Synapses and Memory Storage
Open accessAbstract
The synapse is the functional unit of the brain. During the last several decades we have acquired a great deal of information on its structure, molecular components, and physiological function. It is clear that synapses are morphologically and molecularly diverse and that this diversity is recruited to different functions. One of the most intriguing findings is that the size of the synaptic response in not invariant, but can be altered by a variety of homo- and heterosynaptic factors such as past patterns of use or modulatory neurotransmitters. Perhaps the most difficult challenge in neuroscience is to design experiments that reveal how these basic building blocks of the brain are put together and how they are regulated to mediate the information flow through neural circuits that is necessary to produce complex behaviors and store memories. In this review we will focus on studies that attempt to uncover the role of synaptic plasticity in the regulation of whole-animal behavior by learning and memory.
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The late phase of long-term potentiation depends on transcription and translation for de novo gene expression that mediates structural and enduring functional circuitry changes.
“The late phase of LTP is dependent on transcription and translation activity for de novo gene expression that mediates structural and enduring functional circuitry changes139-141.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [140]
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- Authors
- Mayford, M., Siegelbaum, S. A., & Kandel, E. R.
- Affiliations
- Scripps Research Institute (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-04-10
- Volume
- 4
- Issue
- 6
- Pages
- a005751-a005751
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC3367555
- OpenAlex
- W2167916157
- Cited by
- 500
- References
- 12
- Citations by year
- 2026: 13 · 2025: 29 · 2024: 40 · 2023: 25 · 2022: 47 · 2021: 54 · 2020: 36 · 2019: 42 · 2018: 59 · 2017: 44 · 2016: 31 · 2015: 23 · 2014: 26 · 2013: 26 · 2012: 5
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- synapses, memory storage, synaptic plasticity, synaptic diversity, learning and memory, neural circuits
- MeSH terms
- Amygdala, Animals, Fear, Humans, Memory, Neuronal Plasticity, Synapses
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