The role of early life nutrition in the establishment of gastrointestinal microbial composition and function
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The development of the human infant intestinal microbiota is a sequential process that begins in utero and continues during the first 2 to 3 years of life. Microbial composition and diversity are shaped by host genetics and multiple environmental factors, of which diet is a principal contributor. An understanding of this process is of clinical importance as the microbiota acquired in early life influence gastrointestinal, immune and neural development, and reduced microbial diversity or dysbiosis during infancy is associated with disorders in infancy and later childhood. The goal of this article was to review the published literature that used culture-independent methods to describe the development of the gastrointestinal microbiota in breast- and formula-fed human infants as well as the impact of prebiotic and probiotic addition to infant formula, and the addition of solid foods.
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Generally, breast-fed infants harbor a less diverse and species-rich microbiota dominated by Bifidobacterium species, whereas the microbiota of formula-fed infants is functionally more similar to that of an adult and is often enriched in microbial taxa such as Klebsiella, Enterococcus, Peptostreptococcaceae, Akkermansia, Veillonella, and C. difficile.
“Generally, breast-fed infants harbor a less diverse and species-rich microbiota that is dominated by Bifidobacterium species, whereas the microbiota of formulafed infants is functionally more similar to that of an adult and is often enriched in microbial taxa such as Klebsiella, Enterococcus, Peptostreptococcaceae, Akkermansia, Veillonella, and C. difficile (256, 257).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [257]
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
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Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
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Feeding the microbiota: Transducer of nutrient signals for the host
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Maternal and food microbial sources shape the infant microbiome of a rural Ethiopian population
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- Authors
- Davis, E. C., Wang, M., & Donovan, S. M.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Donovan, Sharon M.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2017-01-09
- Volume
- 8
- Issue
- 2
- Pages
- 143-171
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC5390825
- OpenAlex
- W2569605449
- Cited by
- 169
- References
- 145
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 19 · 2023: 16 · 2022: 20 · 2021: 24 · 2020: 24 · 2019: 17 · 2018: 17 · 2017: 9
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- infant gut microbiota, early life nutrition, microbial development, breast milk, infant formula, prebiotics, probiotics, solid food introduction, dysbiosis, microbial diversity, host genetics, immune system development, neural development
- MeSH terms
- Gastrointestinal Microbiome, Child Development, Child, Preschool, Humans, Infant, Infant Nutritional Physiological Phenomena, Gastrointestinal Tract
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