The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Neural interfaces for somatosensory feedback: bringing life to a prosthesis
Open accessAbstract
PURPOSE OF REVIEW: When an individual loses a limb, he/she loses touch with the world and with the people around him/her. Somatosensation is critical to the feeling of connection and control of one's own body. Decades of attempts to replace lost somatosensation by sensory substitutions have been ineffective outside of the laboratory. This review discusses important recent results demonstrating chronic somatosensory restoration through direct peripheral nerve stimulation. RECENT FINDINGS: Stimulation of peripheral nerves results in somatosensory perception on the phantom limb. Sensations are localized to several independent and functionally relevant locations, such as the fingertips, thenar eminence, ulnar border and dorsal surface. Patterns in stimulation intensity change the perception experience by the user, opening new dimensions on neuromodulation. SUMMARY: Neural interfaces with sophisticated stimulation paradigms create a user's perception of his/her hand to touch and manipulate objects. The pattern of intensity and frequency of stimulation is critical to the quality and intensity of perceived sensation. Restoring feeling has allowed the individuals to, 'feel [my] hand for the first time since the accident,' and 'feel [my] wife touch my hand'. Individuals using a prosthetic hand with sensation can pull cherries and grapes from the stem, open water bottles and move objects without destroying these objects - all while audio and visually deprived. After regaining sensation, phantom pain is eliminated in individuals that had frequent, sometimes debilitating, pain following limb loss. With over 5 subject-years of experience, this work is leading the evolution of a new era in prostheses. Somatosensory prosthetics as a standard procedure to augment and restore somatosensation are now within our reach.
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“Spikes are responsible for conveying information in the axons of a nerve, and the spike rate or frequency is involved in transmitting sensorimotor commands in a single axon (Tyler, 2015).”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Tyler, 2015
In the citing paper
“Optimization of sensory feedback can provide better results, which include the restoration of a sense of touch that allows amputees to experience the world in a natural way and that also helps in allowing the bionic arm/prosthesis to be incorporated into their body image (Tyler, 2015).”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Tyler, 2015
In the citing paper
“Bensmaia (2015) and Tyler (2015) concluded that many challenges are ahead before selective activation of all receptors.”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Tyler (2015)
Citations
Cites
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Cortical control of a prosthetic arm for self-feeding
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Upper limb prosthesis use and abandonment
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My body in the brain: A neurocognitive model of body-ownership.
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Restoring natural sensory feedback in real-time bidirectional hand prostheses
Raspopovic, S., Capogrosso, M., Petrini, F. M., Bonizzato, M., Rigosa, J., Di Pino, G., Carpaneto, J., Controzzi, M., Boretius, T., Fernandez, E., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3006820 · Cited by 1,001
What is embodiment? A psychometric approach
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Mechanisms of sensory transduction in the skin
Lumpkin, E. A., & Caterina, M. J. (2007) · Nature · doi:10.1038/nature05662 · Cited by 860
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“There are several options being explored for peripheral nerve interfaces [84,85].”
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Items 101–105 of 105
Calvert, J. S., Fridley, J., Solinsky, R. J., Shaaya, E. A., Parker, S. R., Borton, D. A., & Resnik, L. J. (2025) · Topics in Spinal Cord Injury Rehabilitation · doi:10.46292/sci24-00092
Pan, L., Yao, X., Lun, J., Li, J., & Li, J. (2026) · IEEE Transactions on Haptics · doi:10.1109/toh.2026.3662489
Nguyen, E., Barkóczi, B., Horváth, C., Judák, L., Rózsa, B. J., Ceyssens, F., Ulbert, I., Wittner, L., Schelles, M., & Fiáth, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.09.704741
Movement is a Sensory Phenomenon
Tereshenko, V., & Aszmann, O. C. (2026) · Hand Clinics · doi:10.1016/j.hcl.2026.03.005
An overview of current and emerging strategies for phantom limb pain
Cascella, M., Simone, M. D., Vittori, A., Fasolino, S., & İaconetta, G. (2026) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2026.2709803
Metadata
- Authors
- Tyler, D. J.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Tyler, Dustin J.
- ORCID
- Tyler, Dustin J.
- Venue
- Current Opinion in Neurology
- Published
- 2015-12
- Volume
- 28
- Issue
- 6
- Pages
- 574-581
- ISSN
- 1350-7540 (ISSN-L)
- PMC
- PMC5517303
- OpenAlex
- W2415521922
- Cited by
- 105
- References
- 125
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 3 · 2023: 15 · 2022: 10 · 2021: 9 · 2020: 10 · 2019: 17 · 2018: 10 · 2017: 14 · 2016: 2
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 RX001334)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- neural interfaces, somatosensory feedback, peripheral nerve stimulation, phantom limb, sensory substitution, prosthetic hand, phantom pain, neuromodulation, limb loss
- MeSH terms
- Artificial Limbs, Electric Stimulation, Hand, Humans, Peripheral Nerves, Touch, Touch Perception, Feedback, Sensory
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