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Cited by 244Skin Protection and AgingRedox biology and oxidative stressEffects of Radiation Exposure

Role of reactive oxygen species in ultraviolet-induced photodamage of the skin

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Wei, Min, He, Xin, Liu, Na, Deng, Hui·2024·Cell Division
DOI 10.1186/s13008-024-00107-zPMC PMC10787507
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Abstract

Reactive oxygen species (ROS), such as superoxides (O 2 •−) and hydroxyl groups (OH·), are short-lived molecules containing unpaired electrons. Intracellular ROS are believed to be mainly produced by the mitochondria and NADPH oxidase (NOX) and can be associated with various physiological processes, such as proliferation, cell signaling, and oxygen homeostasis. In recent years, many studies have indicated that ROS play crucial roles in regulating ultraviolet (UV)-induced photodamage of the skin, including exogenous aging, which accounts for 80% of aging. However, to the best of our knowledge, the detailed signaling pathways, especially those related to the mechanisms underlying apoptosis in which ROS are involved have not been reviewed previously. In this review, we elaborate on the biological characteristics of ROS and its role in regulating UV-induced photodamage of the skin.

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  • Salvage-mediated recycling of nucleotides plays a pivotal role in maintaining genomic stability in dermal cells exposed to UV radiation and ROS.

    “In addition to fueling DNA synthesis, salvage-mediated recycling of nucleotides plays a pivotal role in maintaining genomic stability, particularly in dermal cells exposed to extrinsic insults (e.g., UV radiation) and intrinsic stressors (e.g., mitochondrial-derived reactive oxygen species (ROS)) [81,82].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [81]

    The 'DNA damage by ROS' and 'Mitochondrial DNA damage and apoptosis by ROS' sections discuss UV- and ROS-induced DNA damage and DNA excision repair, but do not address whether salvage-mediated nucleotide recycling maintains genomic stability. Searches for nucleotide salvage and recycling found no passage supporting that mechanism. (LLM, conf=0.75)

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Cited by

Sorted by citations

Authors
Wei, M., He, X., Liu, N., & Deng, H.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Capital Medical University (CN)
Corresponding author
Deng, Hui
ORCID
Venue
Cell Division
Publisher
Springer Science and Business Media LLC
Published
2024-01-12
Volume
19
Issue
1
Pages
1-1
ISSN
1747-1028 (ISSN-L)
DOI
10.1186/s13008-024-00107-z
PMC
PMC10787507
OpenAlex
W4390818321
Cited by
244
References
10
Citations by year
2026: 104 · 2025: 111 · 2024: 29
FWCI
19.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Division (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (82273521)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
reactive oxygen species, ultraviolet radiation, photodamage, skin aging, apoptosis, NADPH oxidase, mitochondria, signaling pathways, oxidative stress

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