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Transcriptional coactivators PGC-1α and PGC-lβ control overlapping programs required for perinatal maturation of the heart
Open accessAbstract
Oxidative tissues such as heart undergo a dramatic perinatal mitochondrial biogenesis to meet the high-energy demands after birth. PPARγ coactivator-1 (PGC-1) α and β have been implicated in the transcriptional control of cellular energy metabolism. Mice with combined deficiency of PGC-1α and PGC-1β (PGC-1αβ −/− mice) were generated to investigate the convergence of their functions in vivo. The phenotype of PGC-1β −/− mice was minimal under nonstressed conditions, including normal heart function, similar to that of PGC-1α −/− mice generated previously. In striking contrast to the singly deficient PGC-1 lines, PGC-1αβ −/− mice died shortly after birth with small hearts, bradycardia, intermittent heart block, and a markedly reduced cardiac output. Cardiac-specific ablation of the PGC-1β gene on a PGC-1α-deficient background phenocopied the generalized PGC-1αβ −/− mice. The hearts of the PGC-1αβ −/− mice exhibited signatures of a maturational defect including reduced growth, a late fetal arrest in mitochondrial biogenesis, and persistence of a fetal pattern of gene expression. Brown adipose tissue (BAT) of PGC-1αβ −/− mice also exhibited a severe abnormality in function and mitochondrial density. We conclude that PGC-1α and PGC-1β share roles that collectively are necessary for the postnatal metabolic and functional maturation of heart and BAT.
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“Previous work has established that repression of either or both co-activators (PGC-1α or PGC-1β) decreases mitochondrial biogenesis and function, elicits cardiomyopathy and impairs de novo glucose production23-25.”
From Telomere dysfunction induces metabolic and mitochondrial compromise (2011) · cites this paper as [25]
In the citing paper
“The existence of compensation for PGC-1 deficiency by PGC-1␣ and vice versa is evidenced by the phenotype of double PGC-1␣ and PGC-1 muscle-specific knockout mice (62).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [62]
In the citing paper
“PGC-1-null mice (59, 62, 65, 66) display phenotypes similar to, but not identical to, those of PGC-1␣ knockouts, including reduced expression of OXPHOS genes, reduced ATP synthesis, reduced exercise capacity, and impaired thermogenesis (59,62).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [62]
In the citing paper
“These animals display normal mitochondrial biogenesis during development but die early after birth due to failure of perinatal mitochondrial proliferation and consequent cardiac failure (62).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [62]
In the citing paper
“Insulin sensitivity in these animals is reported to be normal.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [62]
In the citing paper
“Lai, 2008 (62) PGC-1␣ and PGC-1 2 60%, heart | muscle-specific KO”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [62]
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Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821
Tei, C., Ling, L. H., Hodge, D. O., Bailey, K. R., Oh, J. K., Rodeheffer, R. J., Tajik, A. J., & Seward, J. B. (1995) · PubMed · Cited by 1,547
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
Finck, B. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27794 · Cited by 1,461
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440
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Identification of the molecular basis of doxorubicin-induced cardiotoxicity
Zhang, S., Liu, X., Bawa‐Khalfe, T., Lu, L., Lyu, Y. L., Liu, L. F., & Yeh, E. T. H. (2012) · Nature Medicine · doi:10.1038/nm.2919 · Cited by 2,007
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.09.019 · Cited by 1,281
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872
Transcriptional integration of mitochondrial biogenesis
Scarpulla, R. C., Vega, R. B., & Kelly, D. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.006 · Cited by 798
Self-citationATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767
Lipidomics for studying metabolism
Han, X. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.98 · Cited by 727
Telomeres: history, health, and hallmarks of aging
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Hock, M. B., & Kralli, A. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163119 · Cited by 626
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Kauppila, T. E. S., Kauppila, J. H. K., & Larsson, N.-G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.017 · Cited by 578
The role of mitochondria in the pathogenesis of type 2 diabetes
Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
Mohrin, M., Shin, J., Liu, Y., Brown, K., Luo, H., Xi, Y., Haynes, C. M., & Chen, D. (2015) · Science · doi:10.1126/science.aaa2361 · Cited by 490
Mitochondrial biogenesis and dynamics in the developing and diseased heart
Dorn, G. W., Vega, R. B., & Kelly, D. P. (2015) · Genes & Development · doi:10.1101/gad.269894.115 · Cited by 470
Self-citationVillena, J. A. (2014) · FEBS Journal · doi:10.1111/febs.13175 · Cited by 413
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Nassir, F., & Ibdah, J. A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058713 · Cited by 369
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Rowe, G. C., Jiang, A., & Arany, Z. P. (2010) · Circulation Research · doi:10.1161/circresaha.110.223818 · Cited by 361
Lu, Q., Zhu, Y., Deng, C., Liang, Z., Chen, J., Chen, Y., Wang, X., Liu, Y., Tian, Y., & Yang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01756-w · Cited by 391
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Lai, L., Leone, T. C., Keller, M. P., Martin, O. J., Broman, A. T., Nigro, J. M., Kapoor, K., Koves, T. R., Stevens, R. D., Ilkayeva, O., et al. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001469 · Cited by 293
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Palomer, X., Salvadó, L., Barroso, E., & Vázquez‐Carrera, M. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.07.150 · Cited by 290
Zechner, C., Lai, L., Zechner, J. F., Geng, T., Yan, Z., Rumsey, J. W., Collia, D., Chen, Z., Wozniak, D. F., Leone, T. C., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.008 · Cited by 274
“We and others have shown that PGC-1a-deficient mice exhibit a mild exercise performance phenotype (Leone et al., 2005; Handschin et al., 2007; Lai et al., 2008).”
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Karamanlidis, G., Nascimben, L., Couper, G. S., Shekar, P., del Monte, F., & Tian, R. (2010) · Circulation Research · doi:10.1161/circresaha.109.212753 · Cited by 258
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Rosca, M. G., & Hoppel, C. L. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9340-0 · Cited by 250
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Papanicolaou, K. N., Kikuchi, R., Ngoh, G. A., Coughlan, K. A., Dominguez, I. M., Stanley, W. C., & Walsh, K. X. (2012) · Circulation Research · doi:10.1161/circresaha.112.274142 · Cited by 223
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Forte, M., Schirone, L., Ameri, P., Basso, C., Catalucci, D., Modica, J., Chimenti, C., Crotti, L., Frati, G., Rubattu, S. D., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15068 · Cited by 227
Martin, O. J., Lai, L., Soundarapandian, M. M., Leone, T. C., Antonio Zorzano, A., Keller, M. P., Attie, A., Muoio, D. M., & Kelly, D. P. (2013) · Circulation Research · doi:10.1161/circresaha.114.302562 · Cited by 218
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Hinton, R. B., & Ware, S. M. (2017) · Circulation Research · doi:10.1161/circresaha.116.308996 · Cited by 215
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Pei, L., & Wallace, D. C. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.018 · Cited by 203
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Ulmer, B. M., Stoehr, A., Schulze, M. L., Patel, S., Gucek, M., Mannhardt, I., Funcke, S., Murphy, E., Eschenhagen, T., & Hansen, A. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.039 · Cited by 183
Scarpulla, R. C. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.10.011 · Cited by 173
Ahuja, P., Zhao, P., Angelis, E., Ruan, H., Korge, P., Olson, A., Wang, Y., Jin, E. S., Jeffrey, F. M., Portman, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38331 · Cited by 157
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Riehle, C., Wende, A. R., Zaha, V. G., Pires, K. M. P., Wayment, B. E., Olsen, C. D., Bugger, H., Buchanan, J., Wang, X., Moreira, A. B., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.243964 · Cited by 159
Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models
Komen, J. C., & Thorburn, D. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12413 · Cited by 149
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Desai, M. S., Mathur, B., Eblimit, Z., Vasquez, H., Taegtmeyer, H., Karpen, S. J., Penny, D. J., Moore, D. D., & Anakk, S. (2016) · Hepatology · doi:10.1002/hep.28890 · Cited by 151
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Moslehi, J. J., DePinho, R. A., & Sahin, E. (2012) · Circulation Research · doi:10.1161/circresaha.111.246868 · Cited by 154
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Sakamoto, T., Matsuura, T. R., Wan, S., Ryba, D. M., Kim, J., Won, K., Lai, L., Petucci, C. J., Petrenko, N. B., Musunuru, K., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316100 · Cited by 146
Self-citationJones, A. W. E., Yao, Z., Vicencio, J. M., Karkucińska‐Więckowska, A., & Szabadkai, G. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.09.009 · Cited by 149
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Zhang, D., Li, Y., Heims-Waldron, D. A., Bezzerides, V. J., Guatimosim, S., Guo, Y., Gu, F., Zhou, P., Lin, Z., Ma, Q., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.311349 · Cited by 131
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Diop, S. B., Bisharat‐Kernizan, J., Birse, R. T., Oldham, S., Ocorr, K. A., & Bodmer, R. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.022 · Cited by 101
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Self-citation
Metadata
- Authors
- Lai, L., Leone, T. C., Zechner, C., Schaeffer, P. J., Kelly, S. M., Flanagan, D. P., Medeiros, D. M., Kovacs, A., & Kelly, D. P.
- Affiliations
- Washington University in St. Louis (US)
- Kansas State University (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-07-15
- Volume
- 22
- Issue
- 14
- Pages
- 1948-1961
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC2492740
- OpenAlex
- W2146878987
- Cited by
- 326
- References
- 59
- Citations by year
- 2026: 15 · 2025: 8 · 2024: 14 · 2023: 18 · 2022: 17 · 2021: 31 · 2020: 16 · 2019: 20 · 2018: 16 · 2017: 14 · 2016: 17 · 2015: 19 · 2014: 18 · 2013: 21 · 2012: 26
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- American Heart Association
- Alvin J. Siteman Cancer Center (CA91842, #P30 CA91842)
- Deutsche Forschungsgemeinschaft
- National Institutes of Health (5p60dk020579-35, DK-052574, DK56341, DK020579, CA91842)
- National Heart, Lung, and Blood Institute (R01HL058427)
- National Cancer Institute (P30CA091842)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK045416, P60-DK-020579, P30DK056341, P30DK052574)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- PGC-1α, PGC-1β, mitochondrial biogenesis, cardiac output, atrioventricular block, brown adipose tissue, fetal gene expression, postnatal heart development, energy metabolism
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Adipose Tissue, Brown, Female, Heart, Male, Mice, Inbred C57BL, Mitochondria, Heart, Transcription Factors, Blotting, Southern, Trans-Activators, Polymerase Chain Reaction, Mice, Knockout, Integrases, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice
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