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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Open accessAbstract
In mammals, circadian oscillators exist not only in the suprachiasmatic nucleus, which harbors the central pacemaker, but also in most peripheral tissues. It is believed that the SCN clock entrains the phase of peripheral clocks via chemical cues, such as rhythmically secreted hormones. Here we show that temporal feeding restriction under light–dark or dark–dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving the phase of cyclic gene expression in the SCN unaffected. Hence, changes in metabolism can lead to an uncoupling of peripheral oscillators from the central pacemaker. Sudden large changes in feeding time, similar to abrupt changes in the photoperiod, reset the phase of rhythmic gene expression gradually and are thus likely to act through a clock-dependent mechanism. Food-induced phase resetting proceeds faster in liver than in kidney, heart, or pancreas, but after 1 wk of daytime feeding, the phases of circadian gene expression are similar in all examined peripheral tissues.
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In the citing paper
“However, food intake during the biological night can uncouple peripheral clocks from the SCN (31, 32), confirming that meal timing acts as a zeitgeber for circadian clocks.”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [32]
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“In nocturnal rodents, feeding during the daytime hours for a week completely altered the phase of the circadian expression of clock and clock-controlled genes in the peripheral tissues [261,262].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [262]
In the citing paper
“Exogenous, behavioral time cues associated with externally imposed schedules thus have the capacity to drive endogenous rhythmicity in metabolism, likely by impacting on peripheral oscillators (17, 18) and dissociating them from the rhythm of the central SCN pacemaker.”
From Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism (2018) · cites this paper as [17]
In the citing paper
“A few years later it became clear that the feeding/fasting cycle is the main Zeitgeber in terms of the synchronization of these so-called peripheral clocks [6].”
From Circadian control of glucose metabolism (2014) · cites this paper as [6]
In the citing paper
“In animals, timed feeding is a strong resetting cue for peripheral clocks (51,52).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [51]
In the citing paper
“Feeding rodents only during the rest phase—as similarly occurs during night work when they eat during their night shift—can phase shift peripheral oscillators in the liver, pancreas, kidney, and heart while it has no effect on the phase of the SCN (Damiola et al., 2000; Stokkan et al., 2001).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Damiola et al., 2000
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Citations
Cites
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Self-citationRoles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Self-citationTransplanted Suprachiasmatic Nucleus Determines Circadian Period
Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853
Sleep Homeostasis and Models of Sleep Regulation
Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,546
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402
Neural regulation of circadian rhythms.
Rusak, B., & Zucker, I. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.449 · Cited by 1,402
Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367
Cited by
Sorted by citations
Items 201–300 of 1,014
Genetic analysis of the circadian system in Drosophila melanogaster and mammals
Stanewsky, R. (2002) · Journal of Neurobiology · doi:10.1002/neu.10164 · Cited by 220
Almoosawi, S., Vingeliene, S., Karagounis, L. G., & Pot, G. K. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000306 · Cited by 218
Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism
Krishnaiah, S., Wu, G., Altman, B. J., Growe, J., Rhoades, S. D., Coldren, F., Venkataraman, A., Olarerin-George, A. O., Francey, L. J., Mukherjee, S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.019 · Cited by 211
Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation
Regmi, P., & Heilbronn, L. K. (2020) · iScience · doi:10.1016/j.isci.2020.101161 · Cited by 232
Glucocorticoids as Entraining Signals for Peripheral Circadian Oscillators
Pezük, P., Mohawk, J. A., Wang, L. A., & Menaker, M. (2012) · Endocrinology · doi:10.1210/en.2012-1486 · Cited by 227
Moreno, C. R. D. C., Marqueze, E. C., Sargent, C., Wright, K. P., Ferguson, S. A., & Tucker, P. (2019) · Industrial Health · doi:10.2486/indhealth.sw-1 · Cited by 246
O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination
Li, M., Ruan, H., Hughes, M. E., Lee, J.-S., Singh, J. P., Jones, S. P., Nitabach, M. N., & Yang, X. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.015 · Cited by 225
Bray, M. S., & Young, M. E. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00277.x · Cited by 213
The impact of the circadian timing system on cardiovascular and metabolic function
Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215
Young, M. E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00582.2005 · Cited by 218
Circadian Rhythms, the Molecular Clock, and Skeletal Muscle
Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211
Mendoza, J., Graff, C., Dardente, H., Pévet, P., & Challet, É. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4397-04.2005 · Cited by 215
Schrem, H., Klempnauer, J. L., & Borlak, J. T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.5 · Cited by 210
Circadian regulation of metabolism
Bailey, S. M., Udoh, U. S., & Young, M. E. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0200 · Cited by 219
Lack of Food Anticipation in Per2 Mutant Mice
Feillet, C. A., Ripperger, J. A., Magnone, M. C., Dulloo, A. G., Albrecht, U., & Challet, É. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.053 · Cited by 208
The energy hypothesis of sleep revisited
Scharf, M. T., Naidoo, N. N., Zimmerman, J. E., & Pack, A. I. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.08.003 · Cited by 217
Molecular machinery of the circadian clock in mammals
Okamura, H., Yamaguchi, S., & Yagita, K. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0572-5 · Cited by 206
The intrinsic circadian clock within the cardiomyocyte
Durgan, D. J., Hotze, M. A., Tomlin, T. M., Egbejimi, O., Graveleau, C., Abel, E. D., Shaw, C. A., Bray, M. S., Hardin, P. E., & Young, M. E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00406.2005 · Cited by 210
Mieda, M., Williams, S. C., Sinton, C. M., Richardson, J. A., Sakurai, T., & Yanagisawa, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3171-04.2004 · Cited by 212
The circadian rhythm of body temperature
Refinetti, R. (2009) · Frontiers in bioscience · doi:10.2741/3634 · Cited by 212
mTOR signaling regulates central and peripheral circadian clock function
Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R., & Liu, A. C. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007369 · Cited by 209
Changing the dosing schedule minimizes the disruptive effects of interferon on clock function
Ohdo, S., Koyanagi, S., Suyama, H., Higuchi, S., & Aramaki, H. (2001) · Nature Medicine · doi:10.1038/85507 · Cited by 205
Depner, C. M., Melanson, E. L., Eckel, R. H., Snell-Bergeon, J. K., Perreault, L., Bergman, B. C., Higgins, J. A., Guerin, M. K., Stothard, E. R., Morton, S. J., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.01.069 · Cited by 203
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Sato, S., Dyar, K. A., Treebak, J. T., Jepsen, S. L., Ehrlich, A. M., Ashcroft, S. P., Trost, K., Kunzke, T., Prade, V. M., Small, L., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.016 · Cited by 203
Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice
Bray, M. S., Ratcliffe, W. F., Grenett, M. H., Brewer, R. A., Gamble, K. L., & Young, M. E. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.137 · Cited by 213
Circadian Etiology of Type 2 Diabetes Mellitus
Javeed, N., & Matveyenko, A. V. (2018) · Physiology · doi:10.1152/physiol.00003.2018 · Cited by 219
Effects of light and food schedules on liver and tumor molecular clocks in mice
Filipski, E., Innominato, P. F., Wu, M., Li, X.-M., Iacobelli, S., Xian, L.-J., & Levi, F. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji083 · Cited by 200
Tahara, Y., & Shibata, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.049 · Cited by 198
Nutrients, Clock Genes, and Chrononutrition
Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198
Peschke, E., Frese, T., Chankiewitz, E., Peschke, D., Preiß, U., Schneyer, U., Spessert, R., & Mühlbauer, E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00287.x · Cited by 197
Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199
Circadian disruption and metabolic disease: Findings from animal models
Arble, D. M., Ramsey, K. M., Bass, J., & Turek, F. W. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.08.003 · Cited by 192
Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism
Choi, H., Rao, M. C., & Chang, E. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00452-2 · Cited by 192
Cailotto, C., La Fleur, S. E., Van Heijningen, C., Wortel, J., Kalsbeek, A., Feenstra, M., Pévet, P., & Buijs, R. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04439.x · Cited by 191
Schroeder, A., & Colwell, C. S. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.09.002 · Cited by 201
Weger, B. D., Gobet, C., David, F. P. A., Atger, F., Martín, E., Phillips, N. E., Charpagne, A., Weger, M., Naef, F., & Gachon, F. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015803118 · Cited by 195
Cretenet, G., Clech, M. L., & Gachon, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.002 · Cited by 187
Light Regulates the Cell Cycle in Zebrafish
Dekens, M. P. S., Santoriello, C., Vallone, D., Grassi, G., Whitmore, D., & Foulkes, N. S. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.022 · Cited by 187
Circadian rhythms in the fetus
Serón-Ferré, M., Mendez, N., Abarzua-Catalan, L., Vilches, N., Valenzuela, F. J., Reynolds, H. E., Llanos, A. J., Rojas, A., Valenzuela, G. J., & Torres-Farfan, C. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.039 · Cited by 186
Circadian endocrine rhythms: the hypothalamic–pituitary–adrenal axis and its actions
Nicolaides, N. C., Charmandari, E., Chrousos, G. P., & Kino, T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12464 · Cited by 183
Reduced food anticipatory activity in genetically orexin (hypocretin) neuron‐ablated mice
Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T., & Shibata, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03749.x · Cited by 184
The circadian cycle: daily rhythms from behaviour to genes
Merrow, M. W., Spoelstra, K., & Roenneberg, T. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400541 · Cited by 183
Circadian regulation of lipid metabolism
Gooley, J. J. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000288 · Cited by 194
Nonaka, H., Emoto, N., Ikeda, K., Fukuya, H., Rohman, M. S., Raharjo, S. B., Yagita, K., Okamura, H., & Yokoyama, M. (2001) · Circulation · doi:10.1161/hc4001.098048 · Cited by 183
The Circadian Clock Interacts with Metabolic Physiology to Influence Reproductive Fitness
Xu, K., DiAngelo, J. R., Hughes, M. E., Hogenesch, J. B., & Sehgal, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.001 · Cited by 187
Davies, W. I. L., Tamai, K., Zheng, L., Fu, J. K., Rihel, J., Foster, F., Whitmore, D., & Hankins, M. W. (2015) · Genome Research · doi:10.1101/gr.189886.115 · Cited by 187
Is the food‐entrainable circadian oscillator in the digestive system?
Davidson, A. J., Poole, A. S., Yamazaki, S., & Menaker, M. (2003) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2003.00005.x · Cited by 180
Guo, H., Brewer, J. M., Lehman, M. N., & Bittman, E. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4676-05.2006 · Cited by 180
Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer
Gauger, M. A., & Sancar, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1119 · Cited by 185
Izumo, M., Pejchal, M., Schook, A. C., Lange, R. P., Walisser, J. A., Sato, T., Wang, X., Bradfield, C. A., & Takahashi, J. S. (2014) · eLife · doi:10.7554/elife.04617 · Cited by 184
Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications
Gnocchi, D., & Bruscalupi, G. (2017) · Biology · doi:10.3390/biology6010010 · Cited by 193
The Network of Time: Understanding the Molecular Circadian System
Roenneberg, T., & Merrow, M. W. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00124-6 · Cited by 184
Landry, G. J., Simon, M. M., Webb, I. C., & Mistlberger, R. E. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00874.2005 · Cited by 179
Mammalian circadian signaling networks and therapeutic targets
Liu, A. C., Lewis, W. G., & Kay, S. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.37 · Cited by 184
Circadian metabolism in the light of evolution
Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178
Amir, S., Lamont, E. W., Robinson, B., & Stewart, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4488-03.2004 · Cited by 179
Mukherji, A., Kobiita, A., Damara, M., Misra, N., Méziane, H., Champy, M., & Chambon, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519807112 · Cited by 185
Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells
Silver, A. C., Arjona, A., Hughes, M. E., Nitabach, M. N., & Fikrig, E. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.001 · Cited by 181
The intestinal clock drives the microbiome to maintain gastrointestinal homeostasis
Heddes, M., Altaha, B., Niu, Y., Reitmeier, S., Kleigrewe, K., Haller, D., & Kießling, S. (2022) · Nature Communications · doi:10.1038/s41467-022-33609-x · Cited by 183
Temperature Regulates Transcription in the Zebrafish Circadian Clock
Lahiri, K., Vallone, D., Gondi, S. B., Santoriello, C., Dickmeis, T., & Foulkes, N. S. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030351 · Cited by 177
Skene, D. J., Skornyakov, E., Chowdhury, N. R., Gajula, R. P., Middleton, B., Satterfield, B. C., Porter, K. I., Van Dongen, H. P. A., & Gaddameedhi, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801183115 · Cited by 176
Developmental and reproductive performance in circadian mutant mice
Dolatshad, H., Campbell, E. A., O’Hara, L., Maywood, E. S., Hastings, M. H., & Johnson, M. H. (2005) · Human Reproduction · doi:10.1093/humrep/dei313 · Cited by 176
Rev-erb-α: an integrator of circadian rhythms and metabolism
Duez, H., & Staels, B. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00570.2009 · Cited by 185
Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance
Pando, M. P., Morse, D., Cermakian, N., & Sassone‐Corsi, P. (2002) · Cell · doi:10.1016/s0092-8674(02)00803-6 · Cited by 180
Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism
Frazier, K., & Chang, E. B. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.08.013 · Cited by 171
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types
Guan, D., Xiong, Y., Trinh, T. M., Xiao, Y., Hu, W., Jiang, C., Dierickx, P., Jang, C., Rabinowitz, J. D., & Lazar, M. A. (2020) · Science · doi:10.1126/science.aba8984 · Cited by 178
Forebrain oscillators ticking with different clock hands
Feillet, C. A., Mendoza, J., Albrecht, U., Pévet, P., & Challet, É. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.09.010 · Cited by 173
Mechanisms of Communication in the Mammalian Circadian Timing System
Astiz, M., Heyde, I., & Oster, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020343 · Cited by 180
Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease
Saran, A., Dave, S., & Zarrinpar, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.050 · Cited by 179
Endocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170
Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system
Davidson, A. J., Castanon‐Cervantes, O., Leise, T. L., Molyneux, P. C., & Harrington, M. E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06534.x · Cited by 171
Molecular Interactions Between Components of the Circadian Clock and the Immune System
Hergenhan, S. M., Holtkamp, S., & Scheiermann, C. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.044 · Cited by 178
Greenwell, B. J., Trott, A. J., Beytebiere, J. R., Pao, S., Bosley, A. M., Beach, E., Finegan, P., Hernandez, C., & Menet, J. S. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.064 · Cited by 168
Bmal1 integrates mitochondrial metabolism and macrophage activation
Alexander, R., Liou, Y.-H., Knudsen, N. H., Starost, K. A., Xu, C., Hyde, A. L., Liu, S., Jacobi, D., Liao, N., & Lee, C. (2020) · eLife · doi:10.7554/elife.54090 · Cited by 172
Clock Genes and Clock-Controlled Genes in the Regulation of Metabolic Rhythms
Mazzoccoli, G., Pazienza, V., & Vinciguerra, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.658127 · Cited by 173
Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon
Peschke, E., Bähr, I., & Mühlbauer, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14046981 · Cited by 173
The orphan receptor Rev-erb α gene is a target of the circadian clock pacemaker
Triqueneaux, G., Thénot, S., Kakizawa, T., Antoch, M. P., Safi, R., Takahashi, J. S., Delaunay, F., & Laudet, V. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01554 · Cited by 174
Nakamura, T. J., Moriya, T., Inoue, S., Shimazoe, T., Watanabe, S., Ebihara, S., & Shinohara, K. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20677 · Cited by 165
Alterations of the Circadian Clock in the Heart by Streptozotocin-induced Diabetes
Young, M. E., Wilson, C. R., Razeghi, P., Guthrie, P. H., & Taegtmeyer, H. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1504 · Cited by 167
Interconnections between circadian clocks and metabolism
Guan, D., & Lazar, M. A. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148278 · Cited by 173
Invited Review: Regulation of mammalian circadian clock genes
Albrecht, U. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00759.2001 · Cited by 159
Circadian adaptations to meal timing: neuroendocrine mechanisms
Patton, D. F., & Mistlberger, R. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00185 · Cited by 176
Castellanos, A., Mendoza, J., & Escobar, C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.064 · Cited by 170
Lipid metabolism around the body clocks
Petrenko, V., Sinturel, F., Riezman, H., & Dibner, C. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101235 · Cited by 171
AMPK at the crossroads of circadian clocks and metabolism
Jordan, S. D., & Lamia, K. A. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.017 · Cited by 168
Salgado‐Delgado, R., Saderi, N., Basualdo, M. D. C., Guerrero‐Vargas, N. N., Escobar, C., & Buijs, R. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060052 · Cited by 164
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Metadata
- Authors
- Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U.
- Affiliations
- University of Geneva (CH)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-12-01
- Volume
- 14
- Issue
- 23
- Pages
- 2950-2961
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC317100
- OpenAlex
- W2164628441
- Cited by
- 2,394
- References
- 62
- Citations by year
- 2026: 78 · 2025: 116 · 2024: 112 · 2023: 98 · 2022: 125 · 2021: 129 · 2020: 146 · 2019: 111 · 2018: 124 · 2017: 108 · 2016: 112 · 2015: 116 · 2014: 102 · 2013: 103 · 2012: 97
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Louis-Jeantet Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (47314)
- Bonizzi-Theler Stiftung
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- circadian clock, feed restriction, suprachiasmatic nucleus, peripheral circadian oscillators, phase resetting, circadian gene expression, photoperiod, liver, kidney, heart, pancreas
- MeSH terms
- Animals, Aryl Hydrocarbon Hydroxylases, Biological Clocks, Body Temperature, Circadian Rhythm, Cytochrome P-450 Enzyme System, DNA-Binding Proteins, Eye Proteins, Feeding Behavior, Flavoproteins, Food, Food Deprivation, Mixed Function Oxygenases, Kinetics, Liver, Neurons, Nuclear Proteins, Proteins, Suprachiasmatic Nucleus, Transcription Factors, Photoreceptor Cells, Invertebrate, Receptors, Cytoplasmic and Nuclear, Cell Cycle Proteins, Drosophila Proteins, Receptors, G-Protein-Coupled, Mice, Cryptochromes, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1, Cytochrome P-450 CYP2A6
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