The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Open accessAbstract
In mammals, circadian oscillators exist not only in the suprachiasmatic nucleus, which harbors the central pacemaker, but also in most peripheral tissues. It is believed that the SCN clock entrains the phase of peripheral clocks via chemical cues, such as rhythmically secreted hormones. Here we show that temporal feeding restriction under light–dark or dark–dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving the phase of cyclic gene expression in the SCN unaffected. Hence, changes in metabolism can lead to an uncoupling of peripheral oscillators from the central pacemaker. Sudden large changes in feeding time, similar to abrupt changes in the photoperiod, reset the phase of rhythmic gene expression gradually and are thus likely to act through a clock-dependent mechanism. Food-induced phase resetting proceeds faster in liver than in kidney, heart, or pancreas, but after 1 wk of daytime feeding, the phases of circadian gene expression are similar in all examined peripheral tissues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“However, food intake during the biological night can uncouple peripheral clocks from the SCN (31, 32), confirming that meal timing acts as a zeitgeber for circadian clocks.”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [32]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn the citing paper
“In nocturnal rodents, feeding during the daytime hours for a week completely altered the phase of the circadian expression of clock and clock-controlled genes in the peripheral tissues [261,262].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [262]
In the citing paper
“Exogenous, behavioral time cues associated with externally imposed schedules thus have the capacity to drive endogenous rhythmicity in metabolism, likely by impacting on peripheral oscillators (17, 18) and dissociating them from the rhythm of the central SCN pacemaker.”
From Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism (2018) · cites this paper as [17]
In the citing paper
“A few years later it became clear that the feeding/fasting cycle is the main Zeitgeber in terms of the synchronization of these so-called peripheral clocks [6].”
From Circadian control of glucose metabolism (2014) · cites this paper as [6]
In the citing paper
“In animals, timed feeding is a strong resetting cue for peripheral clocks (51,52).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [51]
In the citing paper
“Feeding rodents only during the rest phase—as similarly occurs during night work when they eat during their night shift—can phase shift peripheral oscillators in the liver, pancreas, kidney, and heart while it has no effect on the phase of the SCN (Damiola et al., 2000; Stokkan et al., 2001).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Damiola et al., 2000
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Self-citationRoles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Self-citationTransplanted Suprachiasmatic Nucleus Determines Circadian Period
Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853
Sleep Homeostasis and Models of Sleep Regulation
Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,546
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402
Neural regulation of circadian rhythms.
Rusak, B., & Zucker, I. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.449 · Cited by 1,402
Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367
Flagged first, then by citations
Cited by
Sorted by citations
Items 1,001–1,014 of 1,014
Circadian clock-controlled drug metabolism and transport
Zhao, M., Xing, H., Chen, M., Dong, D., & Wu, B. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1672120 · Cited by 37
Caloric restriction effects on liver mTOR signaling are time-of-day dependent
Tulsian, R., Velingkaar, N., & Kondratov, R. (2018) · Aging · doi:10.18632/aging.101498 · Cited by 36
The Liver in the Eyes of a Chronobiologist
Zwighaft, Z., Reinke, H., & Asher, G. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416633552 · Cited by 29
The circadian clock control of adipose tissue physiology and metabolism
Lekkas, D., & Paschos, G. K. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.05.001 · Cited by 26
The Health-Promoting Effects and the Mechanism of Intermittent Fasting
Liu, S., Zeng, M., Wan, W., Huang, M., Li, X., Xie, Z., Wang, S., & Cai, Y. (2023) · Journal of Diabetes Research · doi:10.1155/2023/4038546 · Cited by 27
The real-world association between digital markers of circadian disruption and mental health risks
Lee, M. P., Kim, D. W., Fang, Y., Kim, R., Bohnert, A. S. B., Sen, S., & Forger, D. B. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01348-6 · Cited by 29
Physical activity, and not fat mass is a primary predictor of circadian parameters in young men
Tranel, H. R., Schroder, E. A., England, J., Black, W. S., Bush, H., Hughes, M. E., Esser, K. A., & Clasey, J. L. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1043011 · Cited by 22
Feeding Time Entrains the Olfactory Bulb Circadian Clock in Anosmic PER2:LUC Mice
Pavlovski, I., Evans, J. A., & Mistlberger, R. E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.10.009 · Cited by 20
Palm, D., Uzoni, A., Simon, F., Fischer, M., Coogan, A., Tucha, O., Thome, J., & Faltraco, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.007 · Cited by 20
Metabolism as an integral cog in the mammalian circadian clockwork
Gamble, K. L., & Young, M. E. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.786672 · Cited by 18
Li, Y., Lu, L., & Androulakis, I. P. (2024) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2023.08.005 · Cited by 17
Differential responses of peripheral circadian clocks to a short-term feeding stimulus
Wu, T., Fu, O., Yao, L., Sun, L., ZhuGe, F., & Fu, Z. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1844-0 · Cited by 16
Anatomy of the Mammalian Circadian System
Gooley, J. J., & Saper, C. B. (2017) · Principles and Practice of Sleep Medicine · doi:10.1016/b978-0-323-24288-2.00033-7 · Cited by 9
Granero, N., Mancinetti, F., Mecocci, P., & Boccardi, V. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103416
Metadata
- Authors
- Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U.
- Affiliations
- University of Geneva (CH)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-12-01
- Volume
- 14
- Issue
- 23
- Pages
- 2950-2961
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC317100
- OpenAlex
- W2164628441
- Cited by
- 2,394
- References
- 62
- Citations by year
- 2026: 78 · 2025: 116 · 2024: 112 · 2023: 98 · 2022: 125 · 2021: 129 · 2020: 146 · 2019: 111 · 2018: 124 · 2017: 108 · 2016: 112 · 2015: 116 · 2014: 102 · 2013: 103 · 2012: 97
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Louis-Jeantet Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (47314)
- Bonizzi-Theler Stiftung
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- circadian clock, feed restriction, suprachiasmatic nucleus, peripheral circadian oscillators, phase resetting, circadian gene expression, photoperiod, liver, kidney, heart, pancreas
- MeSH terms
- Animals, Aryl Hydrocarbon Hydroxylases, Biological Clocks, Body Temperature, Circadian Rhythm, Cytochrome P-450 Enzyme System, DNA-Binding Proteins, Eye Proteins, Feeding Behavior, Flavoproteins, Food, Food Deprivation, Mixed Function Oxygenases, Kinetics, Liver, Neurons, Nuclear Proteins, Proteins, Suprachiasmatic Nucleus, Transcription Factors, Photoreceptor Cells, Invertebrate, Receptors, Cytoplasmic and Nuclear, Cell Cycle Proteins, Drosophila Proteins, Receptors, G-Protein-Coupled, Mice, Cryptochromes, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1, Cytochrome P-450 CYP2A6
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
