Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 458

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

High-carbohydrate High-fat Diet–induced Metabolic Syndrome and Cardiovascular Remodeling in Rats

Open access
Panchal, Sunil K, Poudyal, Hemant, Iyer, Abishek, Nazer, Reeza, Alam, Ashraful, Diwan, Vishal, Kauter, Kathleen, Sernia, Conrad, Campbell, Fiona, Ward, Leigh, Gobe, Glenda, Fenning, Andrew, Brown, Lindsay·2011·Journal of Cardiovascular Pharmacology
DOI 10.1097/fjc.0b013e3181feb90a
Open this paper in CoChat — free account

Abstract

The prevalence of metabolic syndrome including central obesity, insulin resistance, impaired glucose tolerance, hypertension, and dyslipidemia is increasing. Development of adequate therapy for metabolic syndrome requires an animal model that mimics the human disease state. Therefore, we have characterized the metabolic, cardiovascular, hepatic, renal, and pancreatic changes in male Wistar rats (8-9 weeks old) fed on a high-carbohydrate, high-fat diet including condensed milk (39.5%), beef tallow (20%), and fructose (17.5%) together with 25% fructose in drinking water; control rats were fed a cornstarch diet. During 16 weeks on this diet, rats showed progressive increases in body weight, energy intake, abdominal fat deposition, and abdominal circumference along with impaired glucose tolerance, dyslipidemia, hyperinsulinemia, and increased plasma leptin and malondialdehyde concentrations. Cardiovascular signs included increased systolic blood pressure and endothelial dysfunction together with inflammation, fibrosis, hypertrophy, increased stiffness, and delayed repolarization in the left ventricle of the heart. The liver showed increased wet weight, fat deposition, inflammation, and fibrosis with increased plasma activity of liver enzymes. The kidneys showed inflammation and fibrosis, whereas the pancreas showed increased islet size. In comparison with other models of diabetes and obesity, this diet-induced model more closely mimics the changes observed in human metabolic syndrome.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1097/fjc.0b013e3181feb90a

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Research works printed but not linked: 70

  1. Lakka, 2002, The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men., JAMA, 288, 2709, 10.1001/jama.288.21.2709 · DOI · Paper page
  2. Sattar, 2003, Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study., Circulation, 108, 414, 10.1161/01.CIR.0000080897.52664.94 · DOI · Paper page
  3. Grundy, 2005, A constellation of complications: the metabolic syndrome., Clin Cornerstone, 7, 36, 10.1016/S1098-3597(05)80066-3 · DOI
  4. Magliano, 2006, How to best define the metabolic syndrome., Ann Med, 38, 34, 10.1080/07853890500300311 · DOI
  5. Dandona, 2005, Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation., Circulation, 111, 1448, 10.1161/01.CIR.0000158483.13093.9D · DOI · Paper page
  6. Iyer, 2010, Inflammatory lipid mediators in adipocyte function and obesity., Nat Rev Endocrinol, 6, 71, 10.1038/nrendo.2009.264 · DOI · Paper page
  7. Wang, 2010, Heme oxygenase-1 in cardiovascular diseases: molecular mechanisms and clinical perspectives., Chang Gung Med J, 33, 13
  8. Chen, 2005, Development and application of rodent models for type 2 diabetes., Diabetes Obes Metab, 7, 307, 10.1111/j.1463-1326.2004.00392.x · DOI
  9. Doggrell, 1998, Rat models of hypertension, cardiac hypertrophy and failure., Cardiovasc Res, 39, 89, 10.1016/S0008-6363(98)00076-5 · DOI · Paper page
  10. Flamment, 2008, Fatty liver and insulin resistance in obese Zucker rats: no role for mitochondrial dysfunction., Biochimie, 90, 1407, 10.1016/j.biochi.2008.05.003 · DOI
  11. Liu, 2002, Early events involved in the development of insulin resistance in Zucker fatty rat., Int J Obes Relat Metab Disord, 26, 318, 10.1038/sj.ijo.0801924 · DOI
  12. Bitar, 2005, Oxidative stress-mediated alterations in glucose dynamics in a genetic animal model of type II diabetes., Life Sci, 77, 2552, 10.1016/j.lfs.2005.01.033 · DOI
  13. Cacanyiova, 2008, Adaptive vasoactive response to modulatory effects of endothelin-1 in spontaneously hypertensive rats., Pharmacol Rep, 60, 941
  14. Mizushige, 2000, Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model., Circulation, 101, 899, 10.1161/01.CIR.101.8.899 · DOI · Paper page
  15. Lenzen, 2008, The mechanisms of alloxan- and streptozotocin-induced diabetes., Diabetologia, 51, 216, 10.1007/s00125-007-0886-7 · DOI · Paper page
  16. Marsh, 2009, Interaction of diet and diabetes on cardiovascular function in rats., Am J Physiol Heart Circ Physiol, 296, H282, 10.1152/ajpheart.00421.2008 · DOI
  17. Pang, 2008, Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats., J Ethnopharmacol, 117, 325, 10.1016/j.jep.2008.02.002 · DOI
  18. Thirunavukkarasu, 2004, Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats., J Comp Physiol B, 174, 587, 10.1007/s00360-004-0447-z · DOI
  19. Buettner, 2006, Defining high-fat-diet rat models: metabolic and molecular effects of different fat types., J Mol Endocrinol, 36, 485, 10.1677/jme.1.01909 · DOI · Paper page
  20. Reil, 1999, Diet-induced changes in endothelial-dependent relaxation of the rat aorta., J Surg Res, 85, 96, 10.1006/jsre.1999.5666 · DOI
  21. Schaalan, 2009, Westernized-like-diet-fed rats: effect on glucose homeostasis, lipid profile, and adipocyte hormones and their modulation by rosiglitazone and glimepiride., J Diabetes Complications, 23, 199, 10.1016/j.jdiacomp.2008.02.003 · DOI
  22. Hubbell, 1937, A new salt mixture for use in experimental diets., J Nutr, 14, 273, 10.1093/jn/14.3.273 · DOI
  23. Novelli, 2010, Energy expenditure and oxygen consumption as novel biomarkers of obesity-induced cardiac disease in rats., Obesity (Silver Spring), 18, 1754, 10.1038/oby.2009.470 · DOI
  24. Ward, 2009, Assessment of body composition of rats by bioimpedance spectroscopy validation against dual-energy x-ray absorptiometry., Scand J Lab Anim Sci, 36, 253
  25. Brown, 2002, Echocardiographic assessment of cardiac structure and function in rats., Heart Lung Circ, 11, 167, 10.1046/j.1444-2892.2002.00148.x · DOI
  26. Sahn, 1978, Real-time cross-sectional echocardiographic imaging and measurement of the patent ductus arteriosus in infants and children., Circulation, 58, 343, 10.1161/01.CIR.58.2.343 · DOI
  27. Litwin, 1994, Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat., Circulation, 89, 345, 10.1161/01.CIR.89.1.345 · DOI · Paper page
  28. Allan, 2005, Reversal of cardiac dysfunction by selective ET-A receptor antagonism., Br J Pharmacol, 146, 846, 10.1038/sj.bjp.0706384 · DOI
  29. Chan, 2006, Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats., Br J Pharmacol, 148, 902, 10.1038/sj.bjp.0706801 · DOI
  30. Fenning, 2005, l-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats., Am J Physiol Heart Circ Physiol, 289, H1408, 10.1152/ajpheart.00140.2005 · DOI
  31. Wang, 1999, Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader., Free Radic Biol Med, 27, 612, 10.1016/S0891-5849(99)00107-0 · DOI · Paper page
  32. Sim, 2003, Improved method for plasma malondialdehyde measurement by high-performance liquid chromatography using methyl malondialdehyde as an internal standard., J Chromatogr B Analyt Technol Biomed Life Sci, 785, 337, 10.1016/S1570-0232(02)00956-X · DOI
  33. Muntner, 2004, Prevalence of non-traditional cardiovascular disease risk factors among persons with impaired fasting glucose, impaired glucose tolerance, diabetes, and the metabolic syndrome: analysis of the Third National Health and Nutrition Examination Survey (NHANES III)., Ann Epidemiol, 14, 686, 10.1016/j.annepidem.2004.01.002 · DOI
  34. Musso, 2010, Non-alcoholic fatty liver disease from pathogenesis to management: an update., Obes Rev, 11, 430, 10.1111/j.1467-789X.2009.00657.x · DOI
  35. Zhang, 2009, Slowly digestible starch: concept, mechanism, and proposed extended glycemic index., Crit Rev Food Sci Nutr, 49, 852, 10.1080/10408390903372466 · DOI
  36. Thirunavukkarasu, 2004, Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats., J Comp Physiol B, 174, 587, 10.1007/s00360-004-0447-z · DOI
  37. Patel, 2009, Evaluation of the chronic complications of diabetes in a high fructose diet in rats., Indian J Biochem Biophys, 46, 66
  38. Jo, 2009, Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth., PLoS Comput Biol, 5, e1000324, 10.1371/journal.pcbi.1000324 · DOI
  39. Fam, 2007, Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity., Diabetes Obes Metab, 9, 840, 10.1111/j.1463-1326.2006.00653.x · DOI
  40. Ryan, 2009, The hypolipidemic effect of an ethyl ester of algal-docosahexaenoic acid in rats fed a high-fructose diet., Lipids, 44, 817, 10.1007/s11745-009-3330-6 · DOI
  41. Van Guilder, 2006, Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults., Obesity (Silver Spring), 14, 2127, 10.1038/oby.2006.248 · DOI
  42. Athyros, 2010, Should adipokines be considered in the choice of the treatment of obesity-related health problems?, Curr Drug Targets, 11, 122, 10.2174/138945010790030992 · DOI
  43. Ritchie, 2009, Evidence for a causal role of oxidative stress in the myocardial complications of insulin resistance., Heart Lung Circ, 18, 11, 10.1016/j.hlc.2008.11.003 · DOI
  44. Delles, 2008, Vascular stiffness is related to superoxide generation in the vessel wall., J Hypertens, 26, 946, 10.1097/HJH.0b013e3282f7677c · DOI
  45. Matsuzawa-Nagata, 2008, Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity., Metabolism, 57, 1071, 10.1016/j.metabol.2008.03.010 · DOI
  46. Lamb, 2008, Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function., Int J Clin Pract, 62, 1087, 10.1111/j.1742-1241.2008.01789.x · DOI
  47. Liu, 2010, Allicin protects against cardiac hypertrophy and fibrosis via attenuating reactive oxygen species-dependent signaling pathways., J Nutr Biochem, 21, 1238, 10.1016/j.jnutbio.2009.11.001 · DOI
  48. Tabet, 2004, Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats., J Cardiovasc Pharmacol, 44, 200, 10.1097/00005344-200408000-00009 · DOI
  49. Guerra, 1996, The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes., Br J Pharmacol, 118, 1278, 10.1111/j.1476-5381.1996.tb15534.x · DOI
  50. Yang, 1999, Hydrogen peroxide induces contraction and raises [Ca2+]i in canine cerebral arterial smooth muscle: participation of cellular signaling pathways., Naunyn Schmiedebergs Arch Pharmacol, 360, 646, 10.1007/s002109900128 · DOI
  51. Yang, 1998, Mechanisms of hydrogen peroxide-induced contraction of rat aorta., Eur J Pharmacol, 344, 169, 10.1016/S0014-2999(97)01576-8 · DOI
  52. Ermak, 2002, Calcium and oxidative stress: from cell signaling to cell death., Mol Immunol, 38, 713, 10.1016/S0161-5890(01)00108-0 · DOI · Paper page
  53. Ganau, 1992, Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension., J Am Coll Cardiol, 19, 1550, 10.1016/0735-1097(92)90617-V · DOI · Paper page
  54. Doenst, 2010, Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload., Cardiovasc Res, 86, 461, 10.1093/cvr/cvp414 · DOI · Paper page
  55. Yu, 2009, CHF1/Hey2 promotes physiological hypertrophy in response to pressure overload through selective repression and activation of specific transcriptional pathways., OMICS, 13, 501, 10.1089/omi.2009.0086 · DOI
  56. MacKenna, 2000, Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis., Cardiovasc Res, 46, 257, 10.1016/S0008-6363(00)00030-4 · DOI
  57. Newsholme, 2009, Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide., Clin Sci, 118, 341, 10.1042/CS20090433 · DOI
  58. Cerbai, 1994, Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages., Cardiovasc Res, 28, 1180, 10.1093/cvr/28.8.1180 · DOI
  59. Wei, 2003, The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes., Heart Lung Circ, 12, 44, 10.1046/j.1444-2892.2003.00160.x · DOI
  60. Qin, 2001, Downregulation of K(+) channel genes expression in type I diabetic cardiomyopathy., Biochem Biophys Res Commun, 283, 549, 10.1006/bbrc.2001.4825 · DOI
  61. Cerbai, 2000, Long-term treatment of spontaneously hypertensive rats with losartan and electrophysiological remodeling of cardiac myocytes., Cardiovasc Res, 45, 388, 10.1016/S0008-6363(99)00344-2 · DOI
  62. Furukawa, 2006, Potassium channel remodeling in cardiac hypertrophy., J Mol Cell Cardiol, 41, 753, 10.1016/j.yjmcc.2006.07.021 · DOI
  63. Tamargo, 2004, Pharmacology of cardiac potassium channels., Cardiovasc Res, 62, 9, 10.1016/j.cardiores.2003.12.026 · DOI · Paper page
  64. Del Rio, 2005, A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress., Nutr Metab Cardiovasc Dis, 15, 316, 10.1016/j.numecd.2005.05.003 · DOI · Paper page
  65. Stanhope, 2008, Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance., Curr Opin Lipidol, 19, 16, 10.1097/MOL.0b013e3282f2b24a · DOI · Paper page
  66. Miller, 2008, Dietary fructose and the metabolic syndrome., Curr Opin Gastroenterol, 24, 204, 10.1097/MOG.0b013e3282f3f4c4 · DOI
  67. Le, 2006, Metabolic effects of fructose., Curr Opin Clin Nutr Metab Care, 9, 469, 10.1097/01.mco.0000232910.61612.4d · DOI
  68. Vanni, 2010, From the metabolic syndrome to NAFLD or vice versa?, Dig Liver Dis, 42, 320, 10.1016/j.dld.2010.01.016 · DOI · Paper page
  69. Tozawa, 2007, Metabolic syndrome and risk of developing chronic kidney disease in Japanese adults., Hypertens Res, 30, 937, 10.1291/hypres.30.937 · DOI
  70. Ai, 2005, Development of Wistar rat model of insulin resistance., World J Gastroenterol, 11, 3675, 10.3748/wjg.v11.i24.3675 · DOI

Cited by

Metadata

Authors
Panchal, S. K., Poudyal, H., Iyer, A., Nazer, R., Alam, A., Diwan, V., Kauter, K., Sernia, C., Campbell, F., Ward, L., Gobe, G., Fenning, A., & Brown, L.
Venue
Journal of Cardiovascular Pharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-01
Volume
57
Issue
1
Pages
51-64
ISSN
0160-2446 (ISSN-L)
DOI
10.1097/fjc.0b013e3181feb90a
OpenAlex
W2006702634
Cited by
458
References
7
FWCI
12.11
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.