The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
Abstract
Activated oncogenic signaling is central to the development of nearly all forms of cancer, including the most common class of primary brain tumor, glioma. Research over the last two decades has revealed the particular importance of the Akt pathway, and its molecular antagonist PTEN (phosphatase and tensin homolog), in the process of gliomagenesis. Recent studies have also demonstrated that microRNAs (miRNAs) may be responsible for the modulation of cancer-implicated genes in tumors. Here we report the identification miR-26a as a direct regulator of PTEN expression. We also show that miR-26a is frequently amplified at the DNA level in human glioma, most often in association with monoallelic PTEN loss. Finally, we demonstrate that miR-26a-mediated PTEN repression in a murine glioma model both enhances de novo tumor formation and precludes loss of heterozygosity and the PTEN locus. Our results document a new epigenetic mechanism for PTEN regulation in glioma and further highlight dysregulation of Akt signaling as crucial to the development of these tumors.
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“Finally, the regulated feedback by miR-26a and miR-26b might be important not only in neurons, but for proliferation/differentiation events in general, as both family members have been implicated with differentiation of other cell types, stemness, and cancer (Wong and Tellam 2008;Huse et al. 2009;Kota et al. 2009;Ma et al. 2010).”
From Intronic miR-26b controls neuronal differentiation by repressing its host transcript,ctdsp2 (2012) · cites this paper as Huse et al. 2009
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“Previous miRNA profiling studies, based on miRNA microarrays and PCR arrays, have revealed a number of miRNAs to be altered in gliomas [9], [14]–[16].”
From Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011) · cites this paper as [16]
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Cites
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“Indeed, two large recent studies have further solidified the notion that individual miRNAs impact cellular processes by modestly repressing the levels of numerous proteins (Baek et al. 2008; Selbach et al. 2008).”
BackgroundMicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
Gabriely, G., Wurdinger, T., Kesari, S., Esau, C. C., Burchard, J., Linsley, P. S., & Krichevsky, A. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00479-08 · Cited by 888 · cited 2×
“This discrepancy also raises the possibility that the reported oncogenic effects of miR-21 in glioma cell lines may result from the targeting of other proteins (Chan et al. 2005; Corsten et al. 2007; Zhu et al. 2007, 2008; Gabriely et al. 2008; Papagiannakopoulos et al. 2008).”
BackgroundRegulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
Gil, J., & Peters, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1987 · Cited by 843
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The role of microRNAs in endometriosis and associated reproductive conditions
Ohlsson Teague, E. M. C., Print, C. G., & Hull, M. L. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp034 · Cited by 309
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Saadatpour, L., Fadaee, E., Fadaei, S., Nassiri Mansour, R., Mohammadi, M., Mousavi, S. M., Goodarzi, M., Verdi, J., & Mirzaei, H. (2016) · Cancer Gene Therapy · doi:10.1038/cgt.2016.48 · Cited by 244
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Metadata
- Authors
- Huse, J. T., Brennan, C., Hambardzumyan, D., Wee, B., Pena, J., Rouhanifard, S. H., Sohn-Lee, C., le Sage, C., Agami, R., Tuschl, T., & Holland, E. C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-06-01
- Volume
- 23
- Issue
- 11
- Pages
- 1327-1337
- ISSN
- 0890-9369
- 1549-5477
- Cited by
- 431
- References
- 7
- Language
- en
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