Cited by 23Meta-analysis and systematic reviewsStatistical Methods in EpidemiologyAdvanced Causal Inference Techniques

More Than the Sum of Its Parts: Meta-Analysis and Its Potential to Discover Sources of Heterogeneity in Psychosomatic Medicine

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Tak, Lineke M., Meijer, Anna, Manoharan, Andiappan, de Jonge, Peter, Rosmalen, Judith G. M.·2010·Psychosomatic Medicine

Abstract

Meta-analyses may contribute to more reliable knowledge about the existence of certain relations in the area of psychosomatic research. Surprisingly, the increasing popularity of meta-analysis is not reflected in the number of meta-analyses of observational studies published in Psychosomatic Medicine. This may be due to the specific difficulties that apply to meta-analyses of observational research. The aim of this paper is to provide a nontechnical overview of the principles of meta-analysis applied to observational research. We will highlight general principles of meta-analysis and discuss the major threats to its validity, with an emphasis on its specific merits and pitfalls for psychosomatic research, using several examples. We conclude that meta-analysis is a relatively simple technique, leaving little reason for not routinely applying it when performing a systematic review. An adequately conducted meta-analysis may not only provide a summary estimate of a certain association, but it has additional value in discovering relevant confounders, mediators, and moderators, as well as identifying areas of research that require more attention.

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Registry

Crossref · 10.1097/psy.0b013e3181d714e1

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89 of 89 references verified0 citation errors · 0 not checkable

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Authors
Tak, L. M., Meijer, A., Manoharan, A., de Jonge, P., & Rosmalen, J. G. M.
Affiliations
University Medical Center Groningen (NL)
Corresponding author
Rosmalen, Judith G. M.
Venue
Psychosomatic Medicine
Published
2010-04
Volume
72
Issue
3
Pages
253-265
ISSN
0033-3174 (ISSN-L)
OpenAlex
W2053234536
Cited by
23
References
89
Citations by year
2023: 1 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
2.31
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders
Medical Research Council
Topics
  • Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
  • Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
Keywords
meta-analysis, observational studies, heterogeneity, threats to validity, confounders, mediators, moderators, systematic reviews, research priorities
MeSH terms
Clinical Trials as Topic, Humans, Psychosomatic Medicine, Review Literature as Topic, Meta-Analysis as Topic, Reproducibility of Results, Randomized Controlled Trials as Topic, Biomedical Research

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