Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 2,551

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

IAP family proteins---suppressors of apoptosis

Open access
Deveraux, Q. L., Reed, J. C.·1999·Genes & Development
DOI 10.1101/gad.13.3.239
Open this paper in CoChat — free account

Abstract

Apoptosis is a physiological cell suicide program that is critical for the development and maintenance of healthy tissues.Dysregulation of cell death pathways occur in cancer, autoimmune and immunodeficiency diseases, reperfusion injury after ischemic episodes, and in neurodegenerative disorders.Thus, proteins involved in apoptosis regulation are of intense biological interest and many are attractive therapeutic targets.This review discusses the Inhibitor of Apoptosis (IAP) family of proteins.First discovered in baculoviruses, IAPs were shown to be involved in suppressing the host cell death response to viral infection.Interestingly, ectopic expression of some baculoviral IAPs blocks apoptosis in mammalian cells, suggesting conservation of the cell death program among diverse species and commonalities in the mechanism used by the IAPs to inhibit apoptosis.Although the mechanism used by the IAPs to suppress cell death remains debated, several studies have provided insights into the biochemical functions of these intriguing proteins.Moreover, a variety of reports have suggested an important role for the IAPs in some human diseases.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/gad.13.3.239

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Cited by

Metadata

Authors
Deveraux, Q. L., & Reed, J. C.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
1999-02-01
Volume
13
Issue
3
Pages
239-252
ISSN
0890-9369 (ISSN-L)
DOI
10.1101/gad.13.3.239
OpenAlex
W2167490100
Cited by
2,551
References
2
Type
posted content
Language
en
Open access
diamond

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.