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DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
Open accessAbstract
Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the formation and measurement of oxidatively generated damage in cellular DNA in order to provide a comprehensive and updated survey.This includes single pyrimidine and purine base lesions, intrastrand cross-links, purine 5 0 ,8-cyclonucleosides, DNA-protein adducts and interstrand cross-links formed by the reactions of either the nucleobases or the 2-deoxyribose moiety with the hydroxyl radical, one-electron oxidants, singlet oxygen, and hypochlorous acid.In addition, recent information concerning the mechanisms of formation, individual measurement, and repair-rate assessment of bipyrimidine photoproducts in isolated cells and human skin upon exposure to UVB radiation, UVA photons, or solar simulated light is critically reviewed.I n this article, we emphasize recent develop- ments in the formation of damage to cellular DNA mediated by reactive oxygen species (ROS) and oxidizing agents, including singlet oxygen, the hydroxyl radical ( † OH), one-electron oxidants, hypochlorous acid (HOCl), and ten-eleven translocation (TET) oxygenases involved in epigenetic regulation.These advances have been possible because of the development of sensitive and powerful high-performance liquid chromatography-mass spectrometry (HPLC-MS)/ mass spectrometry (MS) methods allowing one to revise previously reported data obtained using methods such as gas chromatographymass spectrometry (GC-MS), immunoassays, and HPLC with single MS detection (Cadet et al. 2011(Cadet et al. , 2012a)).Considerable progress has also been made in the elucidation of oxidative degradation pathways of isolated DNA and related model compounds (for recent comprehensive reviews, see Gimisis and Cismas ¸2006;Neeley and Essigmann 2006;Pratviel and Meunier 2006;von Sonntag 2006;Cadet et al. 2008Cadet et al. , 2010 Cadet et al. , 2012b;;Dedon 2008;Burrows 2009;Wagner and Cadet 2010).In addition, there is much complementary information on solar-radiation-induced formation of bipyrimidine photoproducts in the DNA of fibroblasts, keratinocytes, and human skin.In particular, the distribution of UVA and UVB photoproducts has been determined, allowing accurate determination of their rates of repair (Cadet et al. 2009(Cadet et al. , 2012c)).
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“Deteriorating effects of UV radiation on DNA include formation of various photoproducts, generation of free radicals and subsequent introduction of strand breaks [3].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [3]
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Oxidative Stress in Cancer Therapy: Friend or Enemy?
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“DNA is the primary target following exposure to stimuli such as ultraviolet (UV) radiation, DNA alkylators, certain environmental carcinogens, oxidative stress and chemotherapeutic drugs (1).”
InfluentialEstrogen-related receptors are targetable ROS sensorsPreprint
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“Excessive ROS can lead to the oxidative damage of macromolecules, in particular nucleic acids (Cadet and Wagner 2013); thus, we next evaluated ROS-induced DNA damage in response to modulation of ERRα and ERRγ activity.”
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“[Addition of a peroxyl radical to an adjacent base is also possible (70).”
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“Contact with such flavorant agents results in elevated level of ROS production and excessive IL-8 secretion in airway epithelium cells, with both mechanisms leading to cell cytotoxicity: oxidative stress is a cause of DNA damage [29].”
BackgroundOxidative Stress and Marine Carotenoids: Application by Using Nanoformulations
Genç, Y., Bardakçı, H., Yücel, Ç., Karatoprak, G. Ş., Akkol, E. K., Barak, T. H., & Sobarzo‐Sánchez, E. (2020) · Marine Drugs · doi:10.3390/md18080423 · Cited by 99
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Next-generation DNA damage sequencing
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Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
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“ROS are destructive to DNA and proteins (11).”
The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
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“The cellular effects of both (1)O2 and HO· are well studied [47,49,54].”
BackgroundOxidative Stress in Poultry: Lessons from the Viral Infections
Rehman, Z. U., Meng, C., Sun, Y., Safdar, A., Pasha, R. H., Munir, M., & Ding, C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5123147 · Cited by 89
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Metadata
- Authors
- Cadet, J., & Wagner, J. R.
- Affiliations
- Université de Sherbrooke (CA)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-02-01
- Volume
- 5
- Issue
- 2
- Pages
- a012559-a012559
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC3552502
- OpenAlex
- W2129637612
- Cited by
- 903
- References
- 139
- Citations by year
- 2026: 55 · 2025: 74 · 2024: 65 · 2023: 77 · 2022: 83 · 2021: 116 · 2020: 105 · 2019: 97 · 2018: 85 · 2017: 45 · 2016: 42 · 2015: 22 · 2014: 32 · 2013: 5
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- DNA base damage, reactive oxygen species, hydroxyl radicals, singlet oxygen, hypochlorous acid, one-electron oxidants, UV-B radiation, UVA, simulated sunlight, DNA repair, interstrand cross-links, intrastrand cross-links, epigenetic regulation, HPLC-MS/MS quantification
- MeSH terms
- Chromatography, High Pressure Liquid, DNA Damage, Nucleotides, Oxidation-Reduction, Mass Spectrometry, Ultraviolet Rays, Reactive Oxygen Species, DNA Adducts
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