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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Open accessAbstract
In mammals, circadian oscillators exist not only in the suprachiasmatic nucleus, which harbors the central pacemaker, but also in most peripheral tissues. It is believed that the SCN clock entrains the phase of peripheral clocks via chemical cues, such as rhythmically secreted hormones. Here we show that temporal feeding restriction under light–dark or dark–dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving the phase of cyclic gene expression in the SCN unaffected. Hence, changes in metabolism can lead to an uncoupling of peripheral oscillators from the central pacemaker. Sudden large changes in feeding time, similar to abrupt changes in the photoperiod, reset the phase of rhythmic gene expression gradually and are thus likely to act through a clock-dependent mechanism. Food-induced phase resetting proceeds faster in liver than in kidney, heart, or pancreas, but after 1 wk of daytime feeding, the phases of circadian gene expression are similar in all examined peripheral tissues.
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In the citing paper
“However, food intake during the biological night can uncouple peripheral clocks from the SCN (31, 32), confirming that meal timing acts as a zeitgeber for circadian clocks.”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [32]
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“In nocturnal rodents, feeding during the daytime hours for a week completely altered the phase of the circadian expression of clock and clock-controlled genes in the peripheral tissues [261,262].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [262]
In the citing paper
“Exogenous, behavioral time cues associated with externally imposed schedules thus have the capacity to drive endogenous rhythmicity in metabolism, likely by impacting on peripheral oscillators (17, 18) and dissociating them from the rhythm of the central SCN pacemaker.”
From Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism (2018) · cites this paper as [17]
In the citing paper
“A few years later it became clear that the feeding/fasting cycle is the main Zeitgeber in terms of the synchronization of these so-called peripheral clocks [6].”
From Circadian control of glucose metabolism (2014) · cites this paper as [6]
In the citing paper
“In animals, timed feeding is a strong resetting cue for peripheral clocks (51,52).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [51]
In the citing paper
“Feeding rodents only during the rest phase—as similarly occurs during night work when they eat during their night shift—can phase shift peripheral oscillators in the liver, pancreas, kidney, and heart while it has no effect on the phase of the SCN (Damiola et al., 2000; Stokkan et al., 2001).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Damiola et al., 2000
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Citations
Cites
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Self-citationRoles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Self-citationTransplanted Suprachiasmatic Nucleus Determines Circadian Period
Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853
Sleep Homeostasis and Models of Sleep Regulation
Borb, A. A., & Achermann, P. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000894 · Cited by 1,546
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402
Neural regulation of circadian rhythms.
Rusak, B., & Zucker, I. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.449 · Cited by 1,402
Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367
Cited by
Sorted by citations
Items 501–600 of 1,014
Functional D-box sequences reset the circadian clock and drive mRNA rhythms
Yoshitane, H., Asano, Y., Sagami, A., Sakai, S., Suzuki, Y., Okamura, H., Iwasaki, W., Ozaki, H., & Fukada, Y. (2019) · Communications Biology · doi:10.1038/s42003-019-0522-3 · Cited by 98
Metabolic and chemical architecture of the mammalian circadian clock
Laothamatas, I., Rasmussen, E. S., Green, C. B., & Takahashi, J. S. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.014 · Cited by 102
Postnatal ontogenesis of the circadian clock within the rat liver
Sládek, M., Jindráková, Z., Bendová, Z., & Sumová, A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00184.2006 · Cited by 96
Chrono-biology, Chrono-pharmacology and Chrono-nutrition
Tahara, Y., & Shibata, S. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13r06cr · Cited by 94
AMP-activated protein kinase as a key molecular link between metabolism and clockwork
Lee, Y., & Kim, E. K. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.65 · Cited by 100
Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice
Kolbe, I., Leinweber, B., Brandenburger, M., & Oster, H. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.012 · Cited by 91
The circadian clock and metabolic homeostasis: entangled networks
de Assis, L. V. M., & Oster, H. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03800-2 · Cited by 104
Regulation and function of insulin and insulin-like growth factor receptor signalling
Choi, E., Duan, C., & Bai, X. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00826-3 · Cited by 102
Levine, J. D., Funes, P., Dowse, H. B., & Hall, J. C. (2002) · BMC Neuroscience · doi:10.1186/1471-2202-3-5 · Cited by 94
Lamont, E. W., Diaz, L. R., Barry-Shaw, J., Stewart, J., & Amir, S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.029 · Cited by 94
Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health
Plano, S. A., Casiraghi, L. P., Moro, P. G., Paladino, N., Golombek, D. A., & Chiesa, J. J. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00558 · Cited by 99
Time restricted eating: A dietary strategy to prevent and treat metabolic disturbances
Schuppelius, B., Peters, B., Ottawa, A., & Pivovarova-Ramich, O. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.683140 · Cited by 93
Circadian blueprint of metabolic pathways in the brain
Greco, C. M., & Sassone‐Corsi, P. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0096-y · Cited by 94
Rumanova, V. S., Okuliarová, M., & Zeman, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155478 · Cited by 100
Cell maturation: Hallmarks, triggers, and manipulation
Alvarez‐Dominguez, J. R., & Melton, D. A. (2022) · Cell · doi:10.1016/j.cell.2021.12.012 · Cited by 96
Ripperger, J. A., Jud, C., & Albrecht, U. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.027 · Cited by 98
van der Veen, D. R., Minh, N. L., Gos, P., Arnerić, M., Gerkema, M. P., & Schibler, U. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507825103 · Cited by 93
Self-citationPeripheral oscillators: the driving force for food‐anticipatory activity
Escobar, C., Cailotto, C., Castellanos, A., Delgado, R. S., & Buijs, R. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06972.x · Cited by 96
“Feeding time” for the brain: A matter of clocks
Feillet, C. A., Albrecht, U., & Challet, É. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2007.05.002 · Cited by 96
The Mammalian Circadian Timing System: Synchronization of Peripheral ClocksPreprint
Saini, C., Suter, D. M., Liani, A., Gos, P., & Schibler, U. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010918 · Cited by 93
Self-citationSREBP-1 as a Transcriptional Integrator of Circadian and Nutritional Cues in the Liver
Brewer, M., Lange, D., Baler, R., & Anzulovich, A. C. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405275952 · Cited by 90
Circadian rhythms have broad implications for understanding brain and behavior
Silver, R., & Kriegsfeld, L. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12593 · Cited by 96
Circadian desynchrony and glucose metabolism
Speksnijder, E. M., Bisschop, P. H. L. T., Siegelaar, S. E., Stenvers, D. J., & Kalsbeek, A. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12956 · Cited by 100
Oishi, K., Miyazaki, K., & Ishida, N. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02427-0 · Cited by 91
The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond
Berenbaum, F., & Meng, Q. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.93 · Cited by 91
The Transcriptional Repressor STRA13 Regulates a Subset of Peripheral Circadian Outputs
Gréchez‐Cassiau, A., Panda, S., Lacoche, S., Teboul, M., Azmi, S., Laudet, V., Hogenesch, J. B., Taneja, R., & Delaunay, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305369200 · Cited by 91
The Circadian Timing System: Making Sense of day/night gene expression
Richter, H. G., Torres‐Farfan, C., Rojas-Garcia, P. P., Campino, C., Torrealba, F., & Serón‐Ferré, M. (2004) · Biological Research · doi:10.4067/s0716-97602004000100003 · Cited by 94
Shimizu, H., Hanzawa, F., Kim, D., Sun, S., Laurent, T., Umeki, M., Ikeda, S., Mochizuki, S., & Oda, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206669 · Cited by 92
Mazzoccoli, G., Vinciguerra, M., Carbone, A., & Relógio, A. (2020) · Pathogens · doi:10.3390/pathogens9020083 · Cited by 91
Circadian Synchrony: Sleep, Nutrition, and Physical Activity
Healy, K. L., Morris, A. R., & Liu, A. C. (2021) · Frontiers in Network Physiology · doi:10.3389/fnetp.2021.732243 · Cited by 98
James, F. O., Boivin, D. B., Charbonneau, S., Bélanger, V., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701800736 · Cited by 90
The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs
Shibata, S., Tahara, Y., & Hirao, A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.06.003 · Cited by 91
A daily palatable meal without food deprivation entrains the suprachiasmatic nucleus of rats
Mendoza, J., Castellanos, A., & Escobar, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04461.x · Cited by 90
Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription
Chaves, I., van der Horst, G. T. J., Schellevis, R. D., Nijman, R., Koerkamp, M. J. A. G., Holstege, F. C. P., Smidt, M. P., & Hoekman, M. F. M. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.018 · Cited by 90
Srour, B., Plancoulaine, S., Andreeva, V. A., Fassier, P., Julia, C., Galan, P., Herçberg, S., Deschasaux, M., Latino‐Martel, P., & Touvier, M. (2018) · International Journal of Cancer · doi:10.1002/ijc.31584 · Cited by 93
The malaria parasite has an intrinsic clock
Rijo‐Ferreira, F., Acosta-Rodríguez, V. A., Abel, J. H., Kornblum, I., Bento, I., Kilaru, G., Klerman, E. B., Mota, M. M., & Takahashi, J. S. (2020) · Science · doi:10.1126/science.aba2658 · Cited by 89
Complex physiology and clinical implications of time-restricted eating
Petersen, M. C., Gallop, M. R., Ramos, S. F., Zarrinpar, A., Broussard, J. L., Chondronikola, M., Chaix, A., & Klein, S. (2022) · Physiological Reviews · doi:10.1152/physrev.00006.2022 · Cited by 94
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses
Schurhoff, N. A., & Toborek, M. J. (2023) · Molecular Brain · doi:10.1186/s13041-023-00997-0 · Cited by 95
A day in the life of the meta-organism: diurnal rhythms of the intestinal microbiome and its host
Thaiss, C. A., Zeevi, D., Levy, M., Segal, E., & Elinav, E. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1016690 · Cited by 90
The New Field of Neuroskeletal Biology
Patel, M. S., & Elefteriou, F. (2007) · Calcified Tissue International · doi:10.1007/s00223-007-9015-3 · Cited by 89
Expectancy for food or expectancy for chocolate reveals timing systems for metabolism and reward
Castellanos, A., Salgado‐Delgado, R., Rodríguez, K., Buijs, R. M., & Escobar, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.001 · Cited by 92
Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress
Agorastos, A., Nicolaides, N. C., Bozikas, V. P., Chrousos, G. P., & Pervanidou, P. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01003 · Cited by 89
Sudo, M., Sasahara, K., Moriya, T., Akiyama, M., Hamada, T., & Shibata, S. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00457-3 · Cited by 89
Liu, S., Cai, Y., Sothern, R. B., Guan, Y., & Chan, P. (2007) · Chronobiology International · doi:10.1080/07420520701672556 · Cited by 88
Filiano, A. N., Millender-Swain, T., Johnson, R., Young, M. E., Gamble, K. L., & Bailey, S. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071684 · Cited by 92
Differential Entrainment of Peripheral Clocks in the Rat by Glucocorticoid and Feeding
Sujino, M., Furukawa, K., Koinuma, S., Fujioka, A., Nagano, M., Iigo, M., & Shigeyoshi, Y. (2012) · Endocrinology · doi:10.1210/en.2011-1794 · Cited by 85
Molecular Connections Between Circadian Clocks and Aging
Welz, P.-S., & Benitah, S. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.036 · Cited by 90
Entrainment to Feeding but Not to Light: Circadian Phenotype of VPAC2Receptor-Null Mice
Sheward, W. J., Maywood, E. S., French, K. L., Horn, J. M., Hastings, M. H., Seckl, J. R., Holmes, M. C., & Harmar, A. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4843-06.2007 · Cited by 86
The circadian epigenome: how metabolism talks to chromatin remodeling
Aguilar‐Arnal, L., & Sassone‐Corsi, P. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.01.003 · Cited by 88
The functional significance of the skeletal muscle clock: lessons from Bmal1 knockout models
Schiaffino, S., Blaauw, B., & Dyar, K. A. (2016) · Skeletal Muscle · doi:10.1186/s13395-016-0107-5 · Cited by 92
Circadian clock and microarrays: mammalian genome gets rhythm
Delaunay, F., & Laudet, V. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02794-4 · Cited by 87
Nuclear Receptors, Metabolism, and the Circadian ClockPreprint
Yang, X., Lamia, K. A., & Evans, R. M. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.058 · Cited by 88
Wu, T., Sun, L., ZhuGe, F., Guo, X., Zhao, Z., Tang, R., Chen, Q., Chen, L., Kato, H., & Fu, Z. (2011) · Chronobiology International · doi:10.3109/07420528.2011.622599 · Cited by 86
Reznick, J., Preston, E., Wilks, D. L., Beale, S. M., Turner, N., & Cooney, G. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.08.010 · Cited by 86
Hirao, A., Nagahama, H., Tsuboi, T., Hirao, M., Tahara, Y., & Shibata, S. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00330.2010 · Cited by 86
Circadian redox oscillations and metabolism
Milev, N. B., & Reddy, A. B. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.05.012 · Cited by 89
Interaction of central and peripheral clocks in physiological regulation
Barclay, J. L., Tsang, A. H. K., & Oster, H. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00030-7 · Cited by 91
The mammalian circadian clock: a network of gene expression
Albrecht, U. (2004) · Frontiers in bioscience · doi:10.2741/1196 · Cited by 87
The Thymus Is Similar to the Testis in Its Pattern of Circadian Clock Gene Expression
Alvarez, J. D., & Sehgal, A. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730404274078 · Cited by 86
Rodent models to study the metabolic effects of shiftwork in humans
Opperhuizen, A., van Kerkhof, L. W. M., Proper, K. I., Rodenburg, W., & Kalsbeek, A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00050 · Cited by 85
Pastore, N., Vainshtein, A., Herz, N. J., Huynh, T., Brunetti, L., Klisch, T. J., Mutarelli, M., Annunziata, P., Kinouchi, K., Brunetti‐Pierri, N., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018101347 · Cited by 87
Circadian Influences of Diet on the Microbiome and Immunity
Zheng, D., Ratiner, K., & Elinav, E. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.04.005 · Cited by 88
Circadian Regulation of Adult Stem Cell Homeostasis and Aging
Benitah, S. A., & Welz, P.-S. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.05.002 · Cited by 81
Organization of cell and tissue circadian pacemakers: A comparison among species
Vansteensel, M. J., Michel, S. H., & Meijer, J. H. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.009 · Cited by 87
Ontogenetic Development of the Mammalian Circadian System
Weinert, D. (2005) · Chronobiology International · doi:10.1081/cbi-200053473 · Cited by 87
Takata, M., Burioka, N., Ohdo, S., Takane, H., Terazono, H., Miyata, M., Sako, T., Suyama, H., Fukuoka, Y., Tomita, K., et al. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.90.263 · Cited by 86
Carr, A. F., Johnston, J. D., Semikhodskii, A. G., Nolan, T., Cagampang, F. R. A., Stirland, J. A., & Loudon, A. S. I. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00619-5 · Cited by 85
Circadian Rhythms, Skeletal Muscle Molecular Clocks, and Exercise
Schroder, E. A., & Esser, K. A. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182a58a70 · Cited by 84
Borniger, J. C., Maurya, S. K., Periasamy, M., & Nelson, R. J. (2014) · Chronobiology International · doi:10.3109/07420528.2014.926911 · Cited by 92
Woller, A., Duez, H., Staels, B., & Lefranc, M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.060 · Cited by 89
Kord‐Varkaneh, H., Salehi‐Sahlabadi, A., Tinsley, G. M., Santos, H. O., & Hekmatdoost, A. (2022) · Nutrition · doi:10.1016/j.nut.2022.111847 · Cited by 89
Circadian Organization Is Governed by Extra-SCN Pacemakers
Pezük, P., Mohawk, J. A., Yoshikawa, T., Sellix, M. T., & Menaker, M. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410385204 · Cited by 84
The Big Breakfast Study: Chrono‐nutrition influence on energy expenditure and bodyweight
Ruddick-Collins, L. C., Johnston, J. D., Morgan, P. J., & Johnstone, A. M. (2018) · Nutrition Bulletin · doi:10.1111/nbu.12323 · Cited by 87
Marjot, T., Tomlinson, J., Hodson, L., & Ray, D. W. (2023) · Gut · doi:10.1136/gutjnl-2023-329998 · Cited by 91
Comparison of clock gene expression in SCN, retina, heart, and liver of mice
Peirson, S. N., Butler, J. N., Duffield, G. E., Takher, S., Sharma, P., & Foster, F. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.118 · Cited by 85
The circadian clock, metabolism and obesity
Albrecht, U. (2017) · Obesity Reviews · doi:10.1111/obr.12502 · Cited by 84
Lamont, E. W., Harbour, V. L., Barry-Shaw, J., Diaz, L. R., Robinson, B., Stewart, J., & Amir, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.027 · Cited by 82
Endocrine regulation of circadian physiology
Tsang, A. H. K., Astiz, M., Friedrichs, M., & Oster, H. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0051 · Cited by 86
Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease
Shetty, A., Hsu, J. W., Manka, P. P., & Syn, W. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5242-x · Cited by 85
Coupling the Circadian Clock to Homeostasis: The Role of Period in Timing Physiology
Kim, P., Oster, H., Lehnert, H., Schmid, S. M., Salamat, N., Barclay, J. L., Maronde, E., Inder, W. J., & Rawashdeh, O. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00049 · Cited by 87
Physiological function of PARbZip circadian clock‐controlled transcription factors
Gachon, F. (2007) · Annals of Medicine · doi:10.1080/07853890701491034 · Cited by 86
Polidarová, L., Sládek, M., Soták, M., Pácha, J., & Sumová, A. (2011) · Chronobiology International · doi:10.3109/07420528.2010.548615 · Cited by 82
Sharma, V. K. (2009) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192400903010110 · Cited by 82
Heath-Heckman, E., Peyer, S. M., Whistler, C. A., Apicella, M. A., Goldman, W. E., & McFall‐Ngai, M. (2013) · mBio · doi:10.1128/mbio.00167-13 · Cited by 86
The daily timing of gene expression and physiology in mammals
Schibler, U. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.3/uschibler · Cited by 83
Self-citationFong, M., Caterson, I. D., & Madigan, C. D. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517002550 · Cited by 82
Neurogenetic basis for circadian regulation of metabolism by the hypothalamusPreprint
Cedernaes, J., Waldeck, N. J., & Bass, J. T. (2019) · Genes & Development · doi:10.1101/gad.328633.119 · Cited by 89
López‐Olmeda, J. F., Tartaglione, E. V., de la Iglesia, H. O., & Sánchez‐Vázquez, F. J. (2010) · Chronobiology International · doi:10.3109/07420528.2010.501926 · Cited by 81
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Metadata
- Authors
- Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U.
- Affiliations
- University of Geneva (CH)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-12-01
- Volume
- 14
- Issue
- 23
- Pages
- 2950-2961
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC317100
- OpenAlex
- W2164628441
- Cited by
- 2,394
- References
- 62
- Citations by year
- 2026: 78 · 2025: 116 · 2024: 112 · 2023: 98 · 2022: 125 · 2021: 129 · 2020: 146 · 2019: 111 · 2018: 124 · 2017: 108 · 2016: 112 · 2015: 116 · 2014: 102 · 2013: 103 · 2012: 97
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Louis-Jeantet Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (47314)
- Bonizzi-Theler Stiftung
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- circadian clock, feed restriction, suprachiasmatic nucleus, peripheral circadian oscillators, phase resetting, circadian gene expression, photoperiod, liver, kidney, heart, pancreas
- MeSH terms
- Animals, Aryl Hydrocarbon Hydroxylases, Biological Clocks, Body Temperature, Circadian Rhythm, Cytochrome P-450 Enzyme System, DNA-Binding Proteins, Eye Proteins, Feeding Behavior, Flavoproteins, Food, Food Deprivation, Mixed Function Oxygenases, Kinetics, Liver, Neurons, Nuclear Proteins, Proteins, Suprachiasmatic Nucleus, Transcription Factors, Photoreceptor Cells, Invertebrate, Receptors, Cytoplasmic and Nuclear, Cell Cycle Proteins, Drosophila Proteins, Receptors, G-Protein-Coupled, Mice, Cryptochromes, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1, Cytochrome P-450 CYP2A6
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