Body mass index, metabolic factors, and striatal activation during stressful and neutral-relaxing states: An FMRI study
Open accessAbstract
Stress is associated with alterations in neural motivational-reward pathways in the ventral striatum (VS), hormonal/metabolic changes, and weight increases. The relationship between these different factors is not well understood. We hypothesized that body mass index (BMI) status and hormonal/metabolic factors would be associated with VS activation. We used functional magnetic resonance imaging (fMRI) to compare brain responses of overweight and obese (OW/OB: BMI ≥ 25 kg/m(2): N=27) individuals with normal weight (NW: BMI<18.5-24.9 kg/m(2): N=21) individuals during exposure to personalized stress, alcohol cue, and neutral-relaxing situations using a validated, autobiographical, script-driven, guided-imagery paradigm. Metabolic factors, including fasting plasma glucose (FPG), insulin, and leptin, were examined for their association with VS activation. Consistent with previous studies, stress and alcohol cue exposure each increased activity in cortico-limbic regions. Compared with NW individuals, OW/OB individuals showed greater VS activation in the neutral-relaxing and stress conditions. FPG was correlated with VS activation. Significant associations between VS activation and metabolic factors during stress and relaxation suggest the involvement of metabolic factors in striatal dysfunction in OW/OB individuals. This relationship may contribute to non-homeostatic feeding in obesity.
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The effects of stress may be different in lean compared to obese individuals.
“The effects of stress may be different in lean as compared to obese individuals”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Jastreboff et al., 2011
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- Authors
- Jastreboff, A. M., Potenza, M. N., Lacadie, C., Hong, K. A., Sherwin, R. S., & Sinha, R.
- Affiliations
- Yale University (US)
- Corresponding author
- Sinha, Rajita
- Venue
- Neuropsychopharmacology
- Published
- 2010-11-03
- Volume
- 36
- Issue
- 3
- Pages
- 627-637
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3055687
- OpenAlex
- W2088294279
- Cited by
- 32
- References
- 51
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 4 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 4
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (PL1-DA02485 9, NIH T32)
- National Institute on Alcohol Abuse and Alcoholism (RL1AA017539, R01AA013892)
- National Institute on Drug Abuse (PL1DA024859)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK063703, T32 DK-07058, R37DK020495, T32DK007058)
- National Institute of Dental and Craniofacial Research (UL1DE019586)
- National Center for Research Resources (UL1RR024139)
- Common Fund (PL1-DA024859, UL1-DE019586)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- body mass index, obesity, overweight, ventral striatum, stress, alcohol cue exposure, fasting blood glucose, insulin, leptin, metabolic factors
- MeSH terms
- Adult, Blood Glucose, Brain Mapping, Corpus Striatum, Female, Humans, Image Processing, Computer-Assisted, Insulin, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Psychiatric Status Rating Scales, Statistics as Topic, Stress, Psychological, Body Mass Index, Mind-Body Relations, Metaphysical, Leptin
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