, ulcerative colitis
MeSH terms
Colitis, Ulcerative, Crohn Disease, Humans, Prognosis, Remission Induction, Randomized Controlled Trials as Topic, Pouchitis, Probiotics, Maintenance Chemotherapy

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