Cited by 129Microbial Metabolites in Food BiotechnologyInfant Nutrition and HealthGut microbiota and health

Mechanisms underlying immune effects of dietary oligosaccharides

Open access
Jeurink, Prescilla V, van Esch, Betty CAM, Rijnierse, Anneke, Garssen, Johan, Knippels, Léon MJ·2013·The American Journal of Clinical Nutrition

Abstract

The WHO refers to human milk as the nutritional gold standard for term infants. Human milk contains many immunomodulatory compounds, including oligosaccharides. Human-milk oligosaccharides can serve as prebiotics because the nondigestible oligosaccharides present in human milk show a clear bifidogenic effect on the gut microbiota. Dietary oligosaccharide structures that have prebiotic effects similar to human-milk oligosaccharides include galacto-oligosaccharides, fructo-oligosaccharides, and pectin-derived acidic oligosaccharides. Both animal studies and human clinical trials showed that dietary intervention with these dietary oligosaccharides in early life could lead to the prevention of atopic dermatitis, food allergy, and allergic asthma. The immune-modulating effects of these oligosaccharides are likely assisted via alteration of the intestinal microbiota or in a microbiota-independent manner by direct interaction on immune cells or both. In this review, an overview of the prebiotic role of dietary oligosaccharides on the microbiota and the microbiota-independent immune modulation by these prebiotics is provided. In addition, recent publications that report on the pathways by which the oligosaccharides might exert their direct immunomodulatory effect are summarized.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3945/ajcn.112.038596

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Prebiotic fibers have been shown to have beneficial effects on immune function, bowel motility and constipation that might be relevant for inflammation and gastrointestinal-related symptoms in Parkinson's disease.

    “Prebiotic fibers have been shown to have beneficial effects on immune function (Jeurink et al., 2013)(de Kivit et al., 2011)(van Hoffen et al., 2009), bowel motility and constipation (Meksawan et al., 2014) (Scholtens et al., 2014) (Rasmussen et al., 2014) that might be very relevant for inflammation and GI-related symptoms in PD.”

    From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Jeurink et al., 2013

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 82 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. van Esch BC. Avoidance versus tolerance: new concepts for allergy management. PhD dissertation. University of Utrecht, Utrecht, Neth- erlands, 2011.

Cited by

Sorted by citations

Authors
Jeurink, P. V., van Esch, B. C., Rijnierse, A., Garssen, J., & Knippels, L. M.
Affiliations
Utrecht University (NL)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2013-08
Volume
98
Issue
2
Pages
572S-577S
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2146896376
Cited by
129
References
82
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 14 · 2022: 5 · 2021: 8 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 14 · 2014: 10 · 2013: 4
FWCI
12.21
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Danone
  • Universiteit Utrecht
  • Top Institute Pharma (T1-214)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
dietary oligosaccharides, human milk oligosaccharides, prebiotics, gut microbiota, immunomodulation, galactooligosaccharides, fructooligosaccharides, atopic dermatitis, food allergy, allergic asthma, early life nutrition
MeSH terms
Animals, Asthma, Clinical Trials as Topic, Dermatitis, Atopic, Diet, Food Hypersensitivity, Humans, Immunologic Factors, Infant, Milk, Human, Oligosaccharides, Trisaccharides, Probiotics, Models, Animal, Gastrointestinal Tract, Metagenome, Prebiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review