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Cited by 61Mindfulness and Compassion InterventionsOpioid Use Disorder TreatmentMusculoskeletal pain and rehabilitation

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Mindfulness is Associated With Increased Hedonic Capacity Among Chronic Pain Patients Receiving Extended Opioid Pharmacotherapy

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Thomas, Elizabeth A., Garland, Eric L.·2017·The Clinical Journal of Pain
DOI 10.1097/ajp.0000000000000379PMC PMC5235319
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Abstract

Objectives: Chronic pain and long-term opioid use may lead to a persistent deficit in hedonic capacity, characterized by increased sensitivity to aversive states and insensitivity to natural rewards. Dispositional mindfulness has been linked with improved emotion regulation and pain coping. The aim of the current study was to examine associations between dispositional mindfulness, hedonic capacity, and pain-related interference in an opioid-using chronic pain sample. Methods: Data were obtained from a sample of 115 chronic pain patients on long-term opioid therapy (68% females, M age=48.3, SD=13.6) who completed the Five Facet Mindfulness Questionnaire (FFMQ), the Snaith-Hamilton Anhedonia and Pleasure Scale (SHAPS), the Brief Pain Inventory, and a psychiatric assessment of major depression. Bivariate correlations, hierarchical multiple regression, and path analysis were used to determine whether dispositional mindfulness scores (FFMQ) predicted variance in hedonic capacity (SHAPS), and whether hedonic capacity mediated the association between mindfulness and pain interference. Results: We observed a significant positive correlation between dispositional mindfulness and hedonic capacity scores (r=0.33, P<0.001). Hierarchical regression indicated that after controlling for pain interference and major depressive disorder diagnosis, dispositional mindfulness explained a significant portion of variance in hedonic capacity (β=0.30, P<0.01). The association between dispositional mindfulness and pain interference was mediated by hedonic capacity (b=−0.011, SE=0.005; 95% CI, −0.004 to −0.024, full model R 2=0.39). Discussion: Findings indicate that dispositional mindfulness was associated with hedonic capacity among this chronic pain sample. In light of this association, it is plausible that interventions that increase mindfulness may reduce pain-related impairment among opioid-using patients by enhancing hedonic capacity.

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  • Mindful people tend to experience more pleasure, have less pain catastrophizing, and recover from stress better than non-mindful people.

    “In fact, mindful individuals exhibit an increased tendency to experience pleasure [72], reduced pain catastrophizing [13; 51; 63], and recover from stress more effectively than non mindful individuals [11].”

    From Neural mechanisms supporting the relationship between dispositional mindfulness and pain (2018) · cites this paper as [72]

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Research works printed but not linked: 41

  1. Narasimhan, 2010, A tale of two comorbidities: understanding the neurobiology of depression and pain, Indian J Psychiatry, 52, 127, 10.4103/0019-5545.64586 · DOI
  2. Kessler, 2005, Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication, Arch Gen Psychiatry, 62, 617, 10.1001/archpsyc.62.6.617 · DOI · Paper page
  3. Grady, 2011, Opioids for chronic pain, Arch Intern Med, 171, 1426, 10.1001/archinternmed.2011.213 · DOI
  4. Okie, 2010, A flood of opioids, a rising tide of deaths, N Engl J Med, 363, 1981, 10.1056/NEJMp1011512 · DOI
  5. Shurman, 2010, Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain, Pain Med, 11, 1092, 10.1111/j.1526-4637.2010.00881.x · DOI · Paper page
  6. Jensen, 2006, 10-year follow-up of chronic non-malignant pain patients: opioid use, health related quality of life and health care utilization, Eur J Pain, 10, 423, 10.1016/j.ejpain.2005.06.001 · DOI
  7. Sullivan, 2006, Association between mental health disorders, problem drug use, and regular prescription opioid use, Arch Intern Med, 166, 2087, 10.1001/archinte.166.19.2087 · DOI
  8. Elvemo, 2015, Reward responsiveness in patients with chronic pain, Eur J Pain, 19, 1537, 10.1002/ejp.687 · DOI
  9. Hummel, 2008, The persistence of a long-term negative affective state following the induction of either acute or chronic pain, Pain, 140, 436, 10.1016/j.pain.2008.09.020 · DOI
  10. Marbach, 1981, Depression, anhedonia and anxiety in temporomandibular joint and other facial pain syndromes, Pain, 11, 73, 10.1016/0304-3959(81)90140-8 · DOI
  11. Marbach, 1983, Illness behavior, depression and anhedonia in myofascial face and back pain patients, Psychother Psychosom, 39, 47, 10.1159/000287720 · DOI
  12. Dimova, 2013, Does severe acute pain provoke lasting changes in attentional and emotional mechanisms of pain-related processing? A longitudinal study, Pain, 154, 2737, 10.1016/j.pain.2013.08.005 · DOI
  13. Hirsh, 2008, Fear of pain, pain catastrophizing, and acute pain perception: relative prediction and timing of assessment, J Pain, 9, 806, 10.1016/j.jpain.2008.03.012 · DOI
  14. Severeijns, 2001, Pain catastrophizing predicts pain intensity, disability, and psychological distress independent of the level of physical impairment, Clin J Pain, 17, 165, 10.1097/00002508-200106000-00009 · DOI · Paper page
  15. Johansen, 2001, The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex, Proc Natl Acad Sci U S A, 98, 8077, 10.1073/pnas.141218998 · DOI
  16. Borsook, 2007, Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders, Eur J Pain, 11, 7, 10.1016/j.ejpain.2005.12.005 · DOI
  17. Gandhi, 2013, Pain increases motivational drive to obtain reward, but does not affect associated hedonic responses: a behavioural study in healthy volunteers, Eur J Pain, 17, 1093, 10.1002/j.1532-2149.2012.00281.x · DOI
  18. Becker, 2012, Awareness is awareness is awareness? Decomposing different aspects of awareness and their role in operant learning of pain sensitivity, Conscious Cogn, 21, 1073, 10.1016/j.concog.2012.03.008 · DOI
  19. Brown, 2007, Mindfulness: theoretical foundations and evidence for its salutary effects, Psychol Inq, 18, 211, 10.1080/10478400701598298 · DOI · Paper page
  20. Schütze, 2010, Low mindfulness predicts pain catastrophizing in a fear-avoidance model of chronic pain, Pain, 148, 120, 10.1016/j.pain.2009.10.030 · DOI · Paper page
  21. Mun, 2014, Trait mindfulness and catastrophizing as mediators of the association between pain severity and pain-related impairment, Pers Individ Differ, 66, 68, 10.1016/j.paid.2014.03.016 · DOI · Paper page
  22. Garland, 2015, Mindfulness broadens awareness and builds eudaimonic meaning: a process model of mindful positive emotion regulation, Psychol Inq, 26, 293, 10.1080/1047840X.2015.1064294 · DOI · Paper page
  23. Chou, 2009, Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain, J Pain, 10, 113.e22, 10.1016/j.jpain.2008.10.008 · DOI · Paper page
  24. Sheehan, 1998, The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10, J Clin Psychiatry, 59, 22
  25. Brown, 2003, The benefits of being present: mindfulness and its role in psychological well-being, J Pers Soc Psychol, 84, 822, 10.1037/0022-3514.84.4.822 · DOI · Paper page
  26. Baer, 2004, Assessment of mindfulness by self-report: the Kentucky Inventory of Mindfulness Skills, Assessment, 11, 191, 10.1177/1073191104268029 · DOI · Paper page
  27. Snaith, 1995, A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale, Br J Psychiatry, 167, 99, 10.1192/bjp.167.1.99 · DOI · Paper page
  28. Preacher, 2008, Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models, Behav Res Methods, 40, 879, 10.3758/BRM.40.3.879 · DOI · Paper page
  29. Finan, 2015, The role of positive affect in pain and its treatment, Clin J Pain, 31, 177, 10.1097/AJP.0000000000000092 · DOI
  30. Duric, 2016, Comorbidity factors and brain mechanisms linking chronic stress and systemic illness, comorbidity factors and brain mechanisms linking chronic stress and systemic illness, Neural Plast, 2016, e5460732, 10.1155/2016/5460732 · DOI
  31. Koob, 2001, Drug addiction, dysregulation of reward, and allostasis, Neuropsychopharmacol, 24, 97, 10.1016/S0893-133X(00)00195-0 · DOI · Paper page
  32. Apkarian, 2011, The brain in chronic pain: clinical implications, Pain Manag, 1, 577, 10.2217/pmt.11.53 · DOI
  33. Apkarian, 2005, Human brain mechanisms of pain perception and regulation in health and disease, Eur J Pain, 9, 463, 10.1016/j.ejpain.2004.11.001 · DOI · Paper page
  34. Baliki, 2006, Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain, J Neurosci Off J Soc Neurosci, 26, 12165, 10.1523/JNEUROSCI.3576-06.2006 · DOI · Paper page
  35. Farmer, 2012, A dynamic network perspective of chronic pain, Neurosci Lett, 520, 197, 10.1016/j.neulet.2012.05.001 · DOI
  36. Martikainen, 2015, Chronic back pain is associated with alterations in dopamine neurotransmission in the ventral striatum, J Neurosci, 35, 9957, 10.1523/JNEUROSCI.4605-14.2015 · DOI
  37. Lintas, 2012, Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission, Eur J Neurosci, 35, 279, 10.1111/j.1460-9568.2011.07943.x · DOI
  38. Garland, 2015, Allostatic dysregulation of natural reward processing in prescription opioid misuse: autonomic and attentional evidence, Biol Psychol, 105, 124, 10.1016/j.biopsycho.2015.01.005 · DOI
  39. Wanigasekera, 2012, Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects, Proc Natl Acad Sci U S A, 109, 17705, 10.1073/pnas.1120201109 · DOI
  40. Peciña, 2015, Effects of the mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures, Neuropsychopharmacology, 40, 957, 10.1038/npp.2014.272 · DOI
  41. Miller, 2009, Comorbid chronic pain and depression: who is at risk?, J Pain, 10, 619, 10.1016/j.jpain.2008.12.007 · DOI

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Metadata

Authors
Thomas, E. A., & Garland, E. L.
Affiliations
  • College of Social Work
  • Huntsman Cancer Institute (US)
Corresponding author
Thomas, Elizabeth A.
ORCID
Venue
The Clinical Journal of Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-02
Volume
33
Issue
2
Pages
166-173
ISSN
0749-8047 (ISSN-L)
DOI
10.1097/ajp.0000000000000379
PMC
PMC5235319
OpenAlex
W2332936126
Cited by
61
References
27
Citations by year
2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 44 · 2019: 2 · 2018: 4 · 2017: 1
FWCI
3.12
Type
journal article
Language
en
Open access
Locations
  • Clinical Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R03DA032517, R34DA037005)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords
trait mindfulness, hedonic capacity, chronic pain, long-term opioid therapy, pain interference, anhedonia, major depressive disorder, mediation, Five Facet Mindfulness Questionnaire
MeSH terms
Adult, Aged, Aged, 80 and over, Analgesics, Opioid, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Surveys and Questionnaires, Regression Analysis, Time Factors, Young Adult, Pleasure, Chronic Pain, Anhedonia, Mindfulness

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