The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.
Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
Open accessAbstract
Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of β-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of β-catenin in the skin. Chronic activation of β-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of β-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/β-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen–anagen transition.
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“The ability of TERT to enhance Wnt signaling explains how TERT activates bulge stem cells since overexpression of b-catenin in mouse skin causes a very similar stem cell-activation phenotype (150-152).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [150]
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Self-citationAt the Roots of a Never-Ending Cycle
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Moore, K. A., & Lemischka, I. R. (2006) · Science · doi:10.1126/science.1110542 · Cited by 1,589
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317
Capturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283
Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
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Metadata
- Authors
- Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R.
- Affiliations
- University of Michigan (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-05-15
- Volume
- 17
- Issue
- 10
- Pages
- 1219-1224
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC196062
- OpenAlex
- W2170319506
- Cited by
- 263
- References
- 21
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 3 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 14 · 2012: 22
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan (T32GM07863)
- National Cancer Institute (CA87837, CA46592, R01CA085463, CA85463, R01CA087837, P30CA046592)
- National Institute of General Medical Sciences (T 32 GM07863, T32GM007863)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045973)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Dentistry › General Dentistry › dental development and anomalies
- Keywords
- β-catenin signaling, Wnt signaling, hair cycle, anagen induction, hair follicle, keratinocytes, transgenic mice, canonical Wnt pathway
- MeSH terms
- Animals, Cell Differentiation, Cytoskeletal Proteins, Epithelium, Hair, Mice, Transgenic, Signal Transduction, Trans-Activators, Keratinocytes, Hair Follicle, beta Catenin, Mice
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