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Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae

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Matheos, Dina P., Kingsbury, Tami J., Ahsan, U. Salma, Cunningham, Kyle W.·1997·Genes & Development

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Abstract

Ca 2+ signals regulate gene expression in animal and yeast cells through mechanisms involving calcineurin, a protein phosphatase activated by binding Ca 2+ and calmodulin. Tcn1p, also named Crz1p, was identified as a transcription factor in yeast required for the calcineurin-dependent induction of PMC1, PMR1, PMR2A, and FKS2 which confer tolerance to high Ca 2+ , Mn 2+ , Na + , and cell wall damage, respectively. Tcn1p was not required for other calcineurin-dependent processes, such as inhibition of a vacuolar H + /Ca 2+ exchanger and inhibition of a pheromone-stimulated Ca 2+ uptake system, suggesting that Tcn1p functions downstream of calcineurin on a branch of the calcium signaling pathway leading to gene expression. Tcn1p contains three zinc finger motifs at its carboxyl terminus resembling the DNA-binding domains of Zif268, Swi5p, and other transcription factors. When fused to the transcription activation domain of Gal4p, the carboxy terminal domain of Tcn1p directed strong calcineurin-independent expression of PMC1–lacZ and other target genes. The amino-terminal domain of Tcn1p was found to function as a calcineurin-dependent transcription activation domain when fused to the DNA-binding domain of Gal4p. This amino-terminal domain also formed Ca 2+ -dependent and FK506-sensitive interactions with calcineurin in the yeast two-hybrid assay. These findings suggest that Tcn1p functions as a calcineurin-dependent transcription factor. Interestingly, induction of Tcn1p-dependent genes was found to be differentially controlled in response to physiological Ca 2+ signals generated by treatment with mating pheromone and high salt. We propose that different promoters are sensitive to variations in the strength of Ca 2+ signals generated by these stimuli and to effects of other signaling pathways.

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Self-citation

Authors: Matheos, D. P., Kingsbury, T. J., Ahsan, U. S., & Cunningham, K. W.
Affiliations: Johns Hopkins University (US)
ORCID: Matheos, Dina P.
Kingsbury, Tami J.
Cunningham, Kyle W.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1997-12-15
Volume: 11
Issue: 24
Pages: 3445-3458
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.11.24.3445
PMC: PMC316804
OpenAlex: W2080565111
Cited by: 332
References: 80
Citations by year: 2026: 5 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 9
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: March of Dimes Foundation
Chicago Community Trust
Searle Scholars Program
National Institutes of Health
National Institute of General Medical Sciences (GM53082, R01GM053082)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: calcineurin, calcium signaling, transcription factors, zinc finger, transactivation domain, PMR1, FKS2, high salt stress, mating pheromone, Saccharomyces cerevisiae
MeSH terms: Calcium-Transporting ATPases, Amino Acid Sequence, beta-Galactosidase, Binding Sites, Calcium, DNA-Binding Proteins, Fungal Proteins, Glucosyltransferases, Membrane Proteins, Molecular Sequence Data, Pheromones, Saccharomyces cerevisiae, Transcription Factors, Trans-Activators, Gene Expression Regulation, Fungal, Genes, Reporter, Calcineurin, Saccharomyces cerevisiae Proteins, Plasma Membrane Calcium-Transporting ATPases

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Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae

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