A Pilot Randomized Controlled Trial of Combined Trauma-Focused CBT and Sertraline for Childhood PTSD Symptoms
Abstract
Objective To examine the potential benefits of adding a selective serotonin reuptake inhibitor, sertraline, versus placebo, to trauma-focused cognitive-behavioral therapy (TF-CBT) for improving posttraumatic stress disorder and related psychological symptoms in children who have experienced sexual abuse.Method Twenty-four 10- to 17-year-old female children and adolescents and their primary caretakers were randomly assigned to receive TF-CBT + sertraline or TF-CBT + placebo for 12 weeks.Results Both groups experienced significant improvement in posttraumatic stress disorder and other clinical outcomes from pre- to posttreatment with no significant group x time differences between groups except in Child Global Assessment Scale ratings, which favored the TF-CBT + sertraline group.Conclusions Only minimal evidence suggests a benefit to adding sertraline to TF-CBT. A drawback of adding sertraline was determining whether TF-CBT or sertraline caused clinical improvement for children with comorbid depression. Current evidence therefore supports an initial trial of TF-CBT or other evidence-supported psychotherapy for most children with PTSD symptoms before adding medication.
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Cognitive behavioral therapy (CBT) including trauma exposure techniques has proven effective for child victims of sexual abuse and other forms of violence.
“In particular, cognitive behavioral therapy (CBT) including trauma exposure techniques has proven to be effective for child victims of sexual abuse [8-10] and other forms of violence [11,12].”
From Treating children traumatized by war and tsunami: a comparison between exposure therapy and meditation-relaxation in north-east Sri Lanka (2009) · cites this paper as [9]
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- Authors
- COHEN, J. A., MANNARINO, A. P., PEREL, J. M., & STARON, V.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- COHEN, JUDITH A.
- ORCID
- COHEN, JUDITH A.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 46
- Issue
- 7
- Pages
- 811-819
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2061598652
- Cited by
- 300
- References
- 27
- Citations by year
- 2026: 11 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 11 · 2020: 17 · 2019: 18 · 2018: 7 · 2017: 13 · 2016: 22 · 2015: 40 · 2014: 15 · 2013: 24 · 2012: 22
- FWCI
- 15.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K02MH001938)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child Therapy and Development
- Keywords
- trauma-focused cognitive behavioral therapy, sertraline, selective serotonin reuptake inhibitors, sexual abuse, comorbid depression, psychotherapy, adolescents, girls
- MeSH terms
- Adolescent, Child, Combined Modality Therapy, Female, Humans, Male, Pilot Projects, Stress Disorders, Post-Traumatic, Cognitive Behavioral Therapy, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Sertraline
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